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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 14 Documents
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Search results for , issue "JPS Volume 7 Nomor 3 (2024)" : 14 Documents clear
Prevalensi dan identifikasi cemaran bakteri patogen staphylococcus aureus pada ayam krispy Daerah Amplas Kota Medan menggunakan rabbit coagulase plasma with EDTA Rahayu, Yayuk Putri; Nasution, Haris Munandar; Supiyani, Supiyani
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.435

Abstract

Staphyococcus aureus bacteria is one of the bacteria that contaminates crispy chicken meat and can cause Extraordinary Events or Kejadian Luar Biasa (KLB) in Indonesia as a cause of diarrhea. This is due to lack of hygiene in processing, storing and serving crispy chicken. Poisoning can occur due to food contamination by S. aureus enterotoxin. The aim of the research was to analyze the prevalence and identify the presence of S. aureus bacteria found in crispy chicken meat in the Amplas area of Medan city using Rabbit Coagulase Plasma with EDTA. Method for identifying S. aureus using BPA (Baird Parker Agar Base) and Egg Yolk media. Specific identification testing using Gram staining, catalase test, and coagulase test using Rabbit Coagulase Plasma with EDTA. The value of S. aureus bacterial contamination using the TPC (Total Plate Count) method and analysis of the prevalence of S. aureus contamination. The results of research on roadside cart krispy chickens were found to be positive for S. aureus with characteristics of Gram positive, positive coagulase and positive catalase as well as contamination values above 1X102 CFU/ml exceeding the threshold so they do not meet SNI standards. Meanwhile, the local fast food crispy chicken value for the presence of S. aureus bacteria does not exceed the threshold of 1X102 CFU/ml so it meets SNI standards. The prevalence value of S. aureus contamination in roadside cart krispy chicken was 75.0% and local fast food was 8.3%.
Vegetables, Heavy metals, FAAS, Kajian Cemaran Logam Berat Timbal (Pb), Kadmium (Cd), Dan Merkuri (Hg) Pada Sayuran Di Daerah Pertambangan Aceh Jaya Secara Spektrofotometri Serapan Atom. Kurniaty , Rina; Adiyana, T.M. Dayan; Yusuf , Muhammad; Mahmudi , Mahmudi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.448

Abstract

Heavy metal contamination in vegetables poses a threat to humans, especially at predetermined thresholds. In this study, Pb, Cd, and Hg metals were analyzed using Flame - Atomic Absorption Spectrometry (F-AAS) and Vapor Generation Accesory - Atomic Absorption Spectrometry (VGA-AAS) methods at mining areas in Krueng Sabee Sub-District, Aceh Jaya District, Aceh Province. Method validation was conducted to obtain accurate heavy metal analysis results on the samples. The results showed that the highest Pb metal contamination was found in cassava leaf I sample with levels of 2.44 ± 1.33 mg/Kg and the lowest was found in spinach III sample with levels of 0.15 ± 0.07 mg/Kg. The high Pb content was also found in kale I and spinach I samples obtained in areas close to the mining area with levels of 1.07 ± 0.59 mg/Kg and 0.93 ± 0.50 mg/Kg, respectively. The highest Cd metal contamination content was found in kale II samples with levels of 0.11 ± 0.01 mg/Kg and the lowest Cd metal contamination with levels of 0.02 ± 0.01 mg/Kg was found in cassava leaf II samples. The highest Hg metal content of 0.58 ± 0.12 mg/Kg was found in cassava leaf I sample and the lowest level was 0.04 ± 0.02 mg/Kg owned by spinach III sample. Contamination of Hg metal in all vegetable samples showed levels that were above the established SNI 7387 (2009) quality standard of 0.03 mg/Kg. The quality standards for Pb and Cd metal contamination are 0.5 mg/Kg and 0.2 mg/Kg, respectively.  This study shows the need for government monitoring of heavy metal contamination in agricultural areas near mining activities to ensure safe food consumption.
Uji aktivitas afrodisiak ekstrak etanol daun cengkeh (Syzygium aromaticum L.) pada tikus putih jantan (Rattus norvegicus) Patala, Recky; Risnawati, Risnawati; Wulandari , Ayu; Yanuarty , Rezky; Handayani , Tien Wahyu
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.485

