Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
Articles
218 Documents
<![CDATA[Preparation of [Fe(paptH)2] (CF3SO3)2 and [Fe(paptH)2] [Fe(CN)5NO] (paptH = bis(2-(pyridin-2-ylamino)-4-(pyridin-2-yl)thiazole: Magnetic, Mössbauer, and Electronic Spectral Properties ]]>
<![CDATA[Kristian Handoyo Sugiyarto]]>;
<![CDATA[Harold Andrew Goodwin]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.6619
<![CDATA[Complexes of [Fe(paptH)2][X]2.nH2O, (paptH = 2-(pyridin-2-ylamino)-4-(pyridin-2-yl)- thiazole, X = CF3SO3 and n = 1.5, and X2 = [Fe(CN)5NO] and n = 3) have been characterized in magnetic, Mössbauer, and electronic spectral properties. The studies reveal that the two complexes are predominantly quintet state at room temperature, but singlet at low temperature (below 91K). The change is assigned as a thermally spin state transition, singlet 1A1g (LS, low-spin) ↔ quintet 5T2g (HS, high-spin), in iron(II), being gradual, continuous, and incomplete at the experimental temperature range, and without hysteresis in these instances. The two complexes were yellowish brown at room temperature (~ 298K) but darkening to reddish brown at the lower temperatures.]]>
<![CDATA[Determination of The Adsorption Kinetics for Adsorption Methylene Blue Dye with C-4-Hydroxy-3-Methoxyphenylcalix[4]resorcinarene ]]>
<![CDATA[ Molekul Vol 18 No 1 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.1.6768
<![CDATA[Adsorption kinetics is part of adsorption and discusses the adsorption rate of an adsorbent on the adsorbate. Adsorption kinetics has an equation to determine the rate constant of adsorption, namely the pseudo-first order and pseudo-second order. In this study, methylene blue was adsorbed using a C-4-hydroxy-3-methoxyphenylcalix[4]resorcinarene (CHMFKR) adsorbent. The aim of this study to determine the effect of process parameters (concentration, pH, and processing time) on the process adsorption, with the Langmuir and Freundlich adsorption isotherm model approach, and to determine the adsorption kinetics of methylene blue with CHMFKR. Ten mL of methylene blue solution with various concentrations of 5, 6, 8, 10, and 11 ppm with a solution pH of 7 was added to as much as 0.001 gram of CHMFKR adsorbent and stirred at 600 rpm for 40 minutes. The solution was measured, and its absorbance was measured using the UV-Vis Spectrophotometer. The results show that the adsorption kinetics follow pseudo second order with an adsorption rate of 0.7217 ± 0.4 g/mg.s. The adsorption isotherm follows the Langmuir equation, and the maximum adsorption amount is 114.94 ± 2.04 mg/g.]]>
<![CDATA[Chemical Profiling and Histamine Inhibitory Activity Assessment of Merremia Vitifolia and Bidens Pilosa Extracts ]]>
<![CDATA[Candra Yulius Tahya]]>;
<![CDATA[Karnelasatri Karnelasatri]]>;
<![CDATA[Nelson Gaspersz]]>
<![CDATA[ Molekul Vol 18 No 1 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.1.6833
<![CDATA[There are two species of plant that grow flourishing all around Indonesia including in Banten and West Java which are Merremia vitifolia and Bidens pilosa. In this study we evaluate how these plants could be potentially used as natural preserver of fish product especially Auxis thazard, to inhibit the histamine formation, and to find out how this activity correlates to the substances in polar extract of B. pilosa flowers and M. vitifolia leaves. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) were used to identify the substances of the plant’s part extracts. There are 27 chemicals in M. vitifolia extract and 14 chemicals in B. pilosa extract that have been detected. A triglyceride has been detected, isolated, and characterized by FTIR, 1H-NMR and 13C-NMR from n-hexane extract of M. vitifolia supported by LC-MS/MS data. Histamine formation in fish was determined after 30 min treatment with 4-hydroxybenzoic acid solution is around 40 – 51 mg / 100 g of fish, while treatment with M. vitifolia and Bidens pilosa extracts were less than 10 mg / 100 g of fish. This is the indication of high potential of both extract as preserver of fish products. Many of the identified substances have bioactivity like antimicrobial, anticancer, anti-inflammatory, antioxidant, and more, which influence the extracts’ ability to inhibit the formation of histamine in fish.]]>
