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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 935 Documents
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I Profil pelepasan nanoemulsi ekstrak etanol daun Jamblang (Syzygium cumini) secara in vitro Jamilah Hamidi Yanti; Dhadhang Wahyu Kurniawan; Muhamad Salman Fareza
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1810

Abstract

Syzygium cumini (L.) Skeels leaves are a source of flavonoid-rich bioactive compounds with potential for nano-based delivery. This study formulated an oil-in-water nanoemulsion containing ethanolic jamblang leaf extract, characterized its physicochemical properties, and evaluated the in vitro release profile and kinetics of quercetin as a marker compound. The extract was obtained by maceration with 70% ethanol and incorporated into a nanoemulsion containing virgin coconut oil, Tween 80, Span 80, propylene glycol, and water. Organoleptic properties, homogeneity, pH, viscosity, droplet size, polydispersity index (PDI), and zeta potential were evaluated. Quercetin release was assessed using a dialysis-membrane method in pH 4.5 buffer and quantified by UV–Vis spectrophotometry. Release data were fitted to zero-order, first-order, Higuchi, Hixson–Crowell, and Korsmeyer–Peppas models. The nanoemulsion had a pH of 4.34 ± 0.09, viscosity of 137.3 ± 1.10 mPa·s, mean droplet size of 88.46 ± 3.46 nm, PDI of 0.05, and zeta potential of +1.027 ± 0.65 mV. Cumulative quercetin release reached 99.56% at 90 min. Among models fitted to the complete release curve, the first-order model provided the best fit (R² = 0.9776; k = 0.0589 min⁻¹). These findings indicate a nanoscale, narrowly distributed system with rapid quercetin release under the selected acidic test condition; extrapolation to other physiological pH conditions requires further study.
Persepsi Ibu dalam Memilih Layanan Pijat bagi Bayi Berusia 3–6 Bulan di Lingkungan Sei Padang, Kecamatan Medan Baru Rahmadiah Khairunnisa; Syovi Akhiarti; Putri Raudha Hasibuan; Wisiani Hia; Debi Novita Siregar
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1839

Abstract

Background: Understanding mothers’ perceptions can help explain how they choose infant massage services. Objective: To explore mothers’ perceptions when choosing massage services for infants aged 3–6 months in Sei Padang Neighborhood, Medan Baru District. Methods: This exploratory qualitative case study involved ten purposively selected mothers who had used infant massage services. Data were collected through semistructured interviews. Interview transcripts and field notes were analysed using inductive thematic analysis. Results: Five interrelated themes emerged: perceived benefits for infants; service quality and professionalism; recommendations from family or relatives; social media as an information source; and comfort, safety, and accessibility. Mothers reported that their infants slept more soundly and appeared calmer, and described perceived changes in appetite. Clean facilities, friendly providers, and explanations of procedures reinforced trust. Recommendations and digital information informed service choices, while proximity facilitated visits. Conclusion: Mothers’ choices reflected interrelated experiences, trust, assessments of service quality, and accessibility. Providers should communicate their qualifications, procedures, costs, and the limitations of the evidence regarding benefits through responsive, family-centred care. The findings describe maternal perceptions rather than clinical effectiveness.
Efektivitas Video Edukasi Berbasis Digital dalam Meningkatkan Pengetahuan Ibu tentang Ketepatan Pemberian MP-ASI Anggun Kumala Sari; Indri Olivia Nababan; Deni Putri B. Simbolon; Citra Hanania Ritonga; Tiarnida Nababan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1840

Abstract

Background: Digital video education may support maternal preparation for complementary feeding. Objective: To assess changes in maternal knowledge of appropriate complementary feeding after digital video education. Methods: This single-group pretest–posttest study included 30 purposively selected mothers of infants aged 0–6 months at Pera Independent Midwifery Practice in April 2026. Knowledge was assessed using a 22-item true–false questionnaire. Descriptive statistics, the Shapiro–Wilk test for paired score differences, and the Wilcoxon signed-rank test were used. Effect size was calculated as r = |Z|/√n, with n representing nonzero pairs. Results: Mean scores increased from 11.83 ± 1.763 to 19.93 ± 1.311, a difference of 8.10 points or a 68.5% relative increase. All mothers had higher posttest scores; the proportion with good knowledge increased from 0% to 100%. The difference was statistically significant (Z = −4.850; p < 0.001; r = 0.89). Conclusion: Knowledge scores increased after digital video education in this sample. Videos may complement midwifery counseling, but the absence of a control group limits causal inference. Knowledge retention and changes in feeding practices require further evaluation.
Karakterisasi dan Uji Stabilitas Clay Mask Isolat Mangostin Sebagai Antijerawat Yola Desnera Putri; Shafa Nurul Fadilla; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1470

