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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 355 Documents
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Uji Efek Antiartritis Ekstrak Etanol 80% Kulit Buah Delima Merah (Punica granatum L) Terhadap Udem Pada Telapak Kaki Tikus Putih Jantan yang diinduksi oleh Complete Freund’s Adjuvant Sari, Rusmalita Pebriana; Amin, Juheini; Sari, Santi Purna
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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Abstract

Rheumatoid arthritis is a chronic inflammatory disease that can degrade the quality of patient survival. Conventional treatments of this disease have potentially dangerous side effects. Therefore, many patients are turning to alternative medicine using medicinal herbs, one of which is the fruit of Punica granatum L. The aim of this research was to determine antiarthritis effect of 80% ethanolic extract of Punica granatum L. fruit peel which had been given orally on 17-30th day based on decreased edema volume and percentage indexes of arthritis. The method was adjuvant induced arthritis by using the complete freund’s adjuvant 0,1 mL by subplantar and allowed to arthritis until day 16. The animals test were used 33 male rats of Sprague Dawley strain that were divided into six groups: normal control, positive control, negative control, and three groups had received suspension of 80% ethanolic extract of Punica granatum L. fruit peel in 0,5% CMC at doses 20, 40, and 80 mg/200 g body weight. The Edema volume was measured by pletismometer on days 17, 20, 23, 26, 29, 31 and indexes of arthritis determined on days 17 and 31. The Results showed that they were not significant difference in the decreased edema volume and the percentage indexes of arthritis, although the percentage inhibition of edema elevated with increasing dose.
Formulasi Tablet salut Teofilin Menggunakan Eksipien Koproses Pregelatinisasi pati Singkong- Metilselulosa sebagai bahan Penyalut Pradana, Rangga; Chaidir, Chaidir; Anwar, Effionora
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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Pregelatinized cassava star ch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient were characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis. Theophylline tablet that coated by PCS, MC, and co-processed PCSMC ratio (4:1) characterized and in vitro drug release were made in chloride medium of pH 1,2 and phosphate medium of pH 7,2. The characterization result of co-processed PCS-MC showed the improvement of functionality from PCS and synergism PCS with MC. Meanwhile, the result of in vitro drug release showed theophylline tablet that coated by MC 1%, co-processed PCS-MC (4:1) 4% and 2% could retard the drug release in both medium.
Pengaruh Ac-Di –Sol Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Sayekti, Indah
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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Orally Disintegrating Tablet (ODT) or Fast Release Tablet is solid dosage form which disintegrated rapidly in mouth and its residue easy to swallowed. This research observed the influence of Ac-Di-Sol concentration as disintegrant on physical characteristics and dissolution rate of piroxicam orally disintegrating tablet which were prepared by direct compression. Ac-Di-Sol was used in concentration of 1%, 3% and 5%, and 0% as control. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm and its hardness, friability, disintegration time and dissolution rate were examined. The results showed that the increasing of Ac-Di-Sol concentration would increase hardness, disintegration time, dissolution rate and decrease friability of the tablet. From statistical analysis (µ =0,05), it was showed that there was significant difference among formulas on the hardness, friability, disintegration time and dissolution rate. The hardness of piroxicam Orally Disintegrating Tablet of all formulas were between 0.99 - 2.77 kP, friability were between 3.45 – 1.35%, disintegration time were between 223.67 – 20,0 sec and drug released at 45 minutes were between 32.71 – 96.25%. From this research, it could be concluded that formula with 3% concentration of Ac- Di-Sol give the most desirable output, even though there was a problem with the friability.
Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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The polymorphismof amoxicillin has been identified after freeze drying process. The freeze dried amoxicillin have some specific physical properties different from their raw material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve from DSC thermogram changes to endothermal curve, diffractogram XRD changes to different profile, and the crystal shows different habit. All of data showed that freeze drying process improve amoxicillin to different crystal form which has higher melting oxidation point and lower hydrate. The improvement of the crystal structure might be impact to change physical-pharmaceutical properties like dissolution, absorption, and change it antibiotic potency.
Stabilitas Fisik dan Efektivitas Sediaan Tabir Surya Kombinasi Oksibenson dan Oktil Metoksisinamat dalam Basis Gel Carbomer 940 dengan Penambahan Asam Glikolat Rosita, Noorma; Purwanti, Tutiek; Agustin, Agustin
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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To fulfill the consumer expectation, cosmetic industries mostly add glycolic acid as whitening agent to the sunscreen preparation. The aim of this research was to know the effect of glycolic acid addition with the concentration of 8, 10, and 12% w/w on physical stability and effectiveness of sunscreen product containing oxybenzone and octyl methoxycinnamate (2: 7% w/w) in carbomer 940 gel. The physical stability test was done by observing physical appearance, pH, and spreading ability during 60 day storages on zone IV condition (temperature 30±0.5° and RH 70±2%). The efficacy was determinated base on SPF (Sun Protection Factor) value by spectrophotometer. The result of the physical stability test showed that glycolic acid addition affects the physical appearance (consistency) of sunscreen product, but pH and spreading ability are relatively stable. The efficacy test result showed that the addition of glycolic acid has an effect on SPF value of sunscreen product. Product which combined with glycolic acid showed a significant increase of SPF value, compared to control formula. The addition of glycolic acid increased SPF value and alter the effectiveness category from extra protection to maximal protection.
