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Jurnal Medika Nusantara
Published by Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro
ISSN : 29867878     EISSN : 29867061     DOI : 10.59680
Core Subject : Health,
Health Professions Nursing Public Health
Jurnal Medika Nusantara mencakup artikel di bidang ilmu kesehatan dan Kedokteran. Kami menyediakan akses terbuka (open access) bagi para akademisi dan praktisi serta mahasiswa kesehatan yang ingin mendapatkan artikel dalam Jurnal Jurnal Medika Nusantara
Arjuna Subject : Kedokteran - Kesehatan Masyarakat, Kesehatan Lingkungan dan Pekerjaan
Articles 240 Documents
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Asuhan Keperawatan Pada An. R Dengan Gangguan Sistem Pencernaan: Dispepsia Di Ruang Dahlia RSUD dr. Soeselo Kabupaten Tegal Afiati Amelia Rosadi; Esti Nur Janah; Wawan Hediyanto
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.621

Abstract

Dyspepsia is a condition or collection of symptoms such as a feeling of discomfort in the upper part of the stomach as well as subjective complaints in the form of nausea, vomiting, burning sensation, bloating in the upper digestive tract, feeling full quickly, feeling full in the stomach after eating and also belching (Ashari , Yuniati & Murti, 2021).
Uji Aktivitas Antioksidan Formulasi Sediaan Krim Tabir Surya Ekstrak Etanol Biji Buah Durian (Durio Zibethiunus Murr) Dengan Menggunakan Metode DPPH Aulia Mifta Huljanah
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.622

Abstract

Durian fruit seeds are seeds that contain chemical compounds, namely flavonoid compounds. Flavonoid compounds are active compounds that are include in the type of antioxidant intermedietes that act as antioxidants. The antioxidant mechanism of flavonoids is to capture free radicals and reactive oxygen species (ROS) directly, prevent the regeneration of ROS and can indirectly increase the activity of antioxidants and cellular antioxidant enzymes. This study aims to determine durian seed extract as a natural sunscreen and determine the formula for a good cream preparation. The method used in the study of durian seed extract (Durio Zibethiunus Murr) is the DPPH (1,1-diphenyl-2-pikrilhidrazil) method. Then the metod of extraction is using maceration with the differences in each formula for sunscreen cream namely 0%, 5%, 10% and 15%. The evaluations used in the study were organoleptic tests, homogeneity tests, pH tests, adhesion tests and spreadability tests. The result of this study indicate that the formulation of sunscreen cearm extract of durian fruit seeds (Durio Zibethiunus Murr) can be used as a sunscreen cream. The best sunscreen cream formulation is the 15% formula. The content of the antioxidant compounds ir more and meets the ultra value.
Uji Antioksidan Ekstrak Dan Formulasi Sediaan Krim Tabir Surya Kulit Delima Putih (Punica Granatum L.) Dengan Metode DPPH Dan Penentuan Nilai SPF Vanni Hilda Kusumawati
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.625

Abstract

White Pomegranate (Punica granatum L.) is a plant that is efficacious as an antioxidant which functions as a natural antioxidant to prevent free radicals from harming the body because it contains flavonoid compounds including flavones and flavonols which are known as natural antioxidants. This study aims to determine the IC50 value of extracts and formulations of white pomegranate skin sunscreen cream (Punica granatum L.) along with its SPF value. The extract was prepared by maceration using 96% ethanol. Testing the antioxidant activity of white pomegranate peel extract (Punica granatum L.) using UV-Vis spectrophotometry with the DPPH method (1,1-Diphenyl-2-Picrylhyrdazyl), the test results showed that white pomegranate peel extract (Punica granatum L.) had an IC50 value of 92,76 ppm in the strong category. Sunscreen cream was made into four formulas, namely F0, FI, FII and FIII with extract concentrations of 5%, 10% and 15% respectively. The physical evaluation was tested, including organoleptic test, homogeneity test, cream type test, spreadability test, adhesion test, pH test, viscosity test and organoleptic stability test which showed that the four formulas met the requirements of the physical evaluation test for sunscreen cream preparations. The four sunscreen cream formulas, an antioxidant activity test was carried out using the DPPH method (1,1-Diphenyl-2-Picrylhyrdazyl) at F0, FI, FII and FIII and obtained IC50 values of 146,9 ppm (weak), 98,22 ppm (strong), 81,37 ppm (strong) and 76,88 ppm (strong). Determination of the SPF (Sun Protection Factor) value was carried out using the mansyur equation method using UV-Vis spectrophotometry at a wavelength of 290-320 nm. The results obtained for the SPF values in the four formulas F0, FI, FII and FIII were 6,02 (extra), 14,39 (maximum), 22,98 (ultra) and 27,60 (ultra).
Identifikasi Sakarin Dalam Sediaan Jamu Pelancar Haid Yang Beredar Di Pasar Kota Klaten Dhiyan Chahyaningrum
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.626