Abstract

Sex drive is what everyone needs to have a beautiful and harmonious sex life. Decreased sex drive is one of the factors that cause discord in relationships between men and women, and sexual dysfunction is a major concern. In Indonesia, this sexual disorder is most prevalent in men with a prevalence rate of 10% (all ages combined) and more than 50% occurs in the age group 50-70 years. The aim of this study was to determine the aphrodisiac effect of the extract by looking at several parameters, namely mount latency (ML), intromission frequency (IL), ejaculation latency (EL), mount frequency (MF), intromission frequency (IF), and ejaculation frequency (EF). This study used an experimental method with a post-test modified randomized control group design with 15 male white rats and 30 female white rats divided into 3 treatment groups with a ratio of (1: 2), each group consisting of 5 male rats and 10 female rats. Normal control group (NaCMC 0.5%), positive control group (X-Gra 52.5 mg/kgBB), and control test clove leaf extract sample at a dose of 250 mg/kgBB. Administration of extracts and comparators was only given to male white rats for 30 days. The results of this study indicate that clove leaf extract contains secondary metabolites of flavonoids, saponins, alkaloids, tannins, and strong antioxidants. The administration of clove leaf of extract at a dose of 250 mg/kg body weight showed a significant difference between the positive group and clove leaf of extract with a value of P < 0.05, this indicates that clove leaf of extract has aphrodisiac activity.
Analisis kadar parasetamol dan kafein dalam sediaan tablet menggunakan metode spektrofotometri derivatif zero crossing Pulungan, Ainil Fithri; Rosaldi, Hikmah; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.489

Abstract

The development of drugs in the form of combination tablets at this time has increased a lot; combining drugs in a tablet preparation can provide an increasing reaction and ability. This makes combining drugs such as Paracetamol and caffeine an effective combination in the pharmaceutical field. Paracetamol is an antipyretic analgesic drug that can be combined with caffeine which can be used in therapy with a combination of these drugs. The objective of this research was to ascertain the concentration of a combination of paracetamol and caffeine in a tablet formulation by employing a zero cross-derivative spectrophotometric method. In this study, solvent optimization was carried out with 17 categories of solvent selection, and acetate: methanol (30:70) was selected using the zero cross-derivative methods with a dA / d plot utilizing the maximum wavelength of paracetamol 258 nm and caffeine 288 nm, because there was an actual wavelength shift in this analysis. To validate the determination of the level of the zero cross-derivative method using the second absorption in the ace solvent (30:70 acetate: methanol). Spectrophotometric analysis of zero crossing derivatives of a mixture of paracetamol and caffeine found that paracetamol levels in tablet A were 95.24 8.47%, in tablet B of 92.86 0%, and in tablet C of 96.5 0%, while the caffeine content was 104.89 0%, 102.09 0%, and 91.6 0%. According to USP 30 NF 25 (2007), it can be concluded that the test results of the composition of paracetamol and caffeine in tablets meet the requirements.
Uji Efektivitas Antihiperurisemia Ekstrak Etanol Kencur (Kaempferia galanga L.) dan Jahe Hitam (Kaempferia parviflora) terhadap Tikus yang Diinduksi Jus Hati Ayam dan Potassium Oxonate Wikantyasning, Erindyah Retno; Wahyuni, Arifah Sri; Julianti, Tri Budi; Putri, Nastity Zhahwa Amalia; Astuti, Devi Dwi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.497

