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Journal of Research in Pharmacy and Pharmaceutical Sciences
Published by Universitas Pembangunan Nasional Veteran Jakarta
ISSN : -     EISSN : 29640458     DOI : https://doi.org/10.33533/jrpps.v1i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other
The aim of this journal publication is to disseminate the conceptual thoughts or ideas and research results that have been achieved in the area of pharmacy. This journal encompasses original article, review article and short communications in the area of pharmacy, including: Pharmacognosy and Phytochemistry. Raw and Crude Materials, Standardisation, Characterisation, Quality Control of Herb, Extraction, Fractionation, Isolation, Purification and Elucidation of Natural Products Pharmacology. Pharmacokinetics, Toxicology, Teratogenicity, Immunopharmacology Clinical Pharmacy. Therapeutic Drug Monitoring, Adverse Drug Reaction, Drug Interaction Pharmaceutics. Formulation of Dosage Forms, Cosmetics, Drug Delivery Systems, Development of Excipients Biotechnology. Microbiology, Cell and Tissue Engineering Community Pharmacy. Pharmacoeconomy, Pharmacovigilance, Pharmacoepidemiology, pharmacy education Pharmaceutical Chemistry. Docking, Biocomputation, Drug Synthesis, Analytical Chemistry
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 30 Documents
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ANTIBACTERIAL ACTIVITY TEST OF N-HEXANE AND ETHANOL EXTRACT OF MELINJO PEEL (GNETUM GNEMON L.) AGAINST SHIGELLA DYSENTERIAE AND BACILLUS CEREUS Anas Gilang Pratama; Saiful Bahri; Herdini
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.6598

Abstract

Melinjo peel (Gnetum gnemon L.) contains secondary metabolites with antibacterial characteristics such as alkaloids, flavonoids, saponins, tannins, and steroids. This study aims to determine the antibacterial activity of 96% ethanol and n-hexane extract of melinjo peel resulting from the multilevel maceration against Shigella dysenteriae and Bacillus cereus bacteria. This research is an experimental study to test the antibacterial activity of melinjo peel extract as measured by the Diameter of Inhibition Zone (DIZ) and Minimum Inhibitory Concentration (MIC) at concentrations of 12.5%, 25%, and 50%. The results found that the extract resulted from maceration with 96% ethanol solvent as much as 70.95 g with a yield of 14.19% and n-hexane solvent as much as 7.07 g with a yield of 1.41%. The 96% ethanol extract of melinjo peel gave the highest DIZ at a concentration of 50% against Bacillus cereus compared to Shigella dysenteriae. In contrast, the DIZ of n-hexane extract of melinjo peel had no inhibitory power against both of bacteria in all concentrations. MIC of 96% ethanol extract of melinjo peel extract against Shigella dysenteriae and Bacillus cereus at concentrations of 50% and 25%, respectively, whereas n-hexane extract melinjo peel had no MIC value against both bacteria.
DESCRIPTION OF THE COMPATIBILITY OF MEDICATION PRESCRIBING WITH THE NATIONAL FORMULARIUM IN BPJS PATIENTS IN THE OUTPATIENT POLICY OF INTERNAL MEDICINE AT EMC TANGERANG HOSPITAL FOR THE PERIOD OF JANUARY – MARCH 2023 Sunny Koswara Rahajeng
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.6810