<![CDATA[Morelloflavone and Molecular Docking from Stembark of Chisocheton lasiocarpus and Its Cytotoxic Activity Against Breast Cancer Mcf-7 Cell Lines ]]>
<![CDATA[Nurlelasari, Nurlelasari]]>;
<![CDATA[Harneti, Desi]]>;
<![CDATA[Maharani, Rani]]>;
<![CDATA[Darwati, Darwati]]>;
<![CDATA[Mayanti, Tri]]>;
<![CDATA[Farabi, Kindi]]>;
<![CDATA[Hanafi, Muhammad]]>;
<![CDATA[Supratman, Unang]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6845
<![CDATA[Chisocheton is a plant of the Meliaceae family which has been known as a source of limonoids, triterpenoids, steroids, alkaloids and phenolics. This plant is the second largest in the Meliaceae, with 53 species widely distributed in tropical and subtropical regions including Indonesia. From this genus, compounds that have interesting activities have been found, including anti-inflammatory, antimalarial, cytotoxic, antitumor and anticancer. One of the species that has the potential to find new compounds is Chisocheton lasiocarpus because there are still few phytochemical studies. This study aims to inform the structural elucidation of one of the compounds from the stem bark of C. lasiocarpus, namely morelloflavone and its cytotoxic potential against breast cancer cells using the in silico method against ER-α receptors (PDB code: 3ERD), ER-β (PDB code: 1QKM). ) and HER-2 (GDP code: 3PP0).]]>
<![CDATA[Isolation and Identification of Cellulolytic Bacteria from Gut of Horn Beetle Larvae (Oryctes rhinoceros L.) ]]>
<![CDATA[Riskawati, Riskawati]]>;
<![CDATA[Natsir, Hasnah]]>;
<![CDATA[Dali, Seniwati]]>;
<![CDATA[Baharuddin, Maswati]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6848
<![CDATA[The horn beetle larvae (Oryctes rhinoceros L.) contain symbiotic bacteria that are used to digest and degrade cellulose as food so that it has the potential to produce cellulase enzymes. This study aims to isolate, characterize and identify microbial symbionts from horn beetle larvae that have the potential to produce cellulase enzymes.The methods in this study include morphology and physiology identification of bacteria, qualitative and quantitative activity tests and species determination using 16S rRNA sequencing technique. Based on the results of morphological observations, five bacterial isolates were taken which has the potential as a cellulase producer is indicated by the presence of a clear zone that is produced when a qualitative test is carried out using congo red staining with different cellulolytic indices. Based on the quantitative bacterial activity test using UV-Vis, the highest activity was found in PES3 isolates at 1.62 x 10-2 and PES5 at 1.61 x 10-2. Species determination results found that PES3 isolates belonged to the genus Acinetobacter and PES5 belonged to Pseudomonas. In addition to the isolates obtained for the environment and the industrial sector, cellulolytic bacteria can provide added value such as hydrolyze cellulose waste into alternative fuels.]]>
<![CDATA[A Novel Enzyme Biosensor Based on Ag/Reduced Graphene Oxide/Chitosan Membrane with Potentiometer for Pesticide Detection ]]>
<![CDATA[Mashuni Mashuni]]>;
<![CDATA[Nur Arfa Yanti]]>;
<![CDATA[Irnawati Irnawati]]>;
<![CDATA[Fitri Handayani Hamid]]>;
<![CDATA[Muhammad Jahiding]]>
<![CDATA[ Molekul Vol 18 No 1 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.1.6864
