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Hardyanto Soebono
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INDONESIA
Indonesian Journal of Biomedicine and Clinical Sciences
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 30323134     DOI : https://doi.org/10.22146/inajbcs.v56i01.11961
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
Indonesian Journal of Biomedicine and Clinical Sciences (InaJBCS) aims to promote the translational of basic research into clinical studies and of clinical evidence into practice. InaJBCS publishes studies that substantially enhance our standing of disease etiology and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments. InaJBCS invites authors to submit articles in the fields of biomedical sciences including biomedical genetics, bioinformatics, cardiovascular medicine, endocrinology, gastroenterology, geriatrics, infectious diseases, medical oncology, physiology, pharmacology and toxicology, and phytomedicine medicine.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 116 Documents
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The activity antibiofilm of betadine leaf (Jatropha multifida Linn) juice on urinary catheters Tania, Rada; Gunardi, Wani Devita; Sudradjat, Susana Elya
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.18065

Abstract

Biofilm formation can reduce the efficacy of antibiotics against pathogenic microorganisms. Flavonoids are proven to have antibiofilm activity. Betadine leaf (Jatrophas multifida Linn) contains abundant flavonoids. This study aimed to evaluate the biofilm activity of the betadine leaf juice on urinary catheters. Biofilm forming Escherichia coli was isolated from a urinary catheter. The betadine leaf juice was prepared by harvesting, washing, drying, juicing, centrifuging, and sterilizing the juice. Phytochemical analysis was performed to identify the presence of steroids, alkaloids, flavonoids, and phenols. Biofilm and antibiofilm assays were conducted by incubating thioglycolate medium with varying concentrations of the betadine leaf juice and E. coli suspension, with bacterial growth and biofilm formation assessed based on turbidity observations. Alkaloids, steroids, flavonoids, and phenolic compounds have been found in the sterilized betadine leaf juice. Bacterial growth was observed in all tubes containing different dilutions of the betadine leaf juice. However, turbidity levels increased as the juice concentration decreased. Additionally, the weight of the urinary catheter was significantly greater in tubes with lower juice concentrations (p=0.02). In conclusion, the J. multifida Linn leaf juice has potential antibiofilm activity against E. coli in urinary catheters.
Familial atrial septal defect: a case report in Indonesia Muhammad Gahan Satwiko; Lucia Kris Dinarti; Armalya Pritazahra; Abdul Majid Halim Wiradhika; Muhammad Reyhan Hadwiono; Dyah Wulan Anggrahini; Anggoro Budi Hartopo
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.20213

Abstract

Familial atrial septal defect (ASD) is defined as the occurrence of ASD in the first-degree family of the ASD patient. Recently, familial ASD has been increasingly studied. Familial ASD could manifest as an isolated ASD or with other abnormalities. Furthermore, because ASD is usually asymptomatic, it is very difficult to recognize ASD in a first-degree family based only on symptoms. However, if the family was screened using electrocardiography or echocardiography, the occurrence of familial ASD could be found. Therefore, screening plays an important role in detecting familial ASD. We reported an ASD patient with several occurrences of familial ASD. ABSTRAK Atrial septal defect (ASD) familial didefinisikan sebagai terjadinya ASD di keluarga tingkat pertama pada pasien ASD. Studi mengenai ASD familial saat ini telah semakin banyak dilakukan. ASD familial dapat bermanifestasi sebagai ASD yang terisolasi ataupun ASD yang disertai dengan abnormalitas yang lain. Selain itu, karena ASD biasanya asimptomatik, sangat sulit mengenali ASD pada keluarga tingkat pertama hanya berdasarkan gejalanya. Meski demikian, jika keluarga tersebut diperiksa menggunakan elektrokardiografi atau ekokardiografi maka dapat ditemukan terjadinya ASD familial. Oleh karena itu, skrining memegang peranan penting dalam deteksi ASD familial. Kami melaporkan pasien ASD dengan beberapa kejadian ASD familial.
The role of bisphosphonate and bone morphogenetic proteins in congenital pseudoarthrosis of the tibia management: a literature review Panji Sananta; Adithya Stephana Mahendra; Eka Noviya Fuzianingsih
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.20291

