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Jurnal Medika Farmaka
Published by Sekolah Tinggi Ilmu Kesehatan Karsa Husada Garut
ISSN : -     EISSN : 2987372X     DOI : https://doi.org/10.33482/jmedfarm.v1i3
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology
Jurnal Medika Farmaka (JMF) adalah jurnal ilmiah di bidang kefarmasian yang dikelola oleh program studi D-3 Farmasi STIKes Karsa Husada Garut di bawah naungan LP4M STIKes Karsa Husada Garut. JMF telah memiliki e-ISSN 2987-372X dengan Nomor SK: 2987372X/II.7.4/SK.ISSN/06/2023) sejak 07 Juni 2023 dan berlaku mulai dari Volume 1 No. 1, April 2023. Jurnal ini diinisiasi oleh "Ikatan Apoteker Indonesia" (IAI) Kabupaten Garut sejak tahun 2023. JMF menerima naskah artikel dalam dua area utama di bidang farmasi diantaranya: Sains Farmasi Biologi Farmasi & Farmakognosi Kimia Farmasi Analisis & Kimia Medisinal Teknologi Farmasi & Farmasetika Farmakologi & Toksikologi Bioteknologi Farmasi Klinis & Komunitas. Farmasi Rumah Sakit Farmasi Klinis Manajemen Farmasi Farmasi Sosial
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 39 Documents
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Literature Review: Quantitative Analysis Method of Medicinal Chemical Sibutramin Hydrochloride in Traditional Slimming Supplements using LC/MS-MS Dea Ayu Anggraeni, Dea Ayu Anggraeni; Frederico, Frederico; Yuhareza Aulia Eka Putri, Yuhareza Aulia Eka Putri; Firdha Senja Maelaningsih, Firdha Senja Maelaningsih
Jurnal Medika Farmaka Vol 2 No 3 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i3.38

Abstract

Pendahuluan: Penggunaan suplemen pelangsing tradisional meningkat seiring pencarian alternatif yang lebih aman. Namun, popularitas ini menyebabkan permintaan terhadap produk yang tidak terstandarisasi, berisiko, dan berbahaya. Salah satu zat yang menjadi perhatian adalah sibutramin hidroklorida, yang digunakan untuk menekan nafsu makan. Uji klinis SCOUT oleh FDA menunjukkan bahwa penggunaannya meningkatkan risiko kejadian kardiovaskular hingga 16percent. Akibatnya, sibutramin hidroklorida dilarang di Amerika Serikat, meskipun di beberapa negara lain masih diperbolehkan dengan dosis 10 hingga 15 mg per hari. Tinjauan ini bertujuan memberikan wawasan tentang teknik analisis kuantitatif untuk hidrolisis garam sibutramin hidroklorida dalam suplemen penurunan berat badan tradisional, dengan fokus pada metode LC/MS-MS. Metode: Tinjauan dilakukan melalui pencarian sistematis online dengan kata kunci seperti "Metode Analisis Sibutramin" dan "LC/MS-MS" dari sumber terpercaya dalam sepuluh tahun terakhir. Hasil: Analisis dari berbagai studi menunjukkan kadar sibutramine dalam produk herbal pelangsing bervariasi antara 0.014 mg hingga 31.7 mg per unit. Kesimpulan: Metode LC/MS-MS terbukti efektif dalam menganalisis sibutramin dengan hasil yang akurat dan dapat diandalkan
Artikel Review: Metode Analisis Kuantitatif Bahan Merkuri (Hg) dalam Produk Pemutih Kulit (Body Lotion) menggunakan Spektrofotometri Serapan Atom (SSA) di Indonesia Andina, Cantika; Salsabila, Fannysa; Muzaqil, Firmansyah; Senja Maelaningsih, Firdha
Jurnal Medika Farmaka Vol 2 No 3 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i3.40

