cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Editor PSR
Contact Email
article@farmasi.ui.ac.id
Phone
+62-21-27608403
Journal Mail Official
psr@farmasi.ui.ac.id
Editorial Address
3rd Floor, A Building, Rumpun Ilmu Kesehatan Kampus Baru UI Depok, 16424, Indonesia
Location
Kota depok,
Jawa barat
INDONESIA
Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 355 Documents
 6   7   8   9   10 
Relevansi Peraturan Dalam Mendukung Praktek Profesi Apoteker Di Apotek Hartini, Yustina Sri
Majalah Ilmu Kefarmasian Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of pharmacy’s duty is being the place of pharmacist to serve patient profesionally. The fact, it was many report in mass media that pharmacist ‘s performance is not good enough. Many pharmacy regulation already issued, this review report and discuss pharmacy regulations related to pharmacy. Regulation that have issued by goverment about pharmacy ie: St. No.419 in 1949, Goverment regulations (PP) No.25 in 1980, Rule of Minister of Health (Permenkes) No.26 in 1981, Kepmenkes No. 278, 279 and 280 in 1981, Permenkes No.240 in 1990, Kepmenkes No.347 in 1990, Permenkes No.922 in 1993, Act (UU) No.5 in 1997, UU No.22 in 1997, PP No.72 in 1998, UU No.8 in 1999, Kepmenkes No.1332 in 2002, UU No.29 in 2004, Kepmenkes No.1027 in 2004, and Permenkes No.384 in 2007. Pharmacy regulations are enouh and relevance to support pharmacist practice, commitment to adhere the regulations and enforcement its implementation still required.
Vaksin Kanker Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cancer vaccines are medicines that work by stimulating or restoring the immune system’s ability to fight cancers and disease. There are two types of cancer vaccines, prophylactic cancer vaccines, which are intended to prevent cancer from developing in healthy people, and treatment cancer vaccines, which are intended to treat already existing cancers by strengthening the body’s natural defenses against cancer. This article discusses about cancer vaccines including the role of microbes that are respon-sible of human tumor, the mode of action of cancer vaccines and the efficacy of human papillomavirus (HPV) vaccines in preventing various benign and malignant condi-tions, including cervical cancers caused by HPV.
Amobilisasi Sel Lactobacillus Acidophilus FNCC116 Untuk Demineralisasi Limbah Kulit Udang Dalam Pengolahan Kitin Betha, Ofa Suzanti; Setyahadi, Siswa; Suryadi, Herman
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Chitin, a homopolimer, is the most abundant renewable natural resources after cellulose. Chitin and its derivatives hold many applications in agriculture, textile, pharmacy and medic. Chitin that extracted from waste shrimp shells by biological fermentation has better quality than chemical procees. Demineralization of chitin by biological procees use lactic acid as product of fermentation. Deproteinization of chitin use proteolytic activity of enzyme that produce by bacteria in fermentation. Lacto-bacillus acidophilus FNCC116 has been immobilized by entrapment methods and 2% sodium alginate in 0,2 M CaCl2 as the matric . The ability of immobilized Lacto-bacillus acidophilus FNCC116 cell in fermentation was tested. The fermentation that was carried out in medium which consist of 6% glukosa, 1,5% yeast extract, 0,003% MnSO4 0,003% FeSO4.7H2O, 0,02% MgSO4.7H2O and has been producted 2,24% lactic acid. Demineralization of waste shrimp shell with 30% immobilized Lactobacillus acidophilus FNCC116 cell has successfully decreased ash content tol 1,18% and produced lactic acid maximum 2.24%. Immobilization of Lactobacillus acidophilus FNCC116 cell promised an efficient method in bioproceesing of chitin recovery.
Aplikasi Ko-Kemoterapi Fraksi Etil Asetat Ekstrak Etanolik Daun Sambung Nyawa (Gynura procumbens (Lour.) Merr.) Pada Sel Kanker Payudara MCF-7 Jenie, Riris Istighfari; Meiyanto, Edy
