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Jurnal Kedokteran Meditek
Published by Universitas Kristen Krida Wacana
ISSN : 26861437     EISSN : 26860201     DOI : https://doi.org/10.36452/jkdoktmeditek
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Jurnal Kedokteran MEDITEK merupakan jurnal ilmiah yang mempublikasikan artikel-artikel dalam lingkup bidang kedokteran dan biomedik secara open access. Proses publikasi artikel melalui proses penelaahan oleh pakar sebidang (peer-review) secara double-blind. Jurnal Kedokteran Meditek berafiliasi pada Fakultas Kedokterandan Ilmu Kesehatan Universitas Kristen Krida Wacana, dengan misi mendorong penyebarluasan perkembangan ilmu kedokteran & biomedis di Indonesia maupun secara global dengan menerbitkan 3 edisi dalam setahun, yaitu: Januari, Mei dan September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 623 Documents
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Applying Project Management to Establish an Academic Health System: A Participatory Action Research Josephine, Jodie; Tj, Hery Winoto; Fushen
Jurnal Kedokteran Meditek Vol 31 No 2 (2025): MARCH
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i2.3666

Abstract

Introduction: Academic Health Systems (AHS) integrate healthcare, education, and research to enhance medical training and patient care. However, initiating AHS in institutions without an existing framework presents challenges in aligning stakeholder expectations and organizational structures. Purpose: This study aims to initiate and establish an appropriate AHS model for Ukrida AHS through Project Management (PM) principles and highlight the importance of PM principles in healthcare organizations. Methods: A qualitative research design was employed using semi-structured interviews with six key stakeholders. Thematic analysis identified recurring patterns in stakeholder perceptions, expectations, and challenges regarding AHS implementation. Data triangulation through a Focus Group Discussion (FGD) refined the findings. Results: The findings are categorized into three phases: Inquiry, which identified three key themes—stakeholder perceptions of their organization, understanding of AHS, and perceived benefits and challenges; Action, which translated these insights into concrete steps, including goal-setting, developing a Gantt chart, and an AHS model; and Reflection, which assessed the research process and emphasizing the benefits of using PM principles in healthcare organizations. Conclusion: Integrating PM with PAR facilitated AHS initiation at Ukrida, revealing benefits, challenges, and key priorities: leadership alignment, financial sustainability, faculty development, stakeholder collaboration, and data systems to ensure long-term success and scalability.
Faktor- faktor yang Berhubungan dengan Kadar 25 Hidroksi Vitamin D Serum pada Anak dengan Lupus Eritematosus Sistemik wibawa, Valerie viola; Takumansang, Raynald O; Mandei, Jose M; Langi, Fima Lanra Fredrik Gerarld
Jurnal Kedokteran Meditek Vol 31 No 4 (2025): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i4.3708

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems. Pediatric-onset SLE (pSLE) often presents with more severe organ involvement and a more aggressive course than adult-onset cases. Vitamin D, known for its immunomodulatory effects, has been implicated in SLE pathogenesis, yet data on serum 25-hydroxy vitamin D [25(OH)D] levels in pediatric patients remain limited. Objective:  This study aimed to assess serum 25(OH)D levels in children with SLE and identify related factors. Methods: A cross-sectional observational study was conducted on 22 pediatric SLE patients aged 5–18 years treated at Prof. Dr. R. D. Kandou General Hospital, Manado. Patients with chronic kidney disease, nephrotic syndrome, chronic liver disease, congenital skeletal disorders, or parathyroid dysfunction were excluded. Serum 25(OH)D levels were measured via ELISA, along with other laboratory parameters. Results: Results showed all patients had vitamin D deficiency, with a mean level of 11.93 ± 5.25 ng/mL. Multivariate regression analysis revealed significant associations between vitamin D levels and complement C3, disease duration, SLEDAI scores, and dsDNA levels.  Conclusion: Vitamin D deficiency is prominent among pSLE patients and is linked to disease activity and severity, suggesting its potential role in disease management and the need for further research
Hubungan Psikopatologi dan Mekanisme Koping dengan Internet Gaming Disorder (IGD) pada Populasi Dewasa di Indonesia Assandi, Pratiwi; Siste, Kristiana; Tobing, Heriani; Kusumaningrum, Profitasari
Jurnal Kedokteran Meditek Vol 31 No 4 (2025): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i4.3728