Abstract

Saccharin is a synthetic chemical substance that is classified as a food or beverage additive. Menstrual facilitating herbs are often consumed by women when they are menstruating, and this would be a bad thing if these herbs contain saccharin. One of the variations of menstrual facilitating herbal medicine that is often consumed is tamarind turmeric. The content of saccharin that is routinely consumed can cause a person to experience metabolic dysfunction. This study aims to look at the characteristics and determine the levels of saccharin in menstrual-promoting herbal preparations circulating in the Klaten City Market. This research is a type of experimental descriptive research. This study used the method of color test, TLC, and FTIR Spectroscopy. The results showed that of the 10 samples of herbal medicine to facilitate menstruation which were analyzed by the Iron (III) Chloride Test and the Absorbinol Test, no saccharin was found. In the Thin Layer Chromatography (TLC) Test, there were no stains or Rf which were the same or almost close to the Rf of the comparator standard for saccharin artificial sweeteners. From the results of the analysis, it can be concluded that of the 10 samples of menstrual-launching herbs that were examined, they were negative for the artificial sweetener saccharin.
Penentuan Kadar Flavonoid Total Dan Uji Antioksidan Ekstrak Dan Fraksi N-Heksana-Etil Asetat-Air Kulit Delima Putih (Punica Granatum L.) Menggunakan Metode FRAP Eny Wijayanti
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.627

Abstract

In the body there are a lot of free radicals that are needed for health in a certain amount free radicals are damaging and dangerous so that there are no excess free radicals the body needs antioxidants as body protectors, so in this study a total flavonoid level test and antioxidant activity test of ethanol extract and n fraction were carried out. -hexane, ethyl acetate efraction, and water fraction using the FRAP method with the aim of knowing the secondary metabolites contained in the ethanol extract of white pomegranate peel (Punica granatum L.) and determining the total flavonoid content in white pomegranate peel (Puunica granatum L.) and determine the value of antioxidant activity in the ethanol extract of white pomegranate peel (Punica granatum L.) using the FRAP method. The method used in this research is experimental research. The research phase started with sampling, determination of plants, manufacture of simplicia, preparation of extracts, screening of phytochemicals, preparation of test solutions, determination of flavonoid levels, testing of antioxidant activity, and data analysis. Secondary metabolite compounds in the ethanol extract of white pomegranate peel (Punica granatum L.) include alkaloids, flavonoids, tannins, terpenoids and saponins. The total flavonoid content of white pomegranate peel extract (Punica granatum L) as seen using UV-Vis spectrophotometry was 55.3 mg QE/g. Ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction of white pomegranate peel extract (Punica granatum L) had antioxidant activity with values of 2,501 mgQE/g sample, 3,125 mgQE/g sample, 3,055 mgQE/g sample, respectively , 30,516 mgQE/g sample, if you look at using the FRAP method.
Formulasi Sediaan Gel Ekstrak Daun Alpukat (Persea americana Mill.) Sebagai Terapi Pengobatan Luka Bakar Terhadap Kelinci New Zeland White Aprilia Rika Alvita; Tatiana Siska Wardani; Tiara Ajeng Listyani
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.628

