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Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 28 Documents
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Search results for , issue "Vol 5 No 1 (2025): August" : 28 Documents clear
Comparative Antibacterial Effects of Honey Bee Propolis on Gram Negative Bacteria Escherichia coli and Gram Positive Bacteria Staphylococcus aureus Hestiyani, Rani Afifah Nur; Handini, Tri Okmawati; Nitihapsari, Galuh Yulieta; Ning Widhi, Anriani Puspita Karunia; Wahyudin, Wahyudin
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.15814

Abstract

Antimicrobial resistance in pathogens such as Escherichia coli and Staphylococcus aureus poses an urgent global health challenge. Honeybee propolis is known for its promising antibacterial potential.This study aimed to compare the antibacterial effectiveness of propolis against E. coli (Gram-negative) and S. aureus (Gram-positive) using the in vitro disk diffusion method. Propolis was tested at concentrations of 6.25%, 12.5%, 25%, 50%, and 100% against both bacterial species. Disk diffusion assays were conducted on Mueller Hinton Agar, and inhibition zones were measured using a vernier caliper. Data were analyzed using one-way ANOVA. The results showed the Inhibition zone diameters increased with higher propolis concentrations. At 100% concentration, S. aureus showed a 15 mm inhibition zone, while E. coli showed only 7 mm. One-way ANOVA indicated significant differences (p < 0.05) in both bacteria. These findings indicate that propolis exhibits antibacterial activity against both S. aureus and E. coli, with greater effectiveness against Gram-positive S. aureus. These findings support the potential use of propolis as a natural antibacterial agent, particularly for Gram-positive infections.
Relationship Between History of Exclusive Breastfeeding and the Incidence of Stunting in Toddlers Jafar, Cindy Puspita Sari Haji
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.16029

Abstract

Stunting is a condition in which the height or length of a toddler is lower than it should be based on age, which is caused by long-term malnutrition, especially in the first 1000 days of life (HPK). The purpose of this study was to determine the relationship between the history of exclusive breastfeeding and the incidence of stunting in toddlers. The researcher used the Purposive Sampling Technique. The samples in this study were mothers and toddlers aged 2-5 years who had been registered at the Tilango Health Center, Gorontalo Regency, totaling 92 samples. The results of the study using the Chi-square test obtained ap value of 0.038 (p <0.05), which showed that the variable history of exclusive breastfeeding had a significant relationship with the incidence of stunting in toddlers aged 2-5 years at the Tilango Health Center, Gorontalo Regency. The Health Center is expected to be able to carry out routine monitoring of children at risk of stunting, with special attention to exclusive breastfeeding.
Mitral and Tricuspid Valve Regurgitation as a Subclinical Manifestation of Rheumatic Heart Disease: A Pediatric Case Report Oliviany, Windy; Aristya, Davina Aqiilah
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17120