Abstract

The Hospital Formulary is a list of drugs agreed upon by medical staff compiled by the Pharmacy and TherapyCommittee/Team determined by the Hospital Management. The Hospital Formulary is prepared referring to the NationalFormulary and must be available to all prescribers, drug dispensers and drug providers in hospitals. The aim of this researchis to determine the appropriateness of drug prescribing according to the National Formulary for BPJS patients in the internalmedicine clinic at EMC Hospital Tangerang City for the period January – March 2023. The type of research is nonexperimental research with a descriptive approach, data collection was carried out retrospectively. Based on the results ofthe research, the description of the suitability of drug prescribing with the National Formulary in BPJS outpatient polyinternal medicine patients at EMC Hospital Tangerang City for the period January – March 2023 can be concluded basedon the characteristics of the gender and age categories of BPJS outpatient poly internal medicine patients, gender is themost the highest, namely female gender, 88 patients (55%) and the highest age, namely early adulthood (26–35 years) asmany as 50 patients (31%), based on conformity between prescription writing and the National Formulary in BPJS internalmedicine patients The highest number was in February with 24 recipes (40%).
COMPARATIVE TEST OF EFFECTIVENESS OF ALCOHOL MIXTURE BASE HAND SANITIZER WITH CHLORHEXIDINE MIXTURE BASE ON ESCHERICHIA COLI AND SHIGELLA SONNEI BACTERIA rahmi, eldiza puji; Farida Muti, Annisa; Pradana, Dhinga Luthfiyani; Valentino, Mikhael; Cahyadi, Salwa Nisrina; Andini, Putri; Ferdian, Muhamad; Widjaja, Tiyon; Razan Fachrudin, Brooklyn; Nabila, Annisa Hasna; Wandira, Salsabilla Puteri; Marliah Saputri, Sirly; Azzahra, Khayla Shifa; Kusumaningrum, Alfina Aprilia; Shabrina, Cut Laila Nur; Nurjannah, Rabbiah Putri
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.7013

Abstract

ABSTRACT Hand sanitizer is a hand cleanser which is easy and practical in use. Using hand sanitizer can be an alternative for washing hands if in condition without water and soap. Hand sanitizer is used to clean pathogens on hands. The ability to kill pathogens in hand sanitizers is due to the active substance content in them. In this research, the effectiveness of 2 hand sanitizers on the market was tested. The test aims to see the effect of the active substances in each preparation on the effectiveness of killing pathogens. Testing was carried out using the Kirby Bauer method and on 2 bacterial media, namely Escherichia coli and Shigella sonnei. Hand sanitizer 1 has a composition consisting of 70% ethyl alcohol and 0.5% chlorhexidine. Hand sanitizer 2 has a composition consisting of 55% ethyl alcohol and 18% isopropyl alcohol with a total of 73% alcohol. Based on observations, it was found that hand sanitizer 1 was more effective than hand sanitizer 2. The chlorhexidine content in hand sanitizer 1 increased its effectiveness in killing pathogens.
ANTIBIOTICS SENSITIVITY TEST DIFFUSION AND DILUTION METHODS Nadia Elzuhria A; Nur Silmi kaffah; Nafis Rizqi N; Ummi Hanidah; Aisyah Mallika S; Firda Ayu Nabilla; Fajwatunnisa Azkadhafina; Taufiq Ahmad Hidayat; Nadya Fierdini Putri; Putri Alifia Zahra; Tristan Setiawan; Fomaembarasi Buulolo
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.7027

Abstract

An antibiotic sensitivity test is a method to test the response of bacteria to antibiotics. This study aims to determine the effectiveness of an antibiotic against microbial activity. The sensitivity test was conducted with two methods, namely, the diffusion method and the dilution method. The diffusion method was performed using paper discs (Kirby-Bauer) against Escherichia coli and Shigella sonnei bacteria with amoxicillin, neomycin, and sulfonamide antibiotics. The data required is the diameter of the inhibition zone. Results showed that Escherichia coli was sensitive to amoxicillin but resistant to sulfonamide and neomycin. Meanwhile, Shigella sonnei was resistant to amoxicillin, neomycin, and sulfanilamide. Furthermore, the dilution method was performed to test the potency of amoxicillin against Escherichia coli bacteria using the liquid dilution method. The data required were test tubes with liquid media that showed no turbidity. The results showed that the minimal inhibitory concentration of amoxicillin against Escherichia coli was 0.25%. Based on the results of the antibiotic sensitivity test using the diffusion and the dilution methods, it can be concluded that amoxicillin has high effectiveness against Escherichia coli bacteria with a minimum inhibitory concentration of 0.25%, while Shigella sonnei is resistant to the antibiotics tested.
ANTIBIOTIC SUSCEPTIBILITY TEST OF PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS WITH DISK DIFFUSION AND DILUTION METHOD Raffi Joe Bhagaskara; Alyaa Shofura Ahmad; Syifa Regina Prasetyawan; Dewi Amelia; Deri Putra Pratama; Innayah Marda Hidayyah Tulloh; Naadhira Alya Putri; Indira Damayanti Putri; Alya Layyina Rabbani; Fathan Mubiin Ibnu Ismail; Jihan Tria Astuti; Naufal Brian Atmaja
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.7029

