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Eldiza Puji Rahmi
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Journal of Research in Pharmacy and Pharmaceutical Sciences
Published by Universitas Pembangunan Nasional Veteran Jakarta
ISSN : -     EISSN : 29640458     DOI : https://doi.org/10.33533/jrpps.v1i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other
The aim of this journal publication is to disseminate the conceptual thoughts or ideas and research results that have been achieved in the area of pharmacy. This journal encompasses original article, review article and short communications in the area of pharmacy, including: Pharmacognosy and Phytochemistry. Raw and Crude Materials, Standardisation, Characterisation, Quality Control of Herb, Extraction, Fractionation, Isolation, Purification and Elucidation of Natural Products Pharmacology. Pharmacokinetics, Toxicology, Teratogenicity, Immunopharmacology Clinical Pharmacy. Therapeutic Drug Monitoring, Adverse Drug Reaction, Drug Interaction Pharmaceutics. Formulation of Dosage Forms, Cosmetics, Drug Delivery Systems, Development of Excipients Biotechnology. Microbiology, Cell and Tissue Engineering Community Pharmacy. Pharmacoeconomy, Pharmacovigilance, Pharmacoepidemiology, pharmacy education Pharmaceutical Chemistry. Docking, Biocomputation, Drug Synthesis, Analytical Chemistry
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 30 Documents
 1   2   3 
NARRATIVE REVIEW: COST-EFFECTIVENESS ANALYSIS OF THE USE OF ORAL ANTIDIABETIC DRUGS BIGUANIDE AND SULFONYLUREA GROUP IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Kezia Ivana; Dhigna Luthfiyani Citra Pradana; Citra Ayu Aprilia
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4046

Abstract

Diabetes Mellitus requires long-term management at a considerable cost. Therefore, a cost-Effectiveness analysis was used to assess several health interventions. Biguanide and Sulfonylurea provided the best results at the cheapest cost in this study. This study aims to gain a supporting theoretical foundation regarding the cost-effectiveness of using oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. The method used in this study is a Narrative Review using literature that discusses the cost-effectiveness of oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. Based on the results of this study, the age range of the occurrence of Type 2 Diabetes Mellitus is 45-65 years, with more percentage of male patients than women and a common complication is hypertension. In this study, the use of the biguanide drug (Metformin) was shown to provide a significant reduction in blood sugar levels at a reasonably low cost. The ICER results showed that combination drugs increased additional costs, but their use was more effective in healing and improving patients' quality of life. In conclusion to this study, the use of biguanide and sulfonylurea groups proved cost-effective compared to other antidiabetic drugs.
ANTIMICROBIAL EFFECTIVENESS OF APPLE CIDER VINEGAR IN THE GROWTH OF Staphylococcus epidermidis and Propionibacterium acnes Imam Prabowo; Arifa Shaliha; Oktania Sandra Puspita
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4171

Abstract

Acne is a skin disease caused by Propionibacterium acnes, Staphylococcus epidermidis-, and Staphylococcus aureus-induced inflammation. Apple cider vinegar contains antibacterial compounds such as acetic acid, chlorogenic acid, polyphenols, alkaloids, flavonoids, and glycosides. This study is conducted to determine the effectiveness of antibacterial compounds contained in apple cider vinegar against the growth of S.epidermidis and P.acnes, in vitro. The study used the disc diffusion method by utilizing the Mueller Hinton Agar medium. The apple cider vinegar inhibition zone was formed at the concentration of 25%, 50%, 75%, and 100% against the growth of P.acnes, whereas the inhibition zone against S.epidermidis was formed at the concentration of 50%, 75%, and 100%. The highest inhibition zone against P. acnes was 8,825 mm and against S.epidermidis was 3,725 mm at the concentration of 75%. Test results One-way ANOVA on P.acnes and Kruskal Wallis to S.epidermidis obtained (p) <0,005. This study concludes the effectiveness of apple cider vinegar in inhibiting the growth of P. acnes and S. epidermidis, where the effectiveness against P. acnes was stronger than against S. epidermidis.
SYNERGISTIC EFFECT OF COMBINATION BETWEEN CYANOMACLURIN AND ARTOCARPIN FROM ARTOCARPUS HETEROPHYLLUS HEARTWOODS AGAINSTS STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS EPIDERMIDIS Abdi Wira Septama; Eldiza Puji Rahmi, M.Sc
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4250

