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Journal of Research in Pharmacy and Pharmaceutical Sciences
Published by Universitas Pembangunan Nasional Veteran Jakarta
ISSN : -     EISSN : 29640458     DOI : https://doi.org/10.33533/jrpps.v1i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other
The aim of this journal publication is to disseminate the conceptual thoughts or ideas and research results that have been achieved in the area of pharmacy. This journal encompasses original article, review article and short communications in the area of pharmacy, including: Pharmacognosy and Phytochemistry. Raw and Crude Materials, Standardisation, Characterisation, Quality Control of Herb, Extraction, Fractionation, Isolation, Purification and Elucidation of Natural Products Pharmacology. Pharmacokinetics, Toxicology, Teratogenicity, Immunopharmacology Clinical Pharmacy. Therapeutic Drug Monitoring, Adverse Drug Reaction, Drug Interaction Pharmaceutics. Formulation of Dosage Forms, Cosmetics, Drug Delivery Systems, Development of Excipients Biotechnology. Microbiology, Cell and Tissue Engineering Community Pharmacy. Pharmacoeconomy, Pharmacovigilance, Pharmacoepidemiology, pharmacy education Pharmaceutical Chemistry. Docking, Biocomputation, Drug Synthesis, Analytical Chemistry
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 30 Documents
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COMPARING ANTIMICROBIAL EFFICACY OF DIFFERENT HAND SANITIZERS IN PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS Ramdhan, Zeashafa Zafira; Roqayyah; Salma Ika Rahmadani; Nasyia Qaanita; Anggita Virginia Naulina Manurung; Tirta Fitri Aryani; Nafis Ikhwana; Anggita Cahya Ningrum; Nasywa Dwi Ayu; Afdhal Raziq Hanania; Deskia Amanda Fitriyani; Kharazi Farand Vitonova; Pradana, Dhigna Luthfiyani Citra; Rahmi, Eldiza Puji; Muti, Annisa Farida
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7017

Abstract

Human activities every day have a lot of physical contact with the environment, this can cause various kinds of diseases. These diseases can come from various types of microorganisms such as bacteria, fungi and viruses. Examples of bacteria that can cause disease are Escherichia coli and Staphylococcus aureus. Escherichia coli and Staphylococcus aureus are Gram-positive and Gram-negative bacteria that most commonly cause diarrhoea. To avoid these bacteria, humans need to wash their hands using soap and clean running water. However, washing hands cannot be done every time and in every place. Therefore, there is an innovation of hand sanitizer without using running water, namely hand sanitizer. Hand sanitizer is a waterless hand sanitizer innovation that contains antiseptic substances. Hand sanitizer works as an antibacterial in inhibiting and even killing bacteria. Antiseptics are chemical compounds used to inhibit or kill microorganisms in living tissue. The purpose of using antiseptics is to inhibit or kill bacteria by inhibiting bacterial enzymes and reducing the permeability of bacterial cell membranes through bacterial precipitation, oxidation, and halogenation. Antiseptics usually contain alcohol, chlorhexidine, and anilides. Antiseptics that are widely used in the medical world are antiseptics with alcohol content based on the ability of alcohol to kill bacteria.
THE EFFECTS OF TEMPERATURE AND TIME OF PLANT EXTRACTION USING ULTRASONIC METHOD ON ANTIOXIDANT ACTIVITY: SYSTEMATIC REVIEW Maharani, Salsabila Nanda; Via Rifkia
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i1.7434

Abstract

Excessive free radicals can induce oxidative stress and provoke degenerative diseases in human body. Plant extracts such as starfruit (Averrhoa bilimbi L.), guava (Psidium guajava L.), red spinach (Alternanthera amoena voss.), soursop (Annona muricata L.), and cherry (Muntingia calabura L.) harbor natural antioxidants that hold promise for theurapeutic use in these conditions. This study aims to determine the effect of temperature (25°C, 30°C, 35°C, 40°C, 42,5°C, 45°C, 50°C, 55°C, 60°C) and time (10, 20, 30, 45, 60 minutes) of plant extraction using ultrasonic method on antioxidant activity. This study used systematic review method that use evidence-based data to be reviewed, valuated, assessed for quality, and analyzed. There were 5 journals that met the inclusion and exclusion criteria which will be used as data sources for further study. The results showed that the treatment of temperature and extraction time using ultrasonic method have notable impact on the antioxidant activity as the increasing temperature and time of extraction are directly proportional to antioxidant compounds in plant extracts, yet after passing a certain point it begins to decrease due to the excessive exposure, the best extraction temperatures to achieve the highest antioxidant activity are 40°C, 42,5°C, 45°C with extraction time of 20 minutes.
FORMULATION OF EMULGEL CONTAINING ROBUSTA GREEN COFFEE (COFFEA CANAPHORA) EXTRACT: FORMULATION OF EMULGEL CONTAINING ROBUSTA GREEN COFFEE (COFFEA CANAPHORA) EXTRACT Evma Rahayu, Feronika; Kusnawardhani, Inggiet Fitria
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i1.7770