<![CDATA[Long-term accumulation of pesticides in the environment to human and animal health. Acetylcholinesterase (AChE) biosensors with highly sensitive potentiometer transducers based on the membranes of Ag, reduced graphene oxide (rGO), and chitosan (CS) has been successfully developed. The membrane was made with a composition of 0.5 mM AgNO3, 2.5 mg/mL rGO, and 2% (w/v) CS coated on the surface of the Au electrode. The composition of the membrane with three ratios, namely 1:1:2, 2:1:3, and 3:1:4. Then, membrane Ag/rGO/CS and the enzyme AChE were immobilized on the membrane surface. The prepared biosensor has excellent conductivity, catalytic activity, and biocompatibility attributed to the synergistic effect of Ag/rGO/CS and glutaraldehyde (GTA) as crosslinkers and providing a hydrophilic surface for AChE adhesion. The linear range in biosensors is 1 × 10-8 to 1 µg L-1 with a regression coefficient of 0.9803 for 1:1:2 membrane, 0.9836 for 2:1:3 membrane, and 0.9850 for 3:1:4 membrane. The LOD is about 1 × 10-7 µg L-1 for all membranes. In addition, the biosensor showed good sensitivity, acceptable reproducibility, and stability, having an RSD of less than 5%. This biosensor makes it possible to provide a new and promising tool for analyzing pesticides, especially organophosphates.]]>
<![CDATA[Synthesis and Evaluation of Some Sulfonamide-Substituted of 1,3,5-Triphenyl Pyrazoline Derivatives as Tyrosinase Enzyme Inhibitors ]]>
<![CDATA[Herfindo, Nofal]]>;
<![CDATA[Frimayanti, Neni]]>;
<![CDATA[ikhtiarudin, Ihsan]]>;
<![CDATA[eryanti, Yum]]>;
<![CDATA[zamri, Adel]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6936
<![CDATA[Pyrazoline is well-known as heterocycles compound that can exhibit many biological effects. In this work, we synthesized a series of sulfonamide-substituted 1,3,5-triphenyl pyrazoline compounds as a promising tyrosinase inhibitor agent. These compounds prepared by multicomponent reaction of corresponding aldehyde, ketone, and hydrazine using seal-vessel reactor. Pyrazolines compound were tested for their tyrosinase inhibitor activity through in vitro assay. The test result found that compound 4c, 4d, and 4e possessed better tyrosinase inhibitory activity compared to the reference drug, kojic acid. Compound 4c exhibited the strongest tyrosinase inhibitory effect with an IC50 value of 30.14 µM. The results suggested that hydroxyl and methoxy substituent at para position are preferable. Furthermore, molecular docking studies result match the pattern of in vitro assay where the compound will provide a stronger binding interaction and lower binding free energies.]]>
<![CDATA[Isolation and Molecular Identification of Amylolytic Bacteria from Oryctes rhinoceros L. Larvae Decomposing Empty Palm Oil Fruit Bunches ]]>
<![CDATA[Uto, Sahriani]]>;
<![CDATA[Arfah, Rugaiyah]]>;
<![CDATA[Dali, Seniwati]]>;
<![CDATA[Baharuddin, Maswati]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6957
<![CDATA[Oryctes rhinoceros L. is an organism that helps the decomposition of oil palm empty fruit bunches (OPEFB). In the larvae's intestines, there are symbiotic bacteria that are used in the process of food degradation in the digestive system, one of which is amylolytic bacteria. This study aims to isolate and molecular identify amylolytic bacteria that produce amylase enzymes from horn beetle larvae. The techniques are used to screen and isolate bacteria from horn beetle larvae. Bacterial identification was accomplished by microscopically identifying amylase-producing bacterial isolates, performing biochemical tests on selected bacterial isolates, quantifying amylase enzyme activity, and molecularly identifying 16S rRNA. The results of screening and bacterial isolation obtained five isolates. The largest amylolytic bacterial colony index value was obtained in the EA3 isolate, which was 1.370 mm. Bacterial isolates with the highest activity were found in isolates coded EA1 and EA2, namely 0.049 U/mL and 0.0479 U/mL. According to the findings of 16S rRNA molecular identification, isolates EA1 and EA2 had similarities with the bacteria Ochrobactrum sp. and Pseudomonas mendocina.]]>
