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Fitria Megawati
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Jalan Kamboja No.11A, Denpasar Utara, Denpasar, Bali, Indonesia
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Usadha
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 29632161     DOI : https://doi.org/10.36733/usadha.v2i2
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Usadha: Jurnal Integrasi Obat Tradisional, bertujuan untuk mendorong integrasi Obat Tradisional ke dalam sistem pelayanan kesehatan modern dalam bentuk pertukaran informasi ilmiah baik di kalangan peneliti, praktisi obat tradisional dan tenaga medis, pemegang kebijakan, industri dan stakeholder lainnya, dalam upaya pengembangan obat tradisional untuk masyarakat. Usadha menerima berbagai macam hasil penelitian dari berbagai bidang ilmu baik dalam bentuk artikel original, artikel review, maupun komunikasi singkat yang berkaitan dengan upaya untuk mendorong integrasi dan pengembangan obat tradisional mulai dari hulu hingga ke hilir, yang dapat meliputi namun tidak terbatas pada: 1) eksplorasi dan identifikasi bahan obat tradisional; 2) identifikasi zat aktif dari bahan alam; 3) pembuktian ilmiah khasiat dan keamanan obat tradisional baik preklinis maupun klinis; 4) pengembangan teknologi ekstraksi dan isolasi senyawa bahan alam; 5) teknologi produksi dan penghantaran obat berbasis bahan alam serta kosmetika herbal; 6) pengembangan produk nutrasetika dari bahan herbal; 7) sistem pelayanan obat tradisional di klinik dan komunitas; 8) kebijakan di bidang obat tradisional, konservasi dan budidaya tanaman obat tradisional; dan lainnya yang dalam lingkup obat tradisional. Usadha diterbitkan oleh Fakultas Farmasi Universitas Mahasaraswati Denpasar, dengan jumlah terbit 3 kali dalam setahun pada bulan April, Agustus, dan Desember.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 68 Documents
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Evaluasi Penyimpanan Obat High Alert Di RSUD Dr. Murjani Sampit lonika, Tesa; Pratomo, Guntur Satrio; Ardhany, Syahrida Dian
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.11124

Abstract

High Alert drugs are drugs that have a high risk of causing serious injury if they are used incorrectly. Drug management in hospitals is an important aspect in ensuring patient safety and the quality of medical services, especially for drugs that are classified as High Alert. This study aims to evaluate the High Alert drug storage system at RSUD Dr. Murjani Sampit to identify potential risks and implement the required standards. Data was collected by making direct observations using a checklist sheet for evaluating the suitability of storing High Alert drugs in the Pharmacy Warehouse at Dr. RSUD. Murjani Sampit. Percentage of suitability for storing High Alert drugs in the Pharmacy Warehouse at RSUD Dr. Murjani Sampit obtained results of 100% for High Alert drugs in the LASA (Look Alike Sound Alike) category, 100% for High Alert drugs in the high concentrate electrolyte category and 100% for High Alert drugs in the cytostatics category with indicators of suitability for storing High Alert drugs based on Minister of Health Regulations Republic of Indonesia Number 72 of 2016 concerning Pharmaceutical Service Standards in Hospitals. Keywords: Evaluation of Storage Suitability, High Alert drugs, RSUD Dr. Murjani Sampit.
Optimasi Formula Kapsul Ekstrak Temu Putih (Curcuma zedoaria) dengan Variasi Bahan Penghancur. Muharromah, Wini Aulia Ika; Rini, Tri Diana Puspita
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.10526

Abstract

Cancer is one of the most common causes of death in the world. Based on data from the World Health Organization (WHO), the number of cancer patients worldwide increases by 6.25 million people, or about 12% of the global population each year. White turmeric contains turmerone, essential oil, and curcuminoids. Curcuminoids have activity against P-388 murine leukemia cells and can inhibit the growth of cancer cells. One of the solid pharmaceutical preparations that is often used is capsules. Capsules require a quick disintegration time immediately after swallowing, and they must be absorbed in the digestive tract to provide bioavailability effects. Therefore, additional materials are needed for the capsule to dissolve quickly after contact with gastric fluid. The population in this study consists of disintegrating agents with various brands. The samples used were sodium starch glycolate, Ac-Di-Sol, and SD600 with a concentration of 4%. The research used an experimental method with a post-test control group design, with four formulations with different disintegrant materials. (sodium starch glycolate, Ac-Di-Sol, dan SD600). The research results show that all formulations meet the requirements for physical quality tests of capsules except for the flow rate test. There is a significant difference between the disintegration time of formula 3 with SD600 and the disintegration time of formula 4 with Ac-Di-Sol. Formula 4 with the disintegrant Ac-Di-Sol has the fastest disintegration time, 15.70 minutes. The factors that influence the results are the moisture and hygroscopicity of the powder.
Identifikasi Senyawa Fitokimia dan Uji Aktivitas Antioksidan pada Cascara (Coffea arabica L.) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Handani, Dewa Ayu Sri; Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Tirtayasa, Gede Agus Ari
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.12181

