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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 112 Documents
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From Prodrug to Multimatrix: Recent Advancement of Colon Specific Drug Delivery System Saha, Sabuj Kumar; Hasan, A.H.M. Nazmul; Anjum, Ramisa; Rimun, Shariun Nahar; Rahman, Nujhat Zayma; Akanda, Md. Khokon Miah; Buhiyan, Mohiuddin Ahmed; Islam, SM Ashraful
Sciences of Pharmacy Volume 3 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0303233

Abstract

Prevalence of colonic diseases such as inflammatory bowel disease, colorectal cancer, angiodysplasia, salmonellosis, etc, are increasing daily and are reducing the quality of life of the patients. These diseases can be difficult to treat due to their ability to alter the normal environment of the colon such as the pH, microbiota, enzymes, and more. Anatomy and physiology of the colon also pose difficulty in case of targeted drug administration. Additionally, there are variations in how each colonic disease influences the colon, making it essential to design a Colon-Specific-Drug-Delivery System (CSDDS) that would ensure proper targeting and delivery of the drugs. To reduce systemic side effects and achieve desired therapeutic effects, the dosage form should be designed in such a way that allows for direct and precise targeting of drugs into the colon, while also preventing premature gastrointestinal drug release. In this review, we discuss the conventional (for example, prodrug, CODES, pulsatile drug delivery) and novel (OPTICORE, Phloral, MMX technology, 3D bicompartmental device) approaches aimed at ensuring drug release and absorption within the colon, as well as examine the factors that affect drug delivery targeted at the colon. Despite considerable progress, significant challenges and gaps remain, including the need for a deeper understanding of colonic environmental variability, the development of advanced biocompatible materials, and the implementation of personalized treatment strategies are highly required.
Assessment of Patient Safety Culture Amongst Pharmacy Staff of Selected Healthcare Facilities in Delta North, Nigeria Arute, John Edjophe; Osarenmwinda, Monday Ikponmwosa; , Omotejohwo Emily Okolosi-Patani
Sciences of Pharmacy Volume 3 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0303245

Abstract

The strategy for improving patient safety in hospitals heavily relies on safety culture. The study aimed to evaluate patient safety cultures amongst pharmacy staffs of selected health facilities in Delta North, Delya State, Nigeria. Data on patient safety amongst 70 pharmacy personnel in two major secondary and 5 general health facilities across Delta North senatorial district, Delta State, were collected using the Hospital Survey on Patient Safety Culture (HSOPSC) tool. Information on communication openness, the frequency of documenting different types of mistakes, as well as the overall patient safety culture rating, was collected. Composite scores were analyzed using SPSS version 22. Measurement data were presented as mean ± standard deviation (SD) and compared using a student t-test. The results were considered significant at p<0.05. The mean scores of all the various composite item responses were calculated and grouped into positive and negative responses with a mean score of ≥4 and <4, respectively. The safety cultures of physical space and environment, staff training and skills, and communication openness had a good composite score of 4.0 – 4.1. The safety culture of procedures for communicating prescriptions across shifts was poorly rated, with composite scores of 3.8. The safety culture of patient counselling had the highest composite score of 4.3. The safety composites for documenting various shades of mistakes had a mean score of 3.5. Overall, 68.1% of the healthcare facilities were rated excellent, although there were some loopholes (documenting mistakes and poor communication across shifts) in the safety composite scores requiring areas for improvement.
Larvicidal Activity of Red Betel Leaves (Piper ornatum) Ethanolic Extract Against Mosquito Larvae Soyata, Amelia; Khoirunnisa, Khoirunnisa; Wahab, Sabda
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302213

