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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO Muhammad Ilyas Y; Muhammad Syaiful Saehu; Ertin Ertin; Irma Irma; Nurhikma Nurhikma
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6107

Abstract

Galing plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such as antidiabetic, immunomodulatory, antibacterial, anti-fungal, anti-diarrhea, gout. This study aims to determine the antiinflammatory effect of several fractions of rod galing using the in vitro model of red blood cell membrane stabilization. This study used an ethanol extract fractionated in a liquid-liquid manner with n-hexane, ethyl acetate, and water as a solvent. Then, the anti-inflammatory effect of each fraction was tested, with a positive control comparison of diclofenac sodium with varying concentrations. Measurement of anti-inflammatory activity was calculated based on the % stability of the red blood cell membrane. The results showed that the ethyl acetate, n-hexane and water fractions from the ethanol extract of galing (Cayratia trifolia L. Domin.) stem had an anti-inflammatory effect based on the % stability of red blood cell membranes, where the ethyl acetate fraction with a concentration of 1000 ppm had the best anti-inflammatory effect with % stability of red blood cell membranes was 91.81%, which was significantly different from the positive control (p<0.05).
CYTOTOXIC ACTIVITY OF KASUMBA FLOWER ETHANOL EXTRACT TURATE (Carthamus tinctorius Linn.) AGAINST THE LINE OF CANCER CELLS T47D BREASTS Fadhliyah Malik; Muhammad Hajrul Malaka; Adryan Fristiohady; Wahyuni Wahyuni; Rini Hamsid; Sahidin Sahidin; Annisa Fatinah Gani
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6113

Abstract

Breast cancer is a type of cancer with a high prevalence in the world and causes death in women. Chemotherapy is one type of treatment that is widely used. However, the problems of chemotherapy drugs such as side effects, drug resistance and inadequate efficacy. So, to overcome these problems, many natural ingredients have been explored to find anticancer agents that are expected to have good efficacy with minor side effects. Kasumba turate flowers (Carthamus tinctorius Linn.) is a plant from the Asteraceae tribe which is known to contain secondary metabolites with pharmacological activity as anticancer. This study aims to determine the types of secondary metabolites and the cytotoxic activity of the ethanolic extract of Kasumba turate flower against the T47D breast cancer cell line using the MTT assay method. Kasumba turate flower extract was obtained by maceration using 96% ethanol solvent, so that a concentrated extract with a weight of 107.8 grams was obtained with a yield value of 10.81%. The extract obtained was then subjected to a phytochemical screening test using the tube method and the results are alkaloids, flavonoids, tannins, and terpenoids. In the cytotoxic activity test, the test samples were varied into 7 concentration series, namely 10, 50, 100, 200, 400, 800 and 1000 ppm. The positive control used was 5-Fu. Cytotoxic parameter (IC50 value) was determined using GraphPad Prism and obtained IC50 5-Fu value of 65.88 ppm with active category while IC50 of the test sample was 157.3 with moderately active category as anticancer breast.
APPLICATION D-OPTIMAL METHOD ON THE OPTIMIZATION OF FORMULATION OF KINTAMANI ARABICA COFFEE GEL (Coffea arabica L.) Hendra Wijaya; I Putu Rizki Karisma Parta Wiratama; Pande Ketut Pramita Desna Putri; Kadek Sutri Ariyanthini; Elisabeth Angelina; Ni Kadek Devi Pradnya Andina; Putu Saradevi Naripradnya; Eka Indra Setyawan
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.6115