Abstract

Background: Rheumatic heart disease (RHD) accounts for approximately 15.6 million cases globally, with 282,000 new cases and 471,000 episodes of acute rheumatic fever (ARF) annually, predominantly affecting children aged 5–15 years in the Pacific region. In 2015, the incidence in Indonesia reached 1.18 million cases, mostly among children and young adults. RHD results from valvular damage due to an autoimmune inflammatory response to Group A Streptococcus (GAS) infection. It primarily affects the mitral valve (75%), aortic valve (25%), and rarely the tricuspid valve. ARF typically precedes RHD, marked by valvular abnormalities. Initial symptoms include sore throat, progressing in 2–4 weeks to fever and clinical signs such as polyarthralgia, polyarthritis, chorea, and erythema marginatum. Complications may include infective endocarditis, heart failure, stroke, and atrial fibrillation. The World Heart Federation recommends prophylactic administration of Benzathine benzylpenicillin G (BPG) every 3–4 weeks to prevent recurrent streptococcal infections. Case Report: An 8-year-old boy presented with left-sided chest pain described as pressure-like and non-radiating, along with fatigue, nausea, and joint pain for four days. He had a history of recurrent pharyngitis beginning a year earlier. A positive Anti-Streptolysin O (ASTO) test was previously recorded. Due to persistent joint pain and chest discomfort, the patient was referred to a tertiary hospital and hospitalized for four days. Physical examination showed a body weight of 20.5 kg, height 119 cm, with no murmur or tachycardia, but arthritis and erythema marginatum were observed. Laboratory findings indicated leukocytosis (14,110/mm³), and echocardiography revealed mild mitral and tricuspid regurgitation consistent with RHD. He was treated with intramuscular BPG (600,000 IU) and oral aspirin. The patient continues monthly outpatient follow-ups for BPG injections. Conclusion: RHD remains a significant contributor to childhood morbidity and mortality. This case highlights an atypical subclinical presentation without murmur, identified through echocardiography showing dual mild valvular insufficiency. Treatment included BPG and aspirin.
Gambaran Histopatologi Jaringan Paru Tikus (Rattus norvegicus) Pada Beberapa Keadaan Tenggelam di Air Tawar Savitri, Annisa; Syamsu Hidayat, Muhammad Zaenuri; Rahmawati, Indah; Pratidina, Rr. Wening Gelar
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.14846

Abstract

Background: Drowning remains a significant cause of mortality, with complex pathophysiological mechanisms that are often challenging to diagnose. Histopathological examination of the lung is one of the tests that supports the diagnosis of the cause of death and manner of death in drowning cases. Objective: This study aims to analyze the histopathological features of rat lungs drowned in freshwater under conscious, unconscious, and post-mortem conditions. Methods: A descriptive experimental study by dividing the rats into three conditions; conscious, unconscious and post-mortem drowning. The lung tissues collected from the drowned rats, processed, stained with hematoxylin eosin and observed under the microscope. The results stated in descriptive form and scores. Results: In Group 1, alveolar edema (score 2), hemorrhage (score 4), inflammatory cell infiltration (score 2.2), and alveolar thickening (score 2.4) were observed. Group 2 exhibited a similar histopathological pattern to Group 1. Group 3 showed mild alveolar edema (score 1), massive hemorrhage (score 4), extensive inflammatory cell infiltration (score 4), and severe alveolar thickening (score 3). Conclusion: Histopathology of lung tissue of rats that drowned alive showed moderate alveolar edema, massive hemorrhage, moderate inflammatory cell infiltration and moderate alveolar thickening. Rats that drowned unconsciously showed moderate alveolar edema, massive hemorrhage, moderate inflammatory cell infiltration and moderate alveolar thickening. Rats that drowned after death showed minimal alveolar edema, massive hemorrhage, massive inflammatory cell infiltration and severe alveolar thickening.
Pengaruh Afirmasi Positif terhadap Tingkat Kecemasan Anak saat Hospitalisasi di RSUD Dr. M.M Dunda Limboto Parawouw, Dewi Carlina; Paramata, Nanang Roswita; Antu, Mihrawaty
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.14871

Abstract

Anxiety is a response to unpleasant situations and is commonly experienced daily, particularly by children. One approach to addressing anxiety is through the use of positive affirmations. This study aims to analyze the effect of positive affirmations on children's anxiety levels during hospitalization at RSUD Dr. M.M. Dunda Limboto. This quantitative study utilized a quasi-experimental design with a non-equivalent control group approach. The sampling technique employed was incidental sampling, with a population of 177 respondents and a sample size of 38 respondents, including 19 in the intervention group and 19 in the control group. The instruments used in this research were a Standard Operating Procedure (SOP) for positive affirmations and the Visual Analog Scale for Anxiety (VAS-A) observation sheet. Non-parametric Wilcoxon testing was used for data analysis within the same group. The p-value for the intervention group was 0.000, indicating a significant change in anxiety levels before and after receiving positive affirmation intervention. In contrast, the p-value for the control group was 0.157, indicating no significant change in anxiety levels before and after the intervention. For data analysis between the two unpaired groups, an independent t-test was conducted, yielding a p-value of 0.001, indicating a significant difference in anxiety levels between the intervention group (receiving affirmations) and the control group (without affirmations) during hospitalization at RSUD Dr. M.M. Dunda Limboto. The study concludes that positive affirmations significantly affect children's anxiety levels during hospitalization at RSUD Dr. M.M. Dunda Limboto. Therefore, this study may serve as valuable information and input for RSUD Dr. M.M. Dunda Limboto to enhance the quality of hospital services and incorporate positive affirmations as an effort to reduce the impact of hospitalization on pediatric patients.
PCI Revascularization Strategies in Patients with Acute Myocardial Infarction and Multivessel Disease Laksono, Sidhi; Widyani, Wella
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.16915

