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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 4 (2023)" : 60 Documents clear
Potensi antibakteri ekstrak daun gendola (Basella alba Linn var. rubra) terhadap Escherichia coli dan Staphylococcus aureus Diah Muldianah; Marsah Rahmawati Utami; Jekmal Malau
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.308

Abstract

Gendola leaves (Basella alba Linn var. rubra) have long been utilized as an alternative treatment for various bacterial infections. This study aims to evaluate and determine the most potent antibacterial activity among three different extracts of gendola leaves, namely n-hexane extract, ethyl acetate extract, and 70% ethanol extract against Staphylococcus aureus and Escherichia coli. The research followed a laboratory-based experimental approach that involved maceration extraction using three different solvents and antibacterial activity testing through the well-diffusion method. Each extract was assessed at five different concentrations (20%, 40%, 60%, 80%, and 100% w/v) and compared to positive control chloramphenicol (0.3% v/v) and negative control DMSO (10% v/v). The results showed that only the n-hexane extract exhibited no antibacterial activity. In contrast, the ethyl acetate and 70% ethanol extracts exhibited more effective antibacterial activity against Staphylococcus aureus than Escherichia coli, with ethyl acetate extract displaying the most potential antibacterial activity.
Skrining fitokimia dan isolasi senyawa steroid/triterpenoid dari ekstrak n-heksana daun Pepaya (Carrica papaya L) Cindy Widya Rosa Br Simarmata; Haris Munandar Nasution; M Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.324

Abstract

In Indonesia, papaya plants are common in several areas, from Sabang to Merauke. As a tropical country, almost all corners of Indonesia have various shapes and different types of papayas. Papaya leaves (Carica papaya L.) contain tannins, alkaloids, flavonoids, terpenoids, and saponins which act as antiparasitics. This research aims to determine the results of the chemical compound groups found in papaya leaves (Carica papaya L.). To determine the characteristics of isolates from n-hexane extract of papaya leaves (Carica papaya L.) using UV and IR spectrophotometry. This research includes making simplicia from papaya leaves, then phytochemical screening, then simplicia characterization, then making extracts from papaya leaf simplicia, after that analysis of the extract using the thin layer chromatography (TLC) method, then isolation using column chromatography (KK), purity testing using Two-way thin layer chromatography (TLC) and the isolation obtained were identified using ultraviolet (UV) spectrophotometry and infrared (IR) spectrophotometry. The results of the characterization of the Carica papaya L Simplicia showed that the water content was 4%, the water-soluble essence content was 16.64%, the ethanol-soluble essence content was 11.6%, the total ash content was 9.88%, the ash content was 0. 66%, the results of the phytochemical screening of Carica papaya L., simplicial contain steroid/triterpenoid compounds, alkaloids, flavonoids, saponins, tannins. The results of the isolated analysis showed that the isolate obtained was a violet-colored steroid/triterpenoid compound. The isolate obtained was analyzed using UV light spectrophotometry, giving an absorbance at a wavelength of 207 nm, indicating that there was a chromophore group. The IR spectrophotometry results showed OH, aliphatic CH, and CH2 groups, CH3, C=O and CO.
Prevalensi bakteri Salmonella sp. pada daging ayam potong di pasar tradisional, pasar modern, dan merek terkenal di kota Medan. Lulu Ilma Khoirun Nissa; Yayuk Putri Rahayu; D. Elysa Putri Mambang; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.330