Abstract

Hyperuricemia is caused by excessive production and/or poor elimination of uric acid. Kencur (Kaempferia galanga L.) and black ginger (Kaemperia parviflora) can be utilised as antihyperurisemic alternatives because their flavonoids block xanthin oxidase (XO). The study determine the efficacy of black ginger ethanol extract (EEJH) as an in vivo antihyperuricemic agent. This research was conducted to determine the effectiveness of kencur ethanol extract (EK) dan black ginger ethanol extract (EEJH) as an antihyperuricemia in vivo. A complete random design used involving 32 mice in 8 groups. Negative control (CMC Na 0.5%); positive control (Allopurinol 10 mg/kgBW); EK and EEJH respectively 12.5; 25; and 50 mg/kgBW. Hyperurisemia was induced by chicken liver juice 4 mL/200 gBB p.o. and potassium oxonate 250 mg/kgBB i.p. UA monitoring was carried out before induction, 0, 7, and 14 days after treatment. Tukey post hoc tests and ANOVA were used to evaluate the data. The results indicate that both of EK and EEJH can reduced UA (p<0.05) however the reduction is significant with Allopurinol (P<0.05). Thus, it can be inferred that the EK and EEJH have potential for enhanced antihyperurysemic in decreasing the UA.
Formulasi gel ekstrak daun kelor (Moringa oleifera Lam.) serta uji karakteristik sediaan dan uji cemaran mikrobiologi Dewi, Asiska Permata; Fadila, Sarah; Darmadi, Darmadi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.550

Abstract

Moringa leaves are a type of medicinal plant that contains flavonoids, polyphenols, saponins, and tannins. The objective of this research is to make a Moringa leaf extract gel formulation and test the characteristics of the preparation's and test for microbial contamination.  The characteristics are tested using organoleptic tests, pH, homogeneity, spreadability, and dosage form consistency. Meanwhile, the microbiological contamination testing included the Total Plate Count and Yeast Mold Count tests. The results of testing the characteristics of the preparation on Moringa leaf extract gel, in the organoleptic test revealed that the dosage form was semi-solid, the color was white to brownish yellow, and the odor of the extract, the pH of the preparation ranged between 6-6.2, spreadability ranged from 6.2-6.4 cm, consistency of the preparation was homogeneous, and no phase separation occurred. Furthermore, the ALT test at concentrations of 2%, 4%, 6%, 8%, positive control, and negative control obtained a colony count of 9.5x106 CFU/mL. 3.8x105 CFU/mL, 6.7x106 CFU/mL, 6.8x105 CFU/mL, 1.47x104 CFU/mL and 1x101 CFU/mL. Meanwhile, the AKK test obtained colony counts of 1.35x105 CFU/mL, 9.7x102 CFU/mL, 1.1x102 CFU/mL, 7.8x103 CFU/mL, 1x101 CFU/mL, and 1x101 CFU/mL. According to the findings of the ALT test, the number of bacterial colonies still surpasses the threshold standards stipulated by BPOM number 32 of 2019. Meanwhile, the AKK test showed that the concentration of 2% exceeds the limit for yeast mold contamination
Analisi manajemen pengetahuan terhadap kepatuhan minum obat pada pasien hipertensi di apotek Medan central care pharmacy Shufyani, Fahma; Siregar , Syati Manaharawan; Yulia , Rahma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.572

Abstract

Introduction: Hypertension is one of the most dangerous health problems in the world, because hypertension is the main risk factor that leads to cardiovascular disease such as heart attack, heart failure, stroke and kidney disease. The aim of this study was to determine the relationship between level of knowledge and adherence to taking medication in hypertensive patients at the Medan Central Care Pharmacy.. This Method This research method uses quantitative descriptive analytical methods using a cross-sectional design. The sampling technique uses purposive sampling technique. Data were analyzed using the Chi Square test. Data collection was carried out in June 2023. The research population was hypertension sufferers at the Medan Central Care Pharmacy. The sample for this research was 97 respondent. The results of this study showed that the frequency distribution of high knowledge was 45 respondents (46.4%), medium was 36 respondents (37.1%) and low was 16 respondents (16.5%). The frequency distribution of medication adherence was 19 respondents (19.6%) high, 45 respondents (46.4%) medium and 33 respondents (34%) low. The results of the chi-square test of knowledge with medication adherence showed a p-value of 0.000<0.05. The conclusion in this study is that the respondent's level of knowledge about hypertension is in the high category, the respondent's level of medication adherence is in the medium category and there is a relationship between the level of knowledge and medication adherence in hypertension patients at the Medan Central Care Pharmacy.
Tingkat pengetahuan dan sikap mahasiswa Fakultas Farmasi Universitas Muhammadiyah Surakarta tentang beyond use date obat Alinda, Oevita Nur; Karuniawati, Hidayah
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.490