Abstract

Congenital pseudoarthrosis of the tibia (CPT) is a rare medical condition characterized by a congenital absence of union in the tibia, which causes the leg to flex anterolaterally. Despite the use of several surgical techniques for the treatment of CPT, there is still a significant risk of failure with surgical interventions. Recent studies have shown that bisphosphonates (BP) and bone morphogenetic proteins (BMP) can be effective adjuncts to surgical procedures, increasing the success rate of bone union and reducing the chance of re-fracture. This review aimed to evaluate the role of BP and BMP in CPT. In this review, a comprehensive literature evaluation was conducted using the PRISMA method. The databases used to search for information included PubMed, ScienceDirect, and Google Scholar for the past 10 years. Six articles were included in this review. The results showed that using pharmacological agents such as BMP and BP is considered safe for pediatric patients as an adjunctive treatment to surgery. This combination can effectively increase the speed of bone union and prevent re-fractures. The small sample size, different protocols, and different doses may have impacted the study results, which should be thoroughly explained.
Correlation between differentiation grade and lymphovascular invasion in colorectal adenocarcinoma Nana Liana; Loli Devianti; Yessy Setiawati; Sri Nani Jelmila; Ruhsyahadati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.20536

Abstract

Colorectal carcinoma is the third most common malignant tumor worldwide. It is a heterogeneous disease with diverse clinicopathological and prognostic characteristics. The TNM (tumor, node, metastasis) staging system is currently used as a prognostic predictor. However, its predictive value is limited, as approximately 30% of patients with lymph node-negative disease die due to metastasis progression. It is suspected that other prognostic factors other than TNM staging system, may play a significant role. Differentiation grade and lymphovascular invasion have been proposed as essential prognostic factors for lymph node-negative colorectal carcinoma. This study aimed to evaluate the correlation between differentiation grade and lymphovascular invasion in colorectal carcinoma. It was an observational study with a cross-sectional design. Samples were collected from 4 Anatomical Pathology laboratories in West Sumatera in 2018. A total of 97 paraffin blocks of colorectal adenocarcinoma met the inclusion criteria. Differentiation grade and lymphovascular invasion were evaluated according to the 2019 World Health Organization (WHO) classification. The correlation between differentiation grade and lymphovascular invasion was analyzed using Fisher's Exact test. A p value <0.05 considered statistically significant. The most prevalent age group for cases of colorectal adenocarcinoma was 51–60 yr (36.1%). Low-grade differentiation was the most common grade of differentiation (72.2%). Lymphovascular invasion in small vessels was commonly encountered (73.3%). High-grade differentiation adenocarcinomas had 100% lymphovascular invasion. A significant correlation between differentiation grade and lymphovascular invasion was observed (p = 0.031). This study confirms that lymphovascular invasion is a valuable predictor of colorectal carcinoma progressiveness.
Misdiagnosed in double primary tumors: a case report Daru Cahayadi, Sigit; Mitchel
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.11877

Abstract

Multiple primary malignancies (MPM) refer to the presence of two or more malignant tumors that are unrelated to each other in the same individual. Double primary malignancies that occurred in the lungs and extremities were relatively rare. We present a case of lung adenocarcinoma as pseudo-lung metastasis and pleomorphic liposarcoma on the extremity. A 62 yo male chronic smoker came with a referral from another hospital with a growing mass on his thigh and some imaging that showed pulmonary metastasis. The patient underwent a transbronchial lung biopsy and wide excision for a tumor on his thigh. However, histopathological examination revealed that both malignancies originated from different cells or as primary malignant. At 8 wk post-surgery, positron emission tomography (PET) scan was performed to rule out residual pleomorphic liposarcoma or any metastasis and the result showed no residual or metastasis. We suggest that the management of MPM be more careful and disciplined, as an error in choosing a diagnosis method might harm or worsen the patient’s condition. In the case of multiple malignancies, particularly in organs with frequent metastasis sites, it is important to consider the possibility of MPM. The diagnosis and management strategy of double primary tumors was expected to provide important information for clinicians.
Effectiveness of disinfectants against methicillin resistant Staphylococcus aureus (MRSA) contamination in hospital: a review Arviansyah; Herman Yosef Limpat Wihastyoko; Yudi Siswanto; Wilma Agustina; Elisabeth Prajanti Sintaningrum; Eka Nugraha Prima; Michelle Gunawan; Dewangga Yudisthira
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.12534