<![CDATA[Green Synthesis of Gold Nanoparticles using Peronema canescens Leaves Extract and Their Catalytic Performance for Dyes and Nitro Compounds ]]>
<![CDATA[Falahudin, Aswin]]>;
<![CDATA[Insin, Numpon]]>;
<![CDATA[Yudha S, Salprima]]>;
<![CDATA[Adfa, Morina]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6972
<![CDATA[The most interesting and well-known research in the field of gold nanomaterials synthesis is the use of "green chemistry" to prepare gold nanoparticles (AuNPs). In this study, Peronema canescens leaf extract was used as the synthesis medium to successfully produce AuNPs in a way that was cheap, quick, and good for the environment. A UV-visible spectrophotometer, particle size analysis (PSA), and transmission electron microscopy (TEM) were used to find out more about the AuNPs that were prepared. The UV-visible spectrophotometer showed a surface plasmon resonance peak at 532 nm, which proves https://www.fortyouncewines.com/ that AuNPs exist in the solution. TEM and PSA both showed that the AuNPs were mostly spherical and had an average diameter of 14.9 nm, respectively. In the presence of NaBH4, the AuNPs were found to speed up the reduction of rhodamine B (RhB), metanil yellow (MY), and 4-nitrophenol (4-NP). The results show that the AuNPs that were prepared in a new way worked very well and could be used in catalysis.]]>
<![CDATA[Potential Indonesian Natural Compound as antiviral for COVID-19 targeting the RdRp: In silico Study ]]>
<![CDATA[Zahra Silmi Muscifa]]>;
<![CDATA[Tony Sumaryada]]>;
<![CDATA[Laksmi Ambarsari]]>;
<![CDATA[Setyanto Tri Wahyudi]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.7017
<![CDATA[Research related to SARS-CoV-2 drugs is still ongoing. In this initial research, we perform a computational approach on SARS-CoV-2 inhibitors. RNA-dependent RNA polymerase (RdRp) is one of the functional proteins in SARS-CoV-2 that can be a target for drug development, which has an essential function in the viral replication process synthesizing the RNA genome of the virus. This study used the RdRp-Remdesivir complex structure from RCSB with ID PDB 7BV2, with a resolution of 2.5 Å. Currently, Remdesivir is under the clinical trial phase as a Covid-19 drug. In this study, we tested a thousand natural Indonesian compounds used as SARS-CoV-2 RdRp inhibitors obtained from the Indonesian natural compounds database (HerbalDB). The first stage of this computational analysis was pharmacophore modeling structure-based drug design. The natural compounds were analyzed based on their steric and electronic similarities to Remdesivir. A molecular docking simulation was then performed to obtain binding energy and bond stability to produce natural compounds that can inhibit RdRp SARS-CoV-2. The final stage was the molecular dynamics simulation that explored the conformational space of natural compounds and proteins. The ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) test was carried out on the five best compounds to obtain these natural compounds' computational pharmacology and pharmacokinetics. The simulation identified Sotetsuflavone (CID: 5494868) from Cycas revoluta, Grossamide (CID: 5322012) from Cannabis sativa, and 6-Hydroxyluteolin-6,7-disulfate (CID: 13845917) from Lippia nodiflora are the best compounds that can inhibit RdRp SARS-CoV-2. These potential compounds can then be tested in-vitro and in-vivo in the future.]]>