Abstract

The susceptibility test is a test used to measure bacteria's sensitivity and vulnerability towards antibiotics. This study was to determine sensitivity of Pseudomonas aeruginosa and Staphylococcus aureus towards amoxicillin, neomycin, and sulfanilamide. In this study, the methods used in susceptibility tests are disk diffusion method and serial dilution. The disk diffusion method is a method with paper disks that already saturated the antibiotics, with one paper disk for each antibiotic, put the disk on the agar media that had been inoculated by the bacteria, then incubated and measured the inhibition zone. The dilution method was done by making a series of antibiotic dilutions in liquid media which added microbes inside. This test is to estimate the smallest concentration or Minimum Inhibitory Concentration (MIC) in the dilution series with no bacterial growth. The diffusion test shows no clear visible zone at all, so Pseudomonas aeruginosa and Staphylococcus aureus are resistant to amoxicillin, neomycin and sulfanilamide. The dilution test shows the clearest sample was on 0,25% concentrate, so amoxicillin's Minimum Inhibitory Concentration towards Staphylococcus aureus is 0,25%.
COMPARISON OF THE ANTIMICROBIAL EFFECTIVENESS OF GARLIC EXTRACT AND THE ANTIBIOTIC CLINDAMYCIN ON THE GROWTH OF THE BACTERIA PROPIONIBACTERIUM ACNES AND STAPHYLOCOCCUS EPIDERMIDIS Prabowo, Imam; Malona, Daniel Natanael; Puspita, Oktania Sandra
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7182

Abstract

Acne vulgaris is an inflammatory disorder of pilosebaceous glands caused by an increase in sebum production, abnormal follicle keratinization, and colonization of positive gram P. acnes and S. epidermidis bacteria. Clindamycin antibiotic resistance has been reported because it is used to bacteria that cause acne vulgaris. Garlic extract has antimicrobial properties called allicin. This study aimed to determine the in vitro antimicrobial effectiveness of garlic extract in the growth of P. acnes and S. epidermidis. The samples of this study are garlic extract. This study was a true experimental study conducted using disc diffusion method with Mueller Hinton Agar. The zone of inhibition was observed on all groups of P. acnes and S. epidermidis in all tested concentrations with allicin concentration of 256µg/ml showing the widest zone of inhibition. Statistical analysis using the One- Way ANOVA resulted in (p)<0.005. Conclusively, garlic extract was effective in inhibiting the growth of P. acnes and S. epidermidis.
ASSESSMENT OF KNOWLEDGE AND SELF-MEDICATION PRACTICE OF DYSMENORRHEA AMONG PHARMACY UNDERGRADUATE STUDENTS: A CROSS-SECTIONAL STUDY Rahmi, M.Sc, Eldiza Puji; Ananda, Bella; Prabowo, Imam; Pradana, Dhigna Luthfiyani Citra
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7207

Abstract

Dysmenorrhea is pain during menstruation that is experienced during adolescence caused by uterine muscle spasms. Data on knowledge of dysmenorrhea and self-medication practice among undergraduate student at Universitas Pembangunan Nasional Veteran Jakarta (UPN Veteran Jakarta) are scarce. This study aimed to assess and determine the relationship between the level of knowledge and primary dysmenorrhea self-medication practice. A cross-sectional study was carried out among female undergraduate Pharmacy Student of UPN Veteran Jakarta. A total of 107 unmarried and nulliparous female students were included in this study using the stratified random sampling technique. Based on the results of the study, 47 students (43.9%) had adequate knowledge, 46 students (43.0%) had moderate knowledge, and 14 students (13.1%) had inadequate knowledge. Forty female students (37.4%) had good practice, 40 female students (37.4%) had moderate practice, and 27 female students (25.2%) had poor practice regarding dysmenorrhea, and in this study, the value of confidentiality (p< 0.05). It is considered significant, with the intention that there is a relationship between the level of knowledge and primary dysmenorrhea self-medication.
EFFECTIVENESS OF GIVING MORINGA LEAF EXTRACT (MORINGA OLEIFERA) IN REDUCING BLOOD PRESSURE SYSTEMATIC REVIEW Rifkia, Via; Zahra, Rahmanita Kamila; Kolib, Abdul
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7229

