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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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SIMULTANEOUS CONTENT ANALYSIS OF RIFAMPICIN, ISONIAZID, AND PYRAZINAMIDE IN TABLET DOSAGE FORM BY SPECTROPHOTOMETRY ULTRAVIOLET WITH DWM AND RSM Luthvia Luthvia; Muhammad Andry
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.6241

Abstract

Treatment of active tuberculosis requires the use of combinations of drugs. One of the common combination of drugs to serve as anti-tubercular medication is rifampin, isoniazid and pyrazinamide. However, a research conducted by the Food Drug Administration (FDA) concluded that the combination of anti-tubercular medication may pose some patients to the risk of sub-optimal drug exposure, which may lead to less optimal treatment. This study aimed to determine the drug level of combination of anti-tubercular medication, namely rifampin, isomiazid, and pyrazinamide and to develop a spectrophotometric method using the dual wavelength method (DWM) and ratio substaction method (RSM) in tablet preparations on the market without separation. During the preparation, methanol was used as the solvent, followed by dilution, determination of calibration curve, determination of wavelength (λ), measurement, data analysis and validity test with several parameters ranging from linearity, accuracy, precision, LOD, and LOQ. The research revealed that the drug levels of rifampin, isoniazid, and pyrazinamide from the ultraviolet spectrophotometric method using sequential DWM were 100.3±1.8785; 99.98±2.5943; 100.03±2.076 and the results of the ultraviolet spectrophotometric method using RSM sequentially were 99.73±0.5437; 99.84±1.7598; 99.91±1.4762. Both methods succeeded in determining the drug level of the combination of rifampin, isoniazid, and pyrazinamide in tablet preparations without separation and the results of the validation parameters met the requirements.
VALIDATION OF SPECTROPHOTOMETRIC METHOD TO QUANTIFY QUERCETIN IN THE IN VITRO DISSOLUTION STUDY OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) Wildan Khairi Muhtadi; Ferdy Firmansyah; Tiara Tri Agustini; Pricillia Rahayu; Siti Arifah Fitriyanti; Rodhia Ulfa
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.6258

Abstract

Quercetin possesses low solubility and decreases oral bioavailability. One way to increase the bioavailability of quercetin is by formulating a self-nanoemulsifying drug delivery system (SNEDDS). In vitro dissolution testing of SNEDDS needs to be carried out using a validated analytical method. This study aims to validate the quercetin analytical method in in vitro dissolution testing. Validation was carried out with two solvents, namely hydrochloric acid buffer pH 1.2 (HCl-1,2) and phosphate buffer pH 6.8 (PO-6.8). It tested some parameters, including linearity, detection limit (LoD), quantification limit (LoQ), accuracy, and precision. The quercetin calibration curve for both solvents has a value of r≥0.999. The LoD at HCl-1,2 and PO-6,8 were 0.26 ppm and 0.27 ppm, respectively. The LoQ of HCl-1,2 and PO-6,8 were 0.86 ppm and 0.91 ppm, respectively. The percentage recovery in both solvents was in the range of 80-110%. The relative standard deviation of the two solvents was less than 7.3%. The quercetin analytical method has been successfully validated as indicated by the results of linearity, detection limit, quantification limit, accuracy, and precision that met the requirements
SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923 Nanik Sulistyani; Zikri Almahdi; Zainab -; Alfian Syarifuddin
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.6268

