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Sciences and Clinical Pharmacy Research Journal
Published by Indonesian Journal Publisher
ISSN : -     EISSN : 30474493     DOI : https://doi.org/10.47134/scpr
Core Subject : Health,
Medicine & Pharmacology
Sciences and Clinical Pharmacy Research Journal is dedicated to the exploration of Pharmaceutical Sciences and Community and Clinical Pharmacy. In the realm of pharmaceutical sciences, the journal welcomes research articles spanning Pharmaceutical Biology and Pharmacognosy, Pharmaceutical Chemistry, pharmaceutics, Pharmacology and Toxicology, as well as Biotechnology. In the domain of Community and Clinical Pharmacy, the journal encompasses discussions on Hospital Pharmacy, Clinical Pharmacy, Pharmacy Management, and Social Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 19 Documents
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Search results for , issue "Vol. 2 No. 4 (2026): January" : 19 Documents clear
A Systematic Review of In Vitro Approaches for Evaluating Bioactive Natural Compound–Target Interactions in Early Drug Discovery Purba, Gratia
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5320

Abstract

This study aims to systematically review and analyze in vitro approaches for evaluating bioactive natural compound–target interactions in early drug discovery, with myristicin highlighted as a representative example. Employing a qualitative descriptive research design, this study utilized a library-based method through the comprehensive analysis of scientific articles, books, and reports published between 2015 and 2025. Data collection involved literature screening and document analysis from peer-reviewed journals, while data analysis followed an inductive thematic approach encompassing identification, reduction, categorization, and synthesis of findings. The results indicate that integrating in vitro assays with computational (in silico) modeling significantly enhances predictive accuracy, efficiency, and mechanistic understanding in early drug discovery. Myristicin demonstrated multitarget bioactivity, including anti-inflammatory, antimicrobial, antioxidant, and anticancer effects, primarily through modulation of COX-2, PI3K/Akt/mTOR, and P-glycoprotein pathways. These findings reinforce the theoretical framework of polypharmacology, supporting the concept that natural compounds often act through multi-target interactions rather than single-receptor specificity. The study contributes to pharmacognosy and molecular pharmacology by providing a conceptual and methodological model for integrating experimental and computational drug discovery approaches. The implications extend to both academic and industrial domains, promoting standardized in vitro validation and translational research for natural product–based drug development.
Kajian Literatur mengenai Peran Apoteker dalam Interprofessional Collaboration di Pelayanan Kesehatan Firman, Imran
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5321

Abstract

Tujuan utama penelitian ini adalah untuk mengeksplorasi peran apoteker dalam kolaborasi interprofesional (interprofessional collaboration/IPC) di pelayanan kesehatan dan memahami dampaknya terhadap hasil klinis, kepatuhan pasien, serta efektivitas tim lintas profesi. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi pustaka, memanfaatkan literatur akademik terbaru yang relevan, termasuk artikel ilmiah dan laporan resmi. Data dikumpulkan melalui penelusuran literatur sistematis dan dianalisis secara deskriptif-induktif dengan tahapan identifikasi tema, reduksi data, kategorisasi konsep, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa apoteker memainkan peran penting dalam lima dimensi kolaborasi: kemitraan, koordinasi, kerja sama, pengambilan keputusan, dan hasil terapeutik. Bentuk kolaborasi yang ditemukan mencakup review obat, manajemen terapi, edukasi pasien, partisipasi dalam ward round, serta integrasi di praktik primer. Faktor pendukung meliputi kejelasan peran, komunikasi efektif, dukungan sistemik, co-location, dan teknologi komunikasi, sedangkan hambatan meliputi keterbatasan waktu, ketidakjelasan deskripsi tugas, serta tantangan dalam membangun identitas kolaboratif. Implikasi penelitian ini menekankan pentingnya strategi pendidikan interprofesional, penguatan identitas profesional, dan adaptasi budaya organisasi untuk meningkatkan efektivitas IPC. Kesimpulannya, optimalisasi peran apoteker dalam kolaborasi interprofesional tidak hanya meningkatkan hasil klinis dan kepatuhan pasien, tetapi juga memberikan kontribusi signifikan terhadap pengembangan teori dan praktik kolaborasi lintas profesi di pelayanan kesehatan.
A Review of Rational Pharmacotherapy in the Use of Antibiotics in Hospitals Haruna, Nadyah; Syakir, Darmawansyih; Nilawati, Andi
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5322

