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Fitria Megawati
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Jalan Kamboja No.11A, Denpasar Utara, Denpasar, Bali, Indonesia
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Usadha
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 29632161     DOI : https://doi.org/10.36733/usadha.v2i2
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Usadha: Jurnal Integrasi Obat Tradisional, bertujuan untuk mendorong integrasi Obat Tradisional ke dalam sistem pelayanan kesehatan modern dalam bentuk pertukaran informasi ilmiah baik di kalangan peneliti, praktisi obat tradisional dan tenaga medis, pemegang kebijakan, industri dan stakeholder lainnya, dalam upaya pengembangan obat tradisional untuk masyarakat. Usadha menerima berbagai macam hasil penelitian dari berbagai bidang ilmu baik dalam bentuk artikel original, artikel review, maupun komunikasi singkat yang berkaitan dengan upaya untuk mendorong integrasi dan pengembangan obat tradisional mulai dari hulu hingga ke hilir, yang dapat meliputi namun tidak terbatas pada: 1) eksplorasi dan identifikasi bahan obat tradisional; 2) identifikasi zat aktif dari bahan alam; 3) pembuktian ilmiah khasiat dan keamanan obat tradisional baik preklinis maupun klinis; 4) pengembangan teknologi ekstraksi dan isolasi senyawa bahan alam; 5) teknologi produksi dan penghantaran obat berbasis bahan alam serta kosmetika herbal; 6) pengembangan produk nutrasetika dari bahan herbal; 7) sistem pelayanan obat tradisional di klinik dan komunitas; 8) kebijakan di bidang obat tradisional, konservasi dan budidaya tanaman obat tradisional; dan lainnya yang dalam lingkup obat tradisional. Usadha diterbitkan oleh Fakultas Farmasi Universitas Mahasaraswati Denpasar, dengan jumlah terbit 3 kali dalam setahun pada bulan April, Agustus, dan Desember.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 78 Documents
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Analisis Kandungan Asam Benzoat dan Kalium Sorbat Dalam Minuman yang Diproduksi UMKM di Bali Selatan Periode 2025 Sugijanto, Milyadi; Rahmadinha, Vallina; Devyantari, Ni Kadek; Waisnawi , Putu Ayu Gaudiya; Dewi , Ni Luh Kade Arman Anita
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13153

Abstract

Bali is one of the world’s tourist destinations that drives the growth of Micro Small and Medium Enterprise (MSME) industries, including the traditional beverage sector. Traditional beverages are generally produced naturally without the addition of preservatives. However, to extend shelf life and maintain product safety until it reaches consumers, some producers add preservatives. Excessive use of preservatives may pose health risks. The aims of the study are to analyze the content of benzoic acid and potassium sorbate as preservatives in beverages produced by MSMEs in South Bali during the 2025 period. The research employed descriptive cross-sectional design with both qualitative and quantitative analyses using High Performance Liquid Chromatography. The study samples consisted of 22 beverage products produced by MSMEs in Bali. All samples were analyzed to identify the presence and levels of benzoic acid and sodium sorbate. The results showed that none of the 22 beverage samples contained benzoic acid or sodium sorbate. Therefore, it can be concluded that the MSME beverages examined during this period did not contain these preservatives.
Skrining Fitokimia Dan Efek Antikoagulan Eliksir Dari Ekstrak Buah Mengkudu (Morinda citrifolia L.) Pada Tikus Putih Santoso, Puguh; Putri, Noviana; Wibawa, Agung Ari Chandra
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13154

Abstract

The increasing prevalence of thrombosis as a manifestation of hemostatic dysfunction has prompted the search for safer and more accessible alternative anticoagulant agents. Morinda citrifolia L. (noni fruit) contains various bioactive compounds suspected to modulate blood coagulation pathways. This study aimed to evaluate the anticoagulant effectiveness of an elixir formulated from ethanolic extract of noni fruit on the bleeding time of male white rats (Rattus norvegicus). A post-test only randomized group design was employed, consisting of four treatment groups: negative control (aquadest), positive control (acetosal 80 mg), elixir at 40 mg/kgBW, and elixir at 80 mg/kgBW. The extract was prepared by ethanol maceration and then formulated into elixirs, followed by physical quality testing. Anticoagulant activity was assessed by measuring tail bleeding time. Results indicated that the elixir at 80 mg/kgBW significantly prolonged the bleeding time compared to other groups. Phytochemical screening revealed the presence of flavonoids, tannins, alkaloids, and steroids as dominant constituents. The findings demonstrate that the noni fruit elixir possesses anticoagulant activity, with the higher dose yielding the most pronounced effect. This study concludes that Morinda citrifolia has strong potential to be developed as a natural anticoagulant in pharmaceutical applications.
Produksi Ramah Lingkungan Granul Instan Antioksidan dari Kulit Jeruk Bali (Citrus maxima) Menggunakan Ekstraksi Berbantuan Enzim Yuda, Putu Era Sandhi Kusuma; Ni Kadek Lita; Adinda Puspita Elisabet Lian; Ni Putu Jayanti Putri; I Gusti Ayu Sri Candramukhi Devi Dasi; Intan Alfira Kolifay; Erna Cahyaningsih; Maria Malida Vernandes Sasadara
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13155

