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INDONESIA
Indonesian Journal of Pharmaceutical Research
Published by Universitas Muhammadiyah Sumatera Barat
ISSN : -     EISSN : 27765075     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Indonesian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed open-access journal related to the pharmaceutical sciences and related disciplines, as well as pharmaceutical practice. It is the journal of the Department of Pharmacy, Faculty of Pharmacy, Muhammadiyah University of Sumatera Barat, published semi-annually online and in print by the UMSB Press. IJPR publishes reviews, opinion articles, research papers, and communications including: Pharmacognosy and Pharmaceutical Biology Medicinal and Pharmaceutical Chemistry Pharmacology Pharmacokinetics and Pharmacodynamics Pharmaceutical Technology Pharmaeconomy Community Pharmacy Practice Pharmaceutical Care and Clinical Pharmacy Social Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 41 Documents
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Treatment Pattern of Patients with Narcotics and Psychotropic Abuse (Case Study at the Bandung Rehabilitation Clinic) Sergeonery, Lively
Indonesian Journal of Pharmaceutical Research Vol 1, No 2 (2021): Indo J Pharm Res 2021 1(2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v1i2.2898

Abstract

Narcotics, psychotropics, and addictive substances abuse can cause addiction, which is a chronic disorder characterized by compulsive drug seeking and use despite adverse consequences. This is a concurrent descriptive study carried out by evaluating medical records and MMAS-8 questionnaire for assessing patients’ adherence. In addition, therapeutic success and quality of life were also evaluated using WHOQOL-BREF questionnaire. The study took place in the period of September-November 2018 at Medika Antapani Clinic. Data collected from patients under drug maintenance was used to identify the types of drug mostly used by the patients and their treatment, assess the impact of the management, and identify factor influencing therapeutic success. The results showed that there were 40 drug abusers at Medika Antapani Clinic. The abused drugs were amphetamine (80%), cannabis (72%), heroin (35%), benzodiazepine (25%), and nitrazepam (20%). Therapeutic measures used to treat drug abuse were alprazolam in 38 patients (95%), clonazepam in 33 patients (82.5%), nitrazepam in 29 patients (72.5%), lorazepam in 22 patients (55%), and diazepam in 14 patients (35%). Drug rehabilitation patients had low adherence of only 50%. Measurement of quality of life revealed social relation as the dimension with the highest score of 69 + 20.44, with most patients categorized as having moderate quality of life. Therapy with benzodiazepine has potential to cause dependence so it must be practiced with caution.
Irritation Test and Effectiveness of The Clean Power Activated Charcoal Palm Shells (Elaeis guineensis Jacg) as Adsorbent Dirt on The Hair Uce Lastari; Syamsurizal Syamsurizal; Faizar Farid
Indonesian Journal of Pharmaceutical Research Vol 1, No 1 (2021): Indo J Pharm Res 2021 1(1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v1i1.2452

Abstract

The dirty and itchy scalp is very annoying in appearance, which is the onset of dandruff. Dandruff is due to the accumulation of dead skin cells, dry and oily scalp as well as the presence of skin infections and fungi in the head. To avoid the onset of dirt or dandruff to hair, it is necessary to do cleaning regularly using cosmetics one of them is active charcoal-based shampoo palm kernel shells. The capability of palm kernel shells can absorb dirt twice from commercial active charcoal to cleanse the skin to the fullest. This research aims to effectively absorption of the dirt in Invitro on the active charcoal shampoo of palm shells with a concentration of 12%. Invitro tests the effectiveness of the impurities absorbent by using a turbidimetry tool with a Nephelometric Turbidity Unit value or frequency number. While the irritation test is done on 10 people panelists. Comparative control used commercial shampoo as a positive control and base shampoo as a negative control. The results showed that a 12% palm shell activated charcoal shampoo provided an NTU value of 11,400 while a commercial shampoo gave an NTU value of 786. No panelists have irritation on the scalp. From the obtained results can be concluded that the active oil palm Shell Shampoo has the absorbent power to the dirt from a commercial shampoo and safe to use.
Description of Knowledge and Attitudes of Young Women in Rowosari Village, Pemalang Regency Against the Dangers of Retinoic Acid in Face Whitening Cream Tyas Putri Utami; Nila Oktaviani
Indonesian Journal of Pharmaceutical Research Vol 2, No 2 (2022): Indo J Pharm Res 2022 2(2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v2i2.4177