Abstract

Chicken is a source of animal protein for humans. Chicken meat generally contains unsaturated fat; chicken meat also has a compact meat texture and simple protein, so it is easily digested. However, chicken meat can also be contaminated with Salmonella sp. Pathogenic bacteria can cause typhus or typhoid fever, caused by traders' lack of cleanliness and hygiene or their environment. Research was conducted to identify the presence of Salmonella sp. Pathogenic bacteria and analysing the value of Salmonella sp. Pathogenic bacteria contamination that met the Indonesian National Standard (SNI), namely harmful/25g in chicken meat from traditional markets, modern markets, and well-known brands in Medan City, and to determine the prevalence value of Salmonella sp. Bacteria. The method of research uses Total Plate Count (TPC). An identification test is first carried out to calculate and determine the presence of bacteria in a test sample for the existence of Salmonella sp. Pathogenic bacteria and choose the total value of contaminants using a Total Plate Count (TPC), then identify using a gram staining test. These biochemical tests include the indole test, MRVP test, citrate test, urea test, TSIA test, and LIA test. Then, the last one determines the Prevalence value of Salmonella sp. Bacteria. The results showed that the samples of traditional market and modern market chicken meat were positive for the presence of the pathogenic bacteria Salmonella sp. by obtaining Subgenus Salmonella Typhimurium on N2H8 sample code APTL and APTB, N3H15 sample code APTL, APTB, APMI and obtaining Subgenus Salmonella Thypi on N3H15 sample code APMS and the contamination value of the pathogenic bacteria Salmonella sp. Exceeds the threshold and does not meet the Indonesian National Standard (SNI), namely negative/25g. The prevalence value obtained by the pathogenic bacteria Salmonella sp. in broiler meat at Traditional Markets, Modern Markets, and well-known brands is 75%, 50%, and 0%, respectively.
Skrining fitokimia dan isolasi senyawa steroid/triterpenoid dari ekstrak n-heksana biji nangka (Artocarpus heterophyllus Lam). Tawir Rina Rezeki; Haris Munandar Nasution; M Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.331

Abstract

Nangka (Artocarpus heterophyllus Lam) merupakan tumbuhan yang dapat berkembang dengan baik di wilayah tropis seperti Indonesia. Biji Nangka mengandung senyawa kimia jenis steroid/triterpenoid, termasuk beberapa jenis steroid yang memiliki manfaat sebagai bahan dalam obat-obatan, seperti estrogen, progestin, dan kardenolida. Penelitian bertujuan untuk melakukan pengujian secara fitokimian dan juga mengisolasi senyawa steroid/ triterpenoid biji Nangka. Penelitian ini menggunakan metode eksperimental, termasuk proses ekstraksi senyawa dengan metode maserasi dan isolasi senyawa aktif melalui kromatografi kolom. Identifikasi isolat murni dilakukan dengan menggunakan spektrofotometri UV dan spektrofotometri IR. Hasil skrining fitokimia menunjukkan keberadaan senyawa steroid/triterpenoid, glikosida, dan alkaloida dalam sampel. Isolat tersebut memiliki warna ungu dengan nilai RF 0,25, dan puncak absorbansi maksimum terletak pada panjang gelombang 208,20 nm, menunjukkan adanya gugus kromofor. Hasil spektrofotometri IR menunjukkan adanya gugus seperti OH, -CH alifatis, CH2, CH3, C=O, C-O, dan C=C. Kesimpulan dari penelitian ini adalah bahwa isolat yang diperoleh termasuk dalam golongan senyawa steroid/triterpenoid.  
Strategi Pencegahan dan Peningkatan Pengawasan BPOM Terkait Kasus Cemaran EG/DEG dalam Sirup Obat Regina Liviandari; Patihul Husni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.341

Abstract

Contamination of ethylene glycol and diethylene glycol (EG/DEG) is suspected to be the cause of the undesirable incident of acute kidney failure in children, which occurred in Indonesia in 2022. As the institution tasked with monitoring the distribution of medicines in Indonesia, the Food and Drug Supervisory Agency (BPOM) has taken scientifically based strategic, responsive, and professional steps in handling and controlling these cases. The purpose of this article is to provide an overview of prevention strategies and increased supervision carried out by BPOM in handling cases of EG/DEG contamination in medicinal syrups. This article review was prepared through a literature study of 22 pieces of literature published between 2013-2023. The results of the literature review show that BPOM has taken responsive and professional steps in the form of strengthening the pharmacovigilance system, ensuring quality assurance in the pharmaceutical industry, monitoring the import of propylene glycol and polyethylene glycol, strengthening pre-market, post-market, and enforcement supervision, and providing information to the public as a prevention strategy and increased supervision in handling cases of EG/DEG contamination.
Uji aktivitas antibakteri formulasi sediaan gel antijerawat ekstrak etanol kulit buah alpukat (Persea americana Mill) terhadap bakteri Staphylococcus aureus Novi Yuliandari; Yayuk Putri Rahayu; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.327

