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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 339 Documents
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Pengaruh Ekstrak Kulit Pisang Kepok (Musa Paradisiaca L.) Sebagai Antidepresan Pada Mencit (Mus Musculus) Dengan Acute Restraint Stress Dhea Safitri Ramadhani; Maftuchah Rochmanti; Erika Vitri Yulianti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 3 (2024): May : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i3.435

Abstract

Introduction: Banana peel is an organic waste which is known to have various benefits, especially as an antidepressant for mental health. It inspired to conduct a research on various type of banana peels in Indonesia, particularly on Kepok banana which has been widely studied. This research aimed to prove the effect of Kepok banana peel extract (Musa paradisiaca L.) as an antidepressant in mice (Mus musculus) with acute restraint stress.Method: This research used a laboratory experimental design. The male mice were acclimatized for 3 days. Twenty-four mice were then divided evenly into 4 groups. The first group was given banana peel extract (Musa paradisiaca L.) at a dose of 200 mg / kgBW, the second group was given a dose of 400 mg / kgBB, the third group was given a dose of 800 mg / kgBW and the fourth group was given water as control. Each group was given a dose orally for 14 days and ARS depressed induction for 7 hours. Subsequently, mice were treated to assess depression behavior using the tail suspension test (TST) and forced-swim test (FST) to determine the duration of immobility.Result: The result showed that there was a significant difference (p<0.01) between the control group and the experimental group, at TST there was a significant difference (p<0.01) between two doses of 400 mg / kgBW and 800 mg / kgBW, as well as on the forced-swim test (FST). In addition, there was a significant difference (p<0.01) between two doses of 200 mg / kgBW and 800 mg / kgBW, and between two doses of 400 mg / kgBW and 800 mg / kgBW. Conclusion: These result confirmed that Kepok banana peel extract (Musa paradisiaca L.) was an effective antidepressant in reducing immobility duration with acute restraint stress.
Linking Patient Safety Culture, Job Satisfaction, And Nursing Care Quality: Evidence From Private Hospitals Asroriyah Zulia Khozanah; Irviana Fitriyati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.447

Abstract

Patient safety and nursing care quality are two crucial aspects of healthcare delivery. Todays, ensuring a robust patient safety culture is fundamental to achieving high standards in nursing care. This present study aims to investigate the relationship between patient safety culture and nursing care quality. In addition, job satisfaction assessed as mediating variable. Using convenience sampling technique, a total of 236 nurse participated in the survey during February until April 2024. The respondents are nurses who works in private hospital, located in Tangerang. SPSS 26 is employed as a statistical tool to assess path analysis. The result showed that patient safety culture has a positive influence on nursing care quality. Patient safety culture also shares positive effect on nurse’s job satisfaction. In addition, based on the sable test result, job satisfaction significantly mediates the connection between patent safety culture and nursing care quality. These findings suggest that enhancing patient safety culture not only improves the quality of nursing care but also boosts nurses’ job satisfaction. Therefore, interventions aimed at strengthening patient safety culture can provide dual benefits in improving healthcare outcomes.
Pengaruh Variasi Konsentrasi Manitol-Sukrosa Sebagai Bahan Pengisi Pada Formulasi Tablet Hisap Terhadap Sifat Fisik Sediaan Salsabilla Dhiya Atik Nuraini; Fitria Ayu Kusumaningtyas; Rahma Dwi Novitasari; Abdullah Syafiq Ahmadi; Nandiyyah Atikah; Shabrina Putri Arianti; Dewi Rahmawati; Yani Ambari
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.451

Abstract

This article discusses the effect of variations in the concentration of mannitol-sucrose as a filler in the formulation of antioxidant lozenges from various plant extracts on the physical properties of the preparation. Lozenges are preparations that can contain active substances with additional ingredients and sweeteners that dissolve in the mouth. The use of mannitol and sucrose as additional ingredients in lozenges provides advantages such as sweet taste and ease of use. The aim of this study is to find the optimal ratio between mannitol and sucrose to obtain good physical properties of lozenges. The research method used is a literature review article (LRA) by accessing information sources from databases such as Google Scholar and PubMed. The results showed that variations in mannitol-sucrose concentration affected the physical properties of lozenges, such as weight uniformity, hardness, friability, and tablet disintegration time. Thus, choosing the right ratio between mannitol and sucrose is important to produce quality lozenges.
Gambaran Self Regulated Learning Pada Mahasiswa yang Telah Menyelesaikan Skripsi Diana Anindita; Afifah Rahmania; Dewi Khurun Aini
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.472