Abstract

Kulit halus dan putih adalah salah satu keindahan Kulit halus dan putih adalah salah satu konsep kecantikan orang Indonesia saat ini, dan sebagian besar orang Indonesia memiliki kulit sawo matang. Filosofi kecantikan ini membuat masyarakat Indonesia khususnya remaja putri, berusaha keras untuk mendapatkan kulit yang cerah, dan salah satunya adalah dengan menggunakan kosmetik yang mengandung krim pemutih dan pencerah. Remaja mulai tertekan terhadap penampilan yang menginginkan kulit putih dengan menggunakan krim pemutih tanpa memperhatikan ada atau tidaknya komposisi dan izin edar atau terdaftar di BPOM. Tujuan penelitian ini adalah untuk mengetahui gambaran pengetahuan dan sikap remaja putri di Desa Rowosari Kabupaten Pemalang terhadap bahaya asam retinoat pada krim pemutih wajah. Jenis penelitian ini adalah survey deskriptif dan penelitian ini dilaksanakan di Desa Rawosari Kecamatan Ulujami Kabupaten Pemarang. Sampel penelitian ini adalah 100 remaja putri berusia antara 15-19 tahun yang diperoleh dengan cara simple random sampling. Hasil penelitian menunjukkan bahwa 56 orang (56,0%) memiliki pemahaman yang baik tentang pengetahuan bahaya asam retinoat dalam krim pemutih, dan 95 orang (95,0%) memiliki sikap tertinggi dengan kategori baik.
STUDY OF POTENTIAL DRUG INTERACTIONS IN PULMONARY TB PATIENTS IN dr. GONDO SUWARNO HOSPITAL SEMARANG DISTRICT 2021 Iswandi Iswandi
Indonesian Journal of Pharmaceutical Research Vol 2, No 2 (2022): Indo J Pharm Res 2022 2(2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v2i2.3941

Abstract

Tuberkulosis (TB) adalah salah satu penyakit menular dengan tingkat kematian tertinggi di dunia yang disebabkan oleh Bakteri Mycobacterium tuberculosis. Pasien tuberkulosis dengan penyakit penyerta diobati dengan obat tambahan untuk mengobati penyakit penyerta, hal ini menyebabkan peningkatkan potensi interaksi obat. Tujuan penelitian adalah untuk mengetahui obat yang berpotensi menyebabkan interaksi obat terhadap pasien TB paru di RSUD dr. Gondo Suwarno Tahun 2021. Jenis penelitian ini deskriptif non eksperimental dengan pengumpulan data retrospektif. Sampel dalam penelitian ini adalah pasien TB Paru yang tertera di rekam medis dan mendapat pengobatan antituberkulosis (OAT) dan non-OAT di RSUD dr. Gondo Suwarno tahun 2021 dan disesuaikan dengan kriteria inklusi. Potensi interaksi obat antar OAT meliputi interaksi farmakokinetik (34%), farmakodinamik (66%) dan unknown tidak teridentifikasi. Berdasarkan tingkat keparahan, major (194 kasus), moderate (96 kasus), dan minor tidak teridentifikasi. Pada potensi interaksi obat OAT dengan non-OAT meliputi interaksi farmakokinetik (94%), farmakodinamik (4%) dan unknown (2%). Berdasarkan tingkat keparahan, major (23 kasus), moderate (214 kasus), dan minor (42 kasus).
VARIASI METODE EKSTRAKSI, SKRINING FITOKIMIA DAN UJI TOKSISITAS EKSTRAK METANOL Eucheuma cottonii Panjaitan, Riong Seulina; Meze, Maria Fortunata
Indonesian Journal of Pharmaceutical Research Vol 3, No 2 (2023): Indo J Pharm Res 2023 3 (2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v3i2.5045

