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Elmiawati Latifah
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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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Analysis Of Drug Indicator At The Procurement Stage In The National Health Insurance Era: A study in Advance Health Facility Indriyati Hadi Sulistyaningrum; Arifin Santoso; Sri Intan Lestari; Kusuma Arbianti
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2964

Abstract

Drug procurement is part of an important hospital management to support the availability of the pharmaceutical logistic in hospital to provide good services for the patients. ineffective procurement can result in not achieving the availability of each drug in the amount which are in accordance with the price and budgeting. This research was conducted to obtain an overview of drug management at the procurement stage in Sultan Agung Islamic Hospital (RSIA SA) for the 2017 – 2018 period. Descriptive Observational research methods were used to collect the qualitative and quantitative data. Qualitative data were obtained through interview, and the quantitative data were collected from the document observation provided in Pharmaceutical installation Sultan Agung Islamic Hospital (IFRSISA). The result showed the percentage of the allocation of drug procurement funds in 2017 was 47,6%, and in 2018 it was 37,1%, the frequency of procurement of each drug type was < 76% at 12 times / year, the frequency of delayed payment by the hospital based on the time agreed was 100%. The conclusion of this study shows that the indicator of drug procurement in IFRSISA categorized as good because it is in line with the quality of drug procurement indicators.
COMPLIANCE TO MEDICATION IN HYPERTENSIVE PATIENTS OF CHRONIC DISEASE MANAGEMENT CONSULTING PHARMACIST AT PUBLIC HEALTH CENTER OF SEMARANG CITY Meki Pranata; Rino Arianti Marswita; Farrah Bintang Sabiti
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.2965

Abstract

One of the pharmaceutical services that can be done by pharmacists is counseling. Counseling lead to increase the obedience to taking medication in reduce hypertension. The objective of this research is to evaluate the obedience to drug therapy of hypertensive patient which already get counseling by pharmacists in Public Health Center in Semarang. This research was carried out by cross sectional design. The research was conducted towards 40 patients who were willing to take part in the research by filling out inform consent. “Pill count” method was used to evaluate the obedience level by counting the remaining drug for 1 month starting from the beginning until the end of July 2019. These results will be analyzed by chi-square test to determine the relationship between the characteristics and the obedience level. Wilcoxon test was done to determine the differences in groups before and after given counseling. The results showed that there was a significant decrease in systolic and diastolik pressure (p = 0,000). Chi-square test results showed that counseling given by pharmacists had no significance effect related to the obedience to drug therapy of hypertensive prolanis patient with a statistic of p> 0.05.
Antibacterial Activity of Acetone and Ethyl Acetate Leaves, Stems and Rhizomes Extract of White Water Lily (Nymphaeae alba) Against Staphylococcus aureus and Escherichia coli Mariam Ulfah; Ade Irawan; Teguh Adiyas Putra
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2999

Abstract

White water lily (Nymphaeae alba) is one of the aquatic plants that is often used for traditional medicine. This plant has anticancer and antioxidant activity. The final result of this experiment is to determine the antibacterial activity of acetone and ethyl acetate extract from several parts of this plant, including leaves, stems and rhizomes againts several types of bacterial including Staphylococcus aureus and Escherichia coli. Kirby-Bauer diffusion Disc method is used in this study. Simplicia of leaves, stems and rhizomes of white water lily were macerated with acetone and ethyl acetate for 3 x 24 hours. Antibacterial tests were carried out to acetone and ethyl acetate leaves, stems and rhizome extract of white water lily. Amoxicillin was used as a positive control and dimethyl sulfoxide (DMSO) with concentration 20% as a negative control. The extract and amoxicillin were diluted with 20% DMSO. Each disk contained 100 µg of extract and 10 µg of amoxicillin. Antibacterial tests that have been carried out show that the acetone extract of leaves, stems and rhizomes white water lily has the highest attack value against bacteria, the diameter of the inhibition zone is 20 mm against S. aureus Acetone and ethyl acetate leaves, stems and rhizomes extract of white water lily did not have inhibitory effect on E. coli.
Anthelmintic Potential Of Moringa Oleifera As Inhibitor Mitochondrial Rhodoquinol-Fumarate Reductase From Ascaris Suum Using The Docking Method Dede Rival Novian
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.3000

