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Astri Desmayanti
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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 154 Documents
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Analysis of Total Flavonoid and Antioxidant Activity of Black Turmeric (Curcuma caesia) using ABTS (2,2-azinobis-3-Ethylbenzothiazoline-6-Sulfonic Acid) Method Tanesib, Molesy Fransina; Indra Kurniasih, Kholif Sholehah; Nugraha, Arde Toga
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9325

Abstract

Black turmeric (Curcuma caesia) has a higher concentration of phytochemical compounds compared to other turmeric species. This means it's an incredibly potent natural antioxidant. Experts believe that black turmeric could have some amazing health benefits, such as protecting against oxidative stress and reducing inflammation. Black turmeric was extracted using the maceration method with a methanol solvent. After extracting black turmeric using the maceration method and methanol solvent, the resulting extracts were tested qualitatively for flavonoids, phenolics, and tannins. Then proceed with the quantitative test to determine the total levels of flavonoids and test the antioxidant activity using the ABTS method. The results of this study obtained a yield of 13.26%, positive qualitative test results for flavonoids, phenolics, and tannins, and total flavonoid levels of 10.326 ± 0.074 mgEQ/g extract with an IC50 of 88.581 ± 3.376 ppm. Based on the results of the antioxidant activity, black turmeric methanol extract has strong antioxidant activity.
Formulation and Evaluation of Ketoconazole Nano-suspension Agustin, Eriska; Sari, Gita Deslia
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9511

Abstract

The use of antifungals that are widely used by the public is ketoconazole. Ketoconazole is included in the Biopharmaceutical Classification System (BCS) II category, where the drug is poorly soluble in water but has high permeability. In this study, ketoconazole was prepared in a nanosuspension formulato increase solubility. The method for preparing 2% ketoconazole nanosuspension used a sonicator bath with variations of tween 80 (F1 8%, F2 10%, F3 12%) and transcutol as surfactant and co-surfactant. The results showed that the particle size of the ketoconazole nanosuspension F1 was 102 ± 4.3 nm, F2 was 105 ± 3.2 nm, and F3 was 90 ± 2.4 nm on day 0. Testing on day 28 showed an increase in particle size in F1 115 ± 3.1 nm, F2 129±4.5nm, F3 97±2.4nm (p>0.05). In testing the morphology of the nanosuspension using Scanning Electron Microscopy (SEM), The results showed that the irregular spheres were scattered. Organoleptic testing showed clear and homogeneous preparations. pH testing for 28 days showed a pH range of 5.6-6 which is included in the physiological skin pH range (p>0.50). Nanosuspension preparations can be said to meet the physical evaluation requirements.
Kaempferia galanga (L.): An Updated Overview of In Vitro and In Vivo Antioxidant Properties Riastri, Anami
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9997

Abstract

Kaempferia galanga L. (K. galanga) locally called aromatic ginger or “kencur" in Bahasa is traditionally for the treatment of various diseases related to antioxidants such as anti-inflammatory, anti-cancer, and immunomodulator. This paper aims to provide a critical review of the current antioxidant activity of K. galanga using in vitro and in vivo assays. The information and data of K. galanga were collected from various resources such as Scopus, PubMed, Science Direct, and Google Scholar. The results showed that K. galanga plays a role in defense systems against oxidative stress. Several in vitro assays have been used to measure the antioxidant activity of K. galanga, namely,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reduction of antioxidant power (FRAP), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Whereas, the parameter in vivo antioxidant assay of K galanga including lifespan, survival life, intracellular reactive oxygen species (ROS) level, malondialdehyde (MDA) level, and antioxidant enzyme activities: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Based on the findings, it can be indicated that K. galanga has powerful antioxidant activities and, therefore could have the potential as a natural antioxidant.
Formaldehyde Content in Indonesian Food and the Analysis Method: A Review Putri, Anggita Rosiana; Awidarta, Kevin; Pratita Ihsan, Bachtiar Rifai; Khaerunisa, Intan; Ulum, Muhammad Bachrul; Huda, Laili Fadhotun
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10060

Abstract

Apart from being rich in culture, Indonesia is also rich in food culture. However, in some cases, there are illegal additions of formalin (37% formaldehyde) to food to extend shelf life. If humans consume food containing formaldehyde, it will have a harmful impact. Formaldehyde has the potential to cause cancer. In recent years, formaldehyde has still been found in several Indonesian foods. There are several analytical methods developed to detect formaldehyde levels in food. This review overview of the formaldehyde effect to human health, formaldehyde content in fish and Indonesian food, and the detection methods.
Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique Kusumorini, Nindya; Adhyatmika
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10062