Abstract

Larvae are the initial carriers of dengue hemorrhagic fever (DHF) and culex, making them significant in disease transmission. Excessive chemical larvicides pose serious risks to human health, thus driving the development of biological alternatives like red betel leaf extract. This study aimed to assess the efficacy of red betel leaf extract in larval control. Using 300 larvae, concentrations of 5%, 6%, and 7% were tested with three replicates over 24 h. The bioassay involved placing the larvae into a plastic container filled with the extract. It was found that ethanol extract from Piper ornatum leaves contained alkaloids, tannins, saponins, flavonoids, and terpenoids. After 24 h, results revealed 83% mortality at 5%, 98% at 6%, and 100% at 7% of extract concentration. Consequently, the 7% concentration showed the fastest efficacy in killing mosquito larvae (100% in 50 min). The LC50 value, representing the concentration at which 50% of larvae are killed, was determined to be 0.04%. Additionally, the LT50 value, indicating the time required to kill 50% of larvae (based on the LC50 value), was found to be 3.34 hours. In conclusion, red betel leaf extract demonstrated promising larvicidal activity against mosquito larvae. Future research is anticipated to prove its safety via in vitro and in vivo test.
Nanosuspension Formula of Curcuma xanthorriza Rhizome Dry Extract: Impact of Tween 80-PEG 400 Ratio Arifin, Moch Futuchul; Shafira, Elza; Noviani, Yuslia; Desmiaty, Yesi; Okta, Fauzia Noprima
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302222

Abstract

Our previous research investigated nanosuspension using the ionic gelation method with a 2:1 ratio of chitosan to sodium tripolyphosphate (TPP) and 0.44% Curcuma xanthorriza rhizome extract. The results indicated an unstable nanosuspension with a particle size of 399.3 nm, a polydispersity index of 0.60, and an entrapment efficiency of 73.37%. This study aims to develop a nanosuspension using Tween 80-PEG 400 to improve the characteristics and dissolution at pH 6.8. Curcuma rhizome was macerated with 96% ethanol and dried using a spray dryer. The nanosuspension formulation was designed using a 22 factorial design with Tween 80 (0.1%-0.4%) and PEG 400 (0.1%-0.4%) as factors, and the formulation was analyzed using Minitab 18. The dissolution of the optimum formulation was tested. The best formulation, comprising 0.1% Tween 80 and 0.4% PEG 400, provided a spherical shape, a particle size of 111.26 nm, a polydispersity index of 0.27, a zeta potential of 30.77 mV, an entrapment efficiency of 84.30%, and a desirability value of 0.9058. The release of curcumin at pH 6.8 after 180 minutes was 37.85% ± 0.1375 with a DE180 of 83.60% ± 0.1457. The 22 factorial design proved effective for enhancing formulation attributes. Based on the result obtained, it can be concluded that the best formulation contains 0.1% Tween 80 and 0.4% PEG 400, with zero-order release kinetics and a diffusion mechanism.
Characterization, In Silico Antimalarial, Antiinflammatory, Antioxidant, and ADMET Assessment of Neonauclea excelsa Merr. Musa, Neksumi; Dahiru, Mubarak Muhammad; Badgal, Enoch Buba
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302232

Abstract

In our study, we identified the phytoconstituents and carried out antimalarial, anti-inflammatory, antioxidant, and ADMET assessments of Neonauclea excelsa. The phytochemicals were detected and quantified followed by identification via GC-MS. The antimalaria, anti-inflammatory, and antioxidant assessments were done by molecular docking (MD) and molecular dynamics simulation (MDS) while ADMET by ADMET predictions. Saponins (27.33% ±1.20) and terpenes (8.33% ±0.73) were detected while alkaloids, steroids, glycosides, and flavonoids were absent. Exactly 29 compounds were identified with squalene being the most abundant (32.41%). Compound II exhibited the lowest BA (-6.4 kcal/mol) and Ki (20.12 µM), interacting with dihydrofolate reductase-thymidylate synthase. IV exhibited the lowest respective BA and Ki interacting with Plasmodium falciparum hexose transporter protein 1 (-6.2 kcal/mol and 28.20 µM), cyclo-oxygenase-2 (-7.2 kcal/mol and 5.21 µM), and myeloperoxidase (-7.4 kcal/mol and 3.71 µM). Compound VII had the lowest respective BA and Ki interacting with inducible nitric oxide synthase (-8.0 kcal/mol and 1.35 µM), xanthine oxidase (-7.2 kcal/mol and 5.21 µM), and cytochrome p450 21A2 (-7.0 kcal/mol and 7.30 µM). The MDS showed various cluster mobilities and residue fluctuations up to 5.26, 2.96, 5.10, 3.51, 5.02, 4.65, and 6.18 Å for dihydrofolate reductase-thymidylate synthase, Plasmodium falciparum hexose transporter protein 1, inducible nitric oxide synthase (INOS), cyclo-oxygenase-2 (COX2), xanthine oxidase (XO), cytochrome p450 21A2, and myeloperoxidase, respectively. Additionally, these compounds demonstrated good pharmacological properties with minimal toxicity. Conclusively, the identified compounds might be significant contributors to the antimalarial, anti-inflammatory, and antioxidant activity of N. excelsa and are good sources of novel antimalarial, anti-inflammatory, and antioxidant drugs.
Bioactive Compounds of Rosa canina L. and Their Effect on Tumor Necrosis Factor-α and Interleukin-1β Activity in Diabetes-Induced Rats YALÇINKAYA, İlayda Sezin; AKTAN, Onur; AÇIK, Leyla; ERKMEN, Gülnihal KULAKSIZ; VURAL, NILUFER; KAYMAK, Sibel; ATEŞ, Yiğit Can
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302221

