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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 11 Documents
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Search results for , issue "Vol 38 No 2 (2021)" : 11 Documents clear
BANGKITAN SIMTOMATIK AKUT: INSIDENSI, ETIOLOGI, DAN MORTALITAS PASIEN RSUD GUNUNGSITOLI TAHUN 2015–2019 Stefanus Erdana Putra; Berkat Hia; Muhammad Hafizhan; Fauzi Novia; Isnaening Tyas; Astrida Fesky Febrianty
NEURONA Vol 38 No 2 (2021)
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Introduction: Acute symptomatic seizures are seizures that occur due to acute disorders of the central nervoussystem due to structural, infectious, inflammatory, and metabolic disorders. Acute symptomatic seizures and unprovokedseizures must be distinguished because they have different prognoses. Aim: To determine the incidence, etiology, and prognosis of acute symptomatic seizure patients treated inGunungsitoli Regional General Hospital during 2015-2019. Methods: This was a cross-sectional study in patients with acute symptomatic seizure in Gunungsitoli RegionalGeneral Hospital Nias District during 2015-2019. Data were obtained from the medical record in Gunungsitoli RegionalGeneral Hospital. Multiple logistic regression analysis was used to calculate odds ratios (ORs) of age for mortality. Results: There were 88 acute symptomatic seizure patients with a proportional comparison between males andfemales (1.1:1). The most prevalent encountered etiology of acute symptomatic seizure patients was metabolic disorders(51.14%) consisting of 25% uremia; 5.68% hyponatremia; 4.54% hyperglycemia; 6.83% hepatic; and 9.09% hypoglycemiawith a case fatality rate of 29.55%. Discussion: Characteristics of acute symptomatic seizures patients treated in Gunungsitoli Regional GeneralHospital were not affected by gender, with the most often encountered etiology was metabolic disorders. Keyword: Acute symptomatic seizure
GAMBARAN ARSITEKTUR TIDUR PADA PASIEN TUMOR OTAK YANG MENGALAMI GANGGUAN TIDUR Yesi Astri; Manfaluthy Hakim; Tiara Aninditha; Renindra Ananda Aman; Astri Budikayanti
NEURONA Vol 38 No 2 (2021)
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Introduction: Sleep disorder is commonly found in brain tumor patients (42-46%). It can be detected using thePittsburg Sleep ????uality Inde???? (PS????I) as a screening tool and confirmed by analyzing the sleep architecture obtainedthrough a Polysomnographic (PSG) examination.Aim: To evaluate the sleep architecture in brain tumor patients who experience sleep disorder.Methods: In this descriptive cross-sectional study, patients with primary brain tumor were screened for sleep disorderusing the PSQI. The ‘poor sleepers’ would proceed to PSG examination.Results: Of 40 participants, 14 were males and 26 were females with a mean age of 45.5±11.7 years old. The mostprevalent tumor was meningioma (42.5%), while the most affected regions were the frontal lobe (40%) and the sellarsuprasellarregion (2????.5%). Poor sleep ????uality and difficulty in initiating sleep (????3 times per week) was reported in77.5% and 60% of participants, respectively. All participants experienced reduced sleep duration, the majority of whichdemonstrated low sleep efficiency (8????.5%). An estimate of 60% participants e????perienced headache at night and 50% tooksleeping pills for these complaints. Most of them reported disruption in daytime activities. On PSG analysis, we observedshortening of sleep latency, reduced sleep efficiency, total sleep time, N2, N3, REM, arousal inde????, and increase of N1.There was a statistically significant difference between ????5 hours of sleep duration and decrease of N3 phase (p????0.05).Discussion: Abnormal sleep architecture presents in brain tumor patients with sleep disorder.Keywords: brain tumor, Pittsburgh Sleep Quality Index, polysomnography, sleep architecture
PERBEDAAN KADAR N-TERMINAL PRO BRAIN NATRIURETIC PEPTIDE PLASMA BERDASARKAN LUARAN FUNGSIONAL STROKE ISKEMIK AKUT Gunawan Septa Dinata; Syarif Indra
NEURONA Vol 38 No 2 (2021)