Abstract

Cascara refers to the dried husk of coffee cherries. It has garnered significant attention in recent research due to its phytochemical composition and potential health benefits. Several studies have highlighted the presence of bioactive compounds and the antioxidant activity exhibited by cascara. This study aims to investigate the phytochemical content and antioxidant potential of cascara. The cascara was extracted using the maceration method with 96% ethanol, followed by phytochemical screening for alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, and quinones using standard color reactions in test tubes. Antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, with ascorbic acid as a reference compound. The phytochemical profile of the extract was identified using gas chromatography-mass spectrometry (GC-MS). The findings indicated that cascara contains alkaloids, flavonoids, tannins, saponins, and triterpenoids. GC-MS analysis identified caffeine, hexadecanoic acid (methyl ester), and hexadecanoic acid (ethyl ester) as the predominant compounds in cascara. The antioxidant activity test using the DPPH method demonstrated that the ethanol extract of cascara possesses moderate antioxidant potential, with an average IC50 value of 108.49 ± 1.28 ppm. Ascorbic acid, the reference compound used in this study, yielded an IC50 of 2.53 ppm, categorized as very strong. This research underscores cascara’s potential as a valuable source of antioxidants with significant health benefits, influenced by geographic factors affecting its bioactive compound profile. Consequently, cascara holds promise for further development as a raw material for functional health-promoting products.
Studi Literatur : Potensi Ekstrak Bioaktif dari Daun Kemangi (Ocimum basillicum) sebagai Gel Anti-Acne Kamilia Zukhrufillah, Dinda; Rosdiana, Laily; Roqobih, Fikky Dian
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i02.9901

Abstract

Acne is a common skin problem, particularly during adolescence. It can affect both appearance and skin health. Literature studies suggest that basil leaf extract has potential as an active ingredient in anti-acne gel due to its antibacterial and anti-inflammatory properties. This article aims to identify the antibacterial potential and activity of basil leaf extract against Staphylococcus epidermidis bacteria and to develop an anti-acne gel using this natural ingredient. The research method employed is a qualitative, non-experimental study using a systematic review approach. The literature review results indicate that basil leaf extract is promising as an active ingredient for anti-acne gel due to its antibacterial and anti-inflammatory properties. Active compounds in basil leaves, such as essential oils, flavonoids, and tannins, have been proven to reduce inflammation, inhibit the growth of acne-causing bacteria, and improve overall skin condition. However, attention must be given to the extract's concentration and the potential for irritation on sensitive skin. In conclusion, gel containing basil leaf extract holds potential as a natural solution for acne treatment. Nevertheless, its use should be carefully considered for individuals with sensitive skin.
Karakteristik Fisik Dan Uji Mikrobiologi Serta Skrining Fitokimia Loloh Kombinasi Daun Jempiring, Daun Pegagan, Daun Katuk, Dan Air Kelapa Puspawati, Made; Sanjaya, Dwi Arymbhi; Mendra, Ni Nyoman Yudianti
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i02.7362

Abstract

Loloh is a traditional herbal beverage specifically produced by the Balinese community to prevent and treat various ailments. One example of loloh used for health maintenance can be formulated from a mixture of jempiring leaves (Gardenia jasminoides), pegagan leaves (Centella asiatica), katuk leaves (Breynia androgyna), and coconut water (Cocos nucifera). A major challenge in loloh production is the risk of microbial contamination. This study aims to examine the physical characteristics, bioactive compound profile, and microbiological quality of loloh formulated from a combination of jempiring leaves (G. jasminoides), pegagan leaves (C. asiatica), katuk leaves (B. androgyna), and coconut water (C. nucifera). The research employed an experimental design with a descriptive approach. Observed variables included organoleptic characteristics (color, form, odor), pH, microbiological parameters (total plate count [TPC] and yeast and mold count [YMC]), and phytochemical screening of the loloh preparation. The samples used in this study were loloh packaged in 250 ml bottles. A total of six bottles were used, with five allocated for microbiological testing and one for phytochemical screening. The resulting loloh exhibited a brown color, a distinctive odor, and a pH of 6. All five microbiological samples showed microbial contamination exceeding the permissible limits, with TPC values surpassing 10⁶ CFU/g and YMC values exceeding 10⁴ CFU/g. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins, and steroids. It can be concluded that loloh is rich in bioactive compounds; however, hygienic practices and microbiological safety must be carefully considered, particularly during production and packaging processes.
Analisis Kuantitatif Kadar Kuersetin Pada Fraksi n-Butanol Biji Kakao (Theobroma cacao L.) Dengan Metode Kromatografi Lapis Tipis (KLT) Densitometri Arbi, Putu; Chandra Wibawa, Agung Ari; Ika Pramitha , Dewa Ayu
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i02.7409