Abstract

This study aims to examine the rational pharmacotherapy of antibiotic use in hospital settings, focusing on patterns, determinants, and the role of antimicrobial stewardship (AMS) in optimizing therapeutic outcomes. Employing a qualitative descriptive design through a literature review, this research synthesized findings from scientific journals, official reports, and academic studies published between 2015 and 2025. Data collection involved systematic literature tracing and document analysis, while the data analysis process consisted of thematic identification, data reduction, categorization, and inductive interpretation. The results reveal that the rationality of antibiotic use in Indonesian hospitals remains low, ranging between 6.67% and 68.03%, with key issues involving inappropriate antibiotic selection, incorrect dosing, and inadequate therapy duration. Limited AMS implementation and minimal pharmacist involvement were identified as major contributing factors. Conversely, evidence demonstrates that multidisciplinary AMS programs, particularly those led by clinical pharmacists, significantly improve prescribing rationality, reduce resistance rates, and lower healthcare costs. The findings provide a comprehensive understanding of how institutional, behavioral, and policy factors influence rational antibiotic use, offering implications for both clinical practice and healthcare policy reform. In conclusion, the study underscores the need for sustained AMS integration, pharmacist empowerment, and standardized evaluation systems to strengthen rational pharmacotherapy and combat antimicrobial resistance.
Pharmacotherapy of Gastroesophageal Reflux Disease: A Descriptive Literature Review of Mechanism of Action and Clinical Rationale Mus, Suwahyuni
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5339

Abstract

Penelitian ini bertujuan untuk menganalisis dan mensintesis pendekatan farmakoterapi terhadap Penyakit Refluks Gastroesofageal (GERD) dengan menelaah mekanisme aksi, landasan klinis, dan paradigma pengobatan yang berkembang. Proses penelusuran literatur mengikuti pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) melalui basis data internasional seperti PubMed, ScienceDirect, dan SpringerLink. Data dianalisis secara tematik untuk mengidentifikasi fokus farmakoterapi GERD. Hasil kajian menunjukkan bahwa Inhibitor Pompa Proton (IPP) tetap menjadi terapi utama karena efektivitasnya dalam menekan asam lambung dan mempercepat penyembuhan mukosa, namun munculnya kasus refraktori terhadap IPP mendorong pengembangan Penghambat Asam Kompetitif Kalium (PCAB) yang menawarkan onset lebih cepat, kontrol asam lebih kuat, dan stabilitas farmakodinamik yang lebih baik. Selain itu, integrasi agen prokinetik, pelindung mukosa, serta terapi herbal menunjukkan tren menuju pendekatan multimodal yang menargetkan motilitas, integritas mukosa, dan jalur inflamasi. Studi ini menegaskan pergeseran paradigma dari terapi tunggal berbasis penekanan asam menuju manajemen GERD yang personal, berbasis mekanisme, dan holistik, serta menyoroti pentingnya validasi klinis jangka panjang yang terstandarisasi.
Narrative Review: The Effect of Counseling on Adherence in Patients with Type 2 Diabetes Mellitus Larasati, Gandis; Ramatillah, Diana; Khan, Kashif
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5357

