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Usadha
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 29632161     DOI : https://doi.org/10.36733/usadha.v2i2
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Usadha: Jurnal Integrasi Obat Tradisional, bertujuan untuk mendorong integrasi Obat Tradisional ke dalam sistem pelayanan kesehatan modern dalam bentuk pertukaran informasi ilmiah baik di kalangan peneliti, praktisi obat tradisional dan tenaga medis, pemegang kebijakan, industri dan stakeholder lainnya, dalam upaya pengembangan obat tradisional untuk masyarakat. Usadha menerima berbagai macam hasil penelitian dari berbagai bidang ilmu baik dalam bentuk artikel original, artikel review, maupun komunikasi singkat yang berkaitan dengan upaya untuk mendorong integrasi dan pengembangan obat tradisional mulai dari hulu hingga ke hilir, yang dapat meliputi namun tidak terbatas pada: 1) eksplorasi dan identifikasi bahan obat tradisional; 2) identifikasi zat aktif dari bahan alam; 3) pembuktian ilmiah khasiat dan keamanan obat tradisional baik preklinis maupun klinis; 4) pengembangan teknologi ekstraksi dan isolasi senyawa bahan alam; 5) teknologi produksi dan penghantaran obat berbasis bahan alam serta kosmetika herbal; 6) pengembangan produk nutrasetika dari bahan herbal; 7) sistem pelayanan obat tradisional di klinik dan komunitas; 8) kebijakan di bidang obat tradisional, konservasi dan budidaya tanaman obat tradisional; dan lainnya yang dalam lingkup obat tradisional. Usadha diterbitkan oleh Fakultas Farmasi Universitas Mahasaraswati Denpasar, dengan jumlah terbit 3 kali dalam setahun pada bulan April, Agustus, dan Desember.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 74 Documents
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Formulasi Dan Uji Mutu Fisik Sediaan Sabun Padat Dengan Penambahan Ekstrak Etanol Buah Pepaya (Carica papaya L.) Putra, Aditya; Sanjiwani, Ni Made Sukma; Suradnyana, I Gede Made; Dewi Agustini, Ni Putu
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7296

Abstract

Papaya fruit contains secondary metabolite compounds such as saponins. The secondary metabolites needed in soap production are saponins. The purpose of this study was to determine whether the addition of ethanol extract of papaya fruit (Carica papaya L.) with concentrations of 2.4 and 6% in solid soap preparations can produce good physical quality and to determine the difference between formula 0 (without extract) and formula I, II and III (with extract concentrations of 2, 4 and 6%) in the physical quality obtained. This research is an experimental study, starting with making extracts formulated into solid soap form with variations in extract concentrations of 2.4 and 6%. The soap produced is white in formula 0 and formula I with an aria fragrance aroma. In contrast, formula II is yellow and formula III is orange with the aroma of papaya fruit ethanol extract and in the four formulas obtained a solid preparation. The homogeneity test results on all formulas are homogeneous. The pH test results obtained the lowest pH value in formula II and formula III with a pH value of 9 while the highest pH value was obtained in formula 0 with a pH value of 11. The test results of the height and stability of the foam obtained the highest foam height in formula III (7.43 cm) with foam stability of 66.82% while the lowest foam height was obtained in formula 0 (6.23 cm) with foam stability of 78.59%. The results of the physical quality test show that the soap meets homogeneous criteria, pH ranges from 9-11, has a foam height of 1.3-22 cm and foam stability between 60-90% in accordance with the requirements of SNI No. 3532-2016.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Subamia Kelong, Tabanan Bali Perayanthi, Reni; Anita Dewi, Ni Luh Kade Arman; Kusuma Yuda, Putu Era Sandhi; Cahyaningsih, Erna; Vernandes Sasadara, Maria Malida; Suradnyana, I Gede Made; Sugiyanto, Milyadi
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7369

