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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 62 Documents
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Search results for , issue "JPS Volume 9 Nomor 1 (2026)" : 62 Documents clear
Kelengkapan Terapi Medis Sesuai Pedoman dan Dampaknya terhadap Luaran Terapi pada Pasien Angina Pektoris Tidak Stabil: Penelitian di Rumah Sakit Rujukan Tersier di Indonesia Saufi, Muhammad Rifki; Cholisoh, Zakky
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1357

Abstract

Unstable angina pectoris (UAP) is a major cause of cardiovascular hospitalization and requires complex inpatient pharmacological management. Variability in the completeness of core guideline-recommended acute pharmacotherapy may influence inpatient therapeutic outcomes, including length of hospital stay (LOS). This study aimed to evaluate the completeness of core guideline-recommended pharmacotherapy and its association with LOS among hospitalized patients with unstable angina pectoris at a tertiary referral hospital in Indonesia. A descriptive observational study with a retrospective design was conducted using secondary data from medical records. Of 214 hospitalized patients screened, 144 adult patients diagnosed with unstable angina pectoris met the inclusion criteria. Data collected included demographic characteristics, smoking status, comorbidities, LOS, and pharmacological therapy administered during hospitalization. Pharmacotherapy completeness was operationally defined based on the documented use of three core disease-modifying drug classes recommended for the acute management of unstable angina pectoris: antiplatelet therapy (single or dual), statin therapy, and beta-blocker therapy based on core acute-phase recommendations in the ESC 2023 and AHA/ACC 2023 guidelines, at any time during the inpatient stay. Descriptive statistics were used to summarize patient characteristics and medication use, while bivariate analysis was performed to assess the association between pharmacotherapy completeness and LOS. Most patients were male (62.5%) and aged 40–59 years (47.9%) or ≥60 years (43.1%), with a median LOS of 4 days (interquartile range 3–5). The most frequently prescribed drug classes were statins (92.4%), beta-blockers (91.7%), aspirin (88.2%), and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (86.1%). Dual antiplatelet therapy was administered in 66.7% of patients, and anticoagulants in 28.5%. Bivariate analysis showed no statistically significant association between pharmacotherapy completeness and length of hospital stay (p = 0.642). In conclusion, hospitalized patients with unstable angina pectoris generally received pharmacological therapy aligned with core guideline-recommended acute-phase management. However, the absence of a significant association between pharmacotherapy completeness and LOS suggests that LOS is a multifactorial outcome influenced by clinical and organizational factors beyond pharmacological management. These findings highlight the importance of comprehensive inpatient care and structured medication review, including the role of clinical pharmacists, in optimizing treatment for patients with UAP.
Optimasi Formula Sediaan Lip Cream Sari Buah Stroberi Kering (Fragaria x ananassa) dan Minyak Jarak dengan Metode Simplex Lattice Design Risyafa, Jihan; Suprapto, Suprapto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1363

Abstract

Strawberries (Fragaria x ananassa) contain striking red anthocyanin pigments that can serve as natural colorants for lip cream preparations and also as antioxidants. The emollient properties of castor oil can rehydrate dry skin, allowing it to function as a moisturizer for the skin and lips. This study aims to obtain the optimal formula for lip cream combining strawberry fruit strawberry juice powder as a natural colouring agent and castor oil as a moisturizer. Both ingredients were optimized using Design Expert V13 Simplex Lattice Design method, resulting in 5 formulas in 8 runs. The lip cream preparations were evaluated based on organoleptic, homogeneity, pH, viscosity, adhesion, spreadability, irritation, hedonic, and antioxidant tests to obtain the optimal formula. Verification of the optimal formula was carried out to ensure the validity of the results. The results of the study obtained an optimal formula with a composition of 33.15 g of strawberry juice powder and 13.85 g of castor oil with a desirability value of 0.524. The optimal formula produced a pH response of 5.6; viscosity of 17686.7 cP; adhesion of 4.06 seconds; spreadability of 6.57 cm; hedonic properties in terms of colour, aroma, and spreadability of 4.7, 4.7, and 4.8, respectively; and antioxidant activity with an IC₅₀ value of 21.31 ppm. The results of the verification formula on the parameters of pH, viscosity, adhesive power and spread power did not show significant differences.  
Deteksi Bahan Kimia Obat (BKO) Pada Jamu Sesak Napas Yang Beredar Di e-Marketplace Melalui Kombinasi Metode KLT dan FTIR. Girvin, Aulia Garnida; Hanwar , Dedi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1372

