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Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta

ISSN : 24606065 EISSN : 25483013 DOI : 10.15408/jkv

Core Subject : Science,

Chemistry

Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of chemistry.

Arjuna Subject : Umum - Umum

Articles 425 Documents

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Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Fajar Rakhman Wibowo; Gesti Munasah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.

Profil Dan Sensitivitas Protein Alergen Ikan Tongkol (Thunnus albacares) Sebagai Reagen Skin Prick Test (SPT) Sri Yadial Chalid; Dahrul Syah; Puspo Edi Giriwono; Fransiska Rungkat; Zakaria Zakaria
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 1, May 2019
Publisher : Syarif Hidayatullah State Islamic University

Ikan tongkol merupakan salah satu produk laut penyebab alergi makanan. Gejala klinis reaksi alergi makanan adalah gatal, bentol, bengkak, sesak nafas, batuk, dan yang terparah adalah syok anafilaksis. Pengobatan dan pencegahan alergi makanan yang terbaik adalah menghindari konsumsi penyebab alergi. Menghindari konsumsi suatu makanan sebaiknya berdasarkan uji alergi seperti Skin Prick Test (SPT). SPT dilakukan menggunakan reagen SPT yang dicukitkan pada lapisan epidermis kulit lengan bagian volar. Reagen alergen pada penelitian ini merupakan protein ikan tongkol yang berasal dari laut Indonesia dan diekstrak dengan buffer fosfat, Profil ekstrak protein menggunakan elektroforesis dan immunoblotting untuk menentukan protein allergen. Sebanyak 15 pita protein terdeteksi pada ekstrak ikan tongkol yaitu protein dengan berat molekul antara 17 sampai 152 kDa. Potensi alergenik terdapat pada pita protein dengan berat molekul antara 12 sampai 50 kDa. Reagen SPT ikan tongkol mempunyai sensitivitas sebesar 81.8% dan spesifitas 100% sehingga disimpulkan bahwa reagen ekstrak ikan tongkol dapat digunakan sebagai reagen skin prick test Kata kunci: Alergi, protein, tongkol, gejala klinis, skin prick test Tuna fish is one of the marine products that can cause allergic. Clinical symptoms of allergic are a bump, swelling, shortness of breath, coughing and anaphylactic shock is the worst symptom. The best medication and treatment is avoiding the consumption of food that could cause allergy. Avoiding consumption of food should be based on an allergy test such as a Skin Prick Test (SPT). SPT using reagent which is applied on the skin of the forearm between the wrist and elbow. The reagent for SPT is a protein solution of tuna which was extracted by phosphate buffer then protein profile was detected using electrophoresis. Immunoblotting was done to determine the molecular weight of the allergen protein. Fifteen protein bands were detected on tuna fish extract; the molecular weight of the protein was obtained between 17 to 152 kDa. Protein allergenic are molecules that have protein bands with a molecular weight between 12 and 50 kDa. Tuna fish extract solution for SPT had a sensitivity is 81.8%, and specificity is 100%, it was concluded that tuna fish reagent could be used as SPT reagent. Keywords: Allergen, protein, tuna fish, skin prick test.

Desain dan Studi In Silico Senyawa Turunan Kuwanon-H sebagai Kandidat Obat Anti-HIV Ruswanto Ruswanto; Tifa Nofianti; Richa Mardianingrum; Tresna Lestari
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