Abstract

  Bali is rich in culture and traditions passed down from generation to generation, especially in the ethnopharmacy aspect as a traditional medecine. This research aims to study ethnopharmacy aspects of the application of herbal plants as traditional medicine including plant parts, processing methods, indications, and usage of herbal plants in Banjar Subamia Kelong, Tabanan, Bali. This research was carried out using survey methods, direct observation in the field, and interviews. This research identified 20 types of plants that are generally used by the community in the Banjar Subamia Kelong. The plant parts generally used are leaves (60%), stems (15%), rhizomes (15%) and fruit (10%). Most of the plants are processed by boiling (60%). These medicinal plants are mostly used orally (65%), and the general indication is to treat joint problems, such as muscle pain and gout (25%).
Uji Aktivitas Sediaan Hand Sanitizer Ekstrak Etanol Daun Euphorbia milli Terhadap Bakteri Staphylococcus epidermidis Sri Budiasih, Putu Eka; Sunadi Putra, I Made Agus; Santoso, Puguh
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7435

Abstract

  Euphorbia milli is a plant that has medicinal properties, one of which is that Euphorbia milli leaves contain peroxidase, saponins, calcium oxalate, peptic substances, and starch. Meanwhile, the sap contains euphorbol, euphol, and cyoartenol. The leaves are widely used as a remedy for boils (furuncle), purulent inflammation of the skin (piodermi), scalds, and burns. Euphorbia milli folia leaves contain saponins, which have potential as antibacterials. This study aims to determine the antibacterial activity of the ethanol extract of the giwang fern cactus leaves on the growth of Staphylococcus epidermidis by making a hand sanitizer gel from the giwang fern cactus leaf extract using three variations of extract concentrations: 5%, 10%, and 15%. The plant extracts were obtained using the maceration method using 70% ethanol with three replications. This research method is laboratory-experimental research. The results showed that the hand sanitizer gel had an inhibitory effect on the growth of the Staphylococcus epidermidis bacteria.
Perbandingan Mutu Fisikokimia Virgin Coconut Oil (VCO) dengan Metode Enzimatis dan Fermentasi Alami Mutu Fisikokimia Virgin Coconut Oil (VCO) dengan Metode Enzimatis dan Fermentasi Alami Dewi Maharani Indah Sari, Ni Komang; Chandra Wibawa, Agung Ari; Pramitha, Dewa Ayu Ika; Megawati, Fitria
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7498

Abstract

VCO is obtained from fresh, old coconut (Cocos nucifera L) flesh through a simple process without heating. Making VCO can be done by several methods, namely enzymatic methods and natural fermentation. The enzyme used in the manufacture of VCO is bromelain enzyme powder. The purpose of this study was to determine differences in the physicochemical quality of Virgin Coconut Oil (VCO) obtained by natural fermentation methods and VCO obtained by enzymatic methods adding 10% bromelain enzyme. The type of research used is experimental research conducted in the laboratory. The results obtained were then evaluated to determine the physicochemical quality of enzymatic VCO and natural fermentation. Physicochemical test parameters include a water content test performed by the gravimetric method and a free fatty acid test carried out by the titrimetric method. Based on the research that has been done, the highest average yield of VCO with the addition of bromelain enzyme powder is (24.45 ± 0.06) %. The results of the pH test on sample 1 (S1) and sample 2 (S2) obtained a pH value of 6. Testing the water content of the two samples S1 and S2 obtained results (4.018 ± 1.93) and (7.949 ± 2.57) %, with statistical testing getting p> 0.05 where there is no significant difference between the two samples. Tests for free fatty acid levels in samples S1 and S2 yielded (0.0086 ± 0.003055) % and (0.0106 ± 0.004619) %, with statistical testing yielding p > 0.05 after being tested by Kruskal Wallis, no there is a significant difference between the two samples. The enzymatic production of VCO has the advantage of obtaining more yield with the same quality as naturally fermented VCO.
Formulasi Dan Evaluasi Mutu Fisik Granul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria) Dengan Variasi Konsentrasi Bahan Pengikat Polivinil Pirolidon Apriliani, Wayan; Juliadi, Debby; Suradnyana, I Gede Made
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7578