Abstract

Introduction: Psychopathology and maladaptive coping can contribute to Internet Gaming Disorder (IGD) in adults, threatening productivity and life. Purpose: This study aimed to explore the associations between psychopathology and coping mechanisms with IGD in Indonesian  adults. Methods: This cross-sectional study included 358 adults aged 18 to 59 who engaged in online gaming through consecutive sampling. Data were collected online using Symptoms Check List-90, Brief COPE, Ten-Item Internet Gaming Disorder Test, and sociodemographic questionnaire and were analyzed using chi-square, Kolmogorov Smirnov, Mann-Whitney, and logistic regression tests. Results: The IGD proportion was 16,5%. Psychopathology (somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobia, paranoia, and psychotic), coping mechanisms (active-coping, use of instrumental support, humor, use of emotional support, positive reframing, self-distraction, denial, substance use, behavioral disengagement, venting, and self-blame), age, marital status, gaming duration, and Multiplayer Online Battle Arena games were significantly associated with IGD (p<0,05). Gaming duration exceeding three hours per day (OR=3,220, CI=1,574-6,588), dysfunctional coping (OR=1,154, CI=1,067-1,248), and hostility (OR=7,231, CI=3,038-17,213) identified as risk factors, while venting (OR=0,727, CI=0,533-0,991) served as protective factor. Conclusion: Psychopathology and dysfunctional coping are associated with IGD. Education on related factors, early detection of psychopathology, and identification of coping mechanisms support comprehensive IGD management.
Susceptibility of Gastroesophageal Reflux Disease Symptoms in Medical Students: A Formative Study Sutanto, Eviana Budiartanti; Sutanto, Luciana Budiati; Hardimarta, Fransisca Pramesshinta; Ernestia , Henrita; To , Lidwina Indra Aprilia Christiana; Tjitradinata , Cynthia; Sebong , Perigrinus Hermin
Jurnal Kedokteran Meditek Vol 31 No 5 (2025): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i5.3758

Abstract

Introduction: Gastroesophageal Reflux Disease (GERD) is a common chronic health problem associated with decreased quality of life and high morbidity. Many factors, including lifestyle, eating habits, medication, and mental stress, can trigger gastroesophageal reflux disease. A medical student who experiences high pressure during their training may have a GERD issue. Hence, this study aims to investigate the correlation between risk factors and the development of GERD in medical students. Methods: We used data from a cross-sectional study conducted at Soegijapranata Catholic University, Semarang, among medical students. Participants were recruited with inclusion criteria, namely all students aged over 18 years who were willing to fill out a questionnaire voluntarily, and were not undergoing treatment for gastric ulcers or mental disorders. Two questionnaires are used: a questionnaire developed to obtain demographic characteristics and a GERDQ questionnaire. A significant relationship is considered to occur if the p-value <0.05. Result: A total of 122 students were included. Among them, 23 students, consisting of 16 (13.11%) women and 7 (5.73%) men, suffered from GERD. It was found that nine people (7.4%) consumed NSAIDs, with a p-value of 0.014. Conclusion: The prevalence of GERD among medical students is relatively high, showing a significant link between the use of NSAIDs and GERD. Practical studies are needed to tackle the issue of uncontrolled NSAID use and to promote lifestyle modifications.
Profil HPV Genotyping dan Pap Smear LBC di MRCCC Siloam Hospitals Semanggi Calista, Angeline; Sugiharto, Sony
Jurnal Kedokteran Meditek Vol 31 No 5 (2025): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i5.3811

Abstract

Introduction: Cervical cancer is the second most common malignancy among Indonesian women after breast cancer, with 36,964  cases and 20,708 deaths in 2022. Cervical cancer screening studies using HPV genotyping and pap smear LBC have already been conducted in Indonesia using different methods.  Purpose: The objectives of this study were to determine the HPV prevalence and genotype distribution, also the cytological results at MRCCC Siloam Hospitals Semanggi.  Methods:  A descriptive study with a cross-sectional design was conducted using 599 samples selected by consecutive non-random sampling from 2023–2024.  HPV genotyping was performed using the DiagCor GenoFlow™ HPV array test, and pap smear analysis was conducted using PathTezt™ liquid-based cytology. Results: This study found 18.2% patients positive for HPV, comprising 58.7% with high-risk HPV only, 23% with low-risk HPV only, and 18.3% with mixed HPV infection Among all HPV-positive women, 53.2% had multiple HPV infections. The prevalence of high-risk HPV infection was 62.4%, with the most frequently detected genotypes were HPV-68, HPV-66, and HPV-52. The most frequent low-risk HPV infections were HPV-42, HPV-43, and HPV-44. Abnormal cytology results were found in 2.8% of patients, specifically ASC-US, LSIL, ASC-H, and AGC. Conclusion: The most prevalent HPV genotypes identified were HPV-68 (10.1%) and HPV-66 (9.6%). The study concludes that a positive HPV test is not always accompanied by abnormal cytology results. Therefore, HPV genotyping should be performed in conjunction with cytological examination for comprehensive screening. 
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) Syndrome Associated with Liver Injury in Patient with Spondylarthritis: A Case Report Fitri, Eyleny Meisyah; Lubis, Fatmah Azzuhra
Jurnal Kedokteran Meditek Vol 31 No 5 (2025): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i5.3902