Abstract

Arabica coffee (Coffea arabica L.) kintamani is a superior agricultural product from Bali. Arabica coffee (Coffea arabica L.) contains many compounds, one of which is caffeine which is beneficial for health and beauty. This study aims to formulate kintamani arabica coffee beans into a gel dosage form. The optimization formula of kintamani arabica coffee bean gel was made using the D-Optimal method using a combination of HPMC and propylene glycol as observation variables and spreadability, pH, and viscosity of the gel preparation as experimental responses. The study of caffeine from the gel preparation was carried out using a Franz diffusion cell. Caffeine content in the gel preparation and its release are determined by spectrophotometric method. The results showed that the amount of HPMC used would increase the viscosity value (+14113.92) and decrease the spreadability (-0.29) and pH (-6.59167E-003) of the gel. The greater the amount of propylene glycol used will decrease the viscosity value (-2484.54) and increase the spreadability value (+0.30) and pH (+0.31802) of the gel. The conclusion of this study is the use of a combination of HPMC and propylene glycol (6%:17%) resulted in the optimum formula with a viscosity value of 44,070 cps, a spreadability value of 3.6 cm, and a pH value of 5.32. The caffeine content obtained in the gel preparation was 188.47 g and the amount of caffeine released from the gel preparation for 6 hours of testing was 4.95%.
ETLINGERA GENUS: PHYTOCHEMICAL SCREENING AND ANTICANCER ACTIVITY Wahyuni Wahyuni; Ajeng Diantini; Mohammad Ghozali; Sahidin Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6120

Abstract

Etlingera is one of the plant genera from the Zingiberaceae family and is widely distributed in Asia to the Pacific Islands, with various species ranging from 150 to 200 species. The Etlingera are commonly used as spices, vegetables, and traditional medicines. Many pharmacological activities have been reported from this genus, including antioxidants, antibacterials, cholesterol-lowering, anticancer, and others. The phytochemical content of Etlingera reported are phenolics, diarylheptanoids, flavonoids, steroids, alkaloids, and terpenoids. Eight species from Etlingera, namely Etlingera elatior, E. pavieana, E. brevilabrum, E. pyramidosphaera, E. megalocheilos, E. coccinea, E. fimbriobracteata, and E. corneri are reported provided anticancer activity. This review article aims to review the phytochemical screening from Etlingera genus, and its anticancer activity.
CYTOTOXIC ACTIVITY OF ETHANOL EXTRACT Petrosia sp. IN VITRO AGAINST CANCER CELLS HeLa Mentarry Bafadal; Wa Ode Mutiara; Muhammad Hajrul Malaka; Adryan Fristiohady; Agung W. M. Yodha; Baru Sadarun; Sahidin Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6121

Abstract

Cervical cancer is one of the highest causes of death in Indonesian women caused by mutations of normal cervical cells turning into abnormal cells. Treatment of cervical cancer causes significant side effects with a relatively long treatment period, so many researchers are exploring various natural ingredients from marine ecosystems as candidates for anticancer drugs. One of them is the sea sponge Petrosia sp. containing various secondary metabolites, one of which is an alkaloid that has a cytotoxic effect on cancer cell lines. This study aims to determine the cytotoxic activity of the ethanol extract of Petrosia sp. in HeLa cervical cancer cells. The ethanol extract of Petrosia sp. obtained by maceration using 96% ethanol and obtained extract as much as 55.9 g and yield value of 2.94%. Cytotoxic activity test was carried out in vitro using the Presto Blue method with varying concentrations of ethanol extract 7.81 ppm; 15.62 ppm; 31.25 ppm; 62.5 ppm; 125 ppm; 250 ppm; 500 ppm; and 1000 ppm. The cytotoxic parameter used was IC50 which was determined using the GraphPad Prism software version 5. The IC50 value of the marine sponge extract Petrosia sp. of 97.20 ppm or 97.20 g/ml with an active category as cervical anticancer. Cervical cancer is one of the highest causes of death in Indonesian women caused by mutations of normal cervical cells turning into abnormal cells. Treatment of cervical cancer causes significant side effects with a relatively long treatment period, so many researchers are exploring various natural ingredients from marine ecosystems as candidates for anticancer drugs. One of them is the sea sponge Petrosia sp. containing various secondary metabolites, one of which is an alkaloid that has a cytotoxic effect on cancer cell lines. This study aims to determine the cytotoxic activity of the ethanol extract of Petrosia sp. in HeLa cervical cancer cells. The ethanol extract of Petrosia sp. obtained by maceration using 96% ethanol and obtained extract as much as 55.9 g and yield value of 2.94%. Cytotoxic activity test was carried out in vitro using the Presto Blue method with varying concentrations of ethanol extract 7.81 ppm; 15.62 ppm; 31.25 ppm; 62.5 ppm; 125 ppm; 250 ppm; 500 ppm; and 1000 ppm. The cytotoxic parameter used was IC50 which was determined using the GraphPad Prism software version 5. The IC50 value of the marine sponge extract Petrosia sp. of 97.20 ppm or 97.20 g/ml with an active category as cervical anticancer.
IN VITRO CYTOTOXICITY ASSAY OF Petrosia sp. ETHANOL EXTRACT BY USING MTT METHOD OF T47D BREAST CANCER CELL LINE Asniar Pascayantri; Mini Bekti Ningsih; Baru Sadarun; Muhammad Hajrul Malaka; Adryan Fristiohady; Fadhliyah Malik; I Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6128

