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FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia
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INDONESIA
Kartika : Jurnal Ilmiah Farmasi
Published by Universitas Jenderal Achmad Yani
ISSN : 23546565     EISSN : 25023438     DOI : https://doi.org/10.26874/kjif.v6i1.135
Core Subject : Health, Science, Social,
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences
Kartika: Jurnal Ilmiah Farmasi (KJIF) merupakan media publikasi ilmiah dalam bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Jenderal Achmad Yani, bekerjasama dengan Ikatan Apoteker Indonesia (PD IAI Jawa Barat). Ruang lingkup artikel yang diterbitkan adalah: Farmasetika, Kimia Farmasi, Kimia Analisa, Farmasi Fisika, Farmakognosi dan Etnobotani, Natural Produk, Farmakologi dan Toksikologi, Praktik Kefarmasian dan Farmasi Rumah Sakit, Farmakogenomik, Farmakoekonomi, Studi Kasus dan Uji Klinis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 126 Documents
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STUDI INTERAKSI OBAT-OBAT JANTUNG YANG DILAKUKAN TERHADAP ORANG SEHAT: TINJAUAN SISTEMATIS Sumartin, Yunita; Sukandar, Elin Yulinah
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.669

Abstract

Patients with cardiovascular disease have a higher prevalence of drug interactions than other patient groups. Drug interactions may result from pharmacokinetic or pharmacodynamic mechanisms. This study is a systematic review that aims to identify drug interactions related to cardiac drugs. Article searches were conducted on PubMed and ScienceDirect databases to identify all articles on cardiac drug-drug interaction studies. The search started from articles published in 2013 to 2023. The keywords used in the article search were as follows: drug-drug interactions, cardiac patient, cardiac drug, cardiovascular drug, pharmacokinetics interaction, pharmacodynamic interaction combined with the boolean operator "AND". Study articles that met the requirements were entered into the study for review. The total number of articles identified from the database used was 805 articles; 7 duplicate articles were excluded; 84 articles were available in full text; but only 30 articles in accordance with the inclusion were reviewed. Potential drug interactions related to cardiac drugs were most common in the Angiotensin II Receptor Blocker (ARB) class of drugs. Other cardiac drug interactions occurred with angiotensin receptor-neprilysin inhibitors (ARNI), anticoagulants, antiplatelets, digoxin, calcium channel blockers and beta blockers. The effects of these cardiac drug interactions vary. To avoid the occurrence of drug interactions, co-administration of cardiac drugs should be administered with caution, dose adjustments may be required, and monitoring for possible adverse drug events should be done.
FORMULASI CLAY MASK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN UJI INHIBISI Staphylococcus aureus Asthyananda, Michelytha; Bakri, Dzaki Fikri Firdaus
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.680

Abstract

Acne is abnormal skin condition is cause by disruption of oil gland production causees in excessive oil production. One of the bacteria that cause acne is Staphylococcus aureus Binahong leaf (Anredera cordifolia (Ten.) Steenis) has been studied and proven to inhibit Staphylococcus aureus bacteria at 20%. Clay mask is one of pharmaceutical formulations to make it easier for using binahong leaf extract. The purpose of this research is to determine the physical quality test and inhibition activity clay mask with binahong leaf extract against Staphylococcus aureusnbacteria. This study uses the maceration extraction method, formulation of clay mask preparations with a concentration of binahong leaf extract of 10%, 12% and 14%, physical quality tests include organoleptical, homogeneity, pH, viscosity, adhesion, spreadability and drying time of preparations and inhibition Staphylococcus aureus bacteria. The results showed that all clay mask formulas of binahong leaf extract give good physical quality results. The clay mask preparation of binahong leaf extract can inhibition Staphylococcus aureus in formula I is 11,87 ± 0,88, formula II is 13,05 ± 0,44 and formula III is 14,006 ± 1,45. The inhibition activity of the three formulas are classified as strong category.
KARAKTERISASI MASSA CETAK DAN TABLET VITAMIN C DENGAN KOMBINASI PATI PREGELATINASI UMBI TALAS PRATAMA DAN AVICEL PH 102 SEBAGAI FILLER-BINDER Fitriyani, Gita; Nawangsari, Desy; Fauziah
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 3 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i3.806

Abstract

Making vitamin C tablets using felt directly because this material is very sensitive to heat.. However, direct felting is difficult to do due to the poor flow of vitamin C, so it is necessary to add excipients such as starch and Avicel PH 102. This study aims to evaluate vitamin C tablets with a combination of pregelatinized starch of primary taro tubers and Avicel PH 102 as a filler-binder. The study was conducted in a laboratory experiment with five different formulas: F1 (1:0), F2 (0:1), F3 (1:1), F4 (1:3), and F5 (3:1). Flow rate results F2, F3, F4, and F5 are eligible, while F1 is not. All formulas meet the requirements of break angle, uniformity of weight, size, and crushing time. F2 meets the requirements of compressibility and hausner ratio, as well as hardness and brittleness. The results of the F1, F2, F4, and F5 solutions are eligible, while F3 is not. The conclusion of this study is that Avicel PH 102 is better at increasing the flow rate, compressibility, and hausner ratio than the pregelatinized starch of primary taro tubers. The five, requirements are met by this formula, including uniformity in weight, size and disintegration time. The use of Avicel PH 102 results in high hardness and low brittleness, while pregelatinized starch results in low hardness and high brittleness. F1, F2, F4, and F5 qualify for resolution, while F3 does not
ANALISIS CEMARAN Escherichia coli DAN Salmonella typhi PADA JAMU GENDONG DENGAN METODE MOST PROBABLE NUMBER (MPN) Salsabila, Salma Fi; Rahmasari, Khusna Santika; Nur, Achmad Vandian; Pambudi, Dwi Bagus
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 3 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i3.809

