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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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DIRECT MEDICAL COST AND LENGTH OF STAY OF HYPERTENSION PATIENTS AT PRIVATE HOSPITAL IN YOGYAKARTA Faridah Baroroh; Ridhaul Maghfiroh
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.6925

Abstract

The province that ranks fourth with the highest incidence of hypertension in Indonesia is the Special Region of Yogyakarta (DIY). Hypertension therapy is carried out in a not short period, so it becomes an economic burden for people with hypertension and the government. This study aims to determine the relationship between the length of hospitalization and direct medical costs—an analytical observational research method with retrospective data collection and data from class III inpatient hypertensive medical records. The calculation of costs is viewed from a payer's perspective—descriptive and analytical data analysis to determine the relationship between the length of hospitalization and direct medical costs. The study's results of 41 patients met the criteria; 53.65% were women aged 22-59 years (53.65%). The most widely used antihypertensive drug was the combination of amlodipine + candesartan (26.82%). The average direct medical costs for hypertensive patients were IDR 7,039,515. The highest direct medical cost component is the cost of other drugs and medical equipment. The component of direct medical costs is the lowest cost of antihypertensive drugs. The average length of hospitalization for hypertensive patients is 6.14 days. There was a significant relationship (p=0.000) between the length of hospitalization and direct medical costs. The conclusion of this study is a significant relationship (p = 0.000) between the length of hospitalization and direct medical costs
LITERATURE REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF THE EUPHORBIACEAE FAMILY PLANTS Maulana Isman Naki; Abulkhair Abdullah; Elis Susilawati
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.5990

Abstract

Euphorbiaceae family plants are spread in Indonesia and empirically, have been used for a long time as medicine. This article review aims to discuss the pharmacological activities of several plants from the Euphorbiaceae family. This research was conducted by conducting a literature review limited to research in the form of scientific articles. The scientific article in question results from research reviewed and published in Indonesian and English. The steps in the search are divided into several stages, starting from identification, screening, eligibility, and data grouping. The articles used in this article review were obtained by searching the internet from online data search media/search engines such as Google/Google Scholar and journal provider sites such as PubMed, NCBI, and SINTA with the keywords "Euphorbiaceae plants," "Ethnopharmacology, "Ethnobotany and Ethnopharmacy," "Plant Activity and Effectiveness," "Euphorbiaceae family activity," and "Pharmacological activity of Euphorbiaceae. After determining the keywords, the next step is filtering multiple data or duplications and filtering the article's title, abstract, and keywords so that data can be determined to be used or not for the following review.This study is a literature review based on several national or international scientific articles about the pharmacological activity of Euphorbiaceae plants. The literature study found that some plants from the Euphorbiaceae family have pharmacological activities, and the most dominant are antimicrobial, antioxidant, and anti-inflammatory. Moreover, many other activities include analgesic, antipyretic, antithrombotic, anti-hypercholesterolemia, antihyperglycemic, antihistamine, diuretic, and antiseptic.
HEALTH-RELATED QUALITY OF LIFE POST-SINOVAC VACCINE IN COMMUNITIES IN TAMPAN DISTRICT AND MARPOYAN DISTRICT, PEKANBARU CITY Seftika Sari; Rickha Octavia; Novelia Sukista
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.6924

Abstract

Giving the Sinovac vaccine for Covid 19 can cause several side effects. The existence of side effects that occur, of course, affect their lives, including a decrease in activity, productivity and quality of life. This study aims to determine the HRQoL score in the community after the Sinovac vaccine in Tampan District and Marpoyan District, Pekanbaru City. The research method is analytic observational with a cross-sectional design. The research sample was people who received the first vaccine recorded at the Puskesmas in Tampan District and Marpoyan District, Pekanbaru City, which was selected by purposive sampling technique according to inclusion and exclusion criteria and obtained a sample of 100 respondents. The instrument is a questionnaire EQ5D5L and EQ-VAS. The study results showed that there was little problem with the dimensions of pain (37%) and usual activities (14%), with a score of 0,944 (EQ5D5L) and 0,975 (EQ-VAS). In conclusion, the HRQoL scores on EQ5D5L and EQ-VAS are close to 1, which means close to perfect. This research is expected to be a reference for stakeholders in selecting preventive therapy for Covid 19 and can be used as initial data for cost-utility analysis research.
HPLC DETERMINATION OF BENZOXAZOLINONE ON JERUJU PLANT (ACANTHUS ILICIFOLIUS): NARRATIVE REVIEW Nurul Umi Salamah; Imron Wahyu Hidayat; Tiara Mega Kusuma; Heni Setyowati Esti Rahayu; Prasojo Pribadi
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7186