Efek Hepatoprotektif Infus Daun Sukun (Artocarpus altilis (Park) Fsb) Terhadap Kerusakan Hati Tikus yang Diinduksi dengan Karbon Tetraklorida K.J, Wahyu Atmaja; Sari, Santi Purna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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Breadfruit leaves (Artocarpus altilis (Park.) Fsb.) are used as traditional medicine in treatment of liver diseases. This study aimed to figure out the hepatoprotective effect of breadfruit leaves infusion in carbon tetrachloride-induced liver damage in male albino rats. The study used 25 male albino rats of Sprague-Dawley strain, which were divided randomly into five groups. Group I (normal control group) and group II (carbon tetrachloride-induced control group) only received 0,5% carboxymethylcellulose (CMC) solution. Group III-V received different dose of breadfruit leaves infusion for seven days respectively, which were 13,5 g/kgBW (dose 1), 27 g/kg BW (dose 2) and 54 g/kg BW (dose 3). On 7th day, all groups, excepted the normal group, were induced by 0,4 ml/kgBW dose of carbon tetrachloride perorally two hours after the last breadfruit leaves infusion given. Parameters of liver damage were estimated by measuring the activity of plasma alanine aminotransferase (ALT), the concentration of lipid peroxide in liver, and the concentration of lipid peroxide in plasma. The results of ANOVA (p<0,05) demonstrated that breadfruit leaves infusion at a dose of 54 g/kgBW (dose 3) consumed for seven days respectively before 0,4 ml/kgBW dose of carbon tetrachloride-induced had hepatoprotective effect estimated by the activity of plasma ALT and the concentration of lipid peroxide in liver.
Eksplorasi dan Karakterisasi berbagai Kristal Ibuprofen Yanuar, Arry; Nursanti, Nursanti; Anwar, Effionora
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofen have a bad flowability because a high cohesivity. Another problem in manufacturing is the high tendency for sticking to the punches. Besides these disadvantageous properties, ibuprofen indicates bad dissolution behavior because of its hydrophobic structure. To improve the properties of ibuprofen can be used crystallization method with using variation of solvents. In this experiment observed crystallization method by cooling, evaporation, and water presence, which used methanol, ethanol, and acetone solvents. Of all the crystallization results are produced white prism-shaped crystalline. The selected method is cooling method, which is characterized using Scanning Electron Microscopy (SEM), powder X-ray diffraction, and Differential Scanning Calorimetry (DSC). These three characterizations indicate transformation of crystal form which compared with ibuprofen’s standard. The selected method also produces non cohesive powder which have the size particle is 710-1180µm, compressibility index: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º, IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’s solubility. The result indicates that crystallization method is able to improve flowrate, compressibility index, and dissolution rate properties of ibuprofen’s standard.
Preparasi dan Karakterisasi Nanosuspensi dengan Polivinilpirolidon (PVP) Sebagai Pembawa Nanopartikel Senyawa Asam Mefenamat Iskandarsyah, Iskandarsyah; Mutakim, Alip
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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Several methods and technologies to increasing the solubility and dissolution rate of a drug substance has been successfully developed, such as forming of a complexing compound, salt preparation, adjusting the pH, making of solid dispersions, etc. One of the technologies that are being developed is nanoparticle technology. Micronization of drug that is processed to produce particles with nano-size. This research aims to create and characterize nanosuspension with Polyvinylpyrrolidone (PVP) as the vehicle of mefenamic acid nanoparticles using vibrating mill and ultrasound equipment. Nanosuspension obtained was characterized by optical microscope and PSA to perform optimization nanosuspension formed. The result of characterization showed that the nanosuspension have an average diameter is 623.9 nm. Then, nanosuspension of mefenamic acid was freeze drying. Nanosuspension and bulk of mefenamic acid were characterization by XRD and put in a hard capsule shell for dissolution test. Profile of dissolution test with tris buffer media indicates that nanosuspension of mefenamic acid has a pattern of drug release is slower and constant compared with the mefenamic acid. bulk.
Eksipien Koproses Pregelatinisasi Pati Singkong Metilselulosa sebagai Bahan Penyalut Tablet Pradana, Rangga; Anwar, Effionora; Chaidir, Chaidir
Majalah Ilmu Kefarmasian Vol. 7, No. 3
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Coating is one of the effective methods used in controlled release dosage form. Lots of variety in the form of a hydrophilic polymer excipient that is used to control the drug release many polymers that can be used for coating purposes, but only a few have been known to serve as a polymeric coating which functions to control the rate of drug release Pregelatinized cassava starch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis.
Analisis Formalin dalam Sampel Ikan dan Udang Segar dari Pasar Muara Angke Suryadi, Herman; Kurniadi, Maryati; Melanie, Yuanki
Majalah Ilmu Kefarmasian Vol. 7, No. 3
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The use of formalin as a food additive has been prohibited by the ministry of health as stipulated in The Indonesia Ministry of Health Regulations No.722/Menkes/Per/IV/88. However, in recent years the Indonesian authorities have found trace amounts of formalin as a preservative in perishable foods such as fish and shrimp. The aim of this research is to identify the use of formalin in fresh fish and shrimp samples sold in Muara Angke Market as the fresh seafood market in Jakarta. The first step of this research was formalin identification in fish and shrimp samples and continued by quantitative analysis to assure the results obtained. Qualitative determination of formalin was carried out by Schryver reagent and the quantitative determination was carried out pectrophotometrically using Nash reagent. Validation of UV-Vis spectrophotometric method for determination of formalin showed that Nash reagent was suitable to determine formalin. The limit of detection, limit of quantitation, and coefficient of variation for formalin were 0,0102 mg/L, 0,0341 mg/L, and 0,09%, respectively. Recovery of formalin in fish samples was 89,79-109,58% and shrimp samples was 82,11-97,76%. Qualitative determination in six fish samples and six shrimp samples showed negative results and the quantitative analysis confirmed that formalin was not found in the fresh fish and shrimp samples from Muara Angke Market.

Page 9 of 36 | Total Record : 355

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