Abstract

The avocado peel contains flavonoids, saponins, tannins, steroids, and glycosides and has antimicrobial properties. Staphylococcus aureus is a gram-positive bacteria and typical skin microorganism that causes acne. It produces lipase, which breaks down free fatty acids from skin lipids. The gel preparation was chosen. It is better used in treating acne because it does not contain oil or affect acne. This study aimed to determine whether the ethanol extract of avocado peel can be used as an anti-acne gel and to choose the inhibitory power of the gel preparation against Staphylococcus aureus. The ethanol extract of avocado peel was prepared using the percolation method; the extract was formulated into anti-acne gel with 10%, 20%, and 30%. Then, a physical evaluation of the preparation was carried out by assessing organoleptic, homogeneity, pH, viscosity, adhesion, spreadability, irritation, skin moisture, and syneresis. Then, the activity of Staphylococcus aureus bacteria was tested on gel preparations. The result is that the ethanol extract of avocado peel can be formulated into gel preparation. It has a distinctive aroma, is homogeneous, has a pH range of 6,2-6,9, has a value of viscosity, spreadability, and good adhesion, does not irritate, can moisturize the skin, and does not cause syneresis. The gel preparation had antibacterial activity against Staphylococcus aureus, namely a concentration of 10% inhibition of 14.56 mm, 20% inhibition of 19.46 mm, and 30% inhibition of 21.2%, so the interpretation of the inhibition zone was included in the susceptible category.
Pengaruh media video terhadap pengetahuan dan sikap remaja putri tentang pencegahan stunting di SMA Negeri 1 Labuhan Delikabupaten Deli Serdang Khairatunnisa Khairatunnisa; Sukamto Sukamto; Andini Mentari Tarigan; Ulan Dari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.335

Abstract

In North Sumatra Province, specifically in the area of Labuhan Deli in Deli Serdang Regency, stunting is still a concern in nutrition among toddlers. In Labuhan Deli, the percentage of instances of stunting rose from 0.48% to 1.46% in 2021. Since adolescent girls will eventually become mothers and bear the next generation, they have a tremendous chance to interrupt the cycle of stunting. Purpose : This study aims to determine the effect of video media on the level of knowledge and attitudes in adolescent girls about stunting prevention at SMA Negeri 1 Labuhan Deli, Deli Serdang Regency.  This is quantitative research with a Quasi Experiment Design. The population of this study was all adolescent girls at the school. The sample of this study was 42 adolescent girls taken by using Proportionate Stratified Random Sampling technique. Data analysis used Paired Sample t-test. The results showed that there were differences in knowledge before (mean = 7.17) and after treatment (mean = 11.00) and there were differences in attitudes before (mean = 28.64) and after treatment with (mean = 39.57). Paired Sample t-test results on the knowledge and attitudes of adolescent girls obtained p value = 0.000 (< α = 0.05). It can be concluded that there was an effect of video media on the level of knowledge and attitudes in adolescent girls about stunting prevention at SMA Negeri 1 Labuhan Deli, Deli Serdang Regency. It is suggested to the local Health Center to be able to utilize video media in the selection of health promotion media.
Hubungan pengetahuan dan sikap perawat rawat inap dengan upaya pencegahan dan penanggulangan kebakaran di RSU Mitra Medika Tanjung Mulia Salmira, Cut Saura; Najihah, Khoirotun; Amalia, Nur
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.344