Abstract

  White turmeric (Curcuma zedoaria) is a medicinal plant that Indonesian people widely use as a treatment for a disease. This plant is processed by blending it and serving it as a traditional medicine. However, the method of processing which is still very traditional allows errors in processing to make the efficacy of white turmeric not optimal, besides that the preparations that are processed cannot be used for a long time. Granule is a solid dosage form intended for oral use, the advantage of this preparation is the flexible dosage weight which allows for the formulation of large amounts of active ingredients such as most extracts. This study aims to obtain white turmeric ethanol extract granules with varying concentrations of polyvinyl pyrrolidone, namely 1%, 3%, and 5% which have good physical quality. The test results from this study showed that the physical quality of the preparation was good, in which the organoleptic preparation obtained was light yellow, smelled of orange aroma, and granular form. The granule compressibility test of the three formulas complied with the requirements because it was <20%. The granule flow rate test showed that the three formulas met the requirements, namely >10 gram/second. Test angle of repose of the three formula granules meet the requirements> 40o. The granule soluble time test showed that the three formulas met the requirements, namely <5 minutes and the granule water content test of the three formulas met the requirements, namely <5%. Polyvinyl pyrrolidone (PVP) binders with concentrations of 1%, 3%, and 5% produced good granules.
Uji Aktivitas Ekstrak Etanol Buah Dewandaru (Eugenia uniflora L.) terhadap Penurunan Kadar Glukosa Darah pada Mencit (Mus musculus) yang Diinduksi Aloksan Nggaba, Ellenoire Rambu Kabeba Hammu; Santoso, Puguh; Udayani, Ni Nyoman Wahyu
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7380

Abstract

Diabetes mellitus is a metabolic disorder characterized by a high increase in blood glucose that exceeds normal limits. Treatment based on natural ingredients can be an alternative to the treatment of diabetes. Plants that can be used are Dewandaru Fruit. This study used an experimental method (Pretest-Posttest Control Group Design) to determine whether there is a difference in blood glucose levels in alloxan-induced mice before and after administration of ethanol extract of dewadaru fruit. The extract was made by maceration method. Experimental animals were divided into 4 groups, each containing 6 mice. Group 1 (negative control) received alloxan, group 2 (positive control) received 5mg glibenclamide, group 3 received 100mg/kgBW extract, and group 4 received 200mg/kgBW extract. Alloxan-induced mice were subcutaneously measured 3 days after (pretest) and 14 days after treatment (posttest) using a glucometer. Data were analyzed using SPSS 26 with the Shapiro-Wilk normality test and pretest and posttest comparison test using Paired T-Test analysis. Based on the results of statistical tests, the study concluded that there was a significant difference in the decrease in blood glucose levels in alloxan-induced mice (Mus musculus) after being given the ethanol extract of Dewadaru fruit at doses of 100 mg/kgBW and 200 mg/kgBW. Keywords: Antidiabetic; Flavonoid; Blood Sugar Levels; Dewandaru  (Eugenia uniflora L.)
Pengaruh Polimorfisme Gen terhadap Risiko Penyakit Gagal Ginjal Kronis: Narrative Review Handani, Dewa Ayu Sri; Megawati, Fitria
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.10956

Abstract

Chronic Kidney Disease (CKD) is an escalating global health issue, particularly in Indonesia. CKD is characterized by a progressive and irreversible decline in renal function, with diabetes mellitus and hypertension as primary risk factors. Genetic polymorphisms, variations in DNA sequences that affect gene function and protein expression, play a critical role in CKD risk and progression. This narrative review examines the role of genetic polymorphisms in CKD risk based on available literature. Scientific articles were sourced from PubMed, ScienceDirect, Google Scholar, and Scopus using keywords related to genetic polymorphisms and CKD. From the 441 articles identified, selection was based on relevance, sample size, and article completeness. Several genetic polymorphisms were found to have significant associations with increased CKD risk, including Renalase (rs2296545), GSTO1 (rs2164624), GSTO2, MMP3 (rs35068180), and MGP (rs4236), among others such as CYP24A1, GPX1, UMOD, CYP2C8, CYP4A11, EPHX2, SPP1, and BGLAP. These polymorphisms influence mechanisms such as blood pressure regulation, oxidative stress, inflammation, and tissue calcification, all contributing to CKD progression. In conclusion, genetic polymorphisms are crucial in CKD risk, offering insights for more personalized approaches in diagnosing, preventing, and treating this condition. These findings support the development of more effective, genetics-based treatment strategies in the future.
Optimasi Waktu Fermentasi Biji Kakao (Theobroma cocoa L.) Menggunakan Ragi Tape Terhadap Aktivitas Antioksidan Dengan Metode DPPH Pratiwi, Dian; Ika Pramitha, Dewa Ayu; Kusuma Wardani, I Gusti Agung Ayu
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.7470