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systemic vascular system when ischemic stroke occur. BNP is secreted by myocardial and causes vasodilatation, natriuresisand diuresis. Increase myocardial wall pressure triggers pre-proBNP synthesis in myocardial. Pre-proBNP then wasdivided into an active form (BNP1-32) and inactive amino-terminal fragmen (NT-proBNP).Objective: To evaluate the differences of plasma N-terminal pro brain natriuretic peptide (NT-proBNP) levels inacute stroke ischemic based on functional outcome of acute ishemic stroke patient.Methods: This is an observational study that was conducted at neurology ward of M. Djamil Padang Hospitalfor acute stroke ischemic patients. The sample was selected by consecutive sampling method. Functional outcome wasassessed by Modified Rankin Scale (mRS). Plasma NT-proBNP levels were analyzed by enzyme-linked immunosorbentassay (ELISA).Results: The mean level of plasma NT-proBNP of acute ischemic stroke patient was 287.8±84.2 pg/mL. Data wasanalyzed using ????ruskal ????allis and the result showed that there is a significant differences in plasma NT-proBNP (????????2hours) levels based on functional outcome of acute ischemic stroke, p value ????0.05 (p????0.018).Discussion: There is an differences in acute phase of NTproBNP plasma level with functional outcome ischaemicstroke.Keywords: BNP, functional outcome, NT-proBNP
KOMPLIKASI VENTRIKULOPERITONEAL SHUNT PADA PASIEN PEDIATRIK USIA 0-2 TAHUN DI RUMAH SAKIT UMUM PUSAT NASIONAL DR CIPTOMANGUNKUSUMO Samsul Ashari; Bhayu Rizallinoor; Hilman Mahyudin; Moh. Saekhu; Renindra Ananda Aman; David Tandian; Abdi Reza; Setyo Widi Nugroho
NEURONA Vol 38 No 2 (2021)
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Introduction: Ventriculoperitoneal shunt is the procedure of choice in the management of hydrocephalus. However,the ventriculoperitoneal shunt procedure also carries a risk of complications. In Indonesia, data on the incidence andprevalence of ventriculoperitoneal shunt complications have not been obtained.Aim: In this study, we examined the complications of shunts and the factors associated with the duration of timeMethods: This study is a retrospective study of pediatric patients aged 0-2 years with hydrocephalus who underwentventriculoperitoneal shunt surgery for the first time at Cipto Mangunkusumo Hospital in 2015-2020 and e????periencedcomplications. The duration of time the complications occurred was divided into before and after six months. Demographicdata, clinical data, and types of complications were analyzed descriptively.Result: From ????anuary 2015 to March 2020 at Cipto Mangunkusumo Hospital, 168 ventriculoperitoneal shuntoperations were performed at 0-2 years. It was found that 20 patients (12%) e????perienced complications with a duration offewer than si???? months by ????.8% and more than si???? months by 4.2%. The total complications that occurred were mechanicalcomplications (????.2%), infection (3.6%), and over drainage (1.2%).Discussion: The percentage of complications of ventriculoperitoneal shunt in patients aged 0-2 years at CiptoMangunkusumo Hospital, in the first si???? months was ????.8%, with the highest incidence was infection (3.6%) which waslower than the literature, while the percentage of complications of ventriculoperitoneal shunts which more than six monthswere 4.2% and caused mainly by distal malfunction (3%).Keywords: aged 0-2 years, complications, pediatric, ventriculoperitoneal shunt
HUBUNGAN ANTARA ANEMIA DEFISIENSI BESI DENGAN FUNGSI KOGNITIF PADA ANAK SEKOLAH DASAR USIA 09-11 TAHUN Hening Widjayanti; Hexanto Muhartomo; M. I. Widiastuti; Amin Husni; Dani Rahmawati; Trianggoro Budisulistyo
NEURONA Vol 38 No 2 (2021)
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Introduction: Iron deficiency anemia is the most common form of anemia found in children. In iron deficiency anemia, levels of hemoglobin and ferritin must be considered. Hence, anemia can cause in impairment of cognitive function in children. Aim: To analyze the correlation between iron deficiency anemia and cognitive function in primary school children aged 9-11 years. Methods: This was an observational study with cross sectional design. The subjects of this study were students at Taqwiyatul Waton Primary School, Semarang and Tanjung Mas Primary School, Semarang, who met the inclusion and exclusion criteria. This study was conducted from March to June 2019. Laboratory tests for hemoglobin levels and ferritin levels were carried out at Paramitha Laboratory, Semarang. The data were obtained either from the study subjects and their parents. The assessment of cognitive function used modified Mini Mental State Examination (MMSE). Data analysis used Spearman's bivariate correlation test and partial correlation. The result was considered significant if the p value <0.05. Results: This study was carried out 70 students from Taqwiyatul Waton Primary School, Semarang and Tanjung Mas Primary School, Semarang. A moderate correlation was found between iron deficiency anemia and cognitive function (r = -0.505; p <0.001). Discussion: Their was a moderate relationship between iron deficiency anemia and cognitive function. Keyword : Cognitive function, iron deficiency anemia, nutritional status