Abstract

Researched on burn wounds healing activity of extract of avocado leaft (Persea americana Mill.) in gel preparation forms were tested on rabbits New Zeland White. This study aimed to determine variations effect of concentration in gel extract of avocado leaft for the treatment of burn wounds in rabbits which had been wounded using hot metal. In this study, avocado leaft extract was obtained through maceration method and formulated into gel preparations with concentration of 1%, 2% and 5%. Gel base was used as a negativ control, namely carbomer 940 and Bioplacenton® gel was used as a positive control, applied to burns on the back of New Zeland White rabbits with a diameter of 1,5 cm. The avocado leaft extract gel activity test was carried out on 3 rabbit, each formulation was replicated 3 times and wound diameter measurements were taken on each day. Data on the percentage of burn wound healing was statistically analyzed using One Way ANOVA method. The result of the data analysis at a concentration of 5% obtained a sig value <0,05. Based on One Way ANOVA analysis of the five treatments, the most effective was avocado leaft extract gel with a concentration of 5%.
Penetapan Kadar Antosianin Dan Formulasi Sediaan Blush On Compact Powder Ekstrak Beras Merah (Oryza Rufipogon Griff.) Rikawati Fitriana
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.630

Abstract

Blush or rouge is one of the decorative cosmetic preparations in beauty products that is widely used by presenting various colors as coloring the cheeks with an artistic touch so as to enhance aesthetics in the nuances of make-up on the face, giving a thinner and fresher accent to the face. One of the natural ingredients that can be used as a dye is Red Rice (Oryza rufipogon Griff.) Red Rice (Oryza rufipogon Griff.) is rice that contains anthocyanin compounds which function to give red color to red rice. This study aims to determine whether brown rice can be used as a coloring agent for blush on compact powder form and to determine the physical evaluation of blush preparations. The formulation of the blush preparation was made using dyes from red rice extract with a concentration of 0%, 5%, 10% and 15%. This research method was carried out experimentally, including: sample preparation, simplicia characterization, extract preparation, phytochemical screening, determination of anthocyanin levels, preparation of preparations. extraction was carried out by maceration and remaceration, using 96% ethanol solvent, then concentrated with a rotary vacuum evaporator. Tests carried out on the physical evaluation of blush on preparations included organoleptic tests, homogeneity tests, pH tests, irritation tests, adhesion / spread tests, crack tests, hedonic (preferability) tests and stability tests. The results of organoleptic testing, homogeneity, pH test, irritation test showed that all formulas were good. In the fracture test results of the 4 formulas it was observed that they were not cracked, cracked, and broken. The results of the hedonic (preference) test for blush with brown rice extract show that on average the ease of use of blush is preferred. The stability test results at room temperature (20-25oC) did not change, the stability test results at refrigerator temperature (5oC), oven temperature (40oC), and temperature to electric light (30oC) underwent changes.
Efektifitas Penggunaan Gel Aloe Vera Dalam Peyembuhan Kulit Berjerawat (Acne Vulgaris) Pada Mahasiswa Kedokteran Universitas Muhammadiyah Sumatera Utara Angkatan 2019 Annisa Cahya Jannaty; Ikhfana Syafina
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.631