Abstract

Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated against S. pyogenes and S. epidermidis using broth microdilution methods. Interaction between two compounds in combination was determined using checkerboard assay. Artocarpin showed strong antibacterial activity with MIC value of 1.9 µg/mL. Cyanomaclurin only exhibited moderate activity with MIC value of 15.6 µg/mL. The mixture of compounds in several ratios tended to increase antibacterial activities of cyanomaclurin. There is no antagonistic effect when compounds used together. It can be concluded that flavonoid compounds in combination may enhance antibacterial activity to prevent development of antibacterial resistance.
THE EFFECTIVITY OF TRIPLE THERAPY COMPOSITION ON DYSPEPSIA WITH HELICOBACTER PYLORI INFECTION: A SYSTEMATIC REVIEW Theodora Putri Simanjaya; Erna Harfiani; Mila Citrawati
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4441

Abstract

Dyspepsia is a disease with one or more symptoms relating to abnormalities in gastroduodenal. One of the factors that influence dyspepsia is Helicobacter pylori (H. pylori). Clarithromycin-based triple therapy is recommended as first line eradication treatment. Resistance towards clarithromycin is increasing and causing eradication rates in Clarithromycin-based triple therapy to decrease. The purpose of this study was to determine the effectiveness of triple therapy variation on dyspepsia with H. pylori infection. Data was collected through literature searches on two different databases using the preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2020. This systematic review included all relevant articles from 2011-2021. Six studies met the inclusion criteria. The results showed that metronidazole-based triple therapy is effective in eradicating H. pylori due to its eradication rate surpassing the target rate of 80%. The highest eradication rates in intention-to-treat (ITT) and per-protocol (PP) were 94.3% and 93.5%, respectively. The best triple therapy composition is metronidazole-based triple therapy with 7 days of duration.
ANTIBACTERIAL ACTIVITY TEST OF BAY LEAF EXTRACTS (SYZYGIUM POLYANTHUM (WIGHT) WALP.) AGAINST STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI: SYSTEMATIC LITERATURE REVIEW Gladys Imanda Sapoetri; Rika Revina; Annisa Farida Muti
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4460

Abstract

Antibiotic resistance is a global health problem that has severe implications for morbidity, mortality, and health costs. Based on the Antimicrobial Resistant in Indonesia (AMRIN-Study), it was reported that there were bacteria that were resistant to antibiotics, including Escherichia coli, which is resistant to ampicillin trimethoprim-sulfamethoxazole and ciprofloxacin; and Staphylococcus aureus which is resistant to oxacillin, vancomycin, clindamycin, and levofloxacin. In Indonesia, Syzygium polyanthum (Wight) Walp. Bay leaf is one of the plants that is often used as spices. Its bay leaf contains secondary metabolites that have an antibacterial function. This study analyzed the antibacterial activities of bay leaf extract against Staphylococcus aureus and Escherichia coli. This research used a systematic literature review with a literature search strategy using Google Scholar and PubMed. The literature discusses bay leaf extract, Staphylococcus aureus, Escherichia coli, and antibacterial activity. From this study, 14 research articles described the antibacterial activity of bay leaf extract by inhibiting the growth of Staphylococcus aureus and Escherichia coli in the medium, strong, and very strong categories. Bay leaf extract can inhibit the growth of Staphylococcus aureus and Escherichia coli because it contains phytochemical compounds with antibacterial properties, including alkaloids, flavonoids, steroids/ triterpenoids, saponins, tannins, phenols, essential oils, and carbohydrate.
COMPARISON OF ANTI-DIARRHEAL ACTIVITY OF METHANOL AND ETHANOL EXTRACTSS OF WATERMELON RIND(CITRULLUS LANATUS L.) IN WHITE MICE (MUS MUSCULUS) Nasruhan Arifianto; Munawaroh; Ermawati; Wahyuni
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 2 (2022): Vol.1 No.2 DECEMBER (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i2.5142