Abstract

Mangrove plants in Indonesia are the largest in the world, both in terms of area quantity (+42,550 km2) and number of species (+45 species). Mangroves are a diverse group of salt tolerant plants that grow in intertidal tropical and subtropical forests and represent a rich biodiversity of plants, animals and microorganisms. Acanthus ilicifolius is one of the true mangrove plants which is used as medicine. This literature review aims to determine the study of benzoxazolinone compounds in jeruju plants (Acanthus ilicifolius) from previous studies and to determine the methods, plant parts and solvents used. The literature review method related to the jeruju plant (Acanthus ilicifolius) uses an electronic data base google scholar. Nuclear Magnetic Resonance (NMR) spectroscopy analysis method is one of the spectroscopic methods widely used in previous studies, because NMR spectroscopy is useful in determining the structure of a chemical compound, both proton (1H) and carbon (13C) NMR. Jeruju leaf extract contains alkaloids, flavonoids, polyphenols, phenyletanoid glycosides and coumarin compounds. The methanol fraction of jeruju leaf extract has a pharmacological effect to inhibit edema (inflammation). The extraction method used is maceration, because this method is simple method and most widely used. Meanwhile, the solvents that are more widely used are methanol and ethanol solvents.
FACTORS ASSOCIATED WITH RATIONALITY OF ANTIMALARIA PRESCRIPTION IN PAPUA PROVINCE Irene Sondang Lingga; Sarhana Sarhana Rassya Aulyah Said; Dina Ayomi; Rusnaeni Rusnaeni; Elsye Gunawan; Nur Fadilah Bakri; Elfride Irawati Sianturi
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.8207

Abstract

Malaria remains a leading cause of death in Papua and combination of Dihydroartemisin -Piperaquine (DHP) and Primaquine (PQ) is recommended treatment to replace chloroquine out since chloroquine resistance present. Moreover, awareness of rational prescription and adherence may be the first priority in malaria treatment in preventing death and resistance in Papua. This study aimed to assess the rationality of antimalaria prescription in the public and private sectors of Papua Province. This cross-sectional study was conducted. Overall, 571 prescriptions were included in this study and more than half of prescription was rational (65%). This study was predominantly female (65%). More than half was diagnosed by P. falciparum (54%), using referred using the public hospital for treatment (54%) and self-identified as Papuan (50%). According to type of malaria, incorrect of prescription DHP and PQ were 20% and 18%, respectively. The multiple logistic regression model showed that female was significantly associated to receive irrational of prescriptions than males (OR = 1.549; 95% CI =1.004-2.389). Participants who had P. falciparum increased the likelihood of irrational of prescriptions (OR= 1.641; 95% CI =1.144-2.355). There is a need to have a continuum strategy to improve access and utilization of malaria case management in both public and private health facilities. Inequality gender based on prescribers needs to be investigated. Competence improvement among healthcare providers needs to be a priority to prevent antimalarial resistance.
THE ROLE OF THE E-PRESCRIBING SYSTEM IN HEALTHCARE: A SYSTEMATIC REVIEW Ayyoehan Tiara Annisa; Nanang Munif Yasin; Susi Ari Kristina
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.8257

Abstract

The electronic prescribing system has a good role in health services with the powerful features that this system has, when compared to manual prescribing. This systematic review aims to determine the role of the electronic prescribing system in health services. The literature search was conducted from 21 November 2022 using PubMed, ProQuest, Google Scholar, ScienceDirect, Scopus, and Sage PUB as literature search area databases. A literature search strategy using BOOLEAN Operator to help specify the search terms. Literature search based on inclusion criteria. After eliminating duplication, title, abstract and full text, 8 articles were obtained for analysis. The electronic prescribing system has a good role in health services, including reducing medication errors, improving the quality of communication and information both between staff and staff and patients, shortening service time, having an alert system that is able to detect allergies, drug interactions, and adverse drug reactions. desired, time and cost efficiency, effectiveness in terms of patient safety, providing satisfaction for users because with these qualified features they can help in terms of service when compared to manual prescriptions. Further research should be conduct to review the role of Clinical Decision Support System and the electronic Health Record in healthcare due to its limitation.
ANTIOXIDANT ACTIVITY OF THE COMBINATION OF AMBARELLA LEAVES (Spondias dulcis Parkinson) AND SOURSOP LEAVES (Annona muricata Linn) EXTRACT Tarso Rudiana; Dimas Danang Indriatmoko; Ken Virginia
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.5082

Abstract

Degenerative diseases can be caused by free radicals, whereas antioxidants can overcome free radicals. Kedondong leaves (Spondias dulcis Parkinson) and soursop leaves (Annona muricata Linn.) are potential sources of suitable antioxidant compounds. This study aims to determine the antioxidant activity and the relationship between antioxidants and total phenolics from the combination of S. dulcis and A. muricata leaf extracts. S. dulcis leaves, and A. muricata leaves were macerated with 96% ethanol and then formulated with a combination of extracts (1:1, 2:1, and 1:2). Each was tested for its antioxidant activity by the DPPH method. The ethanol extract of S. dulcis leaves had an antioxidant activity value of 36.72±4.01 ppm with a total phenol of 76.84±0.50 mgGAE/g extract, an ethanol extract of A. muricata leaves of 81.45±8.19 ppm with a total phenol of 104.48±7.55 mg GAE/g extract and a combination of extracts with a ratio of ethanol extract of S. dulcis leaves and ethanol extract of A. muricata leaves (2:1) of 29.98 ± 0.37 ppm with a total phenol of 36.99 ± 0.98 mgGAE/g extract. The results showed that the phenolic content of the ethanol extract of A. muricata leaves was more significant than the combination (2:1), which had the most excellent antioxidant activity among the other comparisons. Total phenolic is inversely related to antioxidant activity. Antioxidant activity is not only played by phenolic compounds.
PRESCRIPTION COST ANALYSIS IN PATIENTS OF TYPE 2 DM AND HYPERTENSION JOINING CHRONIC DISEASE MANAGEMENT PROGRAM (PROLANIS) AT PUSKESMAS AFTER THE IMPLEMENTATION OF NATIONAL HEALTH INSURANCE Arifin Santoso; Indriyati Hadi Sulistyaningrum; Hesti Dwi Widaryanti; Kusuma Arbianti; Chilmia Nurul Fatiha; Elmiawati Latifah
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.5234