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Combination chemotherapy has been an interesting attention in recent years to cure cancer e.g. non-toxic or less toxic phytochemicals are being combined with chemo-therapeutic agents to sensitize cancer cell and to enhance the efficacy of chemothera-peutic agents as well as to reduce its toxicity to normal tissues. The aim of this research is to examine whether ethyl acetate fraction of Gynura procumbens ethanolic extract (SEF) synergizes the therapeutic potential of doxorubicin (Dox) on breast cancer cell line MCF-7. MTT assay were used to measure the growth inhibitory effect of the combination therapy on MCF-7 cells. SEF (5-250 µg/ml) treatment of cell resulted in 15-76% growth inhibition in a dose dependent manner (IC50 85 µg/ml), while Dox (10-100 nM) treatment did not show any inhibitory effect. The combina-tions of SEF (5-40µg/ml) with Dox (10-75 nM) seemed to not have any synergistic efficacy towards cell growth inhibition. Nevertheless, this result need further observa-tion regarding the IC50 of Dox on MCF-7 has not been determined yet. The cell characterization may influence the result. Doxorubicin could induce Akt survival apoptosis pathway in MCF-7 resulting resistancy of the cell towards doxorubicin.
Studi Penggunaan Antibiotika Pada Penderita Rawat Inap Pneumonia (Penelitian Di Sub Departemen Anak Rumkital Dr. Ramelan Surabaya) Suharjono, Suharjono; T, Yuniati; Sumarno, Sumarno; SJ, Semedi
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pneumonia is an infectious disease that was caused inflammation of acute parenchy-mal compression of the lungs and bacterial exudate from lung tissue on the main from Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumonia, Mycobacterium tuberculosis. Selection of appropriate antibiotic therapy and rational will determine the treatment to avoid the occurrence of bacterial resistance. In addition it is also possible the use of other drugs that can increase the chances of Drug Related Problems (DRP). Pattern of antibiotic use in Rumkital Dr. Ramelan Surabaya has never been done. Studying the pattern use of antibiotics in hospitalized patients with pneumonia in the Sub Department of Pedi-atric Rumkital Dr. Ramelan and related the dose, other therapies, as well as identify the DRP. This research is a method descriptive survey research in the form of a retrospective and descriptive study. Materials research is the Medical Records pa-tients hospitalized with the final diagnosis of pneumonia, starting January 1, 2004 until April 30, 2006 that meet inclusion criteria. Of the study population who account for 50 found 41 patients who fulfilled the inclusion criteria. Antibiotics single most widely accepted patients without comorbidities were ampicillin iv 26.92% (14 patients) and iv sefotaksim 21.15% (11 patients), while the antibiotic combina-tion widely accepted patients is ampicillin iv / po + kloksasilin iv / po 13.46% (7 patients) and kloksasilin iv + ceftriaxone iv 5.77% (3 patients) and the rest other antibiotic combinations. DRP study found 56.9% patients received appropriate anti-biotic dose literature and 43.1% patients receiving doses underdose. Use of antibiotics above is already in ccordance with reference and other therapies. Single antibiotic or combination of 2 antibiotics penicillin and cephalosporin classes often used to treat pneumonia.
Validasi Metode Analisis Rebamipid Dalam Plasma In Vitro Secara Kromatografi Cair Kinerja Tinggi-Ultraviolet Harahap, Yahdiana; Alia, Nu
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Rebamipide is antiulcer agent and it is one of the drug that have to be evaluated with bioequivalency test according to Food and Drug Administration (FDA). The objec-tive of this research is to find out the optimum condition of rebamipide in human plasma in vitro analysis by High Performance Liquid Chromatography (HPLC) with ultraviolet detector, and then the method was validated. The chromatography was carried out by isocratic technique on a reversed-phase Kromasil® C18 (5 µm, Akzo Nobel), column length was 250 x 4.6 mm, with mobile phase consisted of acetonitrile - phosphate buffer pH 3.0 (40:60) at flow rate of 1.0 ml/min, and detection was performed at wavelength of 230 nm. The sample preparation technique was liquid-liquid extraction by phosphoric acid and ethyl acetate. Carbamazepine was used as the internal standard. The method was valid according to FDA in Bioanalitycal Method Validation, with coefficient correlation of 0.9993 and linear in the range concentra-tion of 0.04 – 1.2 µg/ml, the lower limit of quantitation was 42.0 ng/ml, precision less than 6% and recovery percentage was 90.32 to 113.45%. Rebamipide in plasma was stable for 14 days storage in -200C.
Penelitian Antiimplantasi Ekstrak Etanol Daging Buah Burahol (Stelechocarpus burahol Hook F. & Thomson) Pada Tikus Putih Sunardi, Clara; Sumiwi, Sri Adi; Hertati, Ai
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