Abstract

There is a possibility of work accidents at hospitals., especially fires. Ionizing radiation, chemicals, and medicinal gases are flammable elements that pose a significant fire risk. The observation's findings revealed that at Mitra Medika Tanjung Mulia Hospital, small extinguishers for fires of the dry chemical powder type and fire extinguishers for CO2, emergency stairs, routes for evacuation, and assembly points were available. However, some nurses continued to lack the knowledge necessary to utilize them. This study investigates factors associated with inpatient nurses' preventive efforts at Mitra Medika Tanjung Mulia Hospital. This cross-sectional study employs a quantitative methodology. There were 90 participants in the study, all nurses, and a purposive sampling technique was used to select a sample size of 35 participants. The chi-square test statistic is used in data analysis. According to the study, attitude has a p = 0.009 < 0.05, and knowledge has a p = 0.017 < 0.05. Based on these findings, Mitra Medika Tanjung Mulia Hospital's knowledge and attitudes regarding fire prevention. According to the study's findings, Mitra Medika Tanjung Mulia Hospital's fire prevention is influenced by certain factors. Hospitals should consider teaching all their nurses about fire safety so that they are well-versed in the subject and can prevent fires in medical facilities.
Review artikel: metode analisis dalam pengujian kandungan pewarna merah K10 (Rhodamin B) pada kosmetik Vista Kamilania; Patihul Husni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.349

Abstract

Cosmetics are products used to improve the appearance of the outer body. Cosmetics are inseparable from dyes. One dye that is often misused in cosmetic products is Rhodamine B. Rhodamine B can cause liver damage and irritation of the respiratory tract and is carcinogenic. This review article aims to provide information on the use of analytical techniques to identify cosmetic products containing rhodamine B. The method used is a literature review by searching research journals with a period of 2013-2023 on Science Direct and Google Scholar using the keywords "identification of k10 red dye in cosmetics", "rhodamine B analysis in cosmetics," and "k10 red dye analysis method in cosmetics". Based on the literature review that has been carried out, identifying the content of rhodamine B dye can be done with various analysis techniques including Thin Layer Chromatography (TLC), High Performance Liquid Chromatography (HPLC), UV Vis Spectrophotometry, Ultra Performance Liquid Chromatography Tandem Mass Spectrometric (UPLC-MS), and rapid test kit. Qualitative analysis of rhodamine B content in cosmetics can be done with KLT and a rapid test kit. Quantitative analysis can be done using UV Vis, KCKT, and UPLC MS spectrophotometry methods.
Formulasi sediaan salep sari kelopak jantung pisang kepok (Musa paradisiaca L) terhadap penyembuhan luka sayat pada tikus putih jantan (Rattuss norvegicus) Fahma Shufyani; Darwin Syamsul
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.383

Abstract

Background: Banana flower petals also have active compounds such as flavonoids, alkaloids and saponins. These active compounds are thought to be able to suppress the growth of bacteria. These compounds can be used to increase the regeneration of epidermal cells and the formation of new blood vessels to speed up healing and wound closure. This research aims to determine the healing effect of cut wounds from banana flower petals (Musa paradisiaca L) extract on male white rats (Rattus norvegicus) and what concentration is most effective in healing cut wounds. This Method research is an experimental study, including collecting samples, making kepok banana heart calyx juice with concentrations of 2%, 4% and 6%, ointment evaluation tests and cut wound healing activity tests on white mice which were grouped into 5 groups with each group consisting of of 5 mice. Statistical analysis included a one-way ANOVA test to see whether there was a significant difference between concentrations and wound healing in white male mice. The results showed that F1 (2% concentration) could heal mice on the 10th day, F2 (4% concentration) could heal mice on the 8th day, F3 (6% concentration) could heal cut wounds on the 7th day, positive control (Betadine Ointment) the mice recovered on the 6th day. The conclusion of this research is that Kepok banana heart petal juice can be formulated as an ointment for healing cuts in male white rats (Rattus norvegicus), with the most effective concentration being a concentration of 6% because it can heal cuts wounds the fastest among other concentrations.

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