Abstract

Robusta green coffee (Coffea canephora) contains chlorogenic acid compounds, caffeine, carbohydrates, fats, amino acids, volatile compounds, and minerals. Robusta green coffee extract is formulated in the form of emulgel as a topical application because of the potential for chlorogenic acid to improve dry skin diseases. The purpose of this study was to formulate an extract of robusta green coffee (Coffea canephora) in the form of an emulgel and to determine the physical characteristics and stability of the emulgel. The research design used is the experimental method. This research begins with the extraction of robusta green coffee using the maceration method, phytochemical screening, and the manufacture of emulgel preparations with variations in the ratio of emulsion and gel, namely F0 (1:6), F1 (1:6), F2 (3:6), and F3 (6:6). The process of making emulgel is making emulsion, making gel, and incorporating emulsion into gel. The evaluation carried out on the emulgel preparation included physical examination, determination of pH, emulsion type test, viscosity test, centrifugation test, and freeze and thaw test. The results of the physical characteristics of the emulgel preparation were good and met the requirements based on the parameters of physical examination, determination of pH, and emulsion type test and stable emulgel preparation in freeze thaw stability testing based on parameters of physical examination, determination of pH, emulsion type test, and centrifugation test. Analysis of chlorogenic acid levels in emulgel preparations using UV-Vis spectrophotometer. The levels of chlorogenic acid in the emulgel preparations did not contain chlorogenic acid (F0), 76.70% (F1), 82.77% (F2), and 79.64% (F3).
ANTIDEPRESSANT SCREENING OF LITHIUM CARBONATE IN THE PRESENCE OF PHENYTOIN USING A FORCED SWIMMING MAZE IN ALBINO MICE aburawi, suhera; Saad, Shaban; ALgrabli, Amel
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i1.7925

Abstract

Lithium was introduced into modern psychiatric medicine; in 1970, Lithium was approved by the Food and Drug Administration for the treatment of manic illness; later in 1974 is used for the prevention of manic-depressive illness. Aim of the study: To find out the effect of lithium on mental depression in the presence of phenytoin as a sodium channel blocker, using mice Methods: Male albino mice weighing between 25-40g are used. A forced swimming maze is used to screen for the effect of Lithium on mental depression. Drugs subacute administration is applied. Results: Lithium or phenytoin administration, each alone produces an antidepressant effect. While subacute administration of combined treatment of lithium and phenytoin produces an antidepressant effect less than the additive action of both lithium and phenytoin. Conclusion: Lithium has an antidepressant effect; also, phenytoin administration produces antidepressant action. Administration of phenytoin and lithium together, leads to a decrease in the pharmacological effect of each, as antidepressant, due to their interaction. Therefore, patients receiving the combined treatment of phenytoin and lithium should be under observation. Also, the free (unbound) phenytoin and lithium levels should be measured under medical control.
PRESCRIPTION’S COMPLIANCE OVERVIEW IN ADMINISTRATIVE, PHARMACEUTICAL, AND CLINICAL ASPECTS AT PHARMACY DEPOT IN CLINIC X IN DEPOK CITY Wibowo, Putri Larasati; Ilmi, Primayanti Nurul; Harfiani, Erna; Pradana, Dhigna Luthfiyani Citra
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i1.8950

Abstract

Medication error is any incident that occurs during the treatment process that can jeopardize a patient's life, result in inappropriate healthcare services, and fundamentally can be prevented at various stages of treatment The National Patient Safety Map report states that medication administration errors rank first (24.8%) among the top 10 reported incidents of medication errors.Bottom of Form Top of FormBottom of Form The main duty of a pharmacist is to prevent errors in the use of medication or medication errors. Prevention includes steps such as reviewing prescriptions. The standards used are regulated by Minister of Health Regulation Number 73 of 2016, where prescription review activities include administrative review, pharmaceutical suitability, and clinical considerations. The purpose of this study is to determine the completeness of prescriptions in terms of administrative, pharmaceutical, and clinical aspects at Pharmacy X. The method used in this research is descriptive with a retrospective approach. There were 255 patient prescription data that met the study criteria. The compliance of prescriptions at Pharmacy X is still not fulfilled in terms of patient weight (0%), doctor's telephone number (0%), dosage form (16.1%), and drug strength (40%). However, the potential for drug interactions in prescriptions at Pharmacy X is quite good, with 23 out of 255 prescriptions (9%) indicating potential interactions.
FORMULATION AND EVALUATION OF AMOXICILLIN TRIHYDRATE FAST DISINTEGRATING TABLET (FDT) USING SODIUM STARCH GLYCOLATE (SSG) AS SUPER DISINTEGRANT Widjaja, Tiyon; Hasna Nabila, Annisa; Qaanita, Nasya
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.9103

