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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 10 Documents
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Search results for , issue "Vol. 7, No. 2" : 10 Documents clear
Effects of 5% astaxanthin gel on angiogenesis and granulation tissue in second-degree burn animal model Rofiq, Aunur; Yuniaswan, Anggun Putri; Nugraha, Rizki Hapsari
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Burn injuries generate more free radicals and lead to complex immune dysfunction, which can delay wound healing compared to other wound types. Angiogenesis, essential for wound healing, requires granulation tissue as a marker for successful wound healing. Low concentrations of reactive oxygen species (ROS) are necessary to initiate this process. Astaxanthin is a potent antioxidant with anti-inflammatory properties, known to activate angiogenesis and modulate ROS signaling during wound healing. Methods: This experimental study aimed to evaluate 5% astaxanthin gel on second-degree burns using 30 male Wistar rats. Simple random sampling was utilized. A total of 6 groups were divided according to the time the lesions were evaluated i.e., I. Normal saline, day 2 (n=5); II. Normal saline, day 5 (n=5); III. Normal saline, day 7 (n=5); IV. 5% astaxanthin gel, day 2(n=5); V. 5% astaxanthin gel, day 5 (n=5); VI. 5% astaxanthin gel, day 7 (n=5). Histological assessment of angiogenesis and granulation tissue was based on the number of blood vessels and the extent of the wound to the dermis, respectively. Result: The mean of angiogenesis in 5% astaxanthin gel group was higher than the control group on day 5 (p-value < 0.05). The positive correlation between angiogenesis and granulation tissue was observed on day 5 (p-value < 0.05). Conclusion: The primary effect of 5% astaxanthin gel is during the proliferative phase of wound healing in second-degree burns.
Item generation in the development of a questionnaire for predicting multidrug therapy compliance in leprosy Siskawati, Yulia; Asih, Sali Rahadi; Kekalih, Aria; Menaldi, Sri Linuwih; Herqutanto, Herqutanto; Bramono, Kusmarinah
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Lengthy therapeutic regimens in leprosy are prone to defaults, contributing to more antibiotic-resistant Mycobacterium. Intervening patients’ medical habits midway would be more complicated than understanding their perception of undergoing such regimens in advance. We study the factors considered relevant to leprosy patients’ compliance to construct a novel self-reporting questionnaire that can predict the patients’ adherence before initiating multidrug therapy. Methods: According to the Delphi methods, we conducted three rounds of interviews with twenty-three respondents from various backgrounds, including dermatologists, government officials, healthcare workers, and patients with leprosy, to infer the associated factors of the included items. Each item was scored using the Likert scale, and accepted items (scores above 75%) were classified into six-dimensional categories based on the health belief model theory. Result: The initial 236 items were simplified to 72 items. Then, a panel discussion was conducted to score each item. Finally, 48 items were accepted and categorized into 12 indicators from 6 dimensions. The 12 indicators encompass knowledge about leprosy, its severity, therapeutical options, stigma, challenges in the treatment maintenance, availability of medical facilities and workers, therapeutic impact, drug regulation, health personnel, personal beliefs, attitude, and motivation. (p Conclusion: The study identified 12 critical factors influencing adherence to leprosy treatment, contributing to the prevention of antibiotic-resistant mycobacterium and providing valuable insights through the predictive self-reporting questionnaire.