Kuwanon-H merupakan senyawa flavonoid dari kulit akar murbei (Morus alba L) yang secara in vitro berpotensi sebagai anti-HIV dibanding senyawa flavonoid lainnya yang terkandung dalam kulit akar murbei seperti morusin dan morusin 4′-glucosida. Telah dilakukan penelitian desain senyawa, penambatan molekular menggunakan ArgusLab 4.0.1 dengan metode ArgusDock, penerapan aturan Lipinski’s Rule of Five menggunakan Marvin Sketch 5.2.5.1dan uji toksisitas menggunakan aplikasi Toxtree secara in silico terhadap turunan senyawa kuwanon-H. Desain enam puluh senyawa turunan kuwanon-H dilakukan dengan cara model pendekatan Topliss pada rantai samping alifatiknya. Hasil penambatan ke-60 turunan senyawa pada reseptor HIV-1 Reverse Transcriptase (1REV) menunjukkan bahwa senyawa terbaik yaitu 3-[(2Z)-3-(siklopropilmetil)but-2-en-1-il]-8-[6-({3-[(2Z)-3-(siklopropilmetil)but-2-en-1-il]-2,4-dihidroksifenil}karbonil)-5-(2,4-di-hidroksilfenil)-3-metilsiklohek-2-en-1-il]-2-(2,4-dihidroksilfenil),7-dihidroksi-4H-kromen-4-on dengan nilai energi bebas yang lebih rendah (-12.5798 kkal/mol) dibandingkan ligan asli (-11.0445 kkal/mol) dan kuwanon-H (-11.0189 kkal/mol). Senyawa terbaik ini tidak memenuhi aturan Lipinski’s Rule of Five. Hasil prediksi uji toksisitas senyawa terbaik menurut parameter Cramer Rules termasuk kategori III, yaitu diprediksi memiliki toksisitas tinggi, menurut parameter Benigni/Bossa Rulebase diprediksi senyawa yang diuji tidak bersifat karsinogenik, genotoksik, dan nongenotoksik, sedangkan menurut parameter Kroes TTC decision tree diprediksi senyawa uji berpotensi toksik.DOI:http://dx.doi.org/10.15408/jkv.v4i1.6867

Characteristic of Allergen Protein of Nila Baby Fish (Oreochromis niloticus) and Its Processed Product Hendra Wijaya; Sri Yadial Chalid; Ning Ima Arie Wardayanie; Widyaningsih Widyaningsih; Santi Ariningsih
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Allergen protein is a protein that could triggers allergy reaction. This study purposes to examine the characteristic of allergen protein of unripe, boiled, and fried nila baby fish. Characteristic of allergen protein were observed by electrophoresis and immunoblotting method, while the determination of protein concentration was observed by Bradford method. Identification of the used nila baby fish was accomplished in Faculty of Fishery and Marine Science of IPB. The result of identification showed that the used nila baby fish was Oreochromis niloticus. The proximate analysis of unripe, boiled, and fried nila baby fish resulted water content ranged from 19.16%-23.68%, fat content ranged from 1.03%-20.44% and carbohydrate content ranged from 0.16%-20.27%. Protein concentration of unripe, boiled, and fried nila baby fish extract respectively were 1963.45 mg/L; 699.82 mg/L; 607.79 mg/L. The band amount of allergen protein of unripe, boiled, and fried nila baby fish which was detected by electrophoresis, respectively were 16 of protein band, 26 of protein band and 16 of protein band. The immunoblotting showed that the sum of respondent who contained specific IgE that can bind with allergen protein of boiled and fried nila baby fish were more than allergen protein of unripe nila baby fish. It indicated that the processing process by boiling and frying would increase allergenicity toward nila baby fish.

Preconcentration of Ion Ni(II) using Ca-Alginate Modified Resin with Dimethylglyoxime as a Filler Material of Column Aman Sentosa Panggabean; Wirdhaningsih Wirdhaningsih; Subur P. Pasaribu
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

The research about the preconcentration of Ni(II) ions using Ca-alginate resin modified with dimethylglyoxime (DMG) as a material filler of the column has been done. The stage of preconcentration done by using the water sample was passed through the column, then eluted using HNO3. The amount of Ni(II) in the eluate was measured using atomic absorption spectrophotometer (AAS). Several important parameters in the preconcentration stage have been studied. The optimal condition at the stage of preconcentration Ni(II) ions was retention at pH 4, the volume of sample was 10 mL, the volume of HNO3 eluent was 4 mL at a concentration of 1.5 M, with the retention of capacity value was 2.4657 mg Ni(II)/g resin. The analytical performance of this method is good, showed with repeatability value as a percentage of the coefficient of variance value was 4.06%, and can increase the limit detection of Ni(II) ions was 3.94 times if compared to direct measurements with AAS. The method can be applied to the determination of Ni(II) ions in the water samples from Mahakam river at port Samarinda with recovery percentage value was > 95 %, indicating that the matrix of samples did not affect the results of measurements.