Abstract

The circulation of herbal medicines through e-marketplaces raises serious safety concerns due to the illegal addition of chemical drug substances to provide rapid therapeutic effects. This study aimed to detect chemical drug substances, specifically theophylline and chlorpheniramine maleate, in herbal medicines marketed for shortness of breath using a combination of thin-layer chromatography (TLC) and Fourier transform infrared spectroscopy. Qualitative analysis was conducted through optimization and validation of TLC using two mobile phase systems, followed by two-dimensional chromatography to enhance separation selectivity. The optimized systems demonstrated adequate separation with acceptable resolution values. The results showed that all herbal medicine samples had retention factor (Rf) values comparable to the standard. FTIR confirmation showed typical absorption bands of chlorpheniramine maleate (CTM) and theophylline, so that all samples (5 of 5) were declared positive for containing chemical drugs, with CTM identified in samples 1 and 4 and theophylline in samples 2, 3, and 5. These findings indicate that some herbal medicines circulating in e-marketplaces contain chemical drugs, which are not in accordance with the provisions of traditional medicine regulations.
Peramalan Kebutuhan Obat Kronis Berdasarkan Data Klaim BPJS Kesehatan Menggunakan Model ARIMA di Kabupaten Gunungkidul, Daerah Istimewa Yogyakarta, Indonesia. Syarifuddin, Annisaul Karimah; Diana, Ina Kusuma; Verdiana, Antokalina Sari; Kristina, Susi Ari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1379

Abstract

Chronic diseases require continuous pharmacotherapy and generate sustained demand for essential medicines, particularly within universal health coverage systems. In Indonesia, pharmaceutical utilization under the National Health Insurance program is documented through administrative claims data, which provide an important basis for demand analysis and planning. This study aims to forecast chronic drug demand in Gunungkidul Regency, Special Region of Yogyakarta, using health insurance claims data and a time-series forecasting approach. A retrospective analysis was conducted using weekly aggregated claims data. Drug utilization patterns were examined, and demand forecasting was performed using the Autoregressive Integrated Moving Average model following standard time-series procedures. Forecast accuracy was assessed by comparing predicted values with observed utilization. The results indicate that the model effectively captures weekly demand patterns and short-term fluctuations, producing forecasts that closely align with actual utilization trends. These findings demonstrate that time-series forecasting based on claims data can provide reliable estimates of chronic drug demand. The study highlights the potential value of integrating forecasting models into pharmaceutical inventory planning to support timely drug availability and improve logistics efficiency within regional health insurance implementation.
Potensi Antimikroba Ekstrak Infus Daun Pedada (Sonneratia caseolaris L) Mandeh, Sumatera Barat Jannah, Mifthahul; Nurlaili , Nurlaili; Harsachatri , Deasy Ovi; Novia, Novia; Larasati , Julia Veronika; Arfan , Alya Rahmaditya; Pangestika , Yuliandini; Habibi , Alif Rahman; Agustien , Anthoni
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1385

Abstract

The increasing emergence of antibiotic-resistant bacteria poses a serious global health threat, highlighting the need for alternative antimicrobial sources derived from natural products. Pedada mangrove (Sonneratia caseolaris L.), widely distributed in the coastal area of Mandeh, West Sumatra, has been traditionally used as a medicinal plant. This study aimed to evaluate the antimicrobial potential of leaf infusion extracts of Sonneratia caseolaris and to determine the effect of heating time variation on antimicrobial activity. Leaf infusion extracts were prepared using boiling water with heating durations of 10, 15, and 30 minutes. Antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, and Candida albicans using the disc diffusion method. The results showed that all infusion extracts exhibited antimicrobial activity with varying inhibition levels. The optimal heating time was 10 minutes, resulting in inhibition zone diameters of 10.5 mm against E. coli, 10 mm against S. aureus, and 10 mm against C. albicans. These findings indicate that Sonneratia caseolaris leaf infusion extract has potential as a natural antimicrobial agent, with shorter heating time being more effective in preserving antimicrobial activity.
Menelusuri Perkembangan, Kondisi Terkini, dan Prospek Masa Depan Pengujian DNA dalam Aplikasi Forensik Manusia dan Non-Manusia: Tinjauan Naratif Siboro, Dewi Pratiwi Purba; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Malau, Jekmal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Nugraha, Afif Tri; Aprianti, Endeh
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1389