Abstract

Aloe vera leaf (Aloe vera L.) and cherry leaf (Muntingia calabura L.) contain bioactive compounds that serve as the potential antibacterial agent. The combination treatment of multiple extracts can produce a stronger effect than a single compound. This study aims to determine the synergistic combination of aloe vera leaf extract (EDLB) and cherry leaf extract (EDK) as an antibacterial agent against Staphylococcus aureus ATCC 25923. The extract was obtained by maceration using 96% ethanol. Chemical content in the extract was analyzed by tube test and thin layer chromatography (TLC). Antibacterial activity against S. aureus ATCC 25923 was measured by the checkerboard microdilution method on a 96 well microplate. The effect of the combination of extracts on antibacterial activity was based on the fractional inhibitory concentration index (FICI) value. EDLB and EDK contain flavonoids, tannins, alkaloids, and saponins. The second combination showed a synergistic effect with a FICI value of 0.5 in inhibiting the growth of S. aureus with minimal inhibitory levels in a mixture of 0.625 mg/mL EDLB and 2.5 mg/mL EDK.
FORECASTING DRUG DEMAND USING THE SINGLE MOVING AVERAGE 3 PERIODE AT UGM ACADEMIC HOSPITAL Ade Puspitasari; Satibi Satibi; Endang Yuniarti; Taufiqurohman Taufiqurohman
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.7130

Abstract

Drug management at the Academic Hospital of Gadjah Mada University found that the damaged and expired drugs amounted to 4.71% and the dead stock was 7.89%. One of the influential factors to contribute to the considerable amount of damaged and expired drugs and dead stock is inaccurate planning. Forecasting is one aspect of planning, which helps predict the upcoming event as a way to make planning more effective and efficient. One of the forecasting methods is the 3-period Single Moving Average (SMA). This study aims to forecast drug demand in January 2021 at the Academic Hospital of Gadjah Mada and to see the size of the error using the 3-period SMA method. This is an observational study with the retrsospective descriptive analysis. The research population is all drugs used at the Academic Hospital of Gadjah Mada in January 2018-December 2020. The samples are the top 5 most used drugs based on A category resulted from the ABC analysis of consumption in 2020 with certain criteria using purposive sampling technique. The drug demand was forecasted using Eviews 12 software and its error size, particularly the Mean Absolute Percentage Error (MAPE) was calculated using Microsoft Excel. The results showed that the forecast of drug demand in January 2021 was Tutofusin Ops 500ml 496pcs, Hemapo 2000 IU/ml 290pcs, Hemapo 3000 IU/ml 219pcs, Abilify Discmelt 10mg 717pcs, and Otsu-NS Piggyback 3736pcs. The calculated MAPE value was 8-32%, which means that the 3 period SMA forecasting is acceptable and reasonable for further application at the Academic Hospital of Gadjah Mada
STANDARDIZATION OF SECONDARY METABOLITES AND HEAVY METAL CONTAMINATION ASSAY ON ONCHIDIID SLUG (ONCHIDIUM TYPHAE) WEST KALIMANTAN WATERS Bambang Wijianto; Annisa Larasati Nurhidayah; Sri Luliana
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.7296

Abstract

Onchidiid slug or Onchidium typhae is a marine animal commonly found in West Kalimantan waters. This gastropod is commonly used as medicine and cosmetic by the locals. This research aims to assure the content and quality of O. typhae methanol extract by determining its secondary metabolites and heavy metal contamination. Phytochemical screening of alkaloid, steroid/ triterpenoid, flavonoid, tannin, and saponin are done using reagent tests. Chromatography profile was completed using silica gel G60 F254 plate and hexane: ethyl acetate: methanol as mobile phase. Heavy metal contamination analysis was performed using atomic absorption spectrophotometry to determine Hg, As, Cd, and Pb content. The phytochemical screening and chromatography profile of O. typhae methanol extract confirm the presence of alkaloids and steroids. Heavy metal analysis stated Hg, As, Cd, and Pb content in O. typhae are < 0,0008; < 0,001; < 0,001; and 0,05 ppm respectively. Since heavy metal levels are below the maximum contamination limit, it qualifies as a natural product ingredient.
DETERMINATION OF ANTHOCYANIN LEVEL IN KIDNEY BEAN (Phaseolus vulgaris L.) TEMPEH AS A HEPATOPROTECTIVE AGENT Devina Ingrid Anggraini; Listiya Pramesti Mirantana
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.3702