User acceptance of DeSkab mobile application for early detection of scabies in Indonesia Widaty, Sandra; Friska, Dewi; Bramono, Kusmarinah; Sari, Siti Maulidya; Darmawan, Irene; Kekalih, Aria
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Individual case management strategy is not suitable for reducing scabies transmission, especially in high prevalence settings. A community-based approach has been proposed to control scabies. We developed a mobile application, called DeSkab, to empower non-medical personnel in crowded populations e.g., boarding schools, and to aid the identification of skin lesions suggesting scabies based on the cardinal signs of scabies. Early treatment and prevention of scabies transmission is expected to follow this approach. This was the initial development of the DeSkab mobile application which aims to assess user acceptance. Methods: The DeSkab mobile application was designed using Java and XML, supported by Google's Android. The scabies detection and education features were the app’s key distinctive aspects. An online survey was performed, aimed at potential users, including boarding school teachers and healthcare workers. The survey was divided into four sections: application design and user-friendliness, early detection data entry and interpretation, education features, and user recommendations. Result: Overall, users' acceptance of this application was good. More than 70% of the users gave good feedback for the application. Using mobile health makes it easier for the users to find information about scabies and check whether their skin lesions are suggestive of scabies. Conclusion: This application is expected to help expand scabies detection, especially in crowded communities. Improvements must be made to the interface, data entry, and educational material for the app's next iteration. Further study is needed to determine how mobile health application can improve scabies detection in communities.
The importance of multidisciplinary approach in management of pressure injury in elderly with multiple comorbidities Kusumawardhani, Dina; Yusharyahya, Shannaz Nadia; Legiawati, Lili; Astriningrum, Rinadewi; Adistri, Kara
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Pressure injury (PI) can occur as a result of prolonged bed rest in immobilized patients. The healing process is often slow if the wounds are not managed comprehensively, particularly in elderly patients or patients with neurological disorder, diabetes mellitus, and malnutrition. Proper treatment can improve the healing process. Case illustration: A 66-year-old female with multiple comorbidities presented with PI on the left lower back, as well as the sacral and right gluteal regions. She was diagnosed with grade 3 and unstageable PI, and was treated using a multidisciplinary approach. Her wounds were treated with a combination of hydrogels and polyurethane foam dressings. Discussion: Managing comorbidities, optimizing local wound care, regular repositioning in special mattress, and improving nutritional status are necessary to accelerate healing in cases of PI. There was an increase in the wound granulation and epithelialization, as well as a decrease in the ulcer size and exudates after 16 weeks of treatment. A considerable amount of time is needed to treat grade 3 and unstageable PI in an immobile elderly patient with multiple comorbidities. Conclusion: Multidisciplinary collaboration among healthcare workers is essential for the treatment of PI in elderly populations.
A 61-year-old Filipino man with lichen planus concomitant with cicatricial alopecia, mimicking discoid lupus erythematosus Harris, Lie Michelle E.; Carpio, Benedicto dL; Regalado-Morales, Eileen; Guzman, Amelita Tanglao-De; Lapitan-Torres, Armelia
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Abstract

Background: Lichen planus (LP) is an idiopathic inflammatory disease affecting the skin, mucous membranes, hair, and nails. Even though rare, LP may also present as cicatricial alopecia or a condition referred to as lichen planopilaris (LPP). On the other hand, lupus erythematosus (LE) is an autoimmune disorder with a possibility of systemic involvement. Classical discoid lupus erythematosus (DLE) is the most common form of LE and has a hallmark of scarring alopecia. Case Illustration: A 61-year-old Filipino man presented with a 7-month history of persistent multiple erythematous hairless scarring plaques on the scalp with multiple erythematous–violaceous to hyperpigmented atrophic plaques on the face and distal upper extremities. Discussion: The remarkable atrophic scarring alopecia on the scalp, along with the atrophic coin-shaped plaques on the face and extensor aspects of both forearms on this patient, brought DLE as the initial clinical impression. Besides cicatricial alopecia being a prevalent feature of DLE, the noticeable scarring alopecia on the scalp with the concomitant appearance of multiple atrophic skin lesions on sun-exposed areas supported this reasoning. Nevertheless, the skin punch biopsy of this patient showed numerous histopathological features of LP. Conclusion: LP can present with several morphological cutaneous presentations, including atrophic LP, which may mimic cutaneous DLE. Even though LP is a non-scarring disease, a follicular variant of LP, LPP has a distinct clinical and histologic entity with associated scarring alopecia. The presence of atrophic cutaneous LP concomitant with scalp LPP may mimic DLE clinically.
