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Mohammad Rizki Fadhil Pratama
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Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya Building B 1st Floor, RTA Milono St. Km.1,5. Palangka Raya 73111, INDONESIA
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 11 Documents
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Search results for , issue "Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy" : 11 Documents clear
Formulation and Evaluation of Nanoemulsion Kelakai (Stenochlaena palustris) Herbs with Composition of Smix (Tween 80 and Glycerin) and Pine Oil Helsawati, Helsawati; Ratnapuri, Prima Happy; Fitriana, Mia
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.3817

Abstract

Kelakai (Stenochlaena palustris) herb is a typical South Kalimantan plant containing bioactive substances that can serve as antioxidants. It can be formulated into nanoemulsions to increase bioavailability in the skin. This study aimed to determine the ratio of pine oil and Smix (tween 80 and glycerin) as the optimal base for nanoemulsion based on the highest percent transmittance and to determine the physical characteristics of the S. palustris herb extract nanoemulsion with variations in the amount of extract. Bases of nanoemulsion formula were optimized using a ternary phase diagram and D-Optimal Mixture Design. Nanoemulsion contained three extract concentrations: 0.1; 0.25; and 0.5%, respectively, and nanoemulsion was tested for physical characteristics. The results of this study were a light yellow to light brown, clear, and transparent, with a characteristic weak-strong odor, forming an O/W nanoemulsion. Increasing the concentration of the extract significantly increased the viscosity and decreased the pH and percent transmittance. This study concluded that variations in extract concentration affected the percent transmittance, organoleptic, pH, viscosity, and the optimal ratio of nanoemulsion components was 1% pine oil, 9% Smix, and 90% water.
Iron-Overload Conditions: Manifestations to the Kidney Organs – A Review Heriatmo, Nadia Larasinta; Estuningtyas, Ari; Soetikno, Vivian
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4411

Abstract

Excess iron is a risk factor for organ dysfunction and damage resulting in various organ diseases such as liver, heart, and kidney, diabetes mellitus, and neurodegenerative diseases. Iron overload in some individuals is caused by various factors, including genetic predisposition such as genetic hemochromatosis, repeated transfusion of red blood cells, and parenteral iron administration in conditions of transfusion-dependent anemia. A disturbance in the globin gene in diseases such as β-thalassemia major causes an imbalance of the globin chain, resulting in chronic anemia in the sufferer. It has been reported that the human body does not have a mechanism for eliminating excess iron levels. Routine transfusion has become a solution to overcome chronic anemia so that patients can maintain hemoglobin levels, and the result of this transfusion repetition is the accumulation of iron in various organs, such as the heart, liver, endocrine glands, pancreas, lungs, and kidneys. Excess iron can be toxic to the body due to the formation of harmful free radicals that can damage cells and tissues. An increase in excessive ROS can result in the saturation of the antioxidant system. The presence of free radicals can lead to damage and the occurrence of filtration dysfunction in the glomerulus.
Morphology Analysis of Hair Photoinduced and Chemical Damaged After Treatment with Sappan Wood (Caesalpinia sappan L.) Hair Tonic using SEM Sari, Dina Yuspita; Widyasari, Ratna; Astuti, Indri
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4652

Abstract

Exposure to sunlight for a long time and repeatedly can also cause chemical and physical damage to human hair. Clinically, microscopic analysis using a scanning electron microscope (SEM) can assess hair damage by identifying the characteristic morphology of hair damage. This study aims to analyze the morphology of damaged hair chemically induced using 3% H2O2 and photoinduced UVB radiation before and after applying sappan wood (Caesalpinia sappan) hair tonic. The active ingredients used were ethanol extract, ethanol fraction, and chloroform-methanol fraction of C. sappan, which contains an antioxidant compound. Caesalpinia sappan simplicia was macerated using 96% ethanol and then partitioned using n-hexane. The ethanol fraction was then applied using vacuum column chromatography using chloroform : methanol (5 : 1) as eluent. The extracts and fractions were then formulated into hair tonic preparations. For SEM analysis, hair samples were coated with a sputter gold coater machine and divided into five treatments: undamaged hair, damaged hair with 3% H2O2 and UVB rays as a positive control, and treatment I, II, and III, in which the hair was damaged with 3% H2O2 and UVB rays respectively, then FI, FII, and FIII were applied, respectively (2000x magnification). Damaged hair with UVB induction shows moderate damage, and 3% H2O2 shows moderate to severe damage. The results in the treatment group show that the three hair tonics coated the hair cuticle, indicating an interaction with the hair fiber, and modified the cuticle by coating the cuticle.
Anti-Rheumatoid Arthritis Activity of 96% Ethanol Extract of Eleutherine bulbosa Bulbs with Arthritis Induction Adjuvant Method Muthia, Rahmi; Wati, Helmina; Jamaludin, Wahyudin Bin; Kartini, Kartini; Setiawan, Finna; Zanirah, Gina Rizki
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4704