Abstract

Beyond Use Date (BUD) is the expiry time of a drug after it is opened from its primary packaging. The aim is to determine the level of knowledge and attitudes regarding BUD, to analyze whether there are differences between sociodemographics and BUD knowledge and attitudes, as well as whether there is a relationship between knowledge and attitudes of students in the Muhammadiyah University of Surakarta Pharmacy study program regarding BUD. This research is descriptive analytical research with observational methods. The data collection method was cross-sectional. Analysis (using Mann-Whitney and Kurskall-Wallis analysis) was carried out to assess differences in mean knowledge and attitude scores. Linear regression analysis was carried out to identify factors related to knowledge and attitudes about BUD. Spearman Rank analysis was used to test the correlation between knowledge and attitudes. The research results showed that respondents had a sufficient level of knowledge at 53,0% and attitude about BUD were classified as good at 68,8%. Statistical analysis shows that knowledge and attitudes about BUD are significantly related to age and generation (p<0,001). The research results also stated that men, respondents aged 17 and 18 years and the class of 2023 had a lower understanding of knowledges and attitude about BUD. Apart from that, there is a correlation between knowledge and attitude (p=0,000).
Review artikel : pemanfaatan bahan alam pada sediaan face mist Rahmadasmi, Nola; Wulandari , Desti; AH , Ahdi Dinil Haq.
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.492

Abstract

This article review aims to review several journals that formulate face mist preparations by utilizing natural ingredients. Some of the natural ingredients used have a variety of beneficial properties for the skin, especially the face such as facial moisturizers, antioxidants and antibacterials. Face mist is included in cosmetics that are efficacious as skin refreshers, especially to refresh facial skin and can remove residual oil from the skin that may still exist. Refreshers are made according to the type of cleanser that refers to the type of skin on the face. Face mist preparations have advantages when compared to other preparations including easy to use and carry anywhere, and more quickly absorbed into the skin. The formula used is a variation of the concentration of the active substance (sample) with additional substances such as glycerin as a moisturizer and PVP (polyvinyl pyrrolidone) as a dispersing agent and preservatives in the form of nipagin, nipasol, DMDM Hydantoin and sodium benzoate and distilled water as a carrier (solvent).
Evaluasi kualitas fisik dan mikrobiologi daging kambing yang dimarinasi dengan jus buah andaliman Amali, M. Rizky; Sinaga , Kurniawan
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.502

Abstract

The ain of this research was to determine the effect of using andaliman fruit juice on pH, cooking loss, water holding capacity and microbiology in goat meat.The study used a non-factorial Completely Randomized Design (CRD) with 4 treatments and 5 replications, as well as descriptive methods.The data from the research will be processed statistically using analysis of variance and if there is a significant effect, it will be continued with the Duncan further test. Goat meat has become the main choice among the population because of its good nutritional profile. Data analysis showed that marination with andaliman fruit extract had no significant effect on the pH value, cooking shrinkage, and water binding capacity of goat meat. While microbiology research describes the characteristics of a population or a phenomenon that becomes the object of research that is trial and error. From the observation data analyzed by descriptive method as many as 4 samples of goat meat obtained from the traditional market of kampung lalang, it was found that marinated goat meat with andaliman fruit extract had an effect on P2 with a total of 162 colonies, and increased in P3 with 235 colonies.

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