MANIFESTASI NEUROLOGI PADA PASIEN COVID-19 DI RUMAH SAKIT UMUM DAERAH KOTA TANGERANG SEBAGAI PUSAT RUJUKAN COVID-19 PROVINSI BANTEN Hananto Pratignyo; Paulina Thiomas; Hesti Setiastuti; Usynara Usynara; Fitrie Rahayu; Virginia Nuriah
NEURONA Vol 38 No 2 (2021)
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Introduction: Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, first reported in Wuhan by December 2019, spreading rapidly to various countries. World Health Organization (WHO) has designated COVID-19 as a global pandemic. Although the main clinical manifestation is the respiratory system, neurological symptoms have been reported. There are little data on neurological manifestations in COVID-19 patients, especially in Indonesia. Aim: To determine the neurological manifestations in COVID-19 patients. Methods: This is a retrospective observational study. Data were collected from medical records of hospitalized COVID-19 patients at Tangerang City General Hospital in the period April-August 2020. Data collection based on age, sex, comorbidity, general symptoms, neurological symptoms, laboratory and radiological findings. Neurological examinations were done by two neurologists. Results: Of 492 COVID-19 patients, there were 25 (5%) who had neurological manifestations, the proportion was male (52%) and aged over 60 years (44%). Of the 25 patients, 13 (52%) were confirmed COVID-19. Twenty patients (80%) have comorbidities such as hypertension, diabetes mellitus, vascular disease, tuberculosis, and chronic kidney disease. The neurological manifestations that were found were cerebrovascular disease (50%), meningoencephalitis (7.7%), vertigo (23%), anosmia (15.4%), and myalgia (3.8%). Seven patients (28%) died and 18 patients (72%) had clinical improvement. Discussion: COVID-19 can be accompanied by a variety of neurological symptoms. The neurological manifestations can be found in the central nervous system, peripheral nerves, and musculoskeletal. During a pandemic, COVID-19 is considered a differential diagnosis in patients with neurological symptoms to increase awareness and prevent further transmission. Keywords: Cerebrovascular, COVID-19, manifestation, neurology
HUBUNGAN NEUTROPHIL TO LYMPHOCYTE RATIO SEBAGAI FAKTOR PREDIKTIF DEFISIT NEUROLOGIS PADA PASIEN STROKE ISKEMIK AKUT Adrian Djatikusumo; Poppy Kristina Sasmita; Bryany Titi Santi
NEURONA Vol 38 No 2 (2021)
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Introduction: Stroke is defined as a neurological deficit with sudden onset associated with focal and global vascular causes, which leads to morbidity and mortality. In all stages of acute ischemic stroke, an inflammatory process occurs, which is mediated by neutrophils or lymphocytes. Aim: To determine the correlation between neutrophil to lymphocyte ratio (NLR) with neurological deficits or functional outcomes in acute ischemic stroke patients. Methods: This study was conducted using a systematic review method. The studies, filtered through various databases, were assessed for quality and risk of bias using the Newcastle-Ottawa Scale (NOS). Stroke severity and neurological deficits were assessed using the National Institutes of Health Stroke Scale (NIHSS), Scandinavian Stroke Scale (SSS) and modified Rankin Scale (mRS). Results: There were seven studies that met the criteria for the literature search and were assessed as having high quality based on NOS. All included studies stated that there was a significant relationship between NLR and poor stroke functional outcomes in acute ischemic stroke patients (p-value <0.05). The cutoff value of the NLR on the neurological deficits of acute ischemic stroke patients ranged from 2.39 to 4.58 with varying sensitivity and specificity. Discussion: The variations of cutoff, sensitivity and specificity of NLR in predicting neurological deficits could be influenced by the number and characteristics of the sample, race, comorbidity and inclusion and exclusion criteria in the included articles. The significant relationship between NLR and neurological deficits is based on an inflammatory process that occurs at all stages of acute ischemic stroke. Keywords: acute ischemic stroke, functional outcomes, neurological deficits, NLR.