Abstract

The ethnopharmacological significance of Rosa canina, or dog rose, transcends diverse cultures, with traditional applications in treating various diseases. This study investigates the potential pharmacological application of Rosa canina for diabetes treatment, aiming to assess its antidiabetic properties through in vitro, in vivo, and in silico analyses targeting pro-cytokines. Biochemical profiling utilizing HPLC, and phenolic content analyses were conducted to reveal the antioxidant properties of Rosa canina. In diabetic rats, root extracts influenced the expression of TNF-α and IL-1β, with an exploration of DNA-binding and protective activities. DPPH scavenging and iron chelating activities were measured, identifying significant IC50 values. The chromatographic analysis identified various compounds, with Kaempferol 3-O-glucoside and Rutin exhibiting high inhibitory activity against TNF-alpha. In silico analyses highlighted inhibitory activities by molecular docking against TNF-α and IL-1β (PDB IDs 2AZ5 and 9ILB, respectively) and their drug potential based on ADMET properties. The obtained results have demonstrated a significant decrease in blood glucose levels in mice through the reduction of TNF-α and IL-1β mediated diabetic processes, facilitated by the Rosa canina extract. In conclusion, this study exploring the effects of Rosa canina extracts on diabetic rats have provided valuable insights into its potential therapeutic benefits. The observed reductions in blood glucose levels, improvements in lipid profiles, and modulation of antioxidant activity highlight its promising role in managing diabetes-related complications. Further research is warranted to elucidate the underlying mechanisms and optimize the dosage regimens for harnessing the full therapeutic potential of Rosa canina extracts in diabetes management.
Effect of Combination of Porang and Moringa Flour on Blood Glucose Levels and Body Weight in Rats Laksmitawati, Dian Ratih; Marwati, Umi; Okta, Fauzia Noprima; Partana, Citra Prastuti
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302215

Abstract

Porang tuber is rich in fiber and low in calories of carbohydrates. Moringa oleifera leaf has a high protein and a low content of lipids. Obesity and diabetes mellitus are the risk factors of cardiovascular disease, also known as cardiovascular disease risk factors. Combining of porang and moringa as feed can increase nutrition without causing weight gain. This study aims to determine these two materials as antidiabetic and antiobesity agents. The samples are porang tuber, a combination of porang tuber and M. oleifera leaves, a combination of M. oleifera leaves and wheat flour, wheat flour, and standard feed of mice. The parameters tested in this study are analysis of macronutrients of feed, loss of weight of mice, average consuming feed in 28 days, and reduction of blood glucose with a glucometer. The results obtained are a combination of porang tuber and moringa had a low contain carbohydrates and a high contain lipids and protein, can reduction in body weight of 21%, the lowest consumption of feed, and the lowest fasting and postprandial blood glucose levels compared to the other feeds. A combination of porang and moringa can be an antidiabetic and antiobesity agent.
Potential of Ciplukan Leaf (Physalis Angulate L.) Infusion as A Bronchodilator in Pulmonary Histopathology of Sprague Dawley White Rats Dewi, Rika Sari; Saragih, Kristin Grave Gracia
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301216