Abstract

One of the parasitic nematodes that can cause malnutrition, even death in humans, is Ascaris suum. The parasite can survive in its host cell by metabolizing using the fumarate reductase enzyme. With this metabolism, the parasite can produce energy to survive in its host cell. Rhodoquinone (RQ) plays a part in helping the fumarate reductase reaction in parasite metabolism, and energy from metabolism was not produced when the enzyme was disrupted. Thus Mitochondrial rhodoquinol-fumarate reductase can be a good target of anthelmintic drug receptors. The results of investigations using in vitro and in vivo methods showed that Moringa oleifera has various medicinal functions including anti-inflammatory, antimicrobial, antidiabetic, antioxidant, anti-tumour, anti-cancer, and anti-clastogenic properties. However, the potential of the drug Moringa oleifera against anthelmintics has not been further investigated. Simulation docking is the research method used to find the anthelmintic potential of Moringa oleifera as the Ascaris suum inhibitor of Mitochondrial rhodoquinol-fumarate reductase. This study aims to examine the potency of Moringa oleifera bioactive compounds on the anthelmintic receptor Mitochondrial rhodoquinol-fumarate reductase by using efficient and effective research time with the docking simulation model. The results showed the bioactive compound 3,5-bis (1,1-dimethylethyl) -phenol from Moringa oleifera had potential as a new anthelmintic drug compound, 3,5-bis (1,1-dimethylethyl) -phenol activity had affinity energy of - 7.0 kcal / mol and has physicochemical properties that are not contrary to the rules of the drug compounds from Lipinski.
Antibacterial Activity of Etil Acetate Fraction of Chili Leaf Against Streptococcus Pyogenes and Bioautografy Ade Irawan; Nurkhasanah Nurkhasanah; Nanik Sulistyani
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.3002

Abstract

One of the plant that has antibacterial activity is chili leaf (Capsicum frutescens L.). The purpose of this study was to determine the antibacterial activity of ethyl acetate fraction of chili leaf against Streptococcus pyogenes bacteria and conduct bioautography to see compounds that have antibacterial activity. In this study an antibacterial test for ethyl acetate fraction of chili leaf with a concentration of 5%, 10%, 20%, 40%, 80% to Streptococcus pyogenes. From the results of the inhibition zone test 5% ethyl acetate fraction produces an average inhibition zone of 6.3 mm, 10% average inhibition zone 10.3 mm, 20% average inhibition zone of 14 mm, 40% average inhibition zone 18 mm and 80% have 22.7 an average inhibition zone. In the silent phase bioautographic was used test silica gel GF 254 and for the mobile phase was used chloroform : ethyl acetate (3: 7), indicating the presence of inhibition zones on the media which had been inoculated by Streptococcus pyogenes bacteria, namely at RF 0.88. From the research that has been done, the results show that the ethyl acetate fraction of chili leaf has inhibitory zone against Streptococcus pyogenes bacteria and the spotting of compounds which have inhibitory zone has an RF of 0.88.
ANTIDIABETIC ACTIVITY FROM TABLETS EFFERVESCENT EXTRACT OF MIMOSA PUDICA LINN LEAVES Na'ilatul Azizah; Ika Buana Januarti; Annisa Masithoh; Anna Khoirun Nisa
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3008

Abstract

The community has trusted mimosa pudica linn as an alternative antidiabetic treatment. Compounds that have antidiabetic activity in Mimosa pudica linn are flavonoids, alkaloids, and tannins. The selection of effervescent tablet dosage formulations is practical for diabetics with the addition of stevia leaf sweeteners. This study aimed to determine the antidiabetic activity of effervescent tablets of Mimosa pudica linn leaves extract as a natural antidiabetic. The research method begins with the extraction of plants using the maceration method of 70% ethanol; the tablet formulation uses dry granulation. Antidiabetic activity test using 28 male mice (Mus musculus) Swiss strain divided into four groups, namely group I (negative control): Na-CMC 0.5%, group II: effervescent tablets of Mimosa pudica Linn leaves Extract dose 600 mg/kgBB, group III (positive control): metformin 65 mg/kgBB, group IV (normal control): feed and drink. Each group, except normal controls, was induced by DM using alloxan 150 mg/kg body weight. Data on decreased blood glucose levels were analyzed using the Kruskal-Wallis statistical test the study results show that effervescent tablets meet the parameters of disperse time test, pH test, size uniformity test, weight uniformity test, hardness test, moisture test, and friability test. This study concludes is that there is a significant difference between the negative, positive, normal, and treatment control groups, which means that the administration of effervescent tablets of 70% ethanol extract of Mimosa pudica Linn leaves at a dose of 600 mg/kgBB can reduce blood sugar levels in mice (Mus musculus).
CYTOTOXIC ACTIVITY OF COMBINED FIG EXTRACT AND OLIVE OIL AGAINST BREAST CANCER CELLS Naniek Widyaningrum; Atina Hussana; Reza Saeful Adi; Memi Tiastuti; Karina Misti Utami
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3016