Abstract

  Cocoa beans (Theobroma cacao L.) are rich in flavonoids that exhibit antioxidant, antidiarrheal, antibacterial, anti-inflammatory, and antidiabetic activities. Quercetin is one of the marker compounds commonly used in the quantification of flavonoid compounds in natural materials. This study aimed to determine the quercetin content in the n-butanol fraction of cocoa bean extract using the thin-layer chromatography (TLC) - densitometric method. Extraction was performed by maceration with 96% ethanol, yielding 118 g, followed by fractionation using n-butanol to obtain 7 g. The mobile phase consisted of toluene:ethyl acetate:formic acid (4:3:0.4). Based on curve calibration of quercetin standard produced a regression equation of y = 0.000016x + 0.0014 with a correlation coefficient (r) of 0.9882. The mean quercetin content in the n-butanol fraction was 0.115 ± 0.039 mg/100 g with a relative standard deviation. The TLC spots exhibited Rf values averaging 0.55, consistent with the quercetin standard. These findings indicate that the n-butanol fraction of cocoa bean extract contains quercetin. The presence indicate n-buthanol fraction contain of quercetin as flavonoid composition of cocoa beans, supporting their potential use as a natural antioxidant source in traditional medicine formulations.
Uji Aktivitas Antibakteri Sediaan Gel Hand Sanitizer Ekstrak Etanol Daun Kaktus Pakis Giwang (Euphorbia milli) Terhadap Bakteri Pseudomonas aeruginosa Putra, I Made Agus Sunadi; Putri, Ni Putu Devi Nirmala; Santoso, Puguh
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i02.7434

Abstract

The Covid-19 pandemic has heightened public awareness of hand hygiene thus creating a demand for safe and effective natural-based hand sanitizers. This study aimed to determine the antibacterial activity of hand sanitizer gel containing ethanol extract of Euphorbia milli leaves against Pseudomonas aeruginosa. The extract was obtained through maceration of 500 g of powdered leaves in 70% ethanol and formulated into gels with concentrations of 5%, 10%, and 15% using CMC-Na, glycerin, propylene glycol, and methyl paraben as base ingredients. Physical quality tests included organoleptic properties, homogeneity, pH, and spreadability, while antibacterial activity was assessed using the disc diffusion method on Mueller Hinton Agar. All formulations showed brown colour, homogeneous texture, and pH averaging 5.5, meeting standard requirements. The spreadability ranged between 5.0–6.0 cm, indicating good application consistency. Inhibition zone diameters against P. aeruginosa increased with extract concentration: 6.52 ± 0.26 mm (5%), 7.51 ± 0.30 mm (10%), and 8.39 ± 0.35 mm (15%), whereas the positive control (Ciprofloxacin 5 µg) produced 29.92 ± 1.06 mm and the negative control showed 0 mm. Based on inhibition zone classification, all formulations exhibited moderate antibacterial activity. In conclusion, the ethanol extract of Euphorbia milli leaves demonstrates antibacterial potential against Pseudomonas aeruginosa, with effectiveness increasing proportionally to concentration, suggesting its potential as a natural active ingredient for hand sanitizer formulations
Literatur Review : Aktivitas Antiacne Tanaman Daun Kelor (Moringa oleifera) Sebagai Kandidat Kosmetika Halal Isna Primadana, Pradita Fiqlyanur
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Moringa leaves (Moringa oleifera) represent a valuable natural resource with numerous benefits, particularly in the field of cosmetics. These leaves exhibit remarkable pharmacological properties, notably antibacterial effects against acne-causing bacteria. Such antibacterial activity is attributed to the presence of secondary metabolites, including flavonoids, alkaloids, and tannins. From the perspective of Islamic jurisprudence, any substance derived from natural sources is considered halal; therefore, Moringa oleifera holds strong potential as a halal cosmetic ingredient. This study aimed to evaluate the antiacne activity of Moringa oleifera leaves as a prospective halal cosmetic agent. The research employed a literature review method using a narrative, unsystematic review model. The reviewed literature comprised scientific articles published between 2018 and 2022 in either Indonesian or English. A total of 1,104 articles were initially identified, of which 31 met the inclusion criteria. The findings revealed that Moringa oleifera leaves demonstrate significant antibacterial activity against acne-associated bacteria, including Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. This antibacterial potential is closely related to the presence of various secondary metabolites such as flavonoids, tannins, steroids, alkaloids, saponins, benzyl isothiocyanate, and benzyl glucosinolate.

Page 7 of 7 | Total Record : 68

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