Abstract

This study aimed to evaluate the effect of counseling on medication adherence among patients with type 2 diabetes mellitus through a narrative review of 50 national and international articles published between 2020 and 2025. The narrative review method was conducted by selecting journals from Elsevier, MDPI, PubMed, SpringerLink, Wiley, as well as nationally indexed SINTA journals using relevant keywords.The results of the review indicate that pharmacist-led interventions through counseling, including brief counseling, home pharmacy care, and digital media–based education, consistently improved patient knowledge, enhanced medication adherence, and reduced clinical parameters such as blood glucose levels, HbA1c, and HOMA-IR. These interventions also improved patients’ quality of life and disease perception.Based on these findings, it can be concluded that pharmacist-led interventions through structured counseling and pharmaceutical education have a significant positive impact on the management of type 2 diabetes mellitus, particularly in improving patient knowledge, disease perception, and adherence to therapy. Improvements in therapeutic behavior directly contributed to better clinical outcomes, including reductions in blood glucose, HbA1c, HOMA-IR, body weight, and waist circumference after 90 days of intervention. The greatest effects were observed in patients with HbA1c levels > 9%, indicating that high-risk groups derived the greatest benefit from pharmacist involvement in the management of type 2 diabetes mellitus.Future studies are recommended to evaluate the long-term effects of counseling and to standardize adherence assessment instruments. Strengthening pharmaceutical care policies is also recommended to improve the quality and consistency of counseling services and to develop sustainable intervention models in primary healthcare settings.
Activity Of 70% Ethanol Extract From Moringa Olefera Leaves (Moringa oleifera Lam.) On Wound Healing In Hyperglycemia Rats Zaidan, Sarah; Yantih, Novi; Pratami, Diah; Pengasih, Aiy
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5480

Abstract

This study aimed to evaluate the wound healing profile in hyperglycemic rats treated with 70% ethanolic extract of Moringa oleifera Lam. leaves compared with povidone iodine, to determine the most effective extract concentration, and to assess the quality of the leaf extract. The extract was prepared using 70% ethanol maceration and evaluated for yield, moisture content, pH, total flavonoid content, and quercetin levels. Twenty-five rats were divided into five groups: negative control, positive control (povidone iodine), and extract concentrations of 5%, 10%, and 15%. A 2-cm dorsal incised wound was created on each rat, followed by once-daily topical application for 14 days. Macroscopic observations included wound closure, scab formation, and hair growth. Quality evaluation showed a yield of 23.8% (≥ 9.2%), moisture content of 4.05% (< 10%), pH of 5.70 (4.5–6.0), total flavonoid content of 2.58 mg QE/g, and quercetin content of 0.69%. Wound-healing analysis demonstrated significant differences between groups, with a p-value of 0.001 (p < 0.05). The mean percentage of wound-area reduction was 95% for the 5% extract, 94.71% for the 10% extract, 95.87% for the 15% extract, and 90.37% for the positive control group. The 15% extract was the most effective in accelerating scab formation and hair growth. In conclusion, especially at the 15% concentration, the ethanol extract of Moringa oleifera leaves demonstrated good extract quality and successfully accelerated wound healing in hyperglycemic rats.
Medication Therapy Management pada Penyakit Kronis di Layanan Primer: Kajian Pustaka Kualitatif-Deskriptif tentang Proses dan Luaran Klinis Starlista, Viva
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5514

Abstract

Artikel ini bertujuan untuk mengkaji secara kualitatif deskriptif proses dan luaran klinis Medication Therapy Management pada penyakit kronis di layanan primer berdasarkan hasil studi pustaka. Kajian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif melalui studi pustaka terhadap literatur akademik yang relevan dan mutakhir. Data dikumpulkan melalui penelusuran dan analisis dokumen ilmiah yang membahas implementasi MTM, peran farmasis dalam tim interdisipliner, serta dampaknya terhadap pengelolaan penyakit kronis. Analisis data dilakukan secara induktif melalui tahapan identifikasi tema, reduksi data, kategorisasi konsep, dan sintesis temuan untuk memperoleh pemahaman yang komprehensif. Hasil kajian menunjukkan bahwa MTM di layanan primer secara konsisten melibatkan proses inti berupa telaah obat komprehensif, perencanaan terapi individual, edukasi pasien, tindak lanjut terstruktur, dan deprescribing, yang berkontribusi pada perbaikan kontrol klinis, peningkatan kepatuhan, pengurangan masalah terkait obat, serta potensi efisiensi sistem pelayanan kesehatan. Temuan ini menegaskan bahwa MTM berperan penting dalam menjawab tantangan polifarmasi dan multimorbiditas pada penyakit kronis melalui pendekatan kolaboratif dan berpusat pada pasien. Secara keseluruhan, kajian ini berkontribusi dalam memperkuat landasan konseptual dan praktis MTM sebagai strategi penting dalam pengembangan pelayanan kesehatan primer dan dapat menjadi rujukan bagi praktik klinis, kebijakan, serta penelitian lanjutan di bidang manajemen terapi obat.
Pharmaceutical Care Model and Implementation in Clinical Pharmacy Services: A Qualitative-Descriptive Literature Review Yuniar, Cinthya
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5515