Abstract

Breast cancer is increasing as the constraints of side effects, drug-resistant, and high medical costs. Indonesia has a variety of marine biotas that can be explored. The sponge is one of the marines biotas that had potential candidates for anticancer compounds. The secondary metabolites of sponge such as steroids, alkaloids, polyketides, terpenoids, and polyacetylenes have pharmacology effects as anti-inflammation, antineoplastic and cytotoxic activity. The study is aimed to determine the secondary metabolite of Petrosian sp. ethanol extract and the cytotoxic activity at the T47D cell line of breast cancer. The ethanol extract of Petrosian sp. is obtained by maceration using 96% ethanol as a solvent. Extract weight is obtained 274.7 grams with a 2.94% yield of values. Cytotoxicity assay was using MTT methods with IC50 parameters by using software GraphPad prism version 5. Secondary metabolites of Petrosian sp. ethanol extract showing alkaloids, flavonoids, steroids, tannins, and saponins. The possible compound that showed anticancer activity is spinasterol. Cytotoxicity activities of Petrosian sp. ethanol extracts showing IC50 values at 78.13 ppm and IC50 values at 65.88 ppm on positive control. These results proved cytotoxicity activities had moderate cytotoxicity.
COVID-19 PANDEMIC'S IMPACT ON THE DRUG MANAGEMENT AND DRUG AVAILABILITY AT PUUWATU HEALTH CENTER, KENDARI CITY Sabarudin Sabarudin; Sunandar Ihsan; Henny Kasmawati; Rifa’atul Mahmudah; Eka Pebriana
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6129

Abstract

The impact of Corona Virus Disease-19 or COVID-19 pandemic was seen almost all aspects, especially in health facilities. Puskesmas as known as Public Health Center is a primary health service facility that usually became the first choice for seeking treatment so that Puskesmas can be said to be the backbone in facing and fighting the COVID-19 outbreak. This study aimed to determine the impact of the Covid-19 pandemic on drug management and the level of drug availability at Puuwatu Public Health Center, Kendari City. This study was descriptive-evaluative research with quantitative and qualitative methods and retrospective data collection in 2019 (before the pandemic) and 2020 (during the pandemic). Based on the results of the study, the percentage of the suitability of items with National Formulary increased by 1.3% during the pandemic, the percentage of the empty stock increased by 9.8%, the percentage value of damaged and expired items increased by 1.73%, the percentage of less stock decreased by 6, 43%, the percentage of safe stock and excess stock items decreased by 2.36% and 1.06%, respectively. The percentage value of suitability of the physical number of items did not change both in 2019 and in 2020 at the Puuwatu Health Center, Kendari City
POTENTIAL TEST OF GREEN BETEL (PIPER BETLE L.) LEAF EXTRACT CREAM IN COMBINATION WITH BASIL LEAF EXTRACT (OCIMUMSANCTUM L.) AS ANTI-ACNE Ummu Kalsum; Nurfiddin Farid; Nurul Inayah; Muhammad Arman
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6137