Abstract

Background: The incidence of Acute Myocardial Infarction (AMI) accompanied by Multivessel Disease (MVD) has increased annually, necessitating appropriate revascularization strategies to minimize clinical risks. Objective: This study aimed to evaluate various revascularization strategies using Percutaneous Coronary Intervention (PCI) that can be applied in patients with AMI and MVD. Methods: A systematic review was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. The keywords used were (“Revascularization" AND "Multivessel Disease" AND "Acute Coronary Syndrome”) OR (“Revascularization" AND "Multivessel Disease" AND "Acute Myocardial Infarction”). Articles were collected based on inclusion criteria: original articles, published in English, and published between 2020 and 2025. Results: A total of 1,263 articles were found in the initial search. Of these, 169 were excluded due to duplication, 1,069 due to irrelevant PICO criteria, and 6 due to limited access. From the remaining 19 articles, it was found that revascularization strategies could be classified based on the number of vessels treated (culprit-only, incomplete, and complete revascularization) and the timing of the intervention (immediate and staged revascularization). Conclusion: No single strategy was superior in all contexts. The choice of revascularization strategy should be individualized based on each patient’s clinical status and coronary anatomy to optimize outcomes.
Iron Given, Iron Denied: Neonatal Hematologic Alterations in Obese Pregnancies Despite Universal Supplementation Santosa, Qodri; Priyanto, Edy; Muntafiah, Alfi
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17102

Abstract

Background: Maternal obesity, a pro-inflammatory state now highly prevalent among women of reproductive age in Indonesia, may undermine the effectiveness of antenatal iron supplementation. Neonatal iron deficiency remains a public health concern, with maternal inflammation potentially disrupting fetal iron transfer. Objective: To investigate the association between maternal third-trimester Body Mass Index (BMI) and neonatal hematologic and iron parameters, within the context of standardized antenatal iron supplementation. Methods: This hospital-based cross-sectional study in Central Java, Indonesia, enrolled84 full-term neonates whose mothers received iron supplementation. Subjects were stratified by maternal BMI into non-obese (<25 kg/m²) and obese (≥25 kg/m²) groups. Cord blood was analyzed for hematologic indices (hemoglobin, Mean Corpuscular Volume [MCV], Mentzer Index) and iron biomarkers (ferritin and hepcidin). Results: Neonates from obese pregnancies exhibited significantly higher MCV (103.4 ± 5.1 fL vs. 100.1 ± 4.9 fL, p=0.004) and Mentzer Index (21.8 ± 4.7 vs. 21.3 ± 2.9, p=0.040) compared to the non-obese group. These findings suggest macrocytic shifts and possible ineffective erythropoiesis. No significantdifferences were observed in hemoglobin, ferritin, or hepcidin levels between groups. Conclusion: Maternal obesity during late pregnancy is associated with altered neonatal hematologic profiles, despite standardized iron supplementation. These results underscore a potential inflammation-mediated disruption in placental iron transfer and erythropoiesis, reinforcing the need for tailored antenatal strategies that incorporate maternal metabolic screening and functional hematologic monitoring for atrisk infants.
The Effectiveness of FAST Method Education in Early Stroke Detection Efforts for Hypertensive Patients at Pa’betengang Community Health Center, Bantaeng Arafah, Salmah; Dewiyanti, Dewiyanti; Ernawati, Ernawati; Kamriana, Kamriana; Oktaviana, Dina; Alwi, Alwi
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17151