Abstract

An autoimmune condition known as rheumatoid arthritis (RA) results in chronic joint inflammation. Side effects that occur during long-term RA treatment are dangerous. Therefore, many people prefer herbal medicines, estimated to have lower side effects; one such herb is bawang dayak (Eleutherine bulbosa Urb.) bulbs. This study aimed to determine the class of compounds and the effective dose of the 96% ethanol extract of E. bulbosa bulbs, which had an anti-RA effect in the Wistar strain with the Adjuvant Induced Arthritis (AIA) model. Eleutherine bulbosa bulb extract was macerated with 96% ethanol. In the tests with extract doses of 100, 200, and 400 mg/KgBW and methylprednisolone 15 mg/KgBW, the induction used Complete Freund's Adjuvant (CFA). Treatment was provided from day eight through 21 of the test's 21-day duration. Phytochemical screening results contain alkaloids, flavonoids, phenols, quinones, saponins, steroids, and tannins. The percentage inhibition of edema volume and joint thickness, respectively, extract doses of 100, 200, 400 mg/KgBW, and methylprednisolone 15 mg/KgBW were 27.9585%, 49.3446%, 53.3239%, and 58.4629%; as well as 64.9809%, 73.8022%, 74.1444%, and 74.1825%. After analyzing the results, it was determined that E. bulbosa bulb extracts in 96% ethanol can treat RA at effective 200 and 400 mg/KgBW (p-value <0.05).
Bioavailability and Antihyperglycemic Effect of Four Glibenclamide Tablets: A Comparative Study Abdelkarim, Abdelkarim M.; Oshi, Murtada A.
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4820

Abstract

This study compared the bioavailability and antihyperglycemic effect of 5 mg glibenclamide tablets available in Sudan. Nine healthy subjects were given a 5 mg dose of either micronized glibenclamide tablets (Euglucon®) or conventional non-micronized glibenclamide tablets (locally manufactured items). Blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 7, and 8 hours and analyzed for glucose concentrations. The maximum mean serum concentration of the drug (Cmax) and the mean time to maximum serum concentration (Tmax) were calculated, and the area under the concentration versus time curve (AUC) and the drug clearance (Cl) were also recorded. The mean glucose concentration was also determined in different time intervals. The results show no significant difference in the mean Tmax between the tested items. However, the mean Cmax is significantly higher (p 0.001) when the non-micronized tablets are taken (456 ng/mL) rather than the micronized tablets (291 ng/mL). Similarly, the mean AUC0-8h is significantly higher (p 0.001) with the non-micronized tablets (1915 ng/mL.h) than with the micronized tablets (1163 ng/mL.h). After 8 hours, the subjects in the micronized group had a drug clearance of 0.0430 L/Kg.h, and a clearance of 0.0260 L/Kg.h was recorded in the unmicronized group. Both tablets lower the mean glucose concentrations of the nine volunteers after 8 hours, 99 mg/dL for micronized tablets and 98 mg/dL for non-micronized tablets. Overall, the non-micronized glibenclamide tablet used in this study similarly lowered the glucose concentrations in healthy volunteer subjects to that of imported micronized glibenclamide tablets.
Evaluation of Antibiotic Planning in the UNS Hospital Pharmacy Installation in 2021 Zulpadly, Muhammad Fiqri; Syarofina, Nisa’
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4944

Abstract

Planning is a drug selection activity in determining the type and amount of drug to increase efficiency, periodic and rational use of drugs, as well as obtaining an estimate of the amount of drug needed. Antibiotics are drugs that are often used and absorb many funds, so effective planning needs to be done so that inventory can be under control. This study aims to obtain a drug classification for antibiotics with the ABC analysis method to facilitate the control of antibiotic drugs in the Hospital Pharmacy Installation UNS. This research includes non-experimental research with descriptive analysis using quantitative and qualitative data. Quantitative data was obtained from prescriptions containing antibiotic drugs during 2021, and qualitative data regarding planning processes and systems procurement of drugs was obtained based on interviews with the Hospital Pharmacy Installation UNS warehouse coordinator. In this study, the results obtained were that of 100 drug items antibiotics, class A consists of three drug items (22.2%), class B consists of 10 drug items (22.47%), and class C consists of 57 drug items (55.33%). Class A has a planned budget proportion of IDR 413,106,692 (66.73%) of the total budget: IDR 619,100,298; Class B has a planned budget proportion of IDR 140,848,487 (22.75%); Class C has a planned budget proportion of IDR 65,145,119 (10.52%). Using the ABC method can simplify planning and procuring drugs and affect the proportion of the budget for drug procurement in hospitals.
The Potential of Natural Based-Skincare Cosmetic Ingredients for Naturally Glowing Skin Oktaviani, Dede Jihan; Susilawati, Yasmiwar; Tjitraresmi, Ami; Zuhrotun, Ade
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5013