Abstract

Introduction: Heavy metal mercury is often used in cosmetic products such as body lotion to help speed up the skin whitening process. Cosmetics containing mercury can cause side effects such as skin disorders, cancer, and nervous system poisoning. The purpose of this study is to provide information to readers about research that analyzes mercury content in body lotion products using Atomic Absorption Spectrophotometry (AAS) in several regions of Indonesia. Method: This research method is a literature study involving online article searches from 2014 to 2024 in the Google Scholar database. Results: The results of five article reviews showed the presence of mercury in body lotion product samples. Conclusion: in several regions of Indonesia mercury with the highest concentration of 39.51 mg/kg in Mataram and the lowest 0.051 ppb in Banda Aceh. The majority of products identified as positive do not have a permit from BPOM and are sold freely in the market or online. Therefore, strict supervision of the distribution of cosmetics is needed to protect the public from health risks caused by mercury (Hg). Keywords: Quantitative analysis, body lotion, mercury, atomic absorption spectrophotometry (AAS)
POTENSI MINYAK AKAR WANGI SEBAGAI KOSMETIKA.: POTENSI MINYAK AKAR WANGI SEBAGAI KOSMETIKA. Muharam, Firman; Nurul, Nurul; Ekawati, Risrina Nur
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

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Abstract

The cosmetics industry is experiencing rapid development with a variety of beauty products, and vetiver oil is emerging as a safe and effective natural ingredient with antioxidant, antimicrobial, and anti-aging benefits, and has the potential to overcome health problems caused by synthetic ingredients. Indonesia, as a major producer of vetiver oil, has a great opportunity to develop the market for natural cosmetics, increase the economic value of local agricultural products, and fulfil the global demand for environmentally-friendly natural cosmetics. Method: The article preparation method used literature reviews from international and national journals. The search for articles published online was conducted through PubMed and Google Scholar sites and citation writing using the Mendeley® software application. Result: Vetiver oil exhibits strong antioxidant and antimicrobial activities, able to protect cells from oxidative damage and is effective against various bacteria and fungi, with an IC50 of 0.515 µg for antioxidant activity and a Minimum Inhibitory Concentration (MWC) of 62.5 µg/ml against Bacillus cereus. In addition, the oil has anti-aging effects through increased lipid synthesis, aids in the treatment of acne by inhibiting the growth of Cutibacterium acnes, and reduces oxidative stress and melanin production, making it a potential agent in various skincare and health applications. Conclusion. Vetiver oil exhibits a range of significant health and beauty benefits, including antioxidant activity, antimicrobials, anti-aging effects, acne treatment, and oxidative stress reduction. Research and development of vetiver oil-based products can provide effective natural solutions to a wide range of health and cosmetic concerns.
Uji Efektivitas Formulasi Sediaan Patch Ekstrak Daun Binahong (Anredera cordifolia (Tenore) Steenis) Sebagai Penyembuh Luka Sayat Pada Kelinci Sukmawati; Safira, Anita; Marini; Herliningsih
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.29

Abstract

Introduction: A wound is a condition where tissue continuity is broken by trauma from sharp or blunt objects, temperature changes, chemicals, electricity, radiation, or animal bites. One of the plants used as a wound healer is binahong leaves (Anredera Cordifolia (Tenore) Steenis). In previous studies, screening tests have been carried out and the results state that binahong leaves contain alkaloid, flavonoid, saponin, steroid and triterpenoid compounds that can accelerate the wound healing process. The purpose of this study was to determine whether binahong leaf patches can be used as wound healers with extract concentrations of 35%, 40% and 45%. Method: experimental research method in the laboratory. Result: the results of the patch preparation effectiveness test in formula F0 = the incision wound takes a long time to dry and close, F1 = the wound closes very quickly, F2 = the wound closes quickly enough and F3 = the wound takes a while to close. Conclusion. Of the 4 formulas, F1 tends to be more effective as a wound healer.
Uji Aktivitas Antibakteri dan Analisis KLT-Bioautografi Ekstrak Etanol Daun Situduh Langit (Erigeron sumatrensis Retz) Terhadap Bakteri Escherichia coli Saepudin, Syumillah; Kartikawati, Endah; Herliyani, Widya
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.31