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) contamination is still widely reported in various hospital areas. Despite routine cleaning and preventive measures in places such as hospitals, the prevalence of MRSA is still increasing worldwide, especially in Asia. This review aimed to evaluate the effectiveness of disinfectants against MRSA contamination in hospitals. Articles were searched from PubMed, ScienceDirect, Cochrane, and Google Scholar databases using specific keywords and boolean operators. Journal selection from these databases was based on inclusion criteria, exclusion criteria, and PICOS framework. Studies that did not fit the topic or study design and had paid access and duplication were excluded. A total of five valid and reliable articles found that some disinfectants, such as JUC Polymer, a combination of hydrogen peroxide (H2O2) and silver cations (Ag), have effectiveness in eradicating germs or inhibiting the growth of MRSA germs. The application of disinfectants in MRSA also showed benefits in terms of cost. However, the use of disinfectants needs to be considered because they can cause tolerance and resistance. In conclusion, MRSA disinfectants are still proven effective with various methods and precautions. In addition, disinfectants are beneficial in terms of prevention and health financing.
Cryotherapy and balloon dilatation for subglottic stenosis in a neonate: a case report Siswanto, Johanes Edy; Akira Prayudijanto; Muhammad I. Prayudijanto; David D. Putra; Istifa Amalia; Rifan Fauzie; Christophorus AS Pamungkas
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.12718

Abstract

Cryotherapy and balloon dilatation are combined treatments for subglottic stenosis (SGS) in newborns. Cryotherapy involves freezing the affected area with extremely low temperatures, which can result in tissue destruction. Balloon dilatation is a technique in which a balloon is inflated in the narrow subglottic area to widen the airway. We reported a case of SGS in a neonate who was treated with a combination of cryotherapy and balloon dilatation to contribute to the growing body of evidence of the therapy and provide information for clinicians in the care of the vulnerable patients. A 22-day-old female baby, who weighed 2,600 gr at birth, was transferred to our hospital from another facility. We conducted cryotherapy on the granulation tissue area until it was released, then inflated the balloon for 5 cycles (30 sec each) with a pressure of 5-6 atm. After cryotherapy and balloon dilatation, the patient was examined using direct laryngoscopy, which revealed subglottic stenosis up to 9.5 cm from the outer border of the mouth. To maintain airway patency for the next 24 hr, the patient was intubated with an endotracheal tube number 3.5. The patient's condition improved after this intervention, and they no longer required oxygen therapy support. The patient was discharged without the need for supported oxygen. In conclusion, to manage the challenges associated with post-intubation subglottic stenosis (PI-SGS), a comprehensive approach that includes a reliable referral system, thorough bronchoscopy training, and a multi-disciplinary team is essential.
Preoperative and intraoperative predictive factors affecting to the time interval of stoma closure in patients at Dr. Sardjito General Hospital, Yogyakarta in 2018-2023 Pajar Sigit Nugroho; Adeodatus Yuda Handaya; Anis Fuad
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.14158