The Effect of Single Co-expression of The DnaK-DnaJ-GrpE and GroEL/ES Chaperones and Their Combination on Expression Intein-pretrombin-2 in Escherichia coli ER2566 Iman Permana Maksum; D Agus Yusuf Wildan; Khomaini Hasan; Toto Subroto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

The use of recombinant thrombin in the manufacture of fibrin glue allows diseases contamination to be avoided. However, the expression of recombinant protein in E. coli still has a disadvantage of the formation of inclusion bodies, so it needs to be minimized by co-expression of chaperones. Therefore, the aim of this study was to determine the effect of single DnaK-DnaJ-GrpE and GroEL/ES chaperone expression and their combination on the expression of intein-pretrombin-2Ti,pH on E. coli ER2566. The method started with isolation of pTWIN1-prethrombin-2Ti,pH and pG-KJE8 from E. coli TOP10F' and DH5α respectively, the co-transformation of the expression host E. coli ER2566 using pG-KJE8 and pTWIN1-prethrombin-2Ti,pHvectors, the chaperone co-expression was induced using L-Arabinosa before IPTG induction and cell culture growth was incubated at 22 oC. The expression products were characterized by using Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis. The results of the co-expression of chaperone showed that the number of soluble fraction was higher than the one without co-expression of chaperone. In addition, the co-expression of chaperone using pG-KJE8 in intein-prothrombin-2Ti,pH expression was sufficient using tetracycline as an inducer.

Ceftriaxone Degradation by Titanium Dioxide (TiO2) Nanoparticles: Toxicity and Degradation Mechanism Mohammad Rofik Usman; Azmi Prasasti; Sovia Islamiah; Alfian Nur Firdaus; Ayu Wanda Marita; Syamsiyatul Fajriyah; Eka Fitri Yanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Ceftriaxone is a third generation of cephalosporin antibiotics that commonly used in patients with ulcers. Ceftriaxone residues in the environment are degraded using Titanium dioxide (TiO2) nanoparticles. Degradation of ceftriaxone using TiO2 nanoparticles was influenced by environmental conditions, such as light sources, pH of the solution, the mass of TiO2 nanoparticles, and the length of radiation. The remained ceftriaxone was analyzed by using a spectrophotometer UV-visible. The toxicity of the solution after the degradation process was tested on Escherichia coli and the type of products resulted was analyzed using Liquid Chromatography-Mass Spectrophotometry (LC-MS). The optimum conditions in degrading 50 mL 250 ppm ceftriaxone was radiation under a mercury UV lamp (white), pH 8, and 100 mg of TiO2 nanoparticles for 9 hours. The degradation degree of ceftriaxone obtained was 96.52%, producing simpler compounds that not toxic to E. Coli.

The Starting Material Concentration Dependence of Ag3PO4 Synthesis for Rhodamine B Photodegradation under Visible Light Irradiation Febiyanto Febiyanto; Uyi Sulaeman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Synthesis of Ag3PO4 photocatalyst under the varied concentrations of AgNO3 and Na2HPO4·12H2O as starting material has been successfully synthesized using the co-precipitation method. The concentration of AgNO3 is 0.1; 0.5; 1.0; and 2.0 M, whereas Na2HPO4·12H2O is 0.03; 0.17; 0.33; and 0.67 M, respectively. The co-precipitations were carried out under aqueous solution. As-synthesized photocatalysts were examined to degrade Rhodamine B (RhB) under blue light irradiation. The results showed that varying concentrations of starting materials affect the photocatalytic activities, the intensity ratio of [110]/[200] facet plane, and their bandgap energies of Ag3PO4 photocatalyst. The highest photocatalytic activity of the sample was obtained by synthesized using the 1.0 M of AgNO3 and 0.33 M of Na2HPO4·12H2O (AP-1.0). This is due to the high [110] facet plane and increased absorption along the visible region of AP-1.0 photocatalyst. Therefore, this result could be a consideration for the improvement of Ag3PO4 photocatalyst.

