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Jurnal Kedokteran Meditek
Published by Universitas Kristen Krida Wacana
ISSN : 26861437     EISSN : 26860201     DOI : https://doi.org/10.36452/jkdoktmeditek
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Jurnal Kedokteran MEDITEK merupakan jurnal ilmiah yang mempublikasikan artikel-artikel dalam lingkup bidang kedokteran dan biomedik secara open access. Proses publikasi artikel melalui proses penelaahan oleh pakar sebidang (peer-review) secara double-blind. Jurnal Kedokteran Meditek berafiliasi pada Fakultas Kedokterandan Ilmu Kesehatan Universitas Kristen Krida Wacana, dengan misi mendorong penyebarluasan perkembangan ilmu kedokteran & biomedis di Indonesia maupun secara global dengan menerbitkan 3 edisi dalam setahun, yaitu: Januari, Mei dan September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 630 Documents
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Perbandingan Kualitas Hidup Pasien Hemorhoid Sebelum dan Sesudah Laser Hemorrhoidopexy (LHP) di Rumah Sakit Sekunder Multisentra Jakarta Megatia, Ika
Jurnal Kedokteran Meditek Vol 32 No 1 (2026): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i1.3996

Abstract

Laser hemorrhoidopexy (LHP) is a minimally invasive technique increasingly used for hemorrhoid management. This retrospective cohort study evaluated changes in HEMO-FISS-QoL scores among patients with internal hemorrhoids, with or without external components, before and after LHP. Patients completed the questionnaire pre-procedure and at 2 and 6 weeks post-procedure. Data were analyzed using repeated measures ANOVA with Bonferroni post-hoc testing. A total of 69 patients were included, with a mean age of 40 ± 13 years; 42 (60.9%) were female. The total HEMO-FISS-QoL score significantly decreased from baseline to 2 and 6 weeks after treatment (60.83 ± 4.11 vs. 27.01 ± 3.03 vs. 8.27 ± 2.95; p < 0.001). Significant improvements were also seen across all domains from baseline to 6 weeks: physical discomfort (61.89 ± 7.21 vs. 9.25 ± 5.06; p < 0.001), psychological impact (52.43 ± 5.49 vs. 4.15 ± 3.44; p < 0.001), defecation (79.84 ± 11.29 vs. 12.68 ± 6.66; p < 0.001), and sexuality (59.60 ± 12.53 vs. 12.32 ± 8.97; p < 0.001). In conclusion, LHP significantly improved patients’ quality of life across physical, psychological, defecation, and sexual domains, highlighting its effectiveness as a minimally invasive treatment for hemorrhoids. Keywords Hemorrhoids, laser hemorrhoidoplasty, quality of life, HEMO-FISS-QoL
Perbandingan Fungsi Ginjal dan Parameter Klinis pada Ibu Hamil Primipara dan Multipara dengan Preeklamsia Berat Banjarnahor , Dharma Putra; Siahaan, Salmon Charles Pardomuan Tua Siahaan; Idarto , Areta; Yuwono , Natalia; Suryadarma , Antonius Yansen
Jurnal Kedokteran Meditek Vol 32 No 1 (2026): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i1.4009