Abstract

This research aims to determine the description of self-regulated learning that has completed its thesis. The approach used is a qualitative approach with a narrative biography research type. The subjects in this research are the subjects in this research who are participants based on predetermined criteria. The data collection technique used in this research was a semi-structured interview technique. Based on the research results, the picture of self-regulated learning for those who have completed their thesis is reflected in several factors (1) the ability to manage time (2) managing stress and maintaining motivation are important factors in completing the thesis. (3) social support from parents, supervisors and the surrounding environment also plays an important role in motivating students to complete their thesis.
Uji Aktivitas Antibakteri Ekstrak dan Fraksi n-Heksan, Etil Asetat, Air Kulit Buah Naga Putih (Hylocereus Undatus) Terhadap Staphylococcus Epidermidis ATCC 12238 Muhammad Abdul Azis; Tatiana Siska Wardani; Anna Fitriawati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.478

Abstract

Research on the antibacterial test of dragon fruit peel extract carried out by Anggraini & Harris (2017) shows that white dragon fruit extract is able to inhibit the growth of epidermal Staphylococcus bacteria with the lowest concentration, namely 25%, producing an average diameter of the inhibition zone of 13.7 mm, while for the highest concentration, namely 100%, it produces an average diameter of the inhibition zone of 17.7 mm. To determine the more effective antibacterial effect of white dragon fruit peel extract, the research continued to the fractionation stage to separate compounds based on polarity level. The solvents used are water which is a polar solvent, ethyl acetate which is a semi-polar solvent, and n-hexane which is a nonpolar solvent (Yohanes, 2020). Based on the description above, researchers are interested in conducting research on testing the antibacterial activity of ethanol extract and n-hexane fraction of white dragon fruit peel (Hylocereus undatus) against Staphylococcus epidermidis bacteria.
Synthesis and anticancer activity of new heterocyclic derived from diaryl β-lactam supported by molecular docking and toxicity LD50 Mohammed Fadhil Hassan; Duaa Qassim kamil; Thaer khazaal makki; Muqdad Irhaeem Kadhim; Hussein Ali Kadhim Kyhoiesh
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.481

Abstract

A novel compound called 3-chloro-4-(4-(dimethylamino)phenyl)-1-(6-methoxybenzo[d]thiazol-2-yl)azetidin-2-one (3-CDBA), derived from beta-lactams, was investigated for its effects on human leukemia (HL-60) cells, pancreatic cancer (TCP-1026) cells, and healthy cells (WRL68) for comparison. The compound showed an inhibitory concentration (IC50) of 91.55 µg/ml on the leukemia cells, 141.3 µg/ml on the pancreatic cancer cells, and 353.8 µg/ml on the healthy cells. This indicates that the compound selectively kills cancer cells while having minimal effect on healthy cells, as higher concentrations are required to kill half of the healthy cells. These findings suggest that the compound has the potential to inhibit the growth of cancer cells. In comparison to conventional antioxidants like ascorbic acid (vitamin C), the beta-lactam derivative (3-CDBA) exhibited a higher percentage of inhibition at the highest concentration, with a value of 72.95% and an IC50 of 42.67 µg/ml. Furthermore, the compound's effects were studied on two types of pathogenic bacteria, specifically Staphylococcus aureus (positive) and Escherichia coli (negative), as well as various Penicillium species. The compound showed the greatest inhibitory effect at a concentration of 1000 µg/ml. In a theoretical examination, molecular docking was employed to design and synthesize a drug using the beta-lactam derivative and a target associated with cancer cells from a protein database. The compound demonstrated a strong and close interaction with amino acids and different sites within the active pocket, resulting in a higher binding energy. This indicates that the compound has the potential to inhibit the growth of cancer cells by disrupting their metabolic processes. To determine the lethal dose (LD50), the beta-lactam derivative (3-CDBA) was administered to half of the animals in the study.
Evaluasi Kritis Terhadap Peran Bhabinkamtibmas Dalam Mengatasi Penyalahgunaan Narkoba Di Kalangan Remaja Chardelia Penggalih; Cinta Perindu; Shella Amalia Khakim
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.493