Abstract

The use of skincare products is the primary need in modern society. There is an increase in awareness of maintaining beauty and healthy skin, as well as the desire to have naturally glowing, healthy skin, which is in line with the rise in the use of cosmetics, especially skincare products. Nature provides many plants and marine resources (such as algae) that can be utilized as essential ingredients for cosmetics preparations with various benefits such as cleansers, toners, moisturizers, and sun protectors, a primary series of skincare products to gain naturally glowing, healthy skin. This review aims to provide information about plants and marine algae that can be used as skincare ingredients, their phytochemical contents, and their function in cosmetics to achieve naturally glowing skin. Various plants and marine algae categorized based on their benefits as skincare have great potential to be developed as ingredients in cosmetic preparations. The content of phytochemical compounds in these plants and marine algae supports these benefits. Each skincare category has major phytochemical compounds that play a role in providing these benefits.
Diuretic Activity of Various Herbs in India: A Mini Review Shaikh, Sufiyan Yusuf; Shaikh, Aftab Tanveer; Shaikh, Moinuddin Arif
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5217

Abstract

One of the primary uses of medicinal plants is as a diuretic. Both mono- and polyherbal-based diuretic formulations have been used in various parts of the world, including in India. One estimate states that more than 650 mono- and polyherbal formulations are in clinical use, including decoctions, tinctures, pills, and capsules made from over 75 plants. Many studies have been conducted supporting the diuretic properties of conventional herbal remedies. This article discusses many herbal plants from India that have historically been used as diuretics and identifies the chemical components with diuretic activity. In addition, this brief review also discusses several plant drugs and their pharmacological profile, concentrating on the administered dose and the bioactive extracts involved in the diuresis process. For researchers, searching for the best therapeutic plants for diuretic research may be a significant turning point in using various herbs from India.
Multiple Sclerosis: Current Knowledge of the Pathology and Use of Monoclonal Antibodies as a Promising Therapy Castellón-Arias, Josué; Gazel-Meléndez, Luana; Guido-Villalobos, Rebeca; Jiménez-Díaz, Ariela; Valera-Rangel, Johana; Mora-Román, Juan José
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5317

Abstract

Multiple sclerosis is an autoimmune condition characterized by an inflammatory condition and neuron demyelination, leading to a significant deterioration in the patient's quality of life as the disease progresses. The immune system reactivity in this pathology is mainly mediated by reactive T lymphocytes against myelin. The harmful substances production and proinflammatory cell infiltration occur. Currently, there is no cure, so treatment focuses on reducing the development of the individual's long-term disability by addressing symptoms, acute exacerbations, and slowing progress. The traditional treatment includes immunosuppressive substances such as corticosteroids and interferons. However, an approach to more specific, highly effective therapies such as monoclonal antibodies is currently being sought. Ofatumumab, ocrelizumab, alemtuzumab, and rituximab are commercialized monoclonal antibodies. Likewise, therapies in the research phase, such as ublituximab, inebilizumab, GNbAC1, and elezanumab, can be found. Therefore, research must continue to have more information to increase the availability of therapeutic options for patients.
Bibliometric Study of Microwave-Assisted Synthesis of Flavanone Derivatives Poerwono, Hadi; Rudyanto, Marcellino
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5602

Abstract

This study aims to describe various studies related to synthesizing flavanone derivatives using the microwave-assisted method with a bibliometric approach. Metadata information was collected from Scopus on June 30th, 2023, with three keywords (microwave-assisted OR microwave, synthesis, and flavanone) searched for article titles, abstracts, and keywords. Analysis and research mapping were carried out with VOSviewer. Of the 33 articles relevant for analysis, 15 keyword clusters were obtained, most of which contained a list of flavanone derivatives. Interestingly, none of these clusters contain keywords for well-known compounds from the flavanone group, such as pinostrobin, pinocembrin, or hesperetin. In other words, there is an excellent opportunity to obtain novelty for microwave-assisted derivatization studies of flavanones. The chances of publication of these studies are greater in Chemistry of Heterocyclic Compounds (Springer Nature), Oriental Journal of Chemistry (Scientific Publishers), and Tetrahedron Letters (Elsevier), each with three documents. Meanwhile, most researchers on this topic come from India with 13 documents. This information allows researchers on this topic to determine potential flavanones that have the opportunity to be derivatized by the microwave-assisted method.

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