Abstract

Introduction: Repeated pregnancies (multiparity) can result in cumulative physiological changes that adversely affect maternal kidney function, notably through increased risk of recurrent preeclampsia, which may contribute to long-term renal impairment. This study provides a comparative analysis of kidney function parameters between primiparous and multiparous pregnant women, focusing on how glomerular filtration rate (GFR) relates to other clinical indicators. Since current data on how multiparity impacts renal function are limited, this research addresses that gap. Purpose: The study aims to compare renal function parameters in primiparous versus multiparous pregnant women and assess the direction and strength of associations between GFR and key clinical variables. Methods: This quantitative cross-sectional study involved primiparous and multiparous pregnant women (n = 100) during routine examinations at Hospital X between January 3 and July 2025. Clinical data included age, body weight, hemoglobin, leukocytes, blood urea nitrogen (BUN), serum creatinine (SCr), and GFR (estimated by the Cockcroft–Gault formula). Statistical analyses compared groups and used correlation coefficients to quantify the direction and strength of relationships between GFR and clinical variables. Results: Primiparous and multiparous groups differed significantly in age, body weight, SCr, and GFR (p < 0.05). Multiparous women were older and had higher SCr, while primiparous women had higher body weight and GFR. GFR showed a positive correlation with body weight (r > 0, p < 0.05) and a negative correlation with age and SCr (r < 0, p < 0.05). SCr positively correlated with both BUN and body weight (r > 0, p < 0.05). Conclusion: Multiparity is associated with modest declines in kidney function, reflected by higher SCr and lower GFR relative to primiparous women. These findings underscore the need for early assessment and ongoing renal monitoring in multiparous mothers to help prevent nephrological complications and optimize clinical care throughout pregnancy.
Peran Ultrasonografi (US) dalam Pemeriksaan Post-Mortem: Sebuah Studi Literatur Yen, Liauw Djai; Saputro, Alexandra Ambar; Suwito, Michelle Margaretha; Damanik, Eunike Marshya Easter; Hadiwinata, Evellyn; Anastasia, Cindy; Sinurat, Radinka Genevieve Theopilia
Jurnal Kedokteran Meditek Vol 32 No 1 (2026): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i1.4011

Abstract

Introduction: The global decline in autopsy rates has raised concerns about its consequences for education and research. Virtual autopsy offers a non-invasive alternative to conventional procedures, avoiding tissue destruction and gaining wider family acceptance. Ultrasonography (US) is widely available, relatively inexpensive, and has emerging potential in post-mortem evaluation. Purpose: To review the role of US as a post-mortem imaging modality as an alternative method to conventional autopsy. Methods: A literature search was conducted in PubMed, Google Scholar, and the Journal of Forensic Sciences for studies published between 2019 and 2025. Eligible designs included prospective diagnostic studies, case reports, systematic reviews, and descriptive observational research. Reported statistical analyses involved sensitivity and specificity calculations, logistic regression, diagnostic accuracy meta-analyses, and Fisher’s exact test (p<0.05). Results: With the advancement of technology, virtual autopsy can provide important information that helps determine the cause and manner of death. Early post-mortem US has been shown to identify aortic dissection, pericardial and pleural effusions, pneumothorax, deep vein thrombosis (DVT), and pulmonary embolism. In forensic practice, US is used as a complementary technique, reducing the need for extensive autopsy exploration and limiting biological exposure risks to forensic staff. Conclusion: Post-mortem US is a practical and effective tool for detecting pathological findings, particularly in resource-limited settings or when infection risk is high. However, its diagnostic performance is constrained by gas artifacts, tissue cooling, and limited access to internal organs. Further research is needed to standardize techniques and validate diagnostic accuracy.
Hubungan Kecacingan dan Status Gizi Balita Usia 2-5 Tahun di Beberapa Posyandu di Wilayah Kebon Jeruk, Kota Jakarta Barat Sari, Monica Puspa; Susilowati, Rina Priastini; Tekege, Maryana Yenieke; Makatita, Cindy Pricillia Vika Vebriza
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): MARET
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.3925