Abstract

This study was conducted to make a fast-disintegrating amoxicillin tablet formulation using a super disintegrant. Fast disintegrating tablets are tablets that quickly disintegrate after being placed in the mouth so that they can provide benefits for patients who have difficulty getting water or patients who have difficulty swallowing tablet drugs. Amoxicillin fast disintegrating tablet uses lactose monohydrate as filler, avicel pH 102 as binder, sodium starch glycolate as super disintegrant, stearic acid as lubricant, and aspartame as sweetener. The results of the granule evaluation showed that the fines produced from the particle distribution test were 4,56%. The tablet evaluation results showed that the tablets produced had a diameter of 0.6 0,0 cm with a thickness of 0,4 0,0 cm. The average weight of the tablets produced was 143,62 3,04 mg. The hardness of the tablets obtained was 3,962 ± 0,5678 kg with an average tablet friability of 0,63 ± 0,0028%. Tablet dissolution results showed that within 30 minutes tablet 1 dissolved as much as 116,21% and tablet 2 dissolved as much as 116,38%. The results of the disintegration time test showed that the tablets disintegrated for 44,44 ± 15,3957 seconds and the wetting time test was pored for 20 seconds. All evaluations carried out have met the predetermined acceptance requirements. Therefore, this FDT amoxicillin preparation formulation is declared as an optimal and effective formulation for use.
REVIEW ARTICLE: COMPARATIVE TREATMENT PATTERNS OF GERD PATIENTS IN HOSPITALS Dafni Aisyah Fariby; wafa; Isnaini, Anggi; Isnaini, Vian Saltiel Harefa; Feriska, Najwa Adella; Athallah, Falesya Jovanka; Athallah, Shabina Putri Alliya; Atikah, Daniah
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.10923

Abstract

Gastroesophageal Reflux Disease (GERD) adalah gangguan pencernaan kronis yang terjadi ketika asam lambung naik ke esofagus, menyebabkan gejala seperti nyeri ulu hati dan regurgitasi, yang dapat berlanjut menjadi komplikasi serius yang menurunkan kualitas hidup pasien. Penelitian ini menilai pola penggunaan terapi pada pasien GERD di Korea dengan membandingkan tiga jenis terapi: terapi kontinu, terapi on-demand, dan terapi intermittent. Penelitian yang dilakukan oleh Cheal Wung Huh et al. (2023) menggunakan desain observasional, potong lintang (cross-section), dan dilakukan secara multicenter. Penelitian lain yang dilakukan di Bandung merupakan penelitian deskriptif non eksperimental menggunakan metode purposive sampling dan dilaksanakan secara retrospektif yang diperoleh dari 41 rekam medik pasien GERD. Berdasarkan karakteristik responden dalam penelitian Susan Park et al. (2020), Penelitian ini melibatkan 86.936 pasien dalam kelompok pengobatan PPI dan 40 pasien dalam kelompok operasi fundoplikasi. Pasien yang memiliki gejala GERD dengan periode waktu yang singkat atau bahkan NERD (Non Erosive Reflux Disease) lebih menyukai pengobatan secara kontinu dibanding on-demand. Sedangkan pasien yang mengalami gejala GERD dan ERD (Erosive Reflux Disease) jangka panjang lebih memilih terapi secara on-demand. Kombinasi Pantoprazol dan Sukralfat lebih efektif dari monoterapi, namun kombinasi tiga obat tidak direkomendasikan karena efektivitas tidak meningkat dan menambah biaya. Pemilihan terapi perlu disesuaikan dengan kondisi pasien serta kesadaran terhadap risiko jangka panjang.
LITERATURE REVIEW: DETERMINANT FACTORS OF MEDICATION CONTROL COMPLIANCE IN HYPERTENSION PATIENTS IN INDONESIA Rahma Dina, Elsa; Cahyani Putri, Gita; Fakhrunnisa, Najwa; Syifa Urrahma Fauzi, Raifa; Nur Amalina, Nindya; Maraditha, Jeanice; Rifazuli, Aissa; Yonisa putra, Al-Gheni
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.10929