Abstract

Liver is a part of body that is used as a toxin neutralizer as well as a target for increasing free radicals. In counteracting free radicals, body needs antioxidants in one of the plant secondary metabolites, namely anthocyanins. Anthocyanins are organic compounds from the water-soluble flavonoid family that give red, blue, and violet colors. Fermentation can increase anthocyanin levels in kidney beans. This study aimed to determine the presence of anthocyanins in kidney bean (Phaseolus vulgaris L.) tempeh which can be used as a hepatoprotective agent and to determine the anthocyanin levels in kidney bean (Phaseolus vulgaris L.) tempeh. Qualitative analysis using HCl and NaOH with positive results showed the color change to solid red then to bluish green and then faded. Determination of total anthocyanin levels was carried out using UV-Vis spectrophotometric method with the pH differential principal in anthocyanin showed in mg/100gram sample at a maximum wavelength of 525.5 nm. The result was that the average anthocyanin content was 40.37mg/100gram with a variant coefficient is 0.325%.
ANALGETIC POWER OF ETHANOL EXTRACT BROTOWALI (TINOSPORA CORDIFOLIA) IN SWISS MICE Deni Firmansyah; Didin Ahidin; Sulistiorini Indriaty; Siti Nurhasanah; Nahdia Fajri Mahmudah; Titin Sumarni
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.7909

Abstract

Brotowali (Tinospora cordifolia) plants are usually used for various kinds of treatment it is often used as a febrifuge, brotowali stems are proven to contain flavonoid compounds that have benefits in the treatment of various diseases, one of which is analgesic. This purpose is to determine the effectiveness of analgesics on male Swiss mice induced by acetic acid from the ethanol extract of brotowali stem (EETC) doses of 100 mg/Kg BW, 200 mg/Kg BW, and 400 mg/Kg BW. Brotowali stem extraction using maceration method with 70% ethanol solvent. EETC was tested by phytochemical screening and TLC to determine the content of active compounds. The test animals used Swiss male mice, the treatment group was divided into 5, negative control group, positive control, and the dose groups were 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Testing is done by the writhing test method. Induction of pain stimuli using acetic acid, the number of mice writhing every 10 minutes for 1 hour, and the percentage of analgesic power. Research shows the yield of EETC is 16.35%. The percentage of analgetic power of dose I was 39%, dose II was 47% and dose III was 56% less than the percentage of analgesic power of methampyrone dose of 65 mg/KgBB which was 64%. Conclusion EETC doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW have analgesic activity equivalent to methampyrone at a dose of 65 mg/kg BW, with the largest percentage of analgesic protection at a dose of 400 mg/Kg BW of 56%.
ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD Nina Karlina; Aan Kunaedi; Didin Ahidin; Uzlifatul Jannah; Yasmin Zahiyah
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7912

Abstract

African leaves (Vernonia amygdalina Del) is a plant that can be used as a medicinal plant because it contains flavonoid compounds that are effective as natural antioxidants that can suppress free radicals. The purpose of this study was to determine the antioxidant activity of the purified extract of Vernonia amygdalina Del. Antioxidant activity test of purified extract of Vernonia amygdalina Del leaves against 1,1-diphenyl-2-picrylhydrazil (DPPH) was measured with a UV-Vis spectrophotometer at a wavelength of 516nm using Vitamin C as a comparison. The results of the non-specific parameters of Vernonia amygdalina Del leaf Simplicia were drying shrinkage of 0.79±0.02%; water content of 7.33±2.08%; water-soluble essence content of 20.5±1.73 %; and ethanol of 14.5±4.35 %. The results of purified extract screening of Vernonia amygdalina Del leaves, contained chemical compounds, namely the class of flavonoid compounds, tannin compounds, steroid compounds, and saponin compounds. Testing for flavonoids using the Thin Layer Chromatography method on the purified extract contained two spots with Rf values of 0.68 and 0.5 while in quercetin there was one spot with an Rf value of 0.68, thus the purified extract of Vernonia amygdalina Del leaves contained flavonoids. Vernonia amygdalina Del leaf purified extract has a very strong antioxidant activity with an IC50 value of 13.54±0.10 µg/mL. The results showed that the purified extract of Vernonia amygdalina Del leaves had very strong antioxidant activity.
STUDY ON THE OPTIMIZATION OF MULBERRY LEAF EXTRACT BY MACERATING ETHANOL AND MICROWAVE ASSISTED EXTRACTION METHOD (MAE) WITH NATURAL DEEP EUTECTIC SOLVENTS (NADES) Kunaedi, Aan; Indawati, Iin; Karlina, Nina; Fadhillah, Zakie; Cantika, Citra Dhea; Khulfiah, Ade Ayu
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7915