Abstract

Introduction: Soil-transmitted helminth (STH) infections are a global health problem, especially among young children in developing countries. These infections affect children's nutritional status through various mechanisms, such as impaired nutrient absorption and chronic blood loss.  Purpose: This study aims to analyze the relationship between STH infection and the nutritional status of children aged 2–5 years at several integrated Posts in the Kebon Jeruk subdistrict of West Jakarta. Method: This study used an analytic descriptive design with a cross-sectional design.  A total of 153 toddlers were selected through a total sampling technique from six health posts. Worm infestation status was determined through stool examination using the Kato-Katz method. Nutritional status was assessed using three anthropometric indicators: weight for age, height for age and weight for height based on the World Health Organization Child Growth Standards. Data analysis was performed using the Fisher test.  Results: The prevalence of worm infection in toddlers was 5,2%. Ascaris lumbricoides was the most common cause, with mild infection rates. Based on nutritional status, most toddlers infected with STH had normal weight for age, normal height for age, and good nutritional weight for height. There was no significant relationship between STH infections and nutritional status (p>0.05). Conclusion: The prevalence of STH infections in toddlers in the study was quite low. There was no significant association between STH infections and nutritional status in toddlers.  Continuous prevention and control interventions for worm infection, along with routine monitoring of nutritional status, are needed to ensure worm-free status.  
Efek Ekstrak Etanol Kulit Batang Rhizophora apiculata terhadap Kadar Kolesterol Total Darah pada Rattus norvegicus Jantan yang Diinduksi Deksametason Iswara, Karisma Kasih; Andisari, Hendrata Erry; Handajani, Fitri; Puspita, Angela
Jurnal Kedokteran Meditek Vol 31 No 6 (2025): NOVEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i6.3533

Abstract

Introduction: Hyperlipidemia is an increase in blood lipid levels above normal limits, potentially leading to atherosclerosis and cardiovascular disease. Rhizophora apiculata contains flavonoids that have the potential to lower total blood cholesterol levels. Research on the hypolipidemic effects of R. apiculata is still limited, particularly in dexamethasone-induced animal models. Therefore, this study provides a new contribution to the use of mangrove biota as natural antihyperlipidemic agents. Purpose: This study aims to determine the effect of administering Rhizophora apiculata extract on total blood cholesterol levels in dexamethasone-induced Rattus norvegicus. Methods: This experimental study used a post-test only control group design with 40 male rats divided into four groups: negative control (K–), positive control (K+; induced by dexamethasone at 5 mg/kg BW for 7 days), prophylaxis group (KP; given R. apiculata extract at 56 mg/kg BW from day 8 until the end and induced by dexamethasone like K+), and therapy group (KT; given the extract simultaneously with dexamethasone induction). After treatment, total cholesterol levels were measured from intracardially drawn blood. Results: One-way ANOVA analysis showed a significant difference between groups (p < 0.001). However, post-hoc tests showed no significant difference between the positive control group and the prophylaxis (p = 0.435) or therapy (p = 0.397) groups. Conclusion: Although administration of Rhizophora apiculata extract as prophylaxis or therapy did not significantly reduce total cholesterol levels in dexamethasone-induced Rattus norvegicus, these findings suggest that further research is necessary to elucidate the mechanisms and potential efficacy of R. apiculata active compounds as natural antihyperlipidemic agents. Future studies should consider exploring different dosages, modes of administration, or alternative experimental models to better determine the therapeutic potential of this mangrove extract.
Analisis Perbandingan Sistem Investigasi Kematian Pediatri di Berbagai Negara Liauw, Djai Yen; Tantra, Deven Aleron; Koesuma, Freddie Wijaya; Grace; Budiono, Jolene; Putri, Lidwina Nadia Adinda; Wijaya, Stephanie Jeanne; Sharon, Sonya Hedva; Valerie; Silitonga, Virnalisi Lestari Romauli; Palarogo, Yosua Dima Agung
Jurnal Kedokteran Meditek Vol 32 No 1 (2026): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i1.3669

