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Abd. Kakhar Umar
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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Articles 11 Documents
Search results for , issue "volume 5 issue 2" : 11 Documents clear
Effectiveness Test of Epigallocatechin Gallate Cream Formula in Acne Vulgaris Therapy Widyaningrum, Naniek; Dhea, Alda Rasni; Rofi, Alina Nur; Arief, Thendi Abdul; Timur, Willi Wahyu
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502542

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that affects more than 80% of adolescents and young adults. Conventional therapies such as antibiotics and topical retinoids have limitations in the form of resistance and irritation. Epigallocatechin gallate (EGCG) from green tea leaves (Camellia sinensis L.) has antibacterial, anti-inflammatory, and antioxidant activities that make it a safe natural anti-acne candidate. The aim of this study was to assess the clinical efficacy and safety of topical EGCG cream on the improvement of inflammatory and non-inflammatory acne lesions. A pre-post clinical trial was conducted on ten participants aged 17–50 years with active acne. Respondents applied 6% EGCG cream twice daily for six months. The number of lesions (papules, pustules, and blackheads) was evaluated monthly and analyzed using a paired t-test (p<0.05). There was a significant decrease in the number of papules (9.4 ± 5.97 to 3.0 ± 3.13), pustules (1.7 ± 1.57 to 0), and comedones (21.5 ± 10.76 to 4.2 ± 3.05) in five months (p<0.05), with the onset of improvement since the first month without side effects. Topical EGCG cream is effective and safe in reducing acne lesions quickly and sustainably. With its multi-target mechanism, EGCG has the potential to be developed as a phytocosmetic active ingredient for acne vulgaris therapy.

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