Abstract

Introduction: Drug reaction with eosinophilia and systemic symptoms syndrome or DReSS is a rare and life-threatening severe hypersensitivity reaction characterized by multiorgan involvement, with the liver as the common visceral manifestation. Approximately 10% of patients showed no changes in their eosinophil count. Sulfasalazine and non-steroidal anti-inflammatory drugs are frequently associated with DReSS. The diagnosis of this syndrome remains challenging due to the variety of clinical presentations. Case Illustration: We reported a 48-year-old woman who presented with pruritic generalized morbilliform eruption accompanied by facial edema and fever. Five weeks prior, she was treated with sulfasalazine and diclofenac sodium for spondyloarthritis. Her laboratory results showed elevated liver, suggesting drug-induced liver injury. DReSS syndrome was diagnosed by applying the European RegiSCAR. A favorable outcome and recovery of liver function are significantly seen after withdrawal of the suspected drugs, supportive treatment, and administration of systemic corticosteroid. Discussion: Sulfasalazine was one of the drugs frequently reported to cause DReSS syndrome. Liver involvement ranges from reversible elevation of liver function tests to hepatic necrosis. Withdrawal of causative drugs and administration of methylprednisolone were recommended, particularly for DReSS with liver involvement. Conclusions: DReSS syndrome can manifest with typical skin lesions and multiorgan involvement despite the absence of eosinophilia. The leading cause of mortality related to acute liver injury ranges from mild transaminase to acute liver failure. Prompt cessation of the culprit drug, immunosuppressive therapy, and a multidisciplinary approach might prevent further complications and mortality.
Severe Leptospirosis (Weil’s Disease) Complicated by Septic Shock: A Case Report Andrean, Melvin; Sasongko, Calvin; Nabil Mubtadi Falah
Jurnal Kedokteran Meditek Vol 31 No 5 (2025): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i5.3908

Abstract

Introduction: Weil’s disease is the severe manifestation of leptospirosis, characterized by multiorgan dysfunction and high mortality risk without timely diagnosis and treatment. Early clinical suspicion and prompt intervention are critical for favorable outcomes. Case Illustration: a 51-year-old male with fever, left leg myalgia, jaundice, hypotension, and tachycardia consistent with septic shock. Laboratory evaluation revealed leukocytosis, acute liver injury, and severe acute kidney injury. Additionally, chest imaging revealed bilateral pulmonary infiltrates. Initial management included fluid resuscitation, vasopressors, and broad-spectrum antibiotics. Leptospira IgM serology confirmed the presence of leptospirosis on day 2. Despite severe acute kidney injury, renal function improved without dialysis, and vasopressors were discontinued by day 3. The patient was discharged on day 11, having made a full recovery. Discussion: Severe leptospirosis can present with nonspecific symptoms and progress to septic shock and multiorgan dysfunction. In this case, the diagnosis was supported by IgM-ELISA and a history of exposure to floodwater. Early treatment with broad-spectrum antibiotics and supportive care led to a full recovery. Conclusion: This case highlights the uncommon presentation of septic shock as the dominant feature of Weil’s disease, together with rapid renal recovery without dialysis, underscoring the reversibility of multiorgan dysfunction when promptly managed.
Analysis of D-Dimer Levels Based on Histopathological Grading of Breast Cancer Devita, Yessi; Digambiro, Reza Aditya; Hastuty, Dewi
Jurnal Kedokteran Meditek Vol 31 No 6 (2025): November
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i6.3974