Abstract

Introduction: Sudden infant death is a medical and legal issue that requires investigation involving relevant institutions. In various countries, differences in standards, resources, and systems pose challenges. Purpose: To examine the systems and methods of investigating sudden child deaths for the prevention of pediatric mortality. Methods: Databases searched included Google Search, PubMed, and Google Scholar for studies published up to 2024. The analysis applied keywords such as ‘pediatrics,’ ‘death,’ ‘investigation,’ ‘guidelines,’ and ‘system. Results: In Indonesia, the pediatric death investigation system is handled by the Ministry of Health and the Indonesian Police; however, there are limitations, including a shortage of forensic personnel and inadequate autopsy facilities. In contrast, developed countries have stricter regulations and better documentation systems. Several institutions have worked to establish international standards for child death investigations through the Inter-agency Guidelines on Child Death Review. These guidelines are essential to standardize the investigation system and create systematic reporting to prevent pediatric deaths. Conclusion: Despite standardization efforts, investigation systems remain varied between countries, depending on conditions and resources. To improve the system in Indonesia, enhanced forensic personnel and a digitalized reporting system are needed.m
Paradoxical Reaction in Tuberculous Meningitis and Tuberculoma: Diagnostic Challenges Following Incomplete Treatment Situmeang, Rocksy Fransisca V; Gabriella, Nadia
Jurnal Kedokteran Meditek Vol 31 No 6 (2025): NOVEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i6.3856

Abstract

Introduction: Exacerbation of clinical or radiological findings in tuberculous meningitis (TBM) may result from a paradoxical reaction (PR), an immune-mediated response occurring in 6–30% of cases during or after anti-tuberculosis treatment (ATT). This case highlights the potential for PR to occur in the context of an incomplete ATT regimen. Case Illustration: A 20-year-old female presented with a 1-month history of headache, fever, double vision, nuchal rigidity, and bilateral abducens palsy. Cerebrospinal fluid analysis revealed pleocytosis and elevated protein, while brain MRI demonstrated leptomeningeal enhancement with multiple tuberculomas. She received standard ATT (RHZE), but discontinued therapy before completion due to symptom resolution and medication burden. One year later, she developed altered sensorium and behavioral changes; MRI showed new tuberculomas with edema despite negative serology. A diagnosis of PR was made, and high-dose intravenous corticosteroids were administered, resulting in clinical and radiological improvement. Discussion: PR remains a diagnostic challenge, often mistaken for microbiological relapse, drug resistance, or treatment failure. It arises from a distinct immune response to mycobacterial antigens, distinguishing it from relapse or drug resistance. Conclusion: Clinicians should suspect PR in worsening TBM cases, even in the setting of incomplete ATT, to prevent misdiagnosis and initiate prompt treatment.  
Comparison of Motoric Block Duration between 0.5% Hyperbaric Bupivacaine and 0.5% Levobupivacaine Cesarean Section Tanpomas, Irvan; Valentia, Clara; Suparto, Suparto; Wijaya, Monique Asby
Jurnal Kedokteran Meditek Vol 31 No 6 (2025): NOVEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i6.4022

Abstract

Introduction:The choice of anesthesia regimen affected each patient's recovery. Hyperbaric bupivacaine, a racemic mixture of S- and R-enantiomers, was more commonly used, while isobaric levobupivacaine, the S-enantiomer of bupivacaine, had fewer side effects. The anesthetic regimen chosen will determine postoperative recovery outcomes. Several studies have shown that the use of isobaric levobupivacaine accelerated postoperative motor recovery. Objectives: This study aims to compare the duration of motoric block from hyperbaric bupivacaine and isobaric levobupivacaine in pregnant women undergoing cesarean section with spinal anesthesia procedures. Methods: This quantitative analytical study was conducted on 52 cesarean section patients with spinal anesthesia procedures at Ukrida Hospital in 2024. The sample was randomly and equally divided into two groups, namely the Isobaric Levobupivacaine (IL) group of 26 people and the Hyperbaric Bupivacaine (HB) group of 26 people. Then the duration of motoric block will be assessed using the Bromage scale and observed every 30 minutes postoperatively until the patient reaches a Bromage score of 0 (can elevate the lower extremity). Results: The duration of motoric block was longer in the HB group than in the IL group (231.35 ± 16.944 versus 204.50 ± 38.472 minutes), with a significant difference (p < 0.001). Conclusion: Using the same technique and dosage, isobaric levobupivacaine with fentanyl offers faster relief of motoric block than hyperbaric bupivacaine with fentanyl.
Effect of Kawa Gambir (Uncaria gambir Roxb.) Leaves on Serum LDL in Diabetic Model Rats Siregar, Muhammad Abi Ghoffari; Rita, Rauza Sukma; Reza, Mohamad; Ali, Hirowati; Rofinda, Zelly Dia; Welan, Rahmani
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): MARET
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.4012