Abstract

The issue of drug abuse among adolescents has become a significant concern worldwide. This study aims to explore the application of police psychology theories in understanding and addressing the behavior of drug use among adolescents. Through a comprehensive literature review, various psychological theories and approaches are examined to provide insights into the underlying factors contributing to drug use behavior in adolescents. The study analyzes the role of psychological factors, such as personality traits, emotional and cognitive processes, social influences, and environmental factors, in shaping drug use behavior. Additionally, the study discusses the implications of these theories for law enforcement strategies, prevention programs, and rehabilitation efforts targeting adolescent drug users. By integrating psychological perspectives with policing practices, this research aims to contribute to the development of more effective and evidence-based approaches in combating drug abuse among adolescents.
Studi Kasus Penerapan Senam Ergonomis Pada Penderita Hipertensi Di Puskesmas Mamburungan Kota Tarakan Renna Youfristiya Sari; Donny Tri Wahyudi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.512

Abstract

Ergonomic exercises can lower blood pressure by restoring the elasticity of blood vessels and improving blood flow. The research method used was a case study involving 2 different respondents. The aim of this research is to analyze the effectiveness of applying ergonomic exercises to reduce blood pressure in hypertensive clients. This type of research is descriptive in the form of a case study. The subjects in this study were two individuals with the same case in two different families with hypertension. Those who were given the same treatment where blood pressure was measured pre and post doing ergonomic exercises. The implementation was carried out 3 times a week for a duration of 30 minutes. The results of the study showed that the blood pressure of the respondents experienced a decrease in blood pressure in systole 14-37 MmHg and diastole 4-15 MmHg. The application of ergonomic exercises is effective in reducing blood pressure in hypertension sufferers.
DNA Sequencing And Phylogenic Tree Analysis Of 16S Rrna And Bla-Oxa-50 Genes Of Carbapenem Resistant Pseudomonas Aeruginosa In Diwanyah City/ Iraq Ali Sabri Jabbar; Ahmed Majeed Abdzaid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.516

Abstract

Pseudomonas aeruginosa is a major nosocomial pathogen known for its multidrug resistance, including carbapenems. This study aimed to investigate the prevalence of carbapenem resistance in P. aeruginosa of clinical sources and sequencing of 16S rRNA and blaOXA-50 genes Methods: A total of 53 P. aeruginosa isolates from burn, wound, urinary tract, and ear infections were analyzed. Antibiotic susceptibility testing identified carbapenem-resistant isolates. Polymerase Chain Reaction (PCR) detected 16S rRNA and blaOXA-50 genes, followed by DNA sequencing and phylogenetic analysis of 16S rRNA. Results: Among the isolates, 20 (37.73%) originated from wounds, 16 (30.19%) from burns, 10 (18.9%) from urinary tracts, and 7 (13.20%) from ears. Notably, 12 isolates (22.64%) exhibited carbapenem resistance. All carbapenem-resistant isolates harbored both 16S rRNA and blaOXA-50 genes. 16S rRNA sequencing demonstrated 99.66% homology to known P. aeruginosa strains, further confirmed by phylogenetic analysis. The blaOXA-50 gene displayed high sequence identity (98%-100%) with isolates from Russia, suggesting a potential clonal relationship. Conclusion: A moderate prevalence of carbapenem-resistant P. aeruginosa was revealed by this study and based on 16S rRNA and blaOXA-50 genes sequencing, these strains offered a high genetic similarity compared to the global strains. Further investigation is required to determine the role of blaOXA-50 carbapenem resistance in this bacterium.
Pengelolaan Klien dengan Diare Disertai Dehidrasi Berbasis Evidence Nursing di Ruang Dahlia RS Murni Teguh Sudirman Risma Tio Siahaan; Dior Manta Tambunan
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.519

Abstract

Diarrhea is a disease with signs of changes in the shape and consistency of soft or liquid stools and an increase in the frequency of defecation more than 5 times while for infants the frequency is more than 3 times. The existence of this study determines the effect of zinc administration on reducing the frequency of liquid stools and dehydration in children. With the design method or design in this study is to use a case study. Case study is one type of qualitative method in research that wants to explore a particular case in more depth by involving the collection of various sources of information.

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