TERAPI PREDNISON MEMBERIKAN LUARAN KLINIS YANG BAIK PADA MIOSITIS POST VAKSINASI Ivan Santosa; Yudy Goysal; Andi Kurnia Bintang; Cahyono Kaelan
NEURONA Vol 38 No 2 (2021)
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A six-year-old girl was consulted from the Pediatrics department to the Neurology outpatient clinic at Wahidin Sudirohusodo Hospital in Makassar with an initial diagnosis of neuropathy. She complained of weakness on both legs suffered a month before treatment, she had difficulty reaching a standing position from sitting or squatting. She walked quite normally when standing, there was no disturbance in gait, but she had difficulty on climbing stairs, and had myalgia in the leg area. There was a history of intramuscular injection of diphtheria tetanus (Td) vaccine in the right upper arm. She got the vaccine according to the vaccination program. On physical examination, vital signs were within normal limits, there was slight paraparesis, decreased patellar reflex and no pathological reflexes. Sensory and autonomic physical examination were normal. There was Gower’s sign noted. Laboratory investigations findings: SGOT 134, SGPT 49, LDH 1584, CK 1922.80. Biopsy finding shows inflammatory changes consistent with myositis. Prednisone therapy provides significant clinical improvement. Keywords: Myositis, prednisone, vaccination
KEJADIAN STROKE ISKEMIK PADA PASIEN POSITIF COVID-19 TERKONFIRMASI DI RUMAH SAKIT UNIVERSITAS INDONESIA Rakhmad Hidayat; Gemia Clarisa Fathi; Ramdinal Aviesena Zairinal; Raden Rara Diah Handayani; Mohammad Kurniawan; Taufik Mesiano; Al Rasyid; Salim Harris
NEURONA Vol 38 No 2 (2021)
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Coronavirus disease 2019 (COVID-19) is not only disrupts the respiratory system, it can disrupt various organ systems, one of which is the central nervous system. Indonesia still has a little literature that discusses COVID-19 and its relation to ischemic stroke. This study aims to report the course of ischemic stroke cases in patients who have been confirmed positive for COVID-19. A 56 year old man presented with confirmed COVID-19, the patient had a history of type 2 diabetes mellitus and also a history of dyslipidemia. At initial presentation the patient did not complain of neurological symptoms, but after 12 days of treatment the patient complained of weakness in the left side of the upper leg. The CT scan of the head with contrast revealed an infarction in the peripheral area, perfusion CT found that the patient was hypoperfused in the right cerebral hemisphere area without the presence of a large core infarction or a clear perfusion mismatch defect. CT angiography did not reveal stenosis or occlusion of the large vessels. It can be concluded that ischemic stroke in COVID-19 patients can occur due to various underlying factors, one of which is hypercoagulability. Keywords: COVID-19, Stroke, Universitas Indonesia Hospital
POTENSI VITAMIN D SEBAGAI OBAT PREVENTIF UNTUK MENGHAMBAT PROGRESIVITAS TENSION TYPE HEADACHE Elvan Wiyarta; Stefen Weliadi Ali
NEURONA Vol 38 No 2 (2021)
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Tension type headache (TTH) is one of the most common primary headaches. The prevalence of this headache is very high in Indonesia. Even so, many people still ignore this disease and eventually come when it has progressed to chronic. Several drugs have been developed to inhibit the progression of TTH, but they have some drawbacks. As an alternative, vitamin D is alleged to be able to act as an inhibiting drug for TTH progression through its mechanism of muscle spasm. The role of vitamin D is mainly found in the system of muscle contractility disorders that occur in TTH. Several clinical studies also support this theory. Vitamin D also has high applicability as a preventive drug for the progression of TTH, in terms of effectiveness, compliance, safety, and cost. Therefore, vitamin D has the potential to act as an inhibiting drug for TTH progression. However, further studies still need to be done. Keyword: , tension type headache, vitamin D

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