Abstract

Watermelon (Citrulluslanatus L.) is one of the most abundant fruit-producing plants in Indonesia. Watermelon is generally only consumed on the red flesh, while the rind is less desirable so that it becomes waste. The purpose of this study was to comparison of anti-diarrheal activity of  methanol and 70% ethanol extractss of watermelon rind (citrulluslanatus l.) in white miice (musmuscucolus. This study used a protection method with the induction of MgSO4 (Magnesium Sulfate) by calculating the frequency of diarrhea, changes in stool consistency and stool weight. The data obtained from the activity test results of the watermelon rind methanol extracts against white mice were statistically analyzed using the one-way ANOVA test.Methanolic and 70% ethanolicextractss of watermelon rind (Citruluslanatus L.) contain tannin compounds that have antidiarrheal activity against mice (Musmusculus). From the results of the one-way ANOVA test, the weight of feces, the frequency of diarrhea and the consistency of the stools in the methanol extracts of watermelon rind at a dose of 100 mg/KgBW gave an optimal effect, because the weight of the feces obtained a value of p = 0.633, the frequency of diarrhea obtained a value of p = 0.899 and the consistency of the fecesobtained a value of p = 0.899 p-value = 0.525 compared to the positive control (loperamide). Ethanol extracts of Citrulluslanatus L. had antidiarrheal effect at a dose of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW. Based on the results of the One Way ANOVA statistical test, the ethanolicextracts of Citrulluslanatus L. had an antidiarrheal effect at a dose of 100 mg/kgBW and the best dose was a dose of 300 mg/kgBW which was significant with the positive control group loperamide P value = 0.000, meaning that the ethanolicextracts of Citrulluslanatus L. at a dose of 300 mg/kgBW had almost the same effect as the loperamide positive control group based on the parameters of stool weight, frequency of diarrhea, and stool consistency. From this data 70% Ethanolic extracts better than methanolicextracts for antidiarrheal activity in mice.
LITERATURE REVIEW: GREEN TEA EXTRACT POTENCY (Camellia sinensis) in LOWERING GLYCEMIC INDEX OF A WISTAR RAT Filda Nisrina Fajrin; Imam Prabowo; Lisa Safira
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 2 (2022): Vol.1 No.2 DECEMBER (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i2.5162

Abstract

 The aim of the research is to determine the potency of green tea extract (Camellia sinesis) to decrease blood glucose levels in diabetes mellitus model Wistar rats. A systematic review based on PRISMA-P 2020 with a literature search strategy using Google Scholar, PubMed, Science Direct, and Scopus databases. Literature quality was assessed using the JBI Critical Appraisal Checklist which produced 12 comprehensive potential literatures based on selection with inclusion and exclusion criteria. Analysis of 12 journals found that there were 11 studies that showed a significant decrease in blood glucose levels after administration of green tea extract (Camellia sinensis). Green tea extract (Camellia sinensis) has the potential to reduce blood glucose levels in Wistar strain rats with diabetes mellitus model. The mechanism underlying the antihyperglycemic effect is proven to be due to the protective and antidiabetic effects of the compounds contained in green tea extract, especially the flavonoid group, namely catechins. The minimum dose of green tea extract observed to cause an antihyperglycemic effect in experimental animals was 40 mg/kgBW.
POTENCY OF DEVELOPMENT GRAPTOPHYLLUM AS ONE OF INDONESIAN ORIGINAL HERBS; A BIBLIOMETRIC STUDY Feda Anisah Makkiyah
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 2 (2022): Vol.1 No.2 DECEMBER (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i2.5742