Abstract

Pomelo peel (Citrus maxima) is an agricultural by-product rich in bioactive compounds, particularly flavonoids and phenolic compounds, which have potential antioxidant and anti-aging properties. However, the high pectin content in citrus peels can hinder the release of these active compounds. The objective of this study was to improve the extraction efficiency of bioactive compounds from pomelo peel using an environmentally friendly Enzyme-Assisted Extraction (EAE) method employing pectinase enzymes and to formulate the extract into instant effervescent granules. The granules produced using enzymatic extraction, granules prepared without enzymes, and control granules were evaluated through sensory assessment, physical quality analysis, total phenolic content, antioxidant activity (DPPH method), and crude fiber content. The results showed that enzyme-assisted extraction granules (EEG) exhibited significantly higher free radical scavenging activity (49.57 ± 6.10%) compared to non-enzymatic granules (NEG) (28.48 ± 8.67%). EEG also demonstrated a higher total phenolic content (0.027 g/100 g) than NEG (0.017 g/100 g). In addition, EEG showed better sensory acceptance and physical quality, including a more balanced taste, a stronger citrus aroma, and higher fiber content. These findings indicate that the application of the EAE method can enhance phenolic and fiber content, physical quality, and antioxidant activity of instant pomelo peel granules, suggesting their potential development as an environmentally friendly natural antioxidant product.
Penentuan Kadar Total Flavonoid Pada Ekstrak Bunga Kenop (Gomphrena globosa L.) Dengan Metode Spektrofotometri UV-VIS Cahyaningsih, Erna; Dewi , Ni Luh Kade Arman Anita; Yuda, Putu Era Sandhi Kusuma; Irlangga, I Gusti Ngurah Agustia Adi Surya Taksu
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Flavonoids are phenolic compounds widely distributed in plants and are well known for their antioxidant activity, which plays an important role in preventing degenerative diseases. One plant with potential as a flavonoid source is the globe amaranth flower (Gomphrena globosa L.), which has been traditionally used and reported to exhibit various pharmacological activities. This study aimed to determine the total flavonoid content of globe amaranth flower extract grown in Bali. Extraction was carried out using the maceration method with 96% ethanol at a ratio of 1:10, followed by remaceration. Phytochemical screening was performed to identify the presence of flavonoids, while total flavonoid content was determined using UV-Vis spectrophotometry with quercetin as the standard. Phytochemical screening confirmed the presence of flavonoid compounds in the extract. The determination of total flavonoid content showed a maximum wavelength at 433 nm, with a regression equation of Y = 0.0778X + 0.0012 and a correlation coefficient (r) of 0.9982. The total flavonoid content obtained was 81.808 mgQE/100 g extract. In conclusion, the globe amaranth flower (Gomphrena globosa L.) is a promising natural source of flavonoids and has potential to be developed as a raw material for traditional medicine, particularly as a natural antioxidant.
Formulasi dan Uji Mutu Fisik Sediaan Cream Blush Ekstrak Buah Naga Merah (Hylocereus costaricensis) Dengan Variasi Konsentrasi Beeswax Mendra, Ni Nyoman Yudianti; Silvy, Komang Priskila Adelia; Putra, I Made Agus Sunadi
Usadha Vol 5 No 1 (2026): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The use of natural colorants derived from natural sources, such as red dragon fruit (Hylocereus costaricensis), can be applied in cosmetic formulations including blush in, lipstick, eyeshadow, and others. Blush on has several consistencies, such as liquid, cream, solid/cake and powder forms. The factor that affects the physical stability of the cream blush is the viscosity or thickness. Beeswax (cera alba) is one of the ingredients that can increase the viscosity and has a function as a thickener or stiffening. This study aims to determine the optimal concentration of beeswax in red dragon (H.costaricensis) fruit extract cream blush formulations that meet the physical quality standards comparable to similar commercial products. The study was conducted by varying beeswax concentrations in three formulations (FI, FII, and FIII) of red dragon fruit extract cream blush at 10%, 15%, and 20%, respectively.  The physical quality tests included organoleptic tests, homogeneity, pH, and spreadability, which were compared with those of commercial cream blush products. Based on the physical quality evaluation, all three formulations showed good physical properties. However, among the tested formulations, FI (10% beeswax) exhibited the closest physical quality characteristics to commercial blush product.
Literature Review: Fitoterapi Berbasis Tanaman Obat Sebagai Alternatif Pengobatan Infeksi Bakteri Irfana, Nawwar; Febrianti, Salma Fadillah
Usadha Vol 5 No 1 (2026): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v5i1.13488