Abstract

Ostomy procedures, frequently indicated for malignancies, significantly impact patient well-being. In certain instances, stoma closure becomes imperative. Despite the lack of consensus regarding the optimal timeframe for temporary stoma closure, this study aimed to delineate predictors associated with the closure timing, thereby enhancing prognostic precision and augmenting patient care strategies. A cross-sectional study was conducted at Dr. Sardjito General Hospital, Yogyakarta, analyzing medical records of patients who underwent primary stoma creation and subsequent closure between January 2018 and December 2023. Factors, including preoperative, disease-related, and intraoperative variables, were analyzed using SPSS version 26.0. Bivariate and multivariate analyses were performed to identify predictors for stoma closure duration. In the colostomy group, body mass index (BMI), underlying disease, and complications were significantly associated with duration of stoma closure by bivariate analysis (p=0.016; 0.036; 0.040), and BMI and hemoglobin level associated with duration of closure by multivariate analysis (p=0.010; 0.044). Increasing BMI, disease stage, chemotherapy use, complications, and lower hemoglobin level predicted a longer closure duration, while chemotherapy reduced the risk. In the ileostomy group, factors such as underlying disease, cancer stage, chemotherapy status, complications, and type of surgery were associated with duration of closure by bivariate analysis (p=0.010; 0.024; 0.002; 0.013; 0.034), with complications associated with duration of closure by multivariate analysis (p=0.008). In conclusion, BMI, underlying diseases, and complications are associated with stoma closure duration. Understanding these factors can aid in risk stratification and optimizing patient management strategies during stoma closure surgeries.
Computational study of active compounds of Citrullus lanatus Linn peel extract as potential antidiabetics Sari, Shinta Dewi Permata; Budiman, Muhamad Arif; Ningsih, Sri Suciati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.14518

Abstract

Diabetes mellitus (DM) is one of the metabolic diseases that have emerged as a global health problem. Type 2 diabetes mellitus (T2DM), which affect 90-95% of DM, is caused by reduced insulin sensitivity and insulin resistance in peripheral tissues. Oral antidiabetics have resulted side effects, prompting an investigation for a natural-based antidiabetic agent as an alternative treatment. Using network pharmacology, we investigated the mechanism of phytochemical substances of Citrulus lanatus Linn. peel extract and their interactions with target proteins in the DM pathogenesis pathway. Cytoscape 3.6.1 software has created a network of extract compound-protein targets. Investigation of protein interaction, target gene function enrichment, and signal pathway performed via DAVID, STRING database, and the KEGG pathway database. The computational study identified 90 target proteins associated with T2DM based on protein-protein interactions. In addition, Cytoscape analysis and DAVID enrichment revealed the network of extract compound's target and generated proteins such as INS, TNF-α, IL-6, and AKT2. The KEGG pathway analysis presented the crucial role of insulin resistance and AGE-RAGE signaling pathways. This pathway correlated with lower glucose activity in obesity and hyperglycemia. It indicates that the active constituents of C. lanatus Linn peel extract can lower blood sugar levels by interacting with selected proteins. This study's findings will be carried out in further research of in vitro trials.
Combining square-stepping exercise and strengthening exercise improve frailty status in pre-frail community-dwelling older adults Ira Adventia; Lanny Indriastuti; Hari Peni Julianti
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.14599

Abstract

Frailty is a complex syndrome affecting older people, characterized by unintentional weight loss, low muscle strength, feelings of exhaustion, reduced physical activity capacity, and slow walking speed. A decrease of muscle strength has been shown to be a major cause of frailty. The studies further agreed that frailty is a treatable condition. Intervention at the pre-frail state may offer the best opportunity to prevent, delay, or reverse existing symptoms of physical frailty. The evidence that multicomponent exercise (particularly resistance exercise) can have marked effects on frailty and sarcopenia is now forceful. Thus, we combine strengthening exercise and square-stepping exercise (SSE), a popular balance exercise, in community-dwelling pre-frail older adults. To evaluate the effectiveness of additional lower extremity strengthening exercise on frailty phenotype scores in pre-frail older adults who receive SSE. This study used an experimental, randomized control trial on pre-frail older adults aged between 60 and 70 yr. The participants were divided into 2 groups of 19 people each. The control group received SSE 3 x /wk, while the treatment group received SSE 3 x /wk plus lower extremity strengthening exercises 2 x /wk for 6 wk. The analysis of each group revealed an improvement in frailty phenotype scores in both the treatment and control groups. Ten participants (55.56%) in the control group experienced an improvement in the frailty phenotype status to robust (non-frail). Eleven participants (64.71%) in the treatment group experienced an improvement in frailty phenotype status to robust (non-frail). These findings suggest that SSE can improve frailty phenotype scores in pre-frail older adults, and that adding lower extremity strengthening exercises to SSE significantly improves frailty phenotype score compared to SSE alone.

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