Abstract

Introduction: Situduh langit (Erigeron sumatrensis Retz.) is a plant with medicinal benefits for mouthwash, headaches, muscle pain, canker sores, blood pressure regulation, and acne treatment. It also has antimicrobial activity. Secondary metabolites like saponins and flavonoids in situduh langit can treat diarrhea. Method: This study aims to determine the concentration and TLC-Bioautography profile of ethanol extract from situduh langit leaves for inhibiting Escherichia coli. The leaves were extracted using the maceration method with 70% ethanol. The antibacterial activity of the ethanol extract at concentrations of 6.5%, 12.5%, 25%, and 50% was tested using the disc diffusion method. TLC-Bioautography identified the compounds with antibacterial activity. Results: ANOVA analysis showed normal and homogeneous data with a significance value of 0.000 < 0.05. The 6.5% concentration had an average inhibition of 6.0±0.00; 12.5% had 6.23±0.24; 25% had 6.77±0.89. These showed the smallest effect on inhibiting Escherichia coli growth. The 50% concentration had an average inhibition of 7.71±1.17, showing the greatest effect. TLC-Bioautography showed Rf values of 0.97; 0.92; 0.67; 0.60; 0.31; 0.21 and 0.14, with no clear zones forming around the media. Conclusion: The leaf extract of situduh langit has antibacterial activity against Escherichia coli at a 50% concentration with a moderate category, and TLC-Bioautography analysis of the ethanol extract did not form clear zones around the media.
Uji Aktivitas Antioksidan Ekstrak N-Heksana, Etil Asetat, Dan Etanol Bonggol Pisang Kepok (Musa paradisiaca L.) Dengan Metode DPPH (1,1-diphenyl-2-picrylhydrazyl) Supriatnini, Ai; Farhan, Zahara; Hasyim, Dadang Muhammad
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.32

Abstract

Free radicals are atoms, groups of atoms, or molecules that have one or more unpaired electrons in the outermost orbital and are highly reactive. Free radicals are more able to attack cells in the body, especially those that are vulnerable, causing various diseases such as premature aging, cancer, liver, and other degenerative diseases. Antioxidants are compounds that can be considered as free radical reactivity. Sources of natural antioxidants are plants which generally contain phenolic compounds. Phenolic or polyphenolic compounds can be in the form of flavonoids. The ability of flavonoids as antioxidants has been widely studied, where flavonoids have the ability to reduce free radicals and also act as anti-free radicals. Kepok banana hump contains flavonoid compounds. The aim of this study was to determine the antioxidant activity of n-hexane, ethyl acetate, and ethanol extracts of kepok banana weeds using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method based on the IC50 value. The principle of this method is the decrease in color intensity or absorbance of the DPPH solution which is proportional to the increase in the concentration of antioxidant compounds. This research was carried out experimentally, collection and processing of plants, experience of plant materials, manufacture of extracts, and testing of antioxidant activity. The kepok banana weevil was extracted by maceration method using various solvents based on the level of polarity, namely n-hexane, ethyl acetate, and ethanol in stages. The extraction results obtained thick extracts of n-hexane, ethyl acetate and ethanol as much as 2.12 g (0.70%), 1.09 g (0.36%), and 4.64 g (1.54%) . The third antioxidant activity test of kepok banana weevil extract using the DPPH method using a UV-Vis spectrophotometer at a wavelength of 519.0 nm with a series of concentrations of 100 g/mL, 150 g/mL, 200 g/mL, 250 g/mL, and 300 g/mL. The results of the antioxidant activity test using the DPPH method showed that the n-hexane, ethyl acetate, and ethanol extracts of kepok banana weeds had IC50 values of 197.5 g/mL and 257.30 g/mL, 142.51 g/mL, respectively. The ethanol extract had moderate antioxidant activity compared to the n-hexane and ethyl acetate extracts.
Gambaran Peresepan Obat Pada Pasien Penderita Infeksi Saluran Pernapasan Akut Di Puskesmas Tarogong Kabupaten Garut Setiani, Andra Arista; Permana, Gin Gin Sugih; Suwinda, Dina Nirwana
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