Abstract

Acne is a common skin disorder affecting adolescents and young adults, characterized by inflammation of the pilosebaceous follicles associated with the proliferation of Propionibacterium acnes (P. acnes). The use of synthetic anti-acne agents may cause adverse effects, making natural products a promising alternative. This study aimed to evaluate the antibacterial activity of mangostin isolate against P. acnes, formulate it into a clay mask, and assess the antibacterial effectiveness of the resulting preparation. Antibacterial activity was evaluated using the disc diffusion method at mangostin isolate concentrations of 0.275%, 0.55%, and 1.1% (w/v). Clay mask formulations were prepared using a bentonite–kaolin base in four different formulations. The preparations were evaluated for organoleptic properties, pH, homogeneity, viscosity, drying time, spreadability, adhesiveness, and physical stability using the cycling test method. Antibacterial activity of the clay mask formulations was also assessed against P. acnes. The results showed that mangostin isolate at a concentration of 0.275% produced an inhibition zone diameter of 15.10 ± 0.64 mm, indicating strong antibacterial activity. All clay mask formulations met the required physical evaluation criteria and remained stable during the cycling test. Following formulation, antibacterial activity was retained, although the inhibition zone diameter decreased to the moderate category, ranging from 7.00 to 9.18 mm. These findings suggest that mangostin isolate has potential as a natural antibacterial active ingredient in anti-acne clay mask formulations
Hubungan Dukungan Keluarga Dengan Kepatuhan Pengobatan Pada Pasien Tuberkulosis: Tinjauan Sistematis. Putu Dyah Ayu Sekar Nindita; Anna Wahyuni Widayanti; Niken Nur Widyakusuma
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1549

Abstract

Tuberculosis (TB) remains a serious global health threat. The success of therapy depends heavily on patient adherence to long-term treatment. In this context, family support plays a crucial role. Families not only provide emotional support but also ensure adherence to routine treatment and provide support to ensure patients complete their treatment. This systematic review was conducted to identify commonly used research instruments to measure the relationship between family support and treatment adherence. A literature search was conducted using ScienceDirect, PubMed, and Scopus data from December 2025 to February 2026, using the keywords "tuberculosis," "family support," and "treatment adherence." The study selection process was conducted using the Rayyan application and based on a standard PRISMA diagram. The search identified eleven studies using a cross-sectional design. Nine of these studies found a positive association between strong family support and patient adherence, while two studies indicated that a lack of family support was a contributing factor to patient non-adherence to treatment. The use of various instruments in this study, such as the MSPSS, MMAS, MARS, WHOQOL-BREF, PHQ-9, and EQ-5D-5L, reflects a high degree of heterogeneity in the measurement approaches used. Therefore, although this argument confirms a relationship between family support and improved adherence to treatment, the strength of the existing evidence remains limited due to variations in study designs and instruments used. To improve conclusions and comparability between future studies, longitudinal or intervention-based studies using more standardized and consistent measurement instruments are needed.
Kepuasan Pasien terhadap Pelayanan Kefarmasian di RSUD dr. Fauziah Bireuen: Studi Berbasis SERVQUAL Dhea Nur Nurfadhilah; Muhammad Amin Nasution; Nur Irhamni Sabrina; Okpri Meila; Muhammad Andry
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1552