Abstract

Ciplukan leaves contain alkaloid compounds and exhibit pharmacological activity as bronchodilators. Bronchodilators are utilized in chronic inflammatory respiratory conditions such as asthma, involving various cell types such as mast cells, eosinophils, and epithelial cells. The objective of this study was to evaluate the effectiveness of administering Ciplukan leaf infusion as a bronchodilator. A total of 24 Sprague Dawley rats were divided into 6 groups: normal control (K1), negative control (K2), positive control (K3), 200 mg/kg BW dose (K4), 400 mg/kg BW dose (K5), and 800 mg/kg BW dose (K6). On days 1 and 8, rats were sensitized with 0.35 mg OVA + 1 mg AlOH3 in 0.9% NaCl (i.p). On days 15, 17, and 19, rats were re-sensitized with inhaled OVA. From day 20 to 28, K1 and K2 received no treatment, K3 received 2 mL/day of salbutamol, and the dose groups were administered 2 mL/day of Ciplukan leaf infusion; all treatments were carried out simultaneously. On day 29, rats were dissected, and their lung organs were collected for histopathological preparation. Research findings revealed a reduction in bronchiolar epithelial thickness across groups in the following order: 495.05; 584.95; 334.69; 421.70; 482.81; 484.95 µm. The sequential lung eosinophil counts were 19; 44; 37; 23; 17; and 27, and mast cell counts were 9; 22; 13; 15; 13; and 7. Statistical analysis demonstrated significant differences at the 200 mg/kg BW dose for the parameters of bronchiolar epithelial thickness and eosinophil count, as well as significant differences in mast cell counts at the 800 mg/kg BW dose and negative control group.
Enhanced Ability of Agarwood Leaves (Aquilaria malaccensis Lam.) Ointment as Wound Healing to Heal Second-Degree Burns in Rats Desmiaty, Yesi; Sandhiutami, Ni Made Dwi; Fahleni, Fahleni; Griselda, Agnes; Apriliana, Amalia Zahra
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301214

Abstract

Agarwood leaves (Aquilaria malaccensis Lam.) contain chemical substances such as alkaloids, flavonoids, and triterpenoids that contribute to the healing process of burns. This study aims to evaluate the wound healing activity of spray-dried extract from agarwood leaves formulated into an ointment for second-degree burns. The method involves extracting agarwood leaves through the decoction method, followed by spray drying, and subsequent evaluation of the extract. The prepared extract was then formulated into an ointment and tested for wound healing activity on 24 white rats of the Sprague-Dawley strain, divided into four groups, each consisting of 6 rats: negative control (ointment base), positive control (Betadine®), formula 1 (agarwood leaves extract ointment with 20% extract concentration - ALO-20), and formula 2 (agarwood leaves extract ointment with 30% extract concentration - ALO-30). Second-degree burns were induced by exposing the rats' backs to ferrous metal for 3 seconds and treating them for 14 days. Observations were made by assessing changes in burn diameter and scab formation. In this study, ALO-30 demonstrated superior activity. Scab formation was faster on day 3, and the burn diameter was reduced by day 7. The results indicated that ALO-30 led to a quicker reduction in wound diameter compared to ALO-20 and the negative control. Agarwood leaves extract ointment with a concentration of 30% (ALO-30) exhibited a more effective wound healing effect than the ointment with a 20% concentration (ALO-20).
Sterility of Ophthalmic Solutions as a Factor in the Evolution of Primary Packaging for Eye Drops: A Literature Review Ivanov, Ivan Sergeevich; Akhmedova, Diana Alexandrovna; Koroleva, Yulia Anatolyevna; Shatalov, Denis Olegovich
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301211

Abstract

Preservatives in eye drops, while not always necessary, can lead to undesirable effects. Developing preservative-free solutions demands special measures for sterility, utilizing multidose or monodose primary packaging. This review explores the merits and drawbacks of these packaging types. A literature search on PubMed, Google Scholar, and EMBASE until December 2023, using MESH terms, yielded 28 studies on multidose ampoules and 24 on monodose packaging. Heterogeneous data revealed advantages and disadvantages concerning patient use and manufacturing. Chronologically presenting the development of eye drop packaging, this study finds Droptainer® simple but unable to maintain sterility. Comod®, 3K®, ABAK®, Novelia®, and Ophthalmic Squeeze Dispenser show high sterility probability, with Comod® and ABAK® having a contamination risk. Novelia® excels with long-term sterility and better control. Ophthalmic Squeeze Dispenser, FDA-approved, boasts a smaller carbon footprint. Unit-dose systems preserve sterility and offer design flexibility. Proposing an alternative, blister technology maintains sterility, is convenient and safe, and holds promise for recycling. This comprehensive assessment aids in understanding the evolving landscape of eye drop packaging, emphasizing the importance of sterility, convenience, and environmental impact.

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