Abstract

This study investigated the effect of ammonium bicarbonate and citric acid as templating agents using spray drying technique to improve the porosity of D-mannitol powder. It has been shown that textural properties, such as surface area and pore volume produced, are affected by the type and concentration of templating agents, inlet temperature, and outlet temperature of spray drying. The structure of mannitol powder produced changes considerably due to the change in its textural properties to particle powder with high porosity, surface area, and pore volume. The results show that the ratio of D-mannitol to ammonium bicarbonate 10:5 w/w% with water solvent temperature of 30 oC, spray drying inlet temperature of 120 oC, and spray drying outlet temperature of 70 oC, resulting in the highest porosity, surface area, and pore volume. The surface area of mannitol increased from 1.167 m2/g to 3.571 m2/g, followed by an increase in pore volume from 0.0022 cc/g to 0.012 cc/g and pore diameter from 75.33 Å to 115.2 Å. The scanning electron microscope (SEM) results are consistent with the surface area measurement results using the Surface Area Analyzer (SAA). The resulting spray-dried mannitol powder with a high specific surface area allows it to be used as an excipient in solid formulations of oral preparations.
Study of Chemical Composition and Evaluation of Anti-hypertensive Effect of A Fixed Oil Extracted from Linum usitatissimum grains Halima, Oulad Ali; Mebarka, Belboukhari; Nasser, Belboukhari; Khaled, Sekkoum; Kawther, Al Sid Chikh
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10753

Abstract

Globally grown flax seed is regarded as an oilseed with numerous medicinal and health are the outcomes of the physico-chemical analyses: pH value: 0.476; saponification index: 168.3; KOH/g: 28.05; peroxide index: 174; density: 0.951; refractive index: 1.482 at 18.1°C and 1.485 at 18.2°C; peroxide index: 1.70 at 0.96, 1.70 mg/100; all are related to the peroxide index. In this study we tried to test the ” anti-hypertension “ activity of this oil by simulating a blood cycle in the laboratory which allowed us to determine the variation in blood pressure as a function of the volume of oil injected into the blood cycle from 17.4 to 14.10. benefits such as: lowering blood pressure, blood sugar, decreasing the risk of neurological and obesity-related illnesses. The objective of this study is to extract the linseed oil and to characterize it chemically and physically; by pressing the seeds into two different temperatures : 67°C and 90°Coil yields ; 24% and 29% were obtained from linseed. The followings
Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro Aristiani, Windy; Desvita, Widea Rossi; Khayatulisma, Dika; Edityaningrum, Citra Ariani; Guntarti, Any; Nurani, Laela Hayu
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10887

Abstract

(1) Background: Cervical cancer ranks as the fourth most prevalent cancer globally and in Asia, standing as the second most common in Indonesia. Despite its efficacy, doxorubicin chemotherapy is associated with significant side effects. To mitigate these adverse effects, a promising approach involves combining conventional drugs with curcumin. Both curcumin and doxorubicin have demonstrated cytotoxic effects against cervical cancer (HeLa). This research aims to determine the synergistic effect of the combination of doxorubicin and curcumin on HeLa and safety in normal cells (Vero cells). (2) Methods: This study adopted an experimental design utilizing doxorubicin and curcumin samples with HeLa and Vero cells. The investigation was initiated with cytotoxic and combination tests using the MTT method. The obtained results included IC50 values and combination indices, and the analysis involved a comparative examination of outcomes between HeLa and Vero cells. (3) Results: Cytotoxic tests revealed IC50 values for doxorubicin and curcumin on HeLa cells, measured in 2,17 ± 0,06 and 26,37 ± 2,00 µg/mL, and 17,32 ± 1,99 and 181,88 ± 30,48 µg/mL on Vero cells. Combination test results were represented by combination index .(4) Conclusions: The synergistic effect is observed at the combination of curcumin at a concentration of 9 μg/mL and doxorubicin at a concentration of 0,125 μg/mL, resulting in a combination index of 0,50. These findings suggest a promising avenue for enhancing the therapeutic potential of doxorubicin in cervical cancer treatment while minimizing adverse effects.
Formulation and Determination of Tannin and Flavonoid Levels of Anti-Acne Gel Formulation from Red Betel Leaf Extract (Piper crocatum) Putri Deana, Annisha Amelya; Minerva, Prima
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.12644