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Abstract

Infeksi Saluran Pernafasan Akut (ISPA) is a major cause of infectious disease morbidity and mortality in the world. ARI is an acute inflammation of the upper and lower respiratory tract caused by microbial, bacterial or viral infection without or with lung parenchyma. ARI has a disease group with the highest absenteeism rate compared to other disease groups and is also suffered by many people. The purpose of this study was to determine the description of drug prescribing in patients with acute respiratory infections at the Tarogong Health Center, Garut Regency. This research method is descriptive with retrospective data collection, data collection is done by simple random sampling technique. The results of this study were patients with ISPA, which were mostly female patients with a percentage of 52.98% as many as 142 people and men with a percentage of 47.01% as many as 126 people. The data sample regarding the age of late adolescence 17-25 years is the most cases with a percentage of 22.38% as many as 60 people. Based on the classification of ARI drugs that are more widely used are antibiotics with a percentage of 29.77% as many as 268 people, analgesics - antipyretics with a percentage of 27.44% as many as 247 people, expectorants with a percentage of 20.33% as many as 183 people, antihistamines with a percentage of 13, 22% as many as 119 people, corticosteroids with a percentage of 8.22% as many as 74 people, bronchodilators with a percentage of 1% as many as 9 people. Based on the type of ISPA the most widely used drugs were amoxicillin with a percentage of 71.26% as many as 191 people, paracetamol with a percentage of 70.89% as many as 190 people, chlorpheniramine maleate with a percentage of 36.94% as many as 99 people. From these data, it can be concluded that female late adulthood suffers from ISPA, the most widely used drugs are amoxicillin, paracetamol, chlorpheniramine maleate, glyceryl guaiacolate, salbutamol and dexamethasone.
Uji Aktivitas Antibakteri Dari Ekstrak Etanol Bonggol Pisang Kepok (Musa paradisiaca L.) Terhadap Bakteri Staphylococus Aureus Dan Escherichia Coli Dengan Metode Difusi Agar Angrestian, Angga; Renggana, Hesti; nugraha, Yogi rahman
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.34

Abstract

Medicinal plants that have more uses and value in traditional medicine against diseases. One of them is the kepok banana plant (Musa paradisiaca L.) as an herbal treatment the kepok banana plant is an annual shrub, this plant has a root system and rhizome Fruit only once (single fruit) then dies. Banana plants contain compounds such as flavonoids, saponins, tannins, and steroids. The method used in the research to be carried out is the experimental method. This study aims to determine the ethanol extract of kepok banana weevil (Musa paradisiaca L.) to test its antibacterial activity against Staphylococcus aureus and Escherichia coli using the agar diffusion method. In this study, the ethanol extract of kepok banana weevil (Musa paradisiaca L.) with concentrations of 2, 4, and 6 against Staphylococus aureus and Escherichia coli bacteria. In Staphylococus aureus bacteria with a concentration of 2 the average diameter of the inhibitor produced was 3.03 mm, the concentration of 4 of the diameter of the inhibitor produced was 6.4 mm, the concentration of 6 of the diameter of the inhibitor produced was 8.3 mm. In Escherichia coli bacteria with a concentration of 2 the average diameter of 6.7 mm was produced, the concentration of 4 was 7.7 mm in diameter, and the concentration of 6 was 8.2 mm in diameter. The three concentrations have antibacterial effect that is Resistant 14 mm. Ethanol extract of kepok banana weevil (Musa paradisiaca L.) can inhibit the growth of staphylococcus aureus and Escherichia coli bacteria. At concentrations of 2, 4, and 6 the ethanolic extract of the kepok banana weevil (Musa paradisiaca L.) with an average inhibitory diameter of 3.03 mm, 6.4 mm and 8.3 mm, these three concentrations had an antibacterial effect of 14 mm.
Formulasi dan Evaluasi Fisik Sediaan Salep Dari Ektrak Bonggol Pisang Kepok (Musa paradisiaca L) Mubarok, Azis Zamzam; Wahyuni, Nency; Wardani, Diah
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