Abstract

Stroke is a major complication of hypertension that leads to disability and death; however, knowledge among hypertensive patients regarding the early signs of stroke remains low. This study aimed to evaluate theeffectiveness of the FAST (Face, Arm, Speech, Time) educational method in improving early stroke detection skills among hypertensive patients. A one-group pre-experimental pre-post design was used involving 60 hypertensive patients at the Pa’betengang Community Health Center, Bantaeng Regency. The education was delivered in two sessions using visual media and interactive simulations. Knowledge was measured using a questionnaire administered before and after the intervention. The results showed an increase in the average knowledge score from 10.63 (SD ±2.85) to 17.18 (SD ±1.96) after the intervention, with a statistically significant difference (p < 0.001). The FAST method of education was proven effective in enhancing early stroke detection abilities among hypertensive patients. This intervention is recommended as an educational strategy in promotive programs within primary healthcare services.
The Correlation Between Physical Activity Levels With Salivary Cortisol Levels on Medical Students, at Jenderal Soedirman University Nugraha, Raffy Ave; Mustofa, Mustofa; Candrawati, Susiana; Sinensis, Rizki Amelia; Wulansari, Rahmawati
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17175

Abstract

Medical students generally have low levels of physical activity. Medical students also experience more severe stressors than students in other study programs. Salivary cortisol levels can reflect a person's stress level. This study aims to determine the correlation between physical activity levels and salivary cortisol levels in medical students at Jenderal Soedirman University. This study was conducted on 50 medical students at Jenderal Soedirman University aged 18–25 years. The study subjects were selected using purposive sampling. Physical activity levels were measured using the International Physical Activity Questionnaire-Long Form (IPAQ-LF), and saliva cortisol levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The correlation test used was Pearson's correlation test with a significance level of p<0.05. The results showed that the average physical activity level and saliva cortisol levels of the respondents were 1334.31±552.10 MET-minutes/week and 9.76±2.97 ng/mL. Bivariate analysis showed a p-value of 0.507, indicating that there was no correlation between physical activity levels and saliva cortisol levels among medical students at Jenderal Soedirman University.
Relationship Between Diabetes Distress and Self Management on Type 2 Diabetes Mellitus Patients in Sumbang District Banyumas Fadillah, Aulia Nur; Wulansari, Rahmawati; Kuncoro, Prasetyo Tri; Isnaya, Purwa Riana; Oktavilia, Ernasiwi Astri; Anamani, Teguh
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17204

Abstract

Background: Diabetes distress is a form of anxiety, worry, fear, and perceived threat related to the struggles experienced by individuals living with diabetes mellitus. The presence of diabetes distress is associated with reduced self-care (self-management). Diabetes mellitus self-management refers to a series of actions taken by individuals to manage their medical condition, including dietary regulation, physical activity management, regular and consistent intake of diabetes medication, blood glucose monitoring, and routine foot care. Objective: This study aims to determine the relationship between diabetes distress and self- management in patients with type 2 diabetes mellitus in Sumbang District, Banyumas. Method: This research uses an analytical observational study with a cross sectional approach. The sampling technique used was a total sampling of 55 people. Data analysis using the chi-square test. Research Results: The results of the research showed that self-management of type 2 DM patients was mostly in the sufficient category, namely 25 people (45.5%) and diabetes distress of type 2 DM patients is in the mild category, namely 35 people (63.6%). There is a relationship between diabetes distress and self-management in type 2 diabetes mellitus patients in Sumbang District, Banyumas (p = 0.000). Conclusion: Diabetes distress is related to self-management in type 2 diabetes mellitus patients.

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