Abstract

Figs and olive oil are plants containing flavonoids compounds. Flavonoids have antioxidant and cytotoxic activities. This study aims to find out the antioxidant and cytotoxic activities of fig extract, olive oil and combination of fig and olive oil as well. Study using a combination of tin and olive oil with a combination of extracts of 1: 0.1: 3, 1: 1, 3: 1, 0: 1. Cytotoxic and antioxidant activities were tested using MTT assay and DPPH method. Cytotoxic test results were analyzed using probit and antioxidant tests using linear regression. Test results from a single olive on T-47D cells have very strong cytotoxic and antioxidant activities (560,769 and 33.27 µg / ml). In MCF-7 cells the ratio of figs and olives 1: 1 has very strong antioxidant and cytotoxic activity (576,459 and 76.79 µg / ml), in 4T1 cells the ratio of fruitbtin and olive combination of 3: 1 has no cytotoxic activity but has antioxidant activity very strong (1733,517 and 21.81 µg / ml). The combination of fig extract and olive oil had cytotoxic activity on T-47D and MCF-7 cells, but did not have cytotoxic activity on 4T1 cells. This combination had very strong antioxidant activity in T-47D and 4T1 cells, strong in MCF-7 cells.
RATIONAL DRUG USE (RDU) BASED ON PATIENT CARE INDICATOR IN PRIMARY HEALTH CENTER IN SEMARANG Nisa Febrinasari; Arifin Santoso; Abdur Rosyid; Aditya Dwi Meilani
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3021

Abstract

Rational Drug Use has several indicators, one of which is service indicators, where service indicators will play a role in increasing rational drug use so that it can support the success of treatment to achieve a better quality of life and patient welfare. The purpose of this study was to determine rational drug use in the city of Semarang based on service indicator parameters. This research is a descriptive-analytic with a cross-sectional design, data collection is done prospectively with a direct observation approach and direct interviews with respondents. The number of respondents was 744 patients (372 at Puskesmas N and 372 at Puskesmas TK who were taken by consecutive sampling. The data were processed using the Mann-Whitney statistical test with a p-value <0.05. The results of this study indicate that the use of drugs in Puskesmas N and Puskesmas TK There is a significant difference with a p-value <0.05. In the meantime of medical consultation 5-11 minutes; the average time for drug preparation 10-16 minutes; the percentage of drug delivery suitability is 100%; the percentage of adequate labeling is 100% and the percentage of knowledge Patients at the puskesmas approach rationality and there are differences in services between the two Puskesmas. The government needs to increase the number of pharmacists and improve infrastructure, especially in terms of drug counseling at each puskesmas so that it is hoped that patient knowledge of the drug regimen to be consumed will increase.
IMPACT OF SINGLE BULB GARLIC (ALLIUM SATIVUM VAR. SOLO) ON THE NUMBER OF LEYDIG AND SERTOLI CELLS IN RATS Ika Buana Januarti; Fadzil Latifah; Nur Fidia Fatmawati
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3056

Abstract

Single garlic bulb has been studied as aphrodisiac, this is related to the presence of secondary metabolites flavonoids, alkaloids, and saponins. The metabolite content of single garlic tuber ethanolic extract (EEUBPT) will be investigated for its effect on the histopathological picture and the number of Leydig cells and testicular Sertoli cells in rats. Sample research consist of 25 Wistar rats aged 3-4 months divided into 5 groups. Group I was negative control given 0.5% Na-CMC; group II (positive control) was given Jamu Pasak bumi. Groups III, IV, and V were each given EEUBPT at doses of 450 mg/kgBB, 900 mg/kgBB, dan 1350 mg/kgBB of body weight. Each group was given treatment for 14 days, then the testes were taken on the 14th day. The results were analyzed using the One Way Anova parametric test (p <0.05) and post hoc. The ethanolic extract of a single garlic bulb affected the number of Leydig cells at a dose of 1350 mg of body weight but did not significantly influence the number of Sertoli cells.
PHYSICAL CHARACTERISTICS OF COATING FILM COMBINATION OF CORN STARCH-CHITOSAN AND THE DETERMINATION OF VITAMIN C LEVELS IN FRUIT AND VEGETABLE I Kadek Bagiana; Bekti Nugraheni; Dyan Wigati
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3069

Abstract

Coating films is an effort to improve quality and extend the shelf life of a food ingredient. Coating film functions to coat food as well as can be consumed. The study aims to determine the best physical characteristics of the combination of corn starch-chitosan and find out the smallest % decrease in vitamin C levels from chili, tomatoes, and strawberries coated with the coating film. The materials used in this study were a combination of corn starch and chitosan 0.25%; 0.50% and 0.75%. The results showed that the coating film of 0.75% corn starch -chitosan combination has the best physical characteristics. The smallest percent decrease in vitamin C levels in chili, tomatoes, and strawberries that are dipped in coating film on a combination of corn starch-chitosan at a level of 0.75%.

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