Abstract

Acne is a common skin condition that often occurs among teenagers and adults aged 18-23 years. Acne can be triggered by several factors, genetic, psychological, weather, stress, cosmetics, and bacterial infections. In addressing the problem of acne, a good dosage form to use is a gel preparation. Acne skin care by utilizing natural ingredients, one of which is red betel leaf. Red betel leaf contains phytochemical compounds, namely tannins and flavonoids, which function as antibacterial agents. The formulation of anti-acne gel is designed by varying the concentration extract, F0 (0%), F1 (10%), F2 (15%), and F3 (20%), with the aim of determining the best anti-acne gel formulation. Red betel leaf extract is tested for tannin and flavonoid levels using the UV-Vis Spectrophotometer test method. The gel preparation is examined, including organoleptic testing, pH testing, homogeneity testing, and spreading testing. The research results show that red betel leaf extract has a tannin content of 4.7056% and a flavonoid content of 0.0934%. The results of the anti-acne gel preparation study meet the requirements for organoleptic properties, pH, homogeneity, and spreading. Based on the results of various concentrations of extract, satisfactory results are obtained, with formulations F2 and F3 meeting the requirements.Acne; Gel; Extract; Piper crocatum
Optimization of HPMC and Glycerine in Essence of Sheet Mask Containing Centella asiatica (L.) Urb. Extract and Snail Mucus (Achatina fulica) as A Moisturizer Anjani Saskia Putri; Endang Diyah Ikasari; Ungsari Rizki Eka Purwanto
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9889

Abstract

Various natural ingredients have been formulated as moisturizers in cosmetics, both from natural and animal raw material, especially Centella asiatica (L.) Urb. Extract and snail mucus (Achatina fulica). However, there is only a little research to determine the development of both material in one cosmetic preparation, namely sheet mask. The mask sleeve, which is a sheet mask applicator, will dry longer than other masks, therefore the penetration shown as a moisturizer is better. Gelling agents (such as hydroxypropyl methyl cellulose (HPMC)) and humectants (such as glycerinee) are important ingredients in sheet masks. This research aims to optimization HPMC and glycerine in a sheet masks Centella asiatica and snail mucus. Optimization of HPMC and glycerine with a ratio of 0.3–3% HPMC and glycerine was carried out using the Design Expert 10 with Simplex Lattice Design method. The responses from optimization of the preparation were pH, viscosity, absorption power and skin moisture. The optimum formula was obtained at a concentration of 0.589% HPMC and 2.711% glycerine with pH of 5.64 ±0.02; viscosity of 4581.8± 59.80 cPs, absorption power in scale of 4.6+0,55 , and skin moisture of 32.09%+3.21. The irritation test has a score of 0 or does not cause irritation.
Formulation and Evaluation of Wound Healer Waterproof Spray containing Cymbopogon nardus L. and Musa paradisiaca L. Leaves Wax Novitasari, Putri Rachma; Dwi Nugroho, Agung; Adyaqsa Prihatmadi, Farhan; Kesya Riza Purnama, Sarasevita
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10160

Abstract

Red lemongrass (Cymbopogon nardus L.) is an Indonesian plant which has potential as a wound healer. Red lemongrass contain essential oil which has the potential effect to treat wounds, such as citral. The citral content in every 1 mL of this essential oil is 32.28%. A wound is an injury-induced disturbance of the tissues' normal anatomical relationships. Wound is basically prone to infection, and it can infect bacteria, such as Staphylococcus aureus bacteria. Water splashes exposed the Staphylococcus aureus bacteria, which then caused an infection. Water is a medium for bacterial growth. In this research, kepok banana leaves wax (Musa paradisiaca L.) is added as a waterproof base to prevent wounds from being splashed by water, because wounds on skin tissue are protected by a layer of wax originating from kepok banana leaves (Musa paradisiaca L.). The aim of this research was to make a waterproof gel spray from red lemongrass essential oil using wax of banana leaves as a waterproof base. The result showed waterproof gel spray preparation has yellowish white colour; a distinctive aromatic odor, pH 6,28; viscosity 135 cps, and dry time 7.5 minutes and it has waterproof properties.

Page 10 of 16 | Total Record : 154

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