Abstract

To improve the status of public health and carry out social security programs in the health sector, the government started to implement the National Health Insurance. This program covers the participants’ medical care expenses using the capitation system applied in health centers as the First-Level Health Facilities. BPJS Kesehatan has allocated some budget in the form of a capitation rate to first-level health facilities for hypertension and type 2 diabetes mellitus patients after the implementation of National Health Insurance. This research was carried out in 4 health centers, namely Lamper Tengah Health Center, Mangkang Health Center, Mijen Health Center, and Karanganyar Health Center. The data were collected retrospectively from the medical records of 800 patients. The data were analyzed descriptively to determine the prescription cost and Spearman's rho test was used to find the factors that influence the prescription cost. It was revealed that the average prescription cost for type 2 DM patients was IDR 142,293, and for hypertensive patients was IDR 112,735. The prescribing pattern in patients covered by Prolanis program for type 2 DM patients is a combination of glimepiride, metformin with a drug price of IDR 20,670. Factors that have an influence on prescription costs are diagnosis p= 0.033, type of drug (p= 0.000) and drug item (p= 0.000). This study concludes that the factors to influence the drug costs of Prolanis patients at the health centers of Semarang City were the patient's diagnosis, the type of drug given, and the number of drug items given.
A LITERATURE REVIEW: THE POTENTIAL OF KARAMUNTING PLANT (Rhodomyrtus tomentosa) AS ANTIBACTERIAL AGENT Gilang Ramadhan; Annisa Krisridwany; Andy Eko Wibowo; Muhammad Fariez Kurniawan; Vella Lailli Damarwati
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.6415

Abstract

Infectious disease is a major health problem with a relatively high mortality rate. Indonesia is rich in natural ingredients that have potential as antibacterials, one of which is the Karamunting plant (Rhodomyrtus tomentosa). Several studies on this plant have been conducted to observe its activity as an antibacterial. This study aims to determine the antibacterial activity of Karamunting plants using the literature review method. The literature search method uses journals from the Google Scholar, Pub Med and Elsevier databases. Each journal is determined based on inclusion and exclusion criteria. Journals that meet the inclusion criteria are descriptive and explained in detail. From the journals obtained, there were 11 journals that met the criteria. Karamunting plants (Rhodomyrtus tomentosa) contain secondary metabolites namely flavonoids, glycosides, saponins, tannins, triterpenoids, steroids, acylphloroglucinol (rhodomyrtone, tomentosone, rhodomyrtosone) and meroterpenoids (rhotomentodiones). Antibacterial activity test using the diffusion method showed an optimum inhibition zone diameter of 21.5 mm against Staphylococcus aureus bacteria in the ethyl acetate fraction of Karamunting leaves with a concentration of 600 mg/ml, while using the microdilution method of ethanol extract of Karamunting leaves the minimum inhibition level was 0.5 µg/ml on Staphylococcus aureus bacteria. The leaves’ part presents the best antibacterial activity.
ANALGETIC ACTIVITY TEST OF ETHANOL EXTRACT SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MALE MOUSE (Mus musculus) INDUCED WITH ACETIC ACID Lia Wahyuni; Dona Muin; Defirson Defirson; Andy Brata
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7374

Abstract

Traditional medicine, which is generally considered safer than modern medicine, makes people choose alternative treatments using medicinal plants, one of which is to treat pain. One of the medicinal plants used to treat pain is a plant that contains flavonoids, one of which is the Sungkai plant (Penorema canescens Jack). The research design used was The Static Group Comparison, where the test animals used were divided into 5 groups, each group consisting of 5 mice. Group 1 was given 1 percent of CMC. Group II was given ethanol extract of Sungkai leaves at a dose of 300 mg/Kg BW. Group III was given EEDS at a dose of 600 mg/kg BW. Group IV was given EEDS at a dose of 900 mg/Kg BW. Group V was given paracetamol suspension. The results showed that there was an analgesic activity in the EEDS group, dose I was 50 percentage, dose II was 55,798 percentage, and dose III was 69,564 percentage. The study concluded that statisti-cally there was no significant difference in analgesic activity in white male mice between the EEDS doses I, II, and III groups and the paracetamol group.

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