Abstract

DNA typing has become a cornerstone of modern forensic science, profoundly influencing criminal investigations, forensic human identification, and non-human forensic applications. Since its introduction in the mid-1980s, forensic DNA analysis has evolved from restriction fragment length polymorphism-based methods to polymerase chain reaction-based short tandem repeat profiling, and more recently to sequence-based approaches enabled by massively parallel sequencing, resulting in substantial improvements in analytical sensitivity, robustness, and discriminatory power. This narrative review aims to trace the historical development, examine the current state, and explore future directions of DNA typing in both human and non-human forensic contexts, with particular emphasis on empirical case studies from Asia. A narrative review methodology was employed through a comprehensive analysis of peer-reviewed literature published between 2015 and 2026, sourced from major scientific databases including Google Scholar, PubMed, and ScienceDirect, with studies selected based on forensic relevance, methodological rigor, and regional significance. The review highlights the extensive application of DNA typing in routine criminal casework, disaster victim identification, missing persons investigations, wildlife forensic genetics, food fraud detection, and biosecurity, and documents emerging technologies such as portable DNA systems and CRISPR-based detection. Despite these advances, significant challenges remain related to data interpretation, validation requirements, contamination control, ethical and legal governance, and uneven forensic capacity across regions. Overall, this review underscores the continuing evolution of forensic DNA typing and emphasizes the importance of standardized protocols, interdisciplinary collaboration, and region-specific validation to ensure the reliable and responsible application of DNA evidence in modern forensic science.
Pengaruh Kepatuhan Minum Obat terhadap Pengendalian HbA1c pada Pasien Diabetes Melitus Tipe 2: Tinjauan Sistematis Berdasarkan Metode Pengukuran Kepatuhan Diana, Ina Kusuma; Wiedyaningsih , Chairun; Kurniawati , Fivy
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1415

Abstract

Type 2 diabetes mellitus (T2DM) is a major public health concern in Asia, where rapid urbanization and lifestyle changes have contributed to a marked increase in disease prevalence. Poor medication adherence remains a major barrier to achieving optimal glycemic control, leading to an increased risk of complications and greater healthcare burden. This systematic review aimed to examine the relationship between medication adherence and glycated hemoglobin (HbA1c) levels among patients with T2DM, compare the strength of this association across different adherence measurement methods, and identify key factors influencing adherence and glycemic control in Asian populations. A literature search was conducted in PubMed, Europe PMC, Scopus, and ScienceDirect for cross-sectional studies published between January 2015 and April 2025. Eligible studies included adult patients with T2DM who reported medication adherence (e.g., MMAS-8, pill counts) and HbA1c outcomes. Data were synthesized narratively, and study quality was assessed using standardized appraisal tools. Of the 584 records screened, 14 studies met the inclusion criteria. Most studies demonstrated a significant inverse association between medication adherence and HbA1c levels, with stronger associations observed when objective or multidimensional adherence measures were used. Reported adherence levels varied substantially across studies, with the proportion of high adherence ranging from 3.7% to over 58%, depending on the measurement method. Mean HbA1c values ranged from 6.4% to 9.2%. Higher educational level, greater self-efficacy, and supportive healthcare environments were associated with better adherence. In contrast, psychological distress, regimen complexity, and comorbidities were linked to lower adherence and poorer glycemic control. Medication adherence is a critical determinant of glycemic control among patients with T2DM in Asia. The choice of adherence measurement method influences the observed association with HbA1c. Interventions should address psychosocial and clinical barriers and incorporate culturally adapted, multidimensional adherence assessment approaches.
Formulasi Krim yang Mengandung Ekstrak Biji Kopi Robusta (Coffea canephora L.) dan Tantangannya dalam Menghambat Staphylococcus aureus: Studi Potensi Terapi Luka pada Penderita Diabetes Andari, Putri; Sembiring, Novitaria Br; Ginting, Astriani Natalia Br
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1425