Abstract

Pharmaceutical services play an important role in the hospital healthcare system because they support the safe, rational, and patient-centered use of medicines. This study aimed to analyze patient satisfaction with pharmaceutical services and its relationship with service quality dimensions, including tangible, reliability, responsiveness, assurance, and empathy, at the Pharmacy Installation of RSUD dr. Fauziah Bireuen. This study used a descriptive survey design with a quantitative approach. The sample consisted of 109 respondents from a population of 150 outpatients, selected using accidental sampling based on the Slovin formula. The research instrument was a SERVQUAL questionnaire that met the reliability requirement, with a Cronbach’s alpha value of 0.89. The results showed that the majority of respondents, namely 56.9%, were dissatisfied with pharmaceutical services. The tangible dimension obtained the highest satisfaction level at 68%, while the assurance dimension obtained the lowest satisfaction level at 45.2%. The Chi-Square test showed that all SERVQUAL dimensions were significantly associated with patient satisfaction (p < 0.05). Responsiveness had the strongest association (Cramer’s V = 0.68), followed by empathy (0.67), tangibles (0.65), reliability (0.55), and assurance (0.51). Therefore, the Pharmacy Installation of RSUD dr. Fauziah Bireuen needs to improve service quality comprehensively, particularly in the aspects of service assurance, clarity of drug information, staff competence, and staff ability to build patient trust.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Moisturizer Gel dari Ekstrak Daun Seledri (Apium graveolens L.) Miftahul Jannah; Marzella Dea Rossardy; Wahyuni Watora
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1621

Abstract

Background: Free radicals are one of the causes of skin problems and premature aging, so antioxidants are needed to inhibit this process. Celery leaves (Apium graveolens L.) are known to contain flavonoids, tannins, saponins, and steroids that have antioxidant potential. Objective: To formulate celery leaf extract into a moisturizing gel, evaluate the physical properties of the formulation, and test its antioxidant activity. Methods: This study is a quantitative experimental study involving maceration extraction with 70% ethanol, formulation of the product, evaluation of physical properties, and antioxidant testing using the DPPH method. Results: The results showed that the celery leaf extract was successfully formulated into a moisturizing gel that met the physical requirements for gel formulations, as indicated by good organoleptic properties and homogeneity, a pH within the skin’s pH range, spreadability and adhesion meeting standards, viscosity within the required range, and stability without phase separation. The IC50 value for vitamin C of 7,4 µg/mL is classified as very strong, whereas the IC50 values for formulations F0, F1, F2, and F3 were, respectively, 3968,6 µg/mL, 7607,1 µg/mL, 4179,3 µg/mL, and 3060,2 µg/mL. Based on these IC₅₀ values, the antioxidant activity of the celery leaf extract moisturizing gel formulations is classified as weak (>200 µg/mL); however, an increase in extract concentration shows a trend toward increased antioxidant activity. Conclusion: This study demonstrates that celery leaf extract was successfully formulated into a moisturizing gel with good physical properties; however, further optimization of the formulation is needed to enhance its antioxidant activity so that it can provide optimal benefits as a skin care product.
Konsumsi Arsik Dali Ni Horbo dan Konversi Sputum pada Pasien Tuberkulosis Paru yang Mendapatkan Terapi Standar Yunita Purba; Desy Lustiani Rajagukguk; Vierto Irennius Girsang
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1628

Abstract

Pulmonary tuberculosis remains an important public health problem in Indonesia. Standard treatment with anti-tuberculosis drugs is the main component in reducing bacterial load and preventing transmission; however, nutritional support is also needed to assist patient recovery. Arsik Dali Ni Horbo is a traditional Batak local food made from buffalo milk and has the potential to serve as dietary support for tuberculosis patients. This study aimed to determine the difference in sputum acid-fast bacilli counts before and after the consumption of Arsik Dali Ni Horbo among pulmonary tuberculosis patients receiving standard therapy. This study used a quasi experimental design without a control group, using a one-group pretest-posttest approach. The sample consisted of 30 adult pulmonary tuberculosis patients diagnosed between September and December at UPT Puskesmas Helvetia, Medan City. The intervention consisted of consuming 100 grams of Arsik Dali Ni Horbo per serving, four times per week for one month. Acid fast bacilli data before and after the intervention were obtained through laboratory examinations. Data were analyzed using univariate and bivariate analyses, with a dependent t test performed after the data were confirmed to be normally distributed. The results showed that the mean AFB count before the intervention was 6.93 ± 1.51, while the mean AFB count after the intervention was 6.57 ± 1.19. The mean reduction in AFB count was 0.37, with a p-value of 0.046. This study showed a significant difference in AFB counts before and after the consumption of Arsik Dali Ni Horbo, although the magnitude of the reduction was relatively small.
Formulasi, stabilitas fisik, dan perubahan kelembapan kulit setelah penggunaan krim body scrub ekstrak daun kelor (Moringa oleifera) dan beras ketan hitam (Oryza sativa var. glutinosa) Devahimer Harsep Rosi; Putri Nadifa; Rido Farnandi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1669