Abstract

Bacterial infectious diseases remain a significant health problem, particularly due to the increasing incidence of antibiotic resistance. This condition encourages the exploration of alternative antibacterial agents derived from natural sources. This study aims to review the potential of medicinal plants as antibacterial agents based on published literature. The method used was a literature review of scientific articles published between 2020-2025, obtained from Google Scholar and PubMed. The results indicate that various medicinal plants exhibit antibacterial activity with varying levels of inhibition, which are influenced by the presence of secondary metabolites such as flavonoids, alkaloids, tannins, and saponins. These findings suggest that medicinal plants have the potential to be developed as natural antibacterial agents and alternatives for the treatment of bacterial infections.
Tingkat Pengetahuan dan Sikap Masyarakat Tentang Pemanfaatan Tanaman Obat Keluarga (TOGA) Di Pekalongan Andini, Indri; Oktaviani, Nila
Usadha Vol 5 No 1 (2026): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v5i1.13683

Abstract

Family Medicinal Plants (TOGA) are a form of natural resource utilization that plays a role in community health maintenance efforts. The utilization of TOGA in the community is still influenced by the level of knowledge and attitudes of the community towards the use of medicinal plants. This study aims to determine the level of knowledge and attitudes of the people of Pekalongan City towards the utilization of Family Medicinal Plants. The research method used was quantitative descriptive research with a crosssectional approach. Sampling was conducted using purposive sampling with a total of 50 respondents. Data were collected using an online questionnaire and analyzed descriptively by calculating the percentage of respondents' answers. The results showed that most respondents had a sufficient level of knowledge, with ginger, turmeric, and lemongrass being the most widely known medicinal plants. The community's attitude towards the use of TOGA was generally good, indicating support for its use as an alternative in maintaining family health. However, the use of TOGA is still not optimal due to limited knowledge about proper processing and usage methods, as well as the availability of medicinal plants. Based on the results of the study, it can be concluded that the community has a positive attitude towards the use of Family Medicinal Plants, but increased education and socialization are still needed to support more appropriate and sustainable use of TOGA.
Uji Efektivitas Salep Ekstrak Etanol Daun Buni (Antidesma bunius (L.) Spreng) Sebagai Penyembuhan Luka Bakar Grade II (A) Pada Mencit Putra, I Made Agus Sunadi; Pradnyawati, Ni Komang Ayu Trias; Wardani, I Gusti Agung Ayu Kusuma
Usadha Vol 5 No 1 (2026): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v5i1.13940

Abstract

Grade II (A) burn wounds are a common form of skin injury that require proper management to accelerate the healing process and prevent complications. The use of natural products as alternative topical therapies continues to be developed because they are considered safer and possess diverse biological activities. Buni leaves (Antidesma bunius (L.) Spreng) are known to contain bioactive compounds such as flavonoids, tannins, saponins, and alkaloids that potentially support skin tissue regeneration. This study aimed to grade II (A) burn wounds in male white mice (Mus musculus). This study employed an experimental method with a post-test only control group design. The animals were divided into five groups: negative control, positive control (Bioplacenton®), and treatment groups receiving buni leaf extract ointment at concentrations of 2.5%, 5%, and 10%. Grade II (A) burns were induced on the dorsal area of the mice, followed by treatment according to each group. Observations were conducted for 14 days by measuring wound diameter reduction and percentage of wound healing. The data were analyzed statistically using One Way ANOVA followed by a post hoc test to determine differences between treatment groups. The results showed that all concentrations of buni leaf extract ointment accelerated burn wound healing compared to the negative control, with the 10% concentration demonstrating the highest effectiveness and a statistically significant difference (p<0.05). It can be concluded that the 96% ethanolic extract ointment of buni leaves has the potential to be developed as a natural topical preparation for grade II (A) burn therapy. determine the effectiveness of a 96% ethanolic extract ointment of buni leaves in accelerating the healing of

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