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Abstract

Wounds are a condition that is often experienced by everyone, whether with mild, moderate or severe severity, injury is the loss or destruction of body tissue. The wound healing process occurs in damaged tissue which is divided into three phases, namely the inflammatory phase, the proliferative phase and the maturation phase, which is tissue remodeling. Research on kepok bananas shows that banana weevil extract has higher antimicrobial activity than its midrib extract. In addition to accelerating wound healing, banana weevil can help repair damaged skin structures without scars and increase the revitalization of epidermal tissue, formation of fibroblasts and infiltration of inflammatory cells in the wound area. can be developed into cosmetics. this is the reason for making an ointment containing banana weevil extract with formulation 1 containing 1 g ethanol, formulation 2 containing 1.5 g ethanol, and formulation 3 containing 2 g ethanol. By evaluating the preparations to determine the physical stability of the preparations made including organoleptic testing, homogeneity testing, pH testing, testing the dispersion of the preparation and testing the organoleptic stability of the preparation, the pH stability of the preparation. The results showed that in the organoleptic test only 2 formulations met the quality standards, in the homogeneity test there were 2 formulations that met the criteria, in the pH test all formulations met the quality standards, in the dispersion test all formulations met the criteria, and in the stability test there were differences in storage. under exposure to sunlight but there is no change in the stability of the pH of the preparation made. Based on the research that has been done, it can be concluded that all formulations and physical evaluations of ointment preparations from the Kepok Banana Weevil Extract (Musa paradisiaca L). with variations of kepok banana weevil extract at F1 (15%), F2 (20%), and F3 (25%) met the requirements of good organoleptic, pH (4-7), and viscosity (2000-5000 mPas) tests.
Evaluation of Pharmaceutical Wholesaler Supplier Performance in the Procurement Process at Puskesmas ABC Garut Regency Ardi Rustamsyah, Ardi Rustamsyah; Aliep Topa Ubaddillah, Aliep Topa Ubaddillah; Raden Aldizal Mahendra Rizkio Syamsudin, Raden Aldizal Mahendra Rizkio Syamsudin
Jurnal Medika Farmaka Vol 2 No 3 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i3.57

Abstract

The drug procurement process in the Health Center is highly dependent on the effectiveness of the supply chain run by Pharmaceutical Wholesalers (PBF). Supplier performance evaluation is important to ensure timely delivery, stock availability, and compliance with regulations. This study aims to analyze the performance of PBF suppliers in the drug procurement process at ABC Health Center, Garut Regency, and to identify factors that influence the efficiency and effectiveness of the pharmaceutical supply chain. This study uses a non-experimental descriptive method with the Supply Chain Operation Reference (SCOR) approach. The sampling technique uses purposive sampling with a population of pharmacists who are responsible for drug procurement at the Health Center and samples in the form of several PBFs. Data were collected through documentation (order letters and invoices) and interviews with related parties. The evaluation results showed variations in performance scores between PBFs, where only three PBFs obtained very good performance scores. However, the aspects of Responsiveness (timeliness of providing orders) and Agility (ability to adapt to changes in demand) are still major challenges. The factors that most influence supply chain efficiency are timely delivery, stock availability, coordination between PBF and the Health Center, and compliance with pharmaceutical regulations.

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