Abstract

Background: Breast cancer is the most common malignancy among women worldwide. Systemic activation of coagulation, reflected by elevated D-dimer levels, has been associated with advanced stage, metastasis, and poor prognosis in breast cancer. However, it remains unclear whether D-dimer also correlates with histopathological grade as an indicator of intrinsic tumor aggressiveness, particularly among patients with invasive breast cancer in Indonesia. Objective: To evaluate the association between plasma D-dimer levels and histopathological grading of invasive breast cancer. Methods: This cross-sectional study included 180 untreated female patients with primary invasive breast cancer, comprising 60 cases each of Grade I, Grade II, and Grade III tumors. Plasma D-dimer levels were measured using a latex-enhanced immunoturbidimetric assay, and histological grading was determined according to the Nottingham system. Data were analyzed using the Kruskal–Wallis test, ANOVA on log-transformed values, post-hoc tests, and ANCOVA with adjustment for age, body mass index (BMI), clinical stage, C-reactive protein (CRP), lymphovascular invasion, and molecular subtype. Receiver operating characteristic (ROC) analysis was performed to distinguish Grade III from lower grades. Results: Median D-dimer levels increased progressively from Grade I (501.7 ng/mL) to Grade II (831.0 ng/mL) and Grade III (1312.9 ng/mL), with a statistically significant overall difference (p < 0.001). ROC analysis for identifying Grade III yielded an AUC of 0.960 with an optimal cut-off of 965.5 ng/mL FEU (sensitivity 91.7%, specificity 90.0%). Conclusion: Plasma D-dimer levels are significantly associated with histopathological grade in invasive breast cancer, independent of potential confounders. These findings suggest that D-dimer testing may help identify patients with high-grade tumors at an early stage, thereby refining risk stratification, informing more intensive treatment planning, and raising vigilance for thromboembolic complications, particularly in resource-limited settings.. ctice.
Moyamoya Disease dan Neuromyelitis Optica: Sebuah Laporan Kasus Langka dengan Tantangan Diagnosis dan Tata Laksana Hardiati, Rahmi Hijriani; Kholida, Baiq Hilya Kholida; Arigi, Lalu Ahmad Gamal
Jurnal Kedokteran Meditek Vol 32 No 1 (2026): Januari
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i1.3769

Abstract

Introduction:  Moyamoya disease is a cause of stroke in young people with a low prevalence. Neuromyelitis optica (NMO) is also a rare disease with a low incidence.This combination of the two is extremely rare, making it an interesting case. This case report aims to report an incident of Moyamoya Disease that occurred together with Neuromyelitis optica (NMO). Case Illustration: A 37-year-old female patient presented with slurred speech, facial asymmetry, vertigo, blurred vision, and strabismus, all of which occurred suddenly. An MRI revealed partial stenosis of the right vertebral artery, right ACA, right and left MCA arteries, as well as total stenosis of the right and left ACA, right and left MCA arteries. White matter lesions were also found in the right frontal lobe, left parietal lobe, internal capsule, anterior commissure, pons, pontine tegmentum, mesencephalon, and substantia nigra. Hyperintensity lesions were also found in the spinal cord at levels C2-C6. CSF examination revealed a predominance of PMN cells. Based on the history and examination, the patient was diagnosed with Moyamoya Disease and NMO. Treatment consisted of several oral therapies, which showed improvement in complaints of limb weakness, but other complaints did not improve. After several days, the patient's condition worsened so IVIG was planned for treatments. Discussion: There are only three case reports documenting the occurrence of both diseases. The mechanism involved is antibodies, specifically anti-SSA, which contribute to the coexistence of NMO and moyamoya disease. Clinical implications, NMO make accelerating progression of moyamoya disease and leading to ischemic. Conclusion: The patient in this report was diagnosed with moyamoya and NMO. The coexistence of these two diseases necessitates a thorough examination and consideration of the coexistence of multiple diseases in patients with multiple neurological symptoms.
Perbandingan Kualitas Hidup Pasien Hemorhoid Sebelum dan Sesudah Laser Hemorrhoidopexy (LHP) di Rumah Sakit Sekunder Multisentra Jakarta Megatia, Ika
Jurnal Kedokteran Meditek Vol 32 No 1 (2026): Januari
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i1.3996

Abstract

Laser hemorrhoidopexy (LHP) is a minimally invasive technique increasingly used for hemorrhoid management. This retrospective cohort study evaluated changes in HEMO-FISS-QoL scores among patients with internal hemorrhoids, with or without external components, before and after LHP. Patients completed the questionnaire pre-procedure and at 2 and 6 weeks post-procedure. Data were analyzed using repeated measures ANOVA with Bonferroni post-hoc testing. A total of 69 patients were included, with a mean age of 40 ± 13 years; 42 (60.9%) were female. The total HEMO-FISS-QoL score significantly decreased from baseline to 2 and 6 weeks after treatment (60.83 ± 4.11 vs. 27.01 ± 3.03 vs. 8.27 ± 2.95; p < 0.001). Significant improvements were also seen across all domains from baseline to 6 weeks: physical discomfort (61.89 ± 7.21 vs. 9.25 ± 5.06; p < 0.001), psychological impact (52.43 ± 5.49 vs. 4.15 ± 3.44; p < 0.001), defecation (79.84 ± 11.29 vs. 12.68 ± 6.66; p < 0.001), and sexuality (59.60 ± 12.53 vs. 12.32 ± 8.97; p < 0.001). In conclusion, LHP significantly improved patients’ quality of life across physical, psychological, defecation, and sexual domains, highlighting its effectiveness as a minimally invasive treatment for hemorrhoids. Keywords Hemorrhoids, laser hemorrhoidoplasty, quality of life, HEMO-FISS-QoL

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