Abstract

Ethanol extract from the leaves of Morus alba, an herb, has been widely used for medicine, including commercial formulations. This study aims to compare the characteristics of NADES extract using the MAE method and the maceration method. Mulberry leaf simplicia (Morus alba. L) ethanol extract was made with various ethanol concentrations of 50%, 60%, 70%, 80%, and 90%, and NADES (Natural Deep Eutectic Solvents) extract with a solvent ratio of 1:20 and 1: 30 on the MAE (Microwave Assisted Extraction) method with a time of 5 and 10 minutes. Measurement of total flavonoid content and total phenolic content was carried out by UV-vis spectrophotometry with quercetin and gallic acid as reference standards. The results showed that the ethanol extract with ethanol concentrations of 50%, 60%, 70%, 80%, and 90% had an average total flavonoid content; and total phenolic: 0.73%, 0.9%, 1.32%, 1.18%, 0.77%; total phenolic 96.789 mg/g, 71.262 mg/g, 126.465 mg/g, 116.643 mg/g, 93.366 mg/g. NADES extract with a solvent ratio of 1:20 at MAE 5" and 10" minutes obtained flavonoid levels of 0.36%, 0.4%, and total phenolic levels of 36.099 mg/g; 75.621 mg/g. While a ratio of 1:30 with an MAE time of 5" and 10" minutes, the flavonoid content was 0.44%; 0.48%, and the total phenolic content of 61.884 mg/g; 121.237 mg/g. Results of water-soluble essence of ethanol extract; NADES is 26%–31%; 21–24%. Result of ethanol soluble extract content of ethanol extract; NADES is in the range of 36%–42%; 85%–86%. Result of the specific gravity of ethanol extract; NADES is in the range of 0.82 g/mL–0.95 g/mL; 1.08 g/mL–1.18 g/mL. The ethanol extract pH test results were; NADES in the range 6.90–7.01; 7.59–7.89.
STUDY OF THE SEVERITY AND EARLY ANTIVIRAL TREATMENT FOR THE DURATION OF THE RECOVERY COVID-19 PATIENTS Susilo, Rinto; _, Tomi; Hidayati, Nur Rahmi; Asmarandani, Deani; Fadhilah, Daffa
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7916

Abstract

Late antiviral treatment can potentially cause the Covid-19 virus to replicate very quickly, so it is necessary to understand antiviral drugs and optimize treatment for Covid-19 patients. The study aimed to determine the correlation between the severity, speed of administration of antivirals, and the recovery time of Covid-19 patients. This type of research is an observational study with retrospective data collection on 94 Covid-19 medical records at “X” Hospital Cirebon from 316 populations in June-July 2021 according to inclusion criteria. The data analysis used was univariate and bivariate using Spearman's Rho. The 55–59-year age group (28.7%) was the most infected with Covid-19. There are more males than females (52.1% vs 47.9%). Favipiravir therapy (43.6%) was given the most. Moderate severity (74.5%) had the highest proportion. The speed of administration of antivirals was most initiated at 5-8 days (42.6%) after the onset of symptoms. The maximum recovery time for Covid-19 patients is 13-18 days (58.5%). A strong positive correlation between the speed of giving antivirals to the recovery time of Covid-19 patients (sig. 0.000) and the correlation coefficient of 0.659. Does not show a correlation between the severity of recovery time (sig. 0.113) and speed of antiviral administration to the severity of Covid-19 patients (sig. 0.297). There is a correlation between the early antiviral treatment and the recovery time of Covid-19 patients; the earlier antiviral therapy is given, the faster it will heal.

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