Lichen amyloidosis treated with topical combination therapy and narrowband ultraviolet B phototherapy Hasibah, Ulfah Hasna; Ferina, Siti Aisha Nabila; Komarasari, Eka; Esti, Prima Kartika; Angin, Lenti Perangin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Lichen amyloidosis (LA) is characterized by linear rows of firm, pigmented, grouped, hyperkeratotic papules that can form a plaque, usually occurring on the shins and forearms, with intense itch as the prominent symptom. Case Illustration: A 57-year-old female complained of brown spots on her shins and arms that gradually thickened six years ago. The lesions were brown, multiple, discrete, slightly scaly papules forming hyperpigmented plaques. The result of the histopathology examination showed an acanthotic epidermis with hyperkeratotic foci and eosinophilic amorphous mass deposits in the papillary dermis with brown pigments. The working diagnosis was lichen amyloidosis. Topical treatments were ointment consisting of 6% salicylic acid mixed with clobetasol propionate ointment 0.05% used once daily and emollient used twice daily. Narrowband ultraviolet B (NB-UVB) was administered at a dose of 300 mJ/cm2 once a week and increased by 10-20% on the next episodes. After six weeks of treatment, there were no new brown spots, the lesions became thinner and less erythematous, and the itch decreased significantly. Discussion: The factors that induce and worsen LA are pruritus and scratching. Topical combination therapy of salicylic acid and corticosteroid can increase the effectiveness of treatment on thick, scaly plaque lesions. NB-UVB was found to reduce pruritus. Conclusion: Topical combination therapy of keratolytic agents and potent corticosteroids can be used as a non-invasive therapy to improve skin lesions by thinning these lesions in LA patients. NB-UVB phototherapy has also been significantly shown to relieve a patient’s severe itch.
Histoid leprosy mimicking lichen planus Kimberly, Kesya; Alviariza, Annisa; Ferina, Siti Aisha Nabila; Esti, Prima Kartika; Peranginangin, Lenti Br.; Komarasari, Eka
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Histoid leprosy is a rare variant of lepromatous leprosy (LL), characterized by unique clinical, histopathological, and microbiological features. This type of leprosy is caused by multidrug therapy (MDT) drug resistance, train mutation of Mycobacterium leprae, or genetic factors. Case Illustration: A 21-year-old Indonesian woman with a family history of histoid leprosy complained of multiple hypo-esthetic erythematous partly flat-topped papules around the lesion on the face and bilateral superior and inferior extremities for the last two years. A Slit-skin smear examination revealed acid-fast bacilli with a bacterial index (BI) of 4.17+ and morphological index (MI) of 1%. Histopathological examination on hematoxylin & eosin (H&E) stained revealed epidermal atrophy, Grenz zone, and bundles of thin spindle-like histiocytes with Virchow cells. Ziehl-Nielsen stain showed copious acid-fast bacilli. Therefore, the diagnosis of histoid leprosy was established. Discussion: Lichen planus (LP) was considered because LP typically presents as pruritic, polygonal, violaceous flat-topped papules with symmetric distribution on the flexural surfaces of the forearms, wrists, and ankles, as well as the dorsal surface of the hands and shins. However, the face is rarely affected in LP. The patient’s slit-skin smear and histopathological examinations presented strong evidence for histoid leprosy. Treatment with an MDT regimen resulted in clinical improvements as the erythematous lesions transformed into hyperpigmentation after weeks of treatment. Conclusion: Histoid leprosy mimicking LP lesions in this patient developed without any prior administration of agents. Additionally, the patient had a high bacillary load, indicating a potential reservoir of the infection as the patient had a family history of leprosy.