Abstract

Eucheuma cottonii merupakan salah satu jenis makroalga merah yang berubah nama menjadi Kappaphycus alvarezii karena karaginan yang dihasilkan termasuk fraksi kappa- karaginan. Pada penelitian ini metode ekstraksi yang digunakan adalah metode ekstraksi konvensional yakni maserasi dan metode ekstraksi modern yaitu ultrasound assisted extraction (UAE). Senyawa aktif yang terkandung dalam ekstrak metanol Eucheuma cottonii pada metode ekstraksi maserasi adalah: steroid. Sedangkan pada metode ekstraksi ultrasound assisted extraction adalah: flavonoid, saponin, steroid, triterpenoid. Pada penelitian ini juga dilakukan skrining fitokimia dengan pengujian warna yang menggunakan suatu pereaksi warna setelah itu dilakukan uji toksisitas dengan menggunakan metode Brine Shrimp Lethality Test (BSLT). Hasil nilai rendemen yang dihasilkan dari metode ekstraksi maserasi memiliki nilai tertinggi pada hari ketiga yakni 20,0 % sedangkan nilai rendemen tertinggi dari metode ekstraksi UAE yakni pada waktu ke 30 menit dengan nilai rendemennya adalah 32,1 %. Hasil perhitungan nilai LC50 ekstrak metanol dari makromakroalga Eucheuma cottonii yang bersifat sangat toksik terhadap larva Artemia salina Leach yaitu 82,036 μg/mL dari metode ultrasound assited extraction dan bersifat toksik terhadap larva Artemia salina Leach yaitu sebesar 253,294 μg/mL dengan metode maserasi menggunakan aplikasi SPSS IBM statistic 26 , sehingga dapat disimpulkan ekstrak metanol Eucheuma cottonii bersifat sangat toksik dan toksik terhadap larva Artemia salina Leach dan berpotensi sebagai antisitotoksik.
ANALISIS PENYEBAB OBAT KADALUWARSA (EXPIRED DATE) DI INSTALASI FARMASI RUMAH SAKIT "X" PADANG TAHUN 2022 Norianti, Eca; Elvina, Ridha
Indonesian Journal of Pharmaceutical Research Vol 3, No 2 (2023): Indo J Pharm Res 2023 3 (2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v3i2.5232

Abstract

Obat kadaluwarsa adalah obat yang sudah melewati masa kadaluwarsa yang dicantumkan oleh pihak pabrik pada kemasan obat. Waktu kadaluwarsa merupakan waktu yang menunjukkan bahwa obat tersebut sudah tidak layak untuk digunakan yang mengakibatkan zat aktif yang terdapat dalam obat akan berubah menjadi racun (toksik). Penyebab terjadinya obat kadaluwarsa yaitu sumber daya manusia yang belum bekerja secara maksimal dengan pencatatan stok obat yang sebelumnya tidak baik, perencanaan dan pengadaan obat dimana tidak adanya pembagian tanggungjawab yang jelas, obat yang tidak digunakan user, sosialiasi dan komunikasi petugas instalasi farmasi dengan user yang tidak berjalan dengan baik. Tujuan penelitian untuk mengetahui faktor-faktor penyebab obat kadaluwarsa (Expired date) di Instalasi Farmasi Rumah Sakit "X" Padang. Pada penelitian ini menggunakan metode kualitatif deskriptif dengan mengumpulkan data melalui wawancara, observasi, dan dokumentasi. Informan penelitian adalah kepala instalasi, Apoteker, Tenaga Teknik kefarmasian yang di pilih berdasarkan Teknik penarikan sampel wawancara langsung. Seluruh data yang terkumpul akan di analisis dengan teknik analisis data interaktif dengan tahap reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa di Instalasi Farmasi Rumah Sakit "X" Padang terdapat obat kadaluwarsa yang terjadi berdasarkan permenkes Nomor 72 Tahun 2016 belum sesuai dan dapat di lihat pada pendistribusian, penyimpanan, pencatatan dan pelaporan. Kata kunci : kadaluwarsa, instalasi farmasi, rumah sakit
Qualitative Test of Protein in Tempeh Wrapped in Leaf and Plastic Panjaitan, Riong Seulina; Purwati, Purwati; Elawati, Nur; Ghassani, Fatiha Azka; Suryo, Nabila Dwi; Salsabilla, Zuli Astuti; Simatupang, Angel Maria; Afikah, Hana Tri; Langit, Vinsensia Asahi Sulan
Indonesian Journal of Pharmaceutical Research Vol 4, No 1 (2024): Indo J Pharm Res 2024 4 (1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v4i1.5349

Abstract

Tempeh is a food familiar to Indonesians made from fermented soybeans wrapped in leaves or plastic. Protein identification in tempeh is carried out to detect the presence of protein using a qualitative test based on the color changes that form. The aim of this research is to provide scientific information about the qualitative comparison of protein content in samples of tempeh wrapped in leaves and tempeh wrapped in plastic. The qualitative protein identification methods used in this research are the biuret test, the ninhydrin test, the xantoprotein test, the sulfur test, and the Neuman test. From the observations, it can be seen that the biuret test, ninhydrin test, xanthoprotein test, and sulfur test gave positive results for both types of tempeh samples. Meanwhile, in the Neumann test, tempeh with plastic wrapping gave negative results compared to tempeh wrapped in leaves, which gave positive results.
OVERVIEW OF PATIENT COMPLIANCE IN THE USE OF TUBERCULOSIS DRUGS IN THE WORKING AREA OF THE LUBUK ALUNG HEALTH CENTER, PADANG PARIAMAN DISTRICT, 2O22 Sarah Mailisa, Sarah; Reslina, Isra; Elvina, Ridha; Widya, Nurul; Rosa, Rida
Indonesian Journal of Pharmaceutical Research Vol 4, No 1 (2024): Indo J Pharm Res 2024 4 (1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v4i1.5534