Abstract

Diabetes mellitus is a chronic metabolic disorder that can cause wounds that are difficult to heal and susceptible to bacterial infection, especially Staphylococcus aureus. This study aims to formulate an antibacterial cream preparation containing robust coffee bean extract (Coffea canephora L.) and evaluate its activity against Staphylococcus aureus. The extract was obtained through maceration with 96% ethanol with a crude yield of 30% and an extract yield of 14.05%. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, phenols, saponins, and terpenoids. Antibacterial testing of the extract showed inhibitory activity against Staphylococcus aureus at concentrations of 30% (7.73–8.44 mm) and 50% (8.52–13.16 mm). The extract was then formulated into creams with varying concentrations of 0%, 30%, and 50%. All formulations met the physical parameters, except for the cream that did not contain the extract, which showed a pH higher than the ideal range for topical application and showed a decrease in spreadability with increasing extract concentration. However, testing the antibacterial activity of the cream preparations using the disk diffusion method did not produce an inhibition zone in any of the formulations tested. The results of this study indicate that although Robusta coffee bean extract shows activity in vitro, it has not been successfully applied in cream formulations with the existing bases and testing methods. These findings highlight the major challenges in developing natural topical preparations, particularly regarding the selection of formulation bases and appropriate evaluation methods for semisolid preparations.
Efek Ekstrak Etanol Daun Mobe (Artocarpus lacucha Buch-Ham.) terhadap Histopatologi Hati Tikus Diinduksi Karbon Tetraklorida Lubis, Meiva Amelia; Dalimunthe , Aminah; Sitorus , Panal; Satria , Denny; Pertiwi , Indah; Damayanti S , Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1432

Abstract

Background: Liver injury due to exposure to hepatotoxic chemicals remains a major problem in the medical and pharmaceutical fields. Carbon tetrachloride (CCl₄) is a classic hepatotoxic agent that induces oxidative stress, lipid peroxidation, and hepatocyte necrosis through free radical formation. Mobe leaves (Artocarpus lacucha Buch-Ham.) contain bioactive compounds, particularly flavonoids and phenolics, which possess antioxidant and anti-inflammatory properties with potential hepatoprotective effects. Objective: This study aimed to evaluate the effect of ethanol extract of mobe leaves (EEML) on the liver histopathology of rats induced with carbon tetrachloride. Methods: This experimental study used a post-test only control group design. Twenty-five male rats were divided into five groups: negative control (CMC-Na 1% + CCl₄), positive control (silymarin 100 mg/kgBW + CCl₄), and three treatment groups receiving EEML at doses of 50, 100, and 200 mg/kgBW + CCl₄. Hepatotoxicity was induced by intraperitoneal injection of CCl₄ (1 mL/kgBW) twice weekly for 14 days. Liver tissue was processed for hematoxylin-eosin staining, and histopathological changes (hepatocyte degeneration, necrosis, and inflammatory cell infiltration) were assessed semi-quantitatively using a scoring system (0-3). Results: CCl₄ induction caused severe liver damage in the negative control group, characterized by diffuse hydropic degeneration, extensive necrosis, and marked inflammatory infiltration (score 3 for all parameters). EEML administration significantly reduced liver injury in a dose-dependent manner. The 200 mg/kgBW dose showed the most pronounced hepatoprotective effect, with degeneration score 2, necrosis score 1, and inflammation score 2, approaching the protective effect of silymarin (score 1 for all parameters). Conclusion: Ethanol extract of mobe leaves demonstrated hepatoprotective activity against CCl₄-induced liver damage in rats, with the optimal effect at 200 mg/kgBW. These findings support the potential of mobe leaves as a natural hepatoprotective agent.
Pengaruh Pemberian IAA Dan BAP Terhadap Pertumbuhan Vegetatif Timun Suri (Cucumis melo L.) Pada Sistem Aeoroponik Zannah, Miftahul; Rahmadina, Rahmadina
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1446

Abstract

Suri cucumber (Cucumis melo L.) is a local horticultural commodity with high economic value; however, its productivity remains relatively low due to the use of conventional cultivation systems. This study aims to determine the effect of Indole Acetic Acid (IAA) and Benzyl Amino Purine (BAP) application and their interaction on the vegetative growth of Suri cucumber cultivated in a vertical aeroponic system. A factorial completely randomized design (CRD) with two factors was employed: IAA concentration (0, 50, and 100 ppm) and BAP concentration (0, 25, and 50 ppm), each with three replications. The observed parameters included plant height, number of leaves, and root length. Data were analyzed using two-way analysis of variance (ANOVA) followed by Duncan's Multiple Range Test (DMRT) at a 5% significance level. The results showed that the application of IAA and BAP significantly affected several vegetative growth parameters of Suri cucumber, particularly plant height. The interaction between IAA and BAP exhibited a synergistic response in enhancing vegetative growth in the aeroponic system. It can be concluded that the combination of IAA and BAP in a vertical aeroponic system has the potential to serve as an effective and sustainable alternative cultivation technology to increase Suri cucumber productivity.

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