Abstract

Background: Kawa gambir leaves, dried in a furnace and brewed as tea, are rich in flavonoids, phenolics, steroids, and tannins and have antioxidant, antihyperglycemic, and antidyslipidemic properties. In diabetes, elevated low-density lipoprotein (LDL) is a dyslipidemic abnormality that increases atherogenic risk. However, the effect of Kawa gambir on LDL in diabetic conditions remains unclear. Objective: To evaluate the effect of Kawa gambir leaf administration on LDL in alloxan-induced diabetic rats. Methods: This experimental study used a post-test-only control group design in 36 Wistar rats randomized into six groups: K−, K+, MET, P1, P2, and P3. Diabetes was induced with alloxan in K+, MET, and P1–P3. MET received metformin, whereas P1, P2, and P3 received Kawa gambir infusions at 1, 2, and 4 g/100 mL once daily for 4 weeks. Serum LDL was estimated using the Friedewald formula. Data were analyzed by one-way ANOVA followed by Least Significant Difference post hoc testing. Results: Mean±SD LDL levels (mg/dL) were 37.16±3.03, 59.90±8.91, 41.30±6.74, 40.60±5.75, 38.95±10.15, and 40.33±7.01 in K−, K+, MET, P1, P2, and P3, respectively. Group differences were significant (p=0.001). The largest numerical reduction versus K+ was found in P2, with a difference of 20.95 mg/dL (95% CI 8.64–33.26). Conclusion: Kawa gambir infusion significantly reduced LDL compared with the untreated diabetic control. Although the 2 g/100 mL group showed the lowest LDL numerically, no significant differences were observed among active treatment groups. These findings support Kawa gambir as an antidyslipidemic agent in diabetic dyslipidemia.
Hubungan Penggunaan Kontrasepsi Hormonal Dengan Kejadian Preeklampsia Di RSUP Persahabatan Junnata, Agung; Marliany, Lily; Pudyastuti, Sri
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): MARET
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.4120

Abstract

Introduction: Preeclampsia is one of the leading causes of maternal morbidity and mortality in Indonesia. Several studies have reported that hormonal contraception may affect blood pressure and vascular function, thereby potentially contributing to the development of preeclampsia. However, the available evidence remains inconsistent. Purpose: This study aimed to determine the association between maternal age, parity, and history of contraceptive use, particularly hormonal contraception, and the occurrence of preeclampsia among pregnant women. Methods: This study employed an observational analytic design with a cross-sectional approach using secondary data from the medical records of pregnant women at RSUP Persahabatan Jakarta during May–July 2025. A total of 138 respondents were selected using a simple random sampling technique. Univariate analysis was conducted to describe subject characteristics, while bivariate analysis was performed using the Chi-square test or Fisher’s exact test, with a significance level of (p < 0.05.) Results: The prevalence of preeclampsia was 10.87%. There was a significant association between maternal age and the occurrence of preeclampsia (p < 0.001), as well as between parity and preeclampsia (p = 0.049). A history of contraceptive use was also significantly associated with preeclampsia (p = 0.014). However, no significant association was found between the type of contraception (hormonal vs non-hormonal) or the duration of hormonal contraceptive use and preeclampsia. Conclusion: Maternal age, parity, and history of contraceptive use were associated with preeclampsia. However, the type and duration of hormonal contraceptive use were not shown to increase the risk of preeclampsia in this study population.

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