Abstract

Hypertension is a type of cardiovascular disease with a prevalence that continues to increase every year and is a global cause of death, especially among the elderly. The World Health Organization (WHO) notes that approximately 1.13 billion people worldwide live with hypertension. One of the major challenges in its management is low patient adherence to medication therapy, which impacts blood pressure control and increases the risk of complications. The level of non-adherence is caused by several internal and external factors. This research method uses a systematic literature review approach to examine the effect of patient knowledge level on compliance in hypertension treatment control. Literature was searched using Google Scholar with the inclusion criteria of relevant articles published in the range of 2015-2025, resulting in one main article and five supporting articles. The results showed that non-compliance is often caused by low patient knowledge, limited access to health services, advanced age, and socio-economic conditions. Patients who have a good understanding of hypertension and regularly follow medication and patient control tend to show better blood pressure control, so strategies related to education and more support are needed to improve patient compliance. Therefore, to improve adherence, an approach of continuous education, counseling, and support from health workers and families is needed. These strategies are important to prevent long-term complications and improve the quality of life of hypertensive patients
EVALUATION OF THE PHYSICAL STABILITY AND USER ACCEPTANCE OF LEMON WATER TOOTHPASTE (Citrus Limon (L.) Burm. F.) Syarifah, Andiri Niza
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.10986

Abstract

Dental caries remains a prevalent global health concern, often linked to Streptococcus mutans, a primary contributor to plaque formation and tooth demineralization. Conventional toothpaste formulations, while effective, frequently contain fluoride and sodium lauryl sulfate (SLS), which may cause undesirable side effects, prompting a shift toward natural, eco-friendly alternatives. This study aimed to formulate and evaluate a lemon water (Citrus limon L.) toothpaste, assessing its physical stability, antibacterial potential, and consumer acceptability over a 21-day period. The formulation included lemon water, pectin, sorbitol, calcium carbonate, cocamidopropyl betaine, menthol, vitamin E, benzyl alcohol, and distilled water, designed to ensure homogeneity, spreadability, and sensory appeal. The product underwent comprehensive evaluations: organoleptic analysis, pH measurement, homogeneity assessment, spreadability and adhesion testing, foamability evaluation, viscosity analysis, and hedonic testing with 30 respondents. Results demonstrated that the toothpaste maintained a smooth gel texture, white color, and lemon aroma throughout the observation period. pH stability was consistent at 6, supporting antibacterial efficacy and user comfort. Slight non-homogeneity emerged, attributed to natural extract particulates, while viscosity increased over time, affecting spreadability yet remaining within acceptable commercial ranges. Adhesion improved alongside viscosity, ensuring better retention during use. Foam production, though moderate, satisfied sensory preferences without relying on harsh surfactants. Hedonic testing confirmed significant consumer preference, emphasizing the product’s sensory appeal and usability. This study contributes to the advancement of sustainable oral care products by demonstrating that lemon water toothpaste can balance antimicrobial effectiveness, physical stability, and user satisfaction. The formulation offers a viable, eco-conscious alternative to conventional toothpaste, aligning with growing market demand for natural personal care solutions. Future research should explore refining production processes to improve homogeneity, extend stability duration, and broaden antibacterial efficacy against other oral pathogens.
MICROBIAL CONTAMINATION TEST USING THE MOST PROBABLE NUMBER (MPN) METHOD ON SWEET SOY SAUCE AROUND UPN “VETERAN” JAKARTA PONDOK LABU CAMPUS MICROBIAL CONTAMINATION TEST USING THE MOST PROBABLE NUMBER (MPN) METHOD ON SWEET SOY SAUCE AROUND UPN “VETERAN” JAKARTA PONDOK LABU CAMPUS Anggarany, Ariska Deffy; Prasasti, Alisha Dian; Karlina, Amara Ayu; Ningrum, Anisa Puja; Iteh, Aurelie Reginia; Seno, Bimo Asrul; Zahara, Nabilah Siti
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.10997

Abstract

Sweet soy sauce is a fermented soybean product widely used as a traditional Indonesian seasoning. Its production process involves specific microorganisms to develop unique taste, aroma, and texture characteristics. However, poor hygiene and sanitation can lead to microbial contamination, such as Coliform, which may degrade quality and pose health risks. This study aimed to evaluate the microbiological quality of sweet soy sauce using the Most Probable Number (MPN) method. Samples were collected from food vendors around the UPN "Veteran" Jakarta campus and tested using liquid media to detect the presence of Coliform. The results showed that sample 1 (street vendor) had an MPN value of 14 MPN/gram, exceeding the BPOM safety limit (3 MPN/gram), while sample 2 (packaged soy sauce from a minimarket) was within the safety limit at 3 MPN/gram. A confirmatory test detected the presence of Escherichia coli in sample 1 but not in sample 2. Proper product handling, implementation of Good Manufacturing Practices (GMP), and regular microbiological monitoring are necessary to ensure the safety of sweet soy sauce products.

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