Abstract

Hypertension, which is an increase in blood pressure, has a prevalence based on Riskesdas in 2018 at the age ≥18 years, which is around 34.1%. Various treatment methods have been developed because if hypertension is not treated it can cause symptoms and serious complications. Other than using chemical drugs such as beta-blockers or ACE inhibitors, people are starting to consider therapy with natural ingredients such as Moringa leaves (Moringa oleifera). It contains compounds that have an antihypertensive effect such as flavonoids and potassium. This study aims to determine the compound, effectiveness, and mechanism of Moringa leaf as an antihypertensive by using a systematic review method. This method is carried out by searching literature using certain keywords based on PRISMA-P, and then data from ten literatures is extracted to be discussed and concluded based on the objectives. The result, obtained various compounds in Moringa leaf extract have certain mechanisms in lowering blood pressure such as flavonoid compounds, such as kaempferol and quercetin, as well as other compounds such as several organic acids, potassium, and alkaloids. Moringa leaf extract also effectively lowers blood pressure in animals and humans with different doses. This study concludes that the administration of Moringa leaf extract can effectively reduce blood pressure due to the antihypertensive mechanism caused by the phytochemical content.
UPDATE REVIEW OF PHYSALIS: ETHNOGRAPHY VALUE AND ITS USEFULNESS IN STROKE ISCHEMIC DISEASE Makkiyah, Feda
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7232

Abstract

One Indonesian herbal medicine that deserves attention is Physalis minimal Linn. Identifying medications and their use in the correct dosages is crucial for effective treatment. Country gooseberry, or Physalis minima Linn, has anti-cancer, anti-diabetic, analgesic, antipyretic, and anti-inflammatory properties. This paper aims to reveal the potential use of Physalis minima Linn in stroke ischemic disease, a substantial current health issue in Indonesia. We used Scopus and Google databases to screen the intended articles with keywords used are TITLE-ABS- KEY (stroke) AND physalis AND antioxidant OR antiinflammation, "Physalis minima" and stroke ischemic" and "thrombolytic" OR " Antiinflammatory" OR "Antioxidant". Two other fellow researchers screened the resulting articles and read the articles together, and resumed the narration. Ten articles resulted in the screening—however, only 1 article was included in this article from the Scopus Databases. However, we got five articles out of 10 articles from Google databases. We divided the narration based on several items, such as anti-thrombolytic effects, antioxidant and antiinflammation, and ethnography of the plant. Conclusions. Physalis minima have its potency to be explored as an alternative treatment to stroke ischemic. Firstly P.minima tends to thrombolytic clot in case of thrombosis in stroke ischemia. Secondly, P.minima have an effect of antioxidants and anti-inflammation that is useful in acute stroke ischemia.
THE RELATIONSHIP OF COMPLIANCE WITH MEDICATION ON BLOOD PRESSURE STABILITY IN HYPERTENSION PATIENTS AT CINERE DISTRICT HEALTH CENTER 2023 Sumantri, Salsabila; rahmi, eldiza puji; Rifkia, Via; Pradana, Dhinga Luthfiyani
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7416

Abstract

Several reasons for hypertension sufferers who do not comply with taking medication will slow down healing time and worsen the patient's condition and can even cause death. This study aims to determine the characteristics of hypertensive patients at the Cinere Community Health Center, the results of antihypertensive therapy at the Cinere Community Health Center and to determine the relationship between adherence to medication use and the success of therapy at the Cinere Community Health Center. This research uses a correlational analytical research design. Based on the discussion above, it can be concluded that the characteristics of hypertensive patients at the Cinere Community Health Center are the majority aged 45-65 years, female with the highest education level being elementary school and having suffered for > 1 year. The majority of medication adherence among hypertensive patients at the Cinere Community Health Center is still relatively low. The success of therapy in hypertensive patients at the Cinere Community Health Center resulted in a reduction in blood pressure of 31 people and in patients who did not reduce blood pressure there were 71 people. There is a relationship between adherence to taking medication and blood pressure stability in hypertensive patients at the Cinere Community Health Center

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