Abstract

Introduction: acne vulgaris is included in the disease that can heal itself (self-limited disease). Found in all age groups, which is chronic inflammation of the pilosebaceous follicles. The cause of acne vulgaris is multifactorial with clinical features in the form of blackheads, papules, pustules, nodules and cysts. Aloe Vera is a fugsional plant because all parts can be utilized. The part of aloe vera that is cut there is mucus in the form of a gel can stimulate the formation of epidermal tissue and help the skin regeneration process. This study aims to determine the Effectiveness of Aloe Vera Gel in Healing Acne Skin (Acne Vulgaris) in Muhammadiyah North Sumatra Medical Students Class of 2019. Method: Involving 30 respondents who have acne vulgaris. It is a one-group observation experimental study Pretest-Posttes Design. The examination of the degree of acne vulgaris is assessed based on the criteria of the Indonesia Acne Expert Meeting (IAEM). The collected data were analyzed using the Wilcoxon test. Results: From the characteristics of respondents based on sex, dominated by women, namely 22 respondents (73.3%) compared to 8 respondents (26.7%). The majority of mild degrees were 18 respondents (60%), followed by moderate acne 12 respondents (40%). In the first use, there were data results, namely as many as 18 respondents (60%) had mild acne levels, while 12 respondents (40%) had moderate acne levels. In the second use, 18 respondents (60%) had mild skin, while 12 respondents (40%) had moderate skin. In the third use, it can be seen from the results of the data, namely skin that experienced moderate degrees to 7 respondents (23.3%), while 23 respondents (76.7%) still had skin with mild degrees. Conclusion: There is a significant effectiveness of aloe vera gel in healing acne prone skin in Medical Students of the University of Muhammadiyah North Sumatra, Class of 2019.
Asuhan Keperawatan Pada Ny. F Keluarga Tn. S Dengan Gangguan Sistem Pernafasan : Tuberkulosis Paru Di Desa Kutayu RT.01 RW.02 Kecamatan Tonjong Kabupaten Brebes Zaetun Naimah; Esti Nur Janah; Siti Fatimah
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.632

Abstract

The family has an important role in recognizing health problems that exist in society. As families deal with diseases that many people suffer from due to unhealthy lifestyles and irregular eating patterns, such as stroke, heart disease, diabetes, tuberculosis (TB), hypertension and lung disease (Apriliani et al., 2020). Tuberculosis is an infectious disease caused by the bacteria Mycobacterium tuberculosis. This disease enters the body through the air in the lungs and spreads to other parts of the body through the blood system, lymphatic system, respiratory tract (bronchi) or directly to other parts of the body (Faturrahman et al., 2021). In 2021 there were TB cases in Southeast Asia (45%), Africa (23%) and the Western Pacific (18%), with smaller cases in the Eastern Mediterranean (8.1%), America (2.9%) and Europe (2.2%). The 30 countries with high TB ??cases account for 87% of the estimated cases worldwide, and 8 of these countries account for more than two-thirds of the global total: India (28%), Indonesia (9.2%), China ( 7.4%), Philippines (7.0%), Pakistan (5.8%), Nigeria (4.4%), Bangladesh (3.6%) and Democratic Republic of Congo (2.9%) (WHO, 2022).
Uji Efektivitas Sediaan Salep Ekstrak Daun Kenikir (Cosmos Caudatus Kunth) Terhadap Penyembuhan Luka Sayat Pada Kelinci Jantan New Zealand White Annissha Azzahra Wurnasari; Kusumaningtyas Siwi Artini; Bangkit Riska Permata
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.635

Abstract

Kenikir Leaf Extract (Cosmos Caudatus Kunth) is a medicinal plant that can be used to heal cut wounds. This research aims to determine the compound content in kenikir leaves, determine the physical quality and stability of kenikir leaf extract ointment preparations, and determine the effective concentration for healing cuts on the backs of male New Zealand White rabbits. This type of research is experimental, making ointment formulations using kenikir leaf extract made in 3 concentrations, namely 10%, 15% and 20%. In ointment testing, organoleptic tests, homogeneity tests, spreadability tests, adhesion tests, pH and viscosity tests are carried out. Testing the effectiveness of wound healing using 5 groups, namely Betadine ointment (+), ointment base (-), kenikir leaf extract ointment 10%, 15% and 20% on 5 rabbits with a wound length of 1.5 cm was carried out until the 3rd day. 7. The data was processed statistically using One Way ANOVA (Analysis of Variant) and continued with the LSD (Least Significant Difference) test. The results of this research show that kenikir leaf extract ointment 10%, 15% and 20% produces an ointment that meets the requirements of the organoleptic test, homogeneity test, spreadability test, adhesiveness test and pH test, as well as providing healing effects on cuts and wounds in rabbits and The most effective healing power is 20% kenikir leaf extract ointment.

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