We examined antiimplantation effect of ethanol extract from ripening burahol flesh (Stelechocarpus burahol Hook f. & Thomson) using doses 1g and 0.5g per Kg Body Weight (BW) on White Female Rats Wistar Strain. The ethanol extract was given orally on daily basis from diestrus phase until 7th day of pregnancy. Two parameter used in this investigation were number of implants and number of born fetus. The fetus were examined by observing their morphology to identify the existence of teratogenic effect. The result showed that the two doses reduced both the number of implants and born fetus significantly. In addition, the burahol flesh as an antifertility agent has two functions: as antiimplantation and abortifacient. Lastly morphological examination on the fetus did not show any teratogenic effect.
Pengaruh Avicel PH 102 Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam Dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Ningtyas, Zimy Fianti
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolution rate of piroxicam Orally Disintegrating Tablet prepared by direct compression method was observed in this research. Concentration of Avicel PH 102 used were 5%, 10%, 15% and 0% as a control. Physical characteristics of the powder blend including flow rate and angle of repose showed good attributes. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. The physical characteristic of piroxicam orally disintegrating tablet including hardness, friability, disintegration time, and dissolution rate were examined. The hardness of all formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%, disintegration time were between 223,67– 18,33 sec and drug released at 45 minutes were between 32,71%– 88,63%. The results showed that increasing the concentration of Avicel PH 102 would increase the hardness, and dissolution rate and decrease the friability and disintegration time of piroxicam orally disintegrating tablet . From statistical analysis (µ = 0,05), it could be seen that there was significant difference in physical characteristics and dissolution rate of all formulas. Among all formulas, it could be concluded that formula with 10% concentration of Avicel PH 102 was the optimum formula
Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Aktivitas Antioksidan dan Penetapan Kadar Fenol Total Ekstrak Metanol Dedak Bebeapa Varietas padi (Oryza sativa L.) Sugiat, Dede; Hanani, Endang; Mun’im, Abdul
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antioxidant has been known to have an important role in the prevention and treatment of diseases. In recent years, many plants have been explored to obtain new antioxidants from natural products. Rice has been known rich in antioxidative compounds. However, there is little attention to the co- or by- products from rice (Oryza sativa) milling plant. One of the products is rice bran. In this study ten varieties of rice bran, which are commonly cultivated varieties in Indonesia were studied their antioxidant activity and total phenolic content. The antioxidant activity was examined by DPPH scavenging assay and total reducing power, while total phenolic content was determined by Folin-Ciocalteu reagent. The results of this study showed that the methanolic extract of IR-64 variety demonstrated the strongest DPPH radical scavenger activity with IC50 350.64 ppm, while in reducing power activity was exhibited by methanolic extract of IR-42 variety. However, the highest total phenolic content (71.85 mg gallic acid equivalent/gram) was found in methanolic extract of OM-4495 rice bran. These result indicated that the methanolic extract of rice bran might potentially be natural antioxidants.

Page 8 of 36 | Total Record : 355

 6   7   8   9   10 

Filter by Year

2004 2025


Reset
Filter By Issues
All Issue Vol. 12, No. 2 Vol. 12, No. 1 Vol. 11, No. 3 Vol. 11, No. 2 Vol. 11, No. 1 Vol. 10, No. 3 Vol. 10, No. 2 Vol. 10, No. 1 Vol. 7, No. 4 Vol. 9, No. 3 Vol. 9, No. 2 Vol. 9, No. 1 Vol. 8, No. 3 Vol. 8, No. 2 Vol. 8, No. 1 Vol. 7, No. 3 Vol. 7, No. 2 Vol. 7, No. 1 Vol. 6, No. 3 Vol. 6, No. 2 Vol. 6, No. 1 Vol. 5, No. 3 Vol. 5, No. 2 Vol. 5, No. 1 Vol. 4, No. 3 Vol. 4, No. 2 Vol. 4, No. 1 Vol. 3, No. 3 Vol. 3, No. 2 Vol. 3, No. 1 Vol. 2, No. 3 Vol. 2, No. 2 Vol. 2, No. 1 Vol. 1, No. 3 Vol. 1, No. 2 Vol. 1, No. 1 More Issue