Abstract

Tuberculosis (TB) cases are one of the health problems experienced by many Indonesian people. Tuberculosis (TB) is an infectious disease, in Padang Pariaman Regency in 2021 to 2022 it will experience an increase where in 2022 Lubuk Alung sub-district will be recorded as the area with the highest TB cases. This study aims to look at the characteristics and adherence to the use of TB drugs. The data collection method in this study was total sampling where the total number of respondents was 63 people. With the results of the study that the characteristics of the respondents, the sex most affected by TB was male, namely 52.6%, the highest education was high school, 65.8%, and the most common jobs were in other categories (workers, traders, drivers students), namely 50%. Meanwhile, the highest income is 1000000, which is 52.6%, and the distance from home to health services is the highest, which is 5KM, namely 65.8%. Meanwhile, for adherence to the use of TB itself, tuberculosis patients in the working area of the Lubuk Alung Health Center are categorized as high, with a percentage of 36.9%.Keywords: Tuberculosis, Compliance, use of Tuberculosis Drugs
Correlation between Knowledge and Attitude with Compliance with Blood Supplement Tablet Consumption in SMAN 10 Students in the Working Area of Puskesmas Andalas, Padang City Hadi, Al; Novrita, Sisri
Indonesian Journal of Pharmaceutical Research Vol 3, No 1 (2023): Indo J Pharm Res 2023 3(1)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v3i1.4897

Abstract

The high incidence of anemia occurs in the adolescent age group and female sex. In preventing anemia and reducing the incidence of anemia in Indonesia, the government is holding a blood-added tablet supplementation program for young girls at school. To support the program, this research was carried out with the aim of knowing the relationship between knowledge and attitude with adherence to blood supplement consumption by female students of SMAN 10 in the working area of the Andalas Health Center, Padang City. This research was conducted from March to June 2023. The method used was an observational analytic design, the sampling technique used was purposive sampling which met the inclusion and exclusion criteria. The sample used in this study was female students of SMAN 10 in the working area of the Andalas Public Health Center, Padang City. The results of the univariate test of SMAN 10 female students in the work area of the Andalas Health Center, Padang City, most of them had high knowledge (66.5%), negative attitudes (55.7%), low compliance (74.3%). Then the results of the chi square test obtained that the relationship between knowledge and attitudes did not have a significant relationship with a P value of 0.542 (≥ 0.05), and the relationship between attitude and adherence to consumption of iron tablets had a significant relationship with a P value (≤ 0.05). 
The Relationship between Knowledge and Community Attitudes with Use of Herbal Medicine as Tradisional Medicine in Simpang Petai Village, Kampar Regency Elvina, Ridha; Camelia, Indah Nur; Rosa, Rida; Reslina, Isra; Widya, Nurul
Indonesian Journal of Pharmaceutical Research Vol 3, No 2 (2023): Indo J Pharm Res 2023 3 (2)
Publisher : Department of Pharmacy, Muhammmadiyah University of Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/ijpr.v3i2.5043

Abstract

Obat tradisional adalah ramuan atau campuran yang bersumber dari hewan, tumbuhan, sediaan sarian (galenik), dan mineral yang telah digunakan secara turun-temurun untuk pengobatan. Pengetahuan masyarakat Indonesia pada penggunaan obat tradisional masih rendah dan banyak terdapat kekeliruan. Pengetahuan dan sikap merupakan faktor yang mempengaruhi tindakan pemilihan pengobatan seseorang. Penelitan ini dilakukan di Desa Simpang Petai Kabupaten Kampar menggunakan desain penelitian non-eksperimental yang bersifat observasional deskriptif. Sampel yang digunakan pada penelitian yaitu masyarakat Desa Simpang Petai Kabupaten Kampar menggunakan metode purposive sampling. Analisis data menggunakan uji statistik chi square. Hasil penelitian menunjukkan bahwa masyarakat Desa Simpang Petai Kabupaten Kampar pengetahuan dangan kategori baik 86.%. Sedangkan sikap dengan kategori favorable 53.8%. Serta penggunaan obat tradisional dengan kategori cukup 46.2%. Kemudian tidak terdapatnya hubungan signifikan pengetahuan dengan penggunaan obat tradisional dengan P= 0,325 (P value α 0,05) dan tidak adanya hubungan signifikan sikap dengan penggunaan obat tradisonal dengan P= 0,166 (P value α 0,05).

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