Abstract

Background: Moringa leaf extract and black glutinous rice are potential ingredients for body scrub formulations. This study evaluated their incorporation into a cream, its physical stability and sensory acceptability, and changes in skin hydration. Methods: Dried moringa leaves were macerated in 96% ethanol. F1, F2, and F3 contained 1, 2, and 3 g of extract, respectively, and 5 g of black glutinous rice powder. F0 was the negative control, and a commercial rice body scrub was the comparator. Physical characteristics were evaluated over four weeks and after three temperature cycles at 4 ± 2 °C and 40 ± 2 °C. Hedonic testing involved 20 panelists; skin hydration, oil, and softness were assessed in five volunteers over four weeks. Results: Extraction yielded 60.73 g (20.24%); alkaloids, flavonoids, saponins, and tannins were detected. During storage, pH ranged from 4.84 to 6.49, spreadability from 4.90 to 6.40 cm, and adhesion from 4.27 to 6.56 s. No visible changes in color, consistency, or odor occurred during temperature cycling. No redness, itching, or swelling was observed within 24 h of the irritation test. F1 had the highest descriptive preference scores for four sensory attributes; aroma differed among formulations in the reported Kruskal–Wallis analysis (p = 0.003). F3 had the largest observed hydration increase among experimental formulations, from 28.8% to 46.2% at week 4 (relative increase, 60.4%); the reported between-group test yielded p = 0.001. Conclusion: The formulations retained their observed physical characteristics under the tested conditions. F1 was preferred in the sensory evaluation, whereas F3 showed the largest observed improvements in hydration and softness. These exploratory findings do not establish comparative clinical efficacy or long-term safety.
Efektivitas antibakteri ekstrak etanol 70% daun pisang kepok (Musa paradisiaca Linn.) terhadap Staphylococcus aureus: implikasi untuk pengembangan antimikroba alami Ghefira Khoirunnisa; Salwa Sahiya Putri; Ratna Wijayatri; Diyana Romadhoni; Tiwi Oktaviyani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1681

Abstract

Bacterial infections remain a health problem, especially in tropical countries such as Indonesia. The increasing occurrence of antibiotic resistance has resulted in the need for the development of alternative antibacterial agents based on natural resources. Kepok banana leaves (Musa paradisiaca Linn.) contain secondary metabolites that may possess antibacterial activity. This study aimed to determine the secondary-metabolite groups and antibacterial activity of a 70% ethanolic extract of kepok banana leaves (Musa paradisiaca Linn.) against Staphylococcus aureus. The study included plant identification, phytochemical screening, heavy metal analysis for Pb and Cd, extraction by maceration using 70% ethanol, and antibacterial activity testing using the disk diffusion method. The antibacterial test was performed using extract concentrations of 5%, 10%, 15%, 20%, and 25%, with three replications for each treatment. Phytochemical screening revealed the presence of flavonoids, alkaloids, saponins, terpenoids, and tannins in the ethanolic extract of kepok banana leaves. Pb and Cd were not detected in the extract under the conditions of the analysis. The extract inhibited the growth of Staphylococcus aureus at all tested concentrations, with inhibition zones categorized as strong, and the inhibition zone increased with increasing extract concentration. These findings indicate that the 70% ethanolic extract of kepok banana leaves has potential as a source of natural antibacterial compounds against Staphylococcus aureus. The observed activity may be associated with the secondary metabolites detected in the extract; however, their individual contributions and possible interactions were not directly investigated.

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