Nanoporous Carbon Prepared with MOF-5 as a Template and Activated using KOH for Hydrogen Storage Ratna Ediati; Tri Ana Mulyati; Amirul Mukminin; Dety Oktavia Sulistiono; Naimatul Khoiroh; Hamzah Fansuri; Didik Prasetyoko
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

A series of nanoporous carbon was prepared with MOF-5 as a template and furfuryl alcohol as an additional carbon source by carbonation at temperatures of 550 °C and 900 °C, respectively, with and without activation using KOH. XRD patterns of the obtained carbons before and after the activation process showed characteristic peaks at the same 2θ values, which corresponded to the XRD pattern of a ZnO. The Surface morphology of the MOF-5 templated carbon with a carbonation temperature of 550 °C was in the form of a cube. In contrast, the one carbonated at 900 °C had a cubic and circular morphology. The N2 adsorption-desorption isothermal showed that MOF-5 templated carbon had a larger specific surface area, pore diameter, and pore volume than those of the original MOF-5. Activation of the MOF-5 templated carbon using KOH resulted in a decrease in surface area and pore volume. All the materials were measured for their hydrogen adsorption at room temperature and atmospheric pressure using a gravimetric method.

Synthesis, Characterization and In Silico Study of Fe(III) Complex with N'-(4-Chlorobenzoyl)-Isonicotino-Hydrazide as Anti Tuberculosis Candidate Ruswanto Ruswanto; Fajar Setiawan; Nur Rahayuningsih; Richa Mardianingrum; Nur Laili Dwi Hidayati; Elsi Eryanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

The synthesis of Fe(III) complexes with ligands N'-(4-Chlorobenzoyl)isonicotinohydrazide can be synthesized through mixing metal and ligand dissolved in ethanol by reflux at ± 75oC for 5 hours. The instruments for the characterization of the complex were used UV-Visible and Infrared Spectrophotometry. The aims of the study are: to determine the synthesis method, characterize of the complex, and to study the interaction of the complex with target receptors. The weight of the synthesized compound was obtained by 38.1 mg. The purity of the complex has been tested using the determination of melting point and got a melting point range was 196-198oC. The maximum wavelength of Fe(III)N'-(4-Chlorobenzoyl)isonicotinohydrazid) complex was 261.0 nm and provide absorption of Fe-O vibrations at wavenumbers 530.42 cm-1. The docking process was done using AutodockTools-1.5.6 software which shows that the Fe(III)N'-(4-Chlorobenzoyl) isonicotinohydrazide complex can interact with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis and it has better interaction than isoniazid or N'-(4-Chlorobenzoyl)isonicotinohydrazide compound with the acquisition of free energy binding (ΔG) -9.80 kcal/mol and inhibition constant (Ki ) 0.06529 μM.

Page 20 of 43 | Total Record : 425

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Home Page

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Contact Name Dr. Sandra Hermanto, M.Si

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Editorial Address Program Studi Kimia, Fakultas Sains dan Teknologi, UIN Syarif Hidayatullah Jakarta

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Contact Name
Dr. Sandra Hermanto, M.Si

Contact Email
hermantokimia@uinjkt.ac.id

Phone
+6285220042401

Journal Mail Official
kimia@uinjkt.ac.id

Editorial Address
Program Studi Kimia, Fakultas Sains dan Teknologi, UIN Syarif Hidayatullah Jakarta

Location
Kota tangerang selatan,

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