Abstract

Cocoa beans (Theoborma cacao L.) are one part of the cocoa plant that is believed to contain high levels of polyphenol compounds that act as antioxidants. Cocoa beans are said to contain high polyphenol and flaovonoid compounds, which play an important role in the formation of antioxidants. Fermented cocoa beans have better quality in terms of taste, aroma, and color, but the fermentation process can cause a decrease in the content of polyphenol compounds in cocoa beans, causing a decrease in antioxidant activity. In the fermentation process, adding fermenters such as yeast tape can shorten the fermentation time. This study aims to determine the optimization of fermentation time to produce higher antioxidant activity of cocoa beans (Theobroma cacao L.) using the DPPH method. The results of the cocoa bean antioxidant test showed the IC50 value in the unfermented cocoa bean sample was 15.360 ppm, in the 1st day fermentation sample was 23.757 ppm, in the 2nd day fermentation sample was 3.574 ppm, in the 3rd day fermentation sample was 7.985 ppm, in the 4th day fermentation sample was 27.70 ppm, in the 5th day fermentation sample was 33.111 ppm, in the 6th day fermentation sample was 2.456 ppm, and in ascorbic acid as a positive control was 2.463 ppm. The data showed that the most optimum antioxidant value was found in the sample fermented for 6th days.
Potensi Tumbuhan Akuatik Hydrocotyle Sibthorpioides Lam sebagai Zat Antidiabetes Melitus Tipe 2 (T2D) Putra, Aditya Pratama
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.10459

Abstract

Type 2 diabetes mellitus is a condition of hyperglycemia caused by the insensitivity of cells to insulin even though insulin levels in the body are within the normal range. Hydrocotyle sibthorpioides Lam contains several important compounds, such as triterpenoid saponins, genin triterpenoids, essential oils, phytosterols, and flavonoids. This flavonoid compound is one of the potentially dominant compounds for people with type 2 diabetes mellitus. The purpose of writing this article is to determine the potential of the aquatic plant Hydrocotyle sibthorpioides Lam as an antidiabetic substance for type 2 diabetes mellitus (T2D). The research method used is a literature review with the number of articles used more than 10 journal articles. Flavonoids contained in the aquatic plant extract of Hydrocotyle sibthorpioides Lam have the potential as an antidiabetic drug by increasing insulin sensitivity in diabetics through its role in regulating insulin signaling mechanisms in target organs. Extracts from Hydrocotyle sibthorpioides Lam have great potential to be developed as an alternative treatment for type 2 diabetes mellitus (T2D). Further research and testing is needed regarding the effectiveness and side effects of this plant extract as a diabetes therapy.
Tingkat Kepuasaan Pelayanan Kefarmasian Pada Pasien Rawat Jalan di RSUD dr. Murjani Sampit Agusthin, Ishae Tri; Pratomo, Guntur Satrio; Ardhany, Syahrida Dian
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.11105

Abstract

Pharmaceutical services in hospitals play an essential role in supporting the quality of healthcare services and influencing patient satisfaction levels. This study aimed to evaluate patient satisfaction with pharmaceutical services at the outpatient pharmacy of RSUD Dr. Murjani Sampit based on five satisfaction dimensions: reliability, responsiveness, empathy, tangibles, and assurance. This study used a quantitative method with a descriptive approach. Data were collected through a validated questionnaire survey. Patient satisfaction was measured using a Likert scale ranging from one to five points. The results show that pharmaceutical services at RSUD Dr. Murjani have a good level of satisfaction across all measured dimensions. The reliability dimension scored 78.67%, reflecting the accuracy and clarity of information provided by pharmacists. The responsiveness dimension scored 79.79%, indicating fast service despite resource limitations. The empathy dimension scored 78.97%, demonstrating the staff’s attentiveness to patient needs. The tangibles dimension scored 77.95%, describing facility comfort, though some improvements are needed. The assurance dimension scored 75.1%, indicating good medication availability. Overall, pharmaceutical services at RSUD Dr. Murjani meet good quality standards and provide patient satisfaction, although some aspects can be improved to enhance the overall patient experience.

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