The effect of bakuchiol in the skin aging process: A systematic review Priyanto, Olivia Jovina; Sugiyanto, Yosef Ferdinand Rahmat; Salim, Darryl Samuel
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: With aging, the skin gradually loses its structural and morphological coherence, decreasing its function. With aging and chronic ultraviolet (UV) exposure, the skin becomes thin and loses elasticity, and wrinkles, pigmentation, and texture irregularities appear. Today, people of all ages become interested in the cosmetic industry, aiming to make their skin appropriate to their age or look younger. Bakuchiol is a pure meroterpene phenol found mainly in the seeds of the Indian plant Psoralea corylifolia (babchi). It triggers antioxidant and anti-inflammatory activity and has anti-aging properties like retinol. The study aimed to know the effect of bakuchiol on the skin aging process. Methods: A systematic review of the literature was conducted. Data were collected and synthesized from online databases with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) protocol. Results: More than 125 articles were found, and six studies were selected according to this research. Of the six existing clinical trial studies, all showed that bakuchiol had a beneficial effect on reducing signs of skin aging. Conclusion: Bakuchiol has shown beneficial effects in preventing or reducing signs of skin aging, such as fine lines and wrinkles, loss of elasticity and firmness, dull skin, uneven hyperpigmentation, skin dryness, and texture irregularities, with minimal side effects.
Olive oil and hydration based on clinical assessment and transepidermal water loss: A systematic review Paramitha Jaya, Ni Made Ayu Nadia; Hermawan, Melyawati; Regina, Regina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Dry skin or xerosis is a layer of skin that loses moisture due to increased transepidermal water loss (TEWL). Olive oil, one of the most commonly available moisturizers, is often used to keep the skin hydrated. Skin hydration indicates the amount of water in the stratum corneum. This systematic review aimed to determine the association between olive oil application and skin hydration based on clinical assessment and TEWL parameters. Methods: The research design used was a systematic review based on the criteria of preferred reporting items for systematic reviews and meta-analyses (PRISMA). This systematic review search used PubMed, ProQuest, Google Scholar, CINAHL, and NLM Catalog databases. The risk of bias in the literature used in this study was assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Results: Five articles were included in this systematic review in which topical intervention on the skin was used with olive oil and other oils, placebo, or no therapy as controls. Olive oil can improve skin conditions clinically and provide various beneficial effects such as antioxidants and anti-inflammatory, but the oleic acid content, which is the main component of olive oil, has detrimental effects on the skin. Conclusion: This systematic review reveals that olive oil can improve skin condition clinically, but long-term topical application of olive oil may damage the integrity of the skin and increase TEWL.
Favorable benefits of autologous serum therapy in chronic spontaneous urticaria Shantharaju, Sanjana Agrahara; Hongal, Amrita; Gupta, Diksha; Jonnagadla, Girishma
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: In chronic spontaneous urticaria (CSU), autologous serum therapy (AST) is an alternative treatment modality that provides promising benefit of extended relief period without side effects and economic burden of pills. This study aimed to assesses the efficacy of AST in CSU patients irrespective of their autologous serum skin test (ASST) result. Methods: Patients were enrolled based on inclusion and exclusion criteria after taking written informed consent. A detailed history and clinical examination & relevant investigations were done. ASST was performed and irrespective of the test result AST was given to all study subjects that included weekly intramuscular injections for 8 times. Urticaria activity score (UAS), urticaria severity score (USS) and dermatology life quality index (DLQI) were recorded at baseline and 8th visit to note the improvement in the condition. Result: Among 34 patients, 24 patients (70.58%) had a positive ASST result while 10 (29.41%) were negative. In 24 patients with positive ASST result, the average UAS, USS, & DLQI was 2.95, 20.45, & 6.6 respectively at baseline and improved to 0.29, 1.83, & 0.45 respectively at week 8. In 10 patients with negative ASST, the average UAS, USS, and DLQI was 2.4, 20.9, & 8 respectively at baseline and improved to 0.4, 2.8, & 0.6 respectively at week 8 after AST. Irrespective of ASST result, improvement was observed in UAS, USS, & DLQI, which is statistically significant. Conclusion: AST is a beneficial alternative therapy in CSU patients with partial control of symptoms with pills.

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