Abstract

Indonesia is home to thousands of herbal medicine, and one of the species that would gain more popularity is the Graptophyllum species. This indigenous Papua island plant grows as a shrub plant in the garden of many houses. This study aims to map the research available about this species and explore the potential effects of this plant. Methods. The bibliometric study was performed to map the articles. Scopus databases and Vosviewer were used in this study. Results. 53 articles were withdrawn from Scopus databases. Indonesia has the highest number of publications and many Indonesian researchers collaborated with authors from Japan, Switzerland, and Sweden. The keywords were divided into three clusters and most of the composition discussed was flavonoid. The species discussed was the Graptophyllum pictum. Conclusion. As one of the Indonesian herbal medicine, Graptophyllum pictum is more popular in its own country. Hopefully, the development of chemical drugs from Graptophyllum pictum will be in its own country.
PREVALENCE OF POTENTIAL DRUG-DRUG INTERACTIONS AMONG PROLANIS TYPE 2 DIABETES PATIENT WITH HYPERTENTION IN PRIMARY HEALTH CARE: CROSS SECTIONAL STUDY Primayanti Nurul Ilmi; Hilda Fauziah; Annisa Farida Muti
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 2 (2022): Vol.1 No.2 DECEMBER (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i2.6260

Abstract

Potential drug–drug interactions (pDDIs) are important factors resulting in adverse drug reactions or therapeutic failure. Therefore, pDDIs need to be identified to prevent the related risk and improve drug safety. The objective of this study was to assess the prevalence of pDDIs among Prolanis type 2 diabetes patients with hypertension. Additionally, this study aims to categorize and rate the identified pDDIs according to mechanism, severity and level of significance. This cross-sectional study was conducted at Kramat Jati District primary health care. Patient medical records from January to June 2018, were analysed using Drug Interaction Facts and Stockley’s Drug Interaction for pDDIs with a total 138 patients identified. pDDIs were detected in 35 patients (25.4%), with a total 57 interactions. They were clinically relevant with major (42.1%) in severity and refer to level one of significance (42.1%). The interaction type was unknown (64.9%), pharmacodynamic (64.9%) and pharmacokinetic (12.2%) respectively. The most common interaction was amlodipine-simvastatin in 19 cases (33.3%). Prolanis type 2 diabetes patients with hypertension were at risk to pDDIs, particularly to major pDDIs. Screening of prescriptions and medical records for pDDIs also monitoring of pharmacotherapy in terms of response and associated adverse drug events will contribute to patient safety.
FORMULATION AND STABILITY TEST OF CREAM FROM JUICE OF BELIMBING WULUH (AVERRHOA BILIMBI l.) Feronika Evma Rahayu; Annysa Ellycornia Silvyana; Lia Warti; Dentri Asih
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 2 (2022): Vol.1 No.2 DECEMBER (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i2.6309

Abstract

Research on cream formulations using starfruit (Averrhoa bilimbi L.) juice has been carried out to determine the effect of sodium lauryl sulfate on the physical stability of cream from starfruit juice. Carambola wealth as an active substance is made in cream with varying concentrations of sodium lauryl sulfate of 1%, 1.5%, 2%, and 2.5%. The evaluation was carried out in the form of organoleptic tests, homogeneity, cream type, pH, viscosity, centrifugation, and freeze-thaw. Data analysis was carried out using statistical tests using ANOVA which has a 95% confidence level (α = 0.05), the test is continued with the Tukey HSD test, and the analysis results show significant differences in each formula. The research results concluded that the higher the concentration of sodium lauryl sulfate as an emulsifying agent, the physical stability of the viscosity of the cream from starfruit juice increased.

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