Abstract

This article aims to describe and analyze the development, implementation, and challenges of pharmaceutical care–based models in clinical pharmacy services, with emphasis on their contribution to patient-centered care and improved therapeutic outcomes. A qualitative descriptive design using a library research approach was employed, with data collected through systematic searches of peer-reviewed articles, official reports, and relevant policy documents published between 2015 and 2025 focusing on pharmaceutical care models, clinical pharmacy practice, and interprofessional collaboration. A total of 18 eligible studies were analyzed inductively using thematic analysis involving data reduction, categorization, and synthesis. The findings reveal a clear paradigm shift from product-oriented dispensing toward comprehensive patient-centered pharmaceutical care, with 72% of studies reporting increased pharmacist involvement in medication review, therapy monitoring, and identification of drug-related problems, while 67% highlighted improvements in patient counseling and medication adherence. Furthermore, 61% of the studies documented reductions in medication errors or drug-related problems following implementation. Improved clinical outcomes were reported in more than half of the studies (56%), particularly among patients with chronic diseases and high-risk conditions in settings with strong interprofessional collaboration. However, nearly 70% of the studies identified persistent barriers, including limited human resources, inadequate documentation systems, uneven interprofessional collaboration, and insufficient regulatory or infrastructural support, especially in low- and middle-income settings. Overall, pharmaceutical care–based models significantly contribute to advancing clinical pharmacy practice and inform future policy, education, and research.
Aktivitas Antifungi Emulgel Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) Terhadap Malassezia furfur Hasan, Rahmawaty
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5567

Abstract

Buah belimbing wuluh (Averrhoa bilimbi L.) merupakan tanaman tradisional yang berpotensi sebagai antibakteri dan antijamur. Buah belimbing memiliki senyawa flavonoid 276.73±25.25 mg sehingga berpotensi sebagai antijamur. Efektivitas penggunaan ekstrak buah belimbing wuluh pada kulit dapat ditingkatkan dengan memformulasikan sediaan emulgel, yang memiliki kelebihan daya hantar obat yang lebih baik. Tujuan penelitian ini adalah untuk mengetahui aktivitas daya hambat sediaan emulgel ekstrak metanol 80% buah belimbing wuluh (Averrhoa bilimbi L.) terhadap Malassezia furfur dengan metode kertas cakram. Metode ekstraksi maserasi buah belimbing wuluh dengan pelarut methanol 80% didapatkan rendemen 13.3%. Data skrining fitokimia dianalisis secara deskriptif. Hasil skrining fitokimia menunjukkan bahwa pada ekstrak buah belimbing wuluh terdapat kandungan metabolit flavonoid, alkaloid, saponin dan triterpenoid. Ekstrak diformulasikan menjadi emulgel dengan variasi konsentrasi 5%, 10% dan 15%. Berdasarkan evaluasi sediaan, formulasi terbaik adalah formulasi 3 dengan hasil evaluasi yang sesuai standar, meliputi uji organoleptik, uji homogenitas, cycling test, dan uji untuk menentukan emulgel yang dianalisis secara deskriptif. Uji daya sebar, uji pH, uji viskositas, dan uji zona hambat menggunakan analisis One-Way ANOVA menggunakan SPSS. Aktivitas antifungi menunjukkan formulasi 3 dengan konsentrasi ekstrak buah belimbing wuluh 15% memiliki zona hambat yang paling kuat, yaitu 12,00 mm. Emulgel ekstrak buah belimbing wuluh dengan konsentrasi 15% memiliki potensi aktivitas antifungi dengan menghambat pertumbuhan Malassezia furfur.

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