Abstract

Acne problem is the most common problem that many people fight for. Even though is not a dangerous thing, but that problem will make the sufferer feel unconfident. Acne vulgaris is an inflammatory disorder with blockage and accumulation of the Keratin materials that caused by Propionibacterium acnes bacteria. Now on, Herbal plant is the most selected one as an acne treatment because of the lack effect for the sufferer than a medical treatment. The plants are Basil (Ocimum sanctum L.) and green Lemongrass (Piper Betle L.). Both of them have a Saponin and Flavonoid as an antimicroba. Therefore, in this research will combine that two of the plants which is then formulated in to the cream form. The cream formulation made with 3 different concentration variances were 15%, 30% dan 45%. The type of the research is an in vitro of experimental research method. Where the cream formula making process done by manually and to measure that inhibition to Propionibacterium acnes bacteria. That in the concentration of 15% has an inhibition 20.02 mm, the concentration of 30% was 21.24 mm and the concentration of 45% was 25.05 mm. Inhibition zone > 20 mm categorized as very strong inhibition. So that, could be conclude the cream Basil Leaf Extract (Ocimum sanctum L.) in combination with Green Betle Leaf Extract (Piper Betle L.) had a potential and most effective concentration as an anti-acne was the third formulation (45% concentration) with an inhibition was 25.5 mm and categorized as a very strong inhibition to Propionibacterium acnes.
ANTIHYPERGLYCEMIC ACTIVITY TEST OF TEAK LEAVES (Tectona grandis L.) ETHANOL EXTRACT IN STREPTOZOTOCIN-INDUCED RATS Nuralifah Nuralifah; Parawansah Parawansah; Nurul Febrina Rahmawati
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6142

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. This study aimed to determine the antihyperglycemic activity of ethanol extract of teak (Tectona grandis L.) leaves in streptozotocin-induced rats. A total of 24 rats were grouped into 6 groups, normal control (Kn), positive control (K+), negative control (K-), and the three groups of teak leaf ethanol extract doses of 100, 200, and 300 mg/kg BW (K1, K2, respectively). and K3), mice were treated for 7 days. Before being given treatment, the rats were first induced using streptozotocin at a dose of 40 mg/kg BW. The results showed the administration of ethanol extract of teak (Tectona grandis L) leaves. doses of 100, 200, and 300 mg/kg BW with the positive control (K+) had significant antihyperglycemic activity in male Wistar strain rats based on the Oneway ANOVA test and post hoc LSD test.
CASE STUDY OF POSITIVE CONFIRMED MALARIA IN SOUTHEAST SULAWESI BASED ON EPIDEMIOLOGICAL VARIABLES Irma Irma; Yusuf Sabilu
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6143

Abstract

Malaria is one of the most common mosquito-borne infectious diseases in the world. Globally, deaths due to malaria infection reported in 2019 amounted to 405,000 deaths with a total number of sufferers of around 228 million cases. Although malaria cases have continued to decline in the last five years, including in Southeast Sulawesi Province, there are still regencies/cities in Southeast Sulawesi that have not been free from malaria. Therefore, this disease continues to be a burden of pain. This study aims to describe malaria cases in Southeast Sulawesi during the period from 2016 to 2020 based on epidemiological variables, namely people, place and time. The results showed that in general malaria cases from 2016 to 2020 showed a significant decline, based on place it can be seen that the Muna district was the area with the highest prevalence of malaria throughout the year of observation and North Konawe District as the area with the lowest malaria prevalence. From the people variable, the majority (67%) of malaria cases were men and only 33% were women. Meanwhile, based on the time in five years of observation, the highest malaria prevalence occurred in 2016 and the lowest was in 2020. Malaria prevention and control programs need to be carried out strictly to support the achievement of malaria elimination in all districts and cities in Southeast Sulawesi.

Page 15 of 26 | Total Record : 259

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