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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 64 Documents
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Comparative Effectiveness of Sunnah Fasting Variations on Fasting Blood Glucose Monitoring in Type 2 Diabetes Mellitus: A Pragmatic Pilot Study Rosyid, Abdur; Satibi, Satibi; Rahmawati, Fita; Lazuardi, Lutfan
Sciences of Pharmacy Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502673

Abstract

Intermittent fasting has increasingly been incorporated into complementary and alternative medicine (CAM) strategies for the management of type 2 diabetes mellitus (T2DM). The extent to which weekly fasting frequency dictates glycemic outcomes is well-noted; however, the distinct clinical benefit of increasing Sunnah fasting adherence to two days weekly remains an unresolved question in diabetes management. This study aims to compare the effectiveness of Monday-only Sunnah fasting versus combined Monday and Thursday Sunnah fasting on Fasting Blood Glucose (FBG) among patients with Type 2 Diabetes Mellitus (T2DM). This research is a pre-experimental employing a within-subject exploratory pilot comparison with a single-group pre-post design involving 50 participants selected through purposive sampling, with data analyzed using the Wilcoxon Signed Ranks Test (p < 0.05). The results demonstrated that most participants (84%) were between 43 and 54 years of age, and the majority were female (56%). practicing Sunnah fasting twice weekly (Monday and Thursday) resulted in significantly lower average FBG (186,67 mg/dL) compared to fasting only once a week on Mondays (202.28 mg/dL), statistically significant reduction in FBG (Z= -2.660, p= 0.008; r= 0.37, Cohen’s d= 0.79). The study suggests that practicing Sunnah fasting twice weekly offers a more favorable impact on fasting blood glucose control for T2DM patients than fasting only once a week.
Chemometrics in Pharmaceutical Formulation: A Two-Decade Bibliometric Review (2005-2025) Puspitasari, Lia; Larasati, Rizky Dwi; Maharani, Zahra Ayu
Sciences of Pharmacy Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502568

Abstract

Chemometrics is essential in modern pharmaceutical development for enhancing analysis and quality control. Despite its importance, the evolutionary trajectory and thematic shifts of chemometrics within pharmaceutical formulation have not been comprehensively synthesized. This study aims to explore publication trends, scientific collaborations, and keywords in research related to the application of chemometrics to pharmaceutical formulations, using a bibliometric approach. Data were retrieved from Scopus (2005–2025) using a structured search strategy focusing on "pharmaceutical formulation", "drug formulation", and "pharmaceutical development". The search was limited to English-language original articles or reviews. Bibliometric mapping was performed using VOSviewer and the Bibliometrix R-package, applying a minimum keyword occurrence of 5, full counting method, and association strength normalization. A total of 516 documents were identified. Publications have increased significantly in the last decade, with research articles being the dominant document type. Egypt and the United States are the countries with the highest contribution and citation impact. The Journal of Pharmaceutical and Biomedical Analysis is ranked highest in terms of the number of publications and influence. Khan, Mansoor A., is the most productive author, while the Faculty of Pharmacy at Cairo University and the FDA are the most productive organizations. Keyword analysis revealed various main themes and a division into seven clusters, highlighting an evolutionary shift from traditional analysis toward Process Analytical Technology (PAT) and Quality by Design (QbD). These findings highlight the importance of cross-disciplinary collaboration and the potential for further exploration of novel approaches in pharmaceutical product development.
Natural Antidepressant Candidate from Cassia alata L. Ethanolic Extract: Behavioral (TST-FST) Evidence in Mice Putri, Kristina Srirahayu Damaiyanti; Nabella, Juwita Rosalia Sintia; Su’aida, Nily; Erlianti, Karina
Sciences of Pharmacy Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502577

Abstract

Cassia alata L. is a medicinal plant containing various secondary metabolites with reported neuroactive properties. This study aimed to evaluate the antidepressant-like behavioral effects of the ethanolic extract of Cassia alata Leaves in mice using acute behavioral despair tests. Male mice (n = 5 per group) were orally administered ethanolic extract of Cassia alata leaves at doses of 100, 200, and 400 mg/kg body weight. A sub-acute stress exposure protocol using the Tail Suspension Test was applied, and antidepressant-like activity was subsequently evaluated using the Forced Swimming Test, with immobility time at T2 as the primary outcome measure. Amitriptyline served as the standard drug. Data were analyzed using one-way ANOVA followed by Tukey’s HSD post hoc test (p0.05). Chemical profiling was performed using LC–MS/MS. One-way ANOVA revealed a significant difference in immobility time among groups (F (4,20) = 21.465, p0.001). Post hoc analysis showed that all extract-treated groups exhibited significantly lower immobility times compared to the negative control (p0.05). The highest dose (400 mg/kgBW) was not significantly different from amitriptyline (p0.05), while lower doses showed intermediate effects. LC–MS/MS analysis tentatively identified 17 compounds, including flavonoid derivatives, luteolin, and anthraquinones. Under the present experimental conditions, the ethanolic extract of Cassia alata leaves exhibited antidepressant-like behavioral activity in acute animal models. These findings are limited to short-term behavioral observations and do not establish clinical efficacy, safety, or underlying mechanisms. Further studies are required to clarify the pharmacological relevance and translational potential of this extract.
Antiprostatic Activities of Hippocratea africana Root Extract and Fractions Against Testosterone-Induced Benign Prostatic Hyperplasia in Rats Okokon, Jude Efiom; Ekeleme, Daniel; Essien, Grace Emmanuel
Sciences of Pharmacy Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502621

Abstract

Hippocratea africana (Willd.) Loes. ex Engl. (Celastraceae) syn. Loeseneriella africana (Willd.) N.Hallé root which is used as medicine traditionally to treat various diseases by the Ibibios was investigated for antiprostatic effect against testosterone-induced benign prostatic hyperplasia (BPH). The dried root powder was cold extracted in 50% ethanol and the extract dissolved in distilled water and partitioned with dichloromethane (DCM) to obtain DCM and aqueous fractions of H. africana root. BPH was induced in groups of male rats (n=5) using testosterone propionate (3 mg/kg). Based on previously determined median lethal dose, the root extract and fractions of H. africana (200-600 mg/kg) were investigated for effects on prostate weight and histology, prostate sensitive antigen (PSA), testosterone levels, lipid profile, oxidative stress markers, semen analysis and testis histology of rats with testosterone propionate–induced BPH. Finasteride (5 mg/kg) was used as standard drug. The root extract/fractions were found to cause significant (p<0.05- 0.01) decreases in PSA and testosterone levels, reductions in prostate and testis weights, improvement of semen volume and health, elevations of antioxidant enzymes (SOD, CAT,GPX) and molecule (GSH) and also reduced MDA level. These results suggest that the root extract and fractions of H. africana possess antiprostatic potentials against testosterone-induced BPH in rats which may be due to the antioxidant activities of its phytochemical constituents.

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