Abstract

The consumption of jamu kunyit asam and beras kencur is an integral part of Indonesian culture. Jamu kunyit asam, a mixture of turmeric and tamarind, is believed to enhance the immune system and aid digestion. Jamu beras kencur, made from rice and aromatic ginger, is known for boosting stamina and alleviating fatigue. However, the traditional production of jamu, often lacking strict hygiene standards, can lead to contamination by pathogenic microorganisms such as Escherichia coli and Salmonella typhi. This study aims to detect the presence of E. coli and S. typhi in jamu kunyit asam and beras kencur, and to analyze whether these traditional herbal drinks sold across districts in Pekalongan City comply with the established quality standards for traditional medicine. The analysis of pathogenic microorganisms using the Most Probable Number (MPN) method revealed that MPN values in the presumptive test using Lactose Broth and the confirmatory test using Brilliant Green Lactose Broth ranged from 0 to 18.98 MPN/mL. Out of four samples of jamu kunyit asam, one did not meet the permissible contamination limits, and three out of four samples of jamu beras kencur were non-compliant. The complementary tests showed that seven samples were positive for E. coli (samples coded A1, A2, B1, B2, C2, D1, and D2) and four samples were positive for S. typhi (samples coded A1, D1, C2, and D2).
ANALISIS KADAR D-DIMER PADA PASIEN STROKE ISKEMIK DAN HEMORAGIK DI RSUD SULTAN IMANUDDIN Yuliyanti; Hidayati, Larantika; Romaidha, Iqlila; Arifin, M. Zainul
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 3 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i3.844

Abstract

Stroke is a neurological cerebrovascular disorder caused by disruption of blood supply to the brain and is a leading cause of disability worldwide. 15 million people worldwide experience stroke each year. Stroke is divided into two types, namely ischemic stroke and hemorrhagic stroke. D-dimer is a fibrin degradation product that indicates an impaired fibrinolysis coagulation system. This study aimed to analyze the results of D-dimer examination in patients with ischemic stroke and hemorrhagic stroke at Sultan Imanuddin Hospital, Pangkalan Bun. This study is quantitative analytical with a cross-sectional design. The sampling technique used was purposive sampling. The study sample was 29 ischemic stroke patients and 14 hemorrhagic stroke patients from January - December 2023. Examination of D-dimer levels using the Immunoturbidimetry assay method with the Automated Blood Coagulation Analyzer SYSMEX CS-2100i with a normal limit value of <0.55 mg / L. The results of the study showed that the average D-dimer level of respondents with ischemic stroke was 6.11 mg/L. In comparison, in hemorrhagic stroke, it was 4.8 mg/L and the statistical test results obtained a p-value = 0.378 so that H0 was accepted and Ha was rejected. This study concluded that 1) the average D-dimer level in ischemic stroke patients was 6.11 mg/L with the results showing that most of D-dimer levels being abnormal, 2) the average D-dimer level in hemorrhagic stroke patients was 4.8 mg/L with the results showing that almost all D-dimer levels being abnormal, 3) there was no significant difference between D-dimer levels in ischemic stroke patients and hemorrhagic stroke patients. Keywords: d-dimer, hemorrhagic stroke, ischemic stroke, stroke, thrombus
FORMULASI DAN EVALUASI MIKROEMULSI KALIUM DIKLOFENAK Sari, Suci Wulan; Sutarna, Titta Hartyana; Ngadeni, Achmad
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 3 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i3.870

Abstract

Diclofenac potassium is a anti-inflammatory drug that can treat mild to severe pain. Diclofenac potassium is often used but has low water solubility and high permeability. This research aimed to evaluate the microemulsion formulation containing diclofenac potassium in vitro. The microemulsion was made by mixing Tween 80: Span 80 (9: 1) as a surfactant, oleic acid as the oil phase, and propylene glycol as a co-surfactant. Evaluation of the diclofenac potassium microemulsion formulation included determining diclofenac potassium levels and in vitro release studies carried out using a modified flow-through method from a Franz diffusion cell and samples were measured by UV-visible spectrophotometry. The results showed that the levels of potassium diclofenac in the microemulsion preparation were respectively 1: 102.57%, formula 2: 101.38%, formula 3: 102.15, and the average diffusion rate test of the microemulsion preparation at F1 0.1147mg/cm2 F2 0.1552 mg/cm2 F3 0.1633 mg/cm2 with a permeation percentage of F1 6.5%, F2 8.8%, F3 9.2% for 180 minutes.

Page 13 of 13 | Total Record : 126

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