Garuda - Garba Rujukan Digital

REVIEW: POTENSI BOREH USADA BALI BERBASIS KEARIFAN LOKAL DENGAN BAHAN UTAMA MELATI PUTIH SEBAGAI ANTIBAKTERI PROPIONIBACTERIUM ACNES Giri, Gede Sugiartha; Paramita, Ni Luh Putu Vidya
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.643

Boreh Usada Bali merupakan sarana pengobatan masyarakat Hindu Bali terbuat dari kombinasi tumbuh-tumbuhan yang memiliki khasiat obat. Berdasarkan Usada Taru Pramana tanaman melati putih (Jasminum sambac) memiliki potensi untuk mengurangi jerawat. Boreh Usada Bali dibuat dengan bahan utama khasiat daun melati putih dikombinasikan dengan bahan pendukung khasiat seperti beras, kulit batang kayu manis, kayu cendana, rimpang lempuyang, rimpang kunyit, buah pala, dan garam. Review dilakukan terhadap sediaan boreh dengan komposisi bahan melati putih dan bahan alam lainnya sebagai pendukung khasiat antibakteri terhadap Propionibacterium acnes. Penyusunan artikel ini menggunakan metode studi literatur yang tergolong dalam penelitian deskriptif kualitatif secara sistematis. Potensi boreh Usada Bali melati putih didukung oleh beberapa penelitian tentang antibakteri dari komponen di dalam boreh. Hal ini karena, melati putih dilaporkan memiliki senyawa tanin dan flavonoid dan untuk bahan pendukung khasiat boreh lainnya mengandung senyawa aktif utama seperti kulit batang kayu manis (sinamaldehid dan eugenol), kayu cendana (alfa-santalol, beta-santalol, dan epi-beta-santalen), lempuyang (zerumbon), kunyit (kurkuminoid), dan pala (monoterpen) dengan mekanisme masing-masing yang berperan sebagai antibakteri terhadap bakteri Propionibacterium acnes. Sediaan boreh dengan bahan utama khasiat melati putih dan bahan pendukung khasiat boreh (kulit batang kayu manis, kayu cendana, rimpang lempuyang, rimpang kunyit, buah pala) berpotensi sebagai antibakteri terhadap Propionibacterium acnes. Kata kunci: Antibakteri, boreh, jasminum sambac, propionibacterium acnes, usada bali. Abstract Boreh Usada Bali is a Balinese Hindu community healing tool made from a combination of plants that have medical efficacy. White jasmine (Jasminum sambac), is a plant in Usada Taru Pramana, that potentially reduces acne. Boreh Usada Bali is made by leaf white jasmine’s efficacy combined with supporting ingredients such as rice, cinnamon, sandalwood, bitter ginger, turmeric, nutmeg, and salt. Review boreh preparations with a composition of white jasmine’s and other natural ingredients as supporting antibacterial properties against Propionibacterium acnes. Review article was conducted with a literature review method which is classified as a systematic qualitative descriptive study. Potentially of boreh Usada Bali white jasmine’s is supported by several studies on the antibacterial properties of the components in boreh. This is because, white jasmine is reported to have tannins and flavonoids compounds and supporting efficacy ingredients boreh contain active compounds with cinnamon (cinnamaldehyde and eugenol), sandalwood (alpha-santalol, beta-santalol, and epi-beta-santalen), bitter ginger (zerumbon), turmeric (curcuminoid), and nutmeg (monoterpen) with their respective mechanisms which act as antibacterial agents against bacteria Propionibacterium acnes. Boreh with the main ingredient of white jasmine and combined with supporting ingredients (cinnamon, sandalwood, bitter ginger, turmeric, nutmeg) potentially to antibacterial activity of Propionibacterium acnes. Keywords: Antibacterial, boreh, jasminum sambac, propionibacterium acnes, usada bali

REVIEW: STUDI KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIBAKTERI TAKOKAK (Solanum torvum SW.) Wiryani, Ida Ayu; Sinta Devi, Ni Nyoman Ayu Sri; Melinda, Meylana Ayu; Leliqia, Ni Putu Eka
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.644

Takokak (Solanum torvum Sw.) merupakan tanaman yang banyak digunakan sebagai pengobatan tradisional untuk menyembuhkan berbagai penyakit, salah satunya dikaitkan dengan efeknya untuk mengobati infeksi karena bakteri. Penulisan artikel ini dimaksudkan untuk memberikan informasi terkait kandungan kimia dalam S. torvum dan potensinya sebagai antibakteri. Penyusunan artikel ini menggunakan metode literature review terhadap artikel yang telah terpublikasi baik di jurnal ilmiah nasional maupun internasional. Hasil: Daun, batang, buah, dan bunga S. torvum diketahui mengandung beberapa golongan metabolit primer dan sekunder yaitu karbohidrat, protein, flavonoid, alkaloid, glikosida, saponin, tanin, triterpenoid, dan steroid. Akar S. torvum diketahui mengandung jurubine. S. torvum juga mengandung beberapa mineral makro dan mikro diantaranya sulfur, kalsium, magnesium, besi, klorin, fosfor dan natrium. S. torvum mampu menghambat pertumbuhan berbagai bakteri Gram positif dan negatif yang telah terbukti melalui pengujian secara in vitro dengan menggunakan metode dilusi dan difusi. Kesimpulan: Daun, batang, buah, bunga dan akar. S. torvum memiliki aktivitas sebagai antibakteri. Senyawa yang terkandung di dalam S. torvum diduga berperan terhadap aktivitas antibakterinya. Metabolit sekunder yang diduga memiliki efek antibakteri yaitu alkaloid, flavonoid, glikosida, saponin, tanin, triterpenoid, dan steroid. Kata kunci: Antibakteri, kandungan fitokimia, solanum torvum, takokak ABSTRACT Takokak (Solanum torvum Sw.) is a plant that is widely used in traditional medicine to cure various diseases, one of which is associated with its effect on treating bacterial infections. The article aimed to provide information regarding the phytochemical content of S. torvum and its potential as an antibacterial agent. The preparation of this article used the literature review of articles that have been published in both national and international scientific journals. Results: The leaves, stems, fruits, and flowers of S. torvum contained several classes of primary and secondary metabolites, namely carbohydrates, proteins, flavonoids, alkaloids, glycosides, saponins, tannins, triterpenoids, and steroids. The root of S. torvum was known to contain jurubine. S. torvum also contained several macro and micro minerals including sulfur, calcium, magnesium, iron, chlorine, phosphorus, and sodium. S. torvum was able to inhibit the growth of various Gram-positive and negative bacteria which have been proven through in vitro testing with dilution and diffusion methods. Conclusion: Leaves, stems, fruit, flowers, and roots S. torvum had antibacterial activities. The compounds contained in S. torvum are thought to have a role in its antibacterial activities. Secondary metabolites that are thought to have antibacterial effects namely flavonoids, alkaloids, glycosides, saponins, tannins, triterpenoids, and steroids. Keywords: Antibacterial, phytochemical content, solanum torvum, takokak.

POTENSI EKSTRAK JAHE MERAH (Zingiber officinale Roscoe var. sunti), PEGAGAN (Centella asiatica (L.) Urb.) DAN KAYU MANIS (Cinnamomum Burmanni (C.Ness & T.Ness)) SEBAGAI HERBAL PENUNDA KEPIKUNAN Emeralda, Gerardine; Riyanti, Soraya; Karlina, Yenni
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.650

Demensia atau kepikunan merupakan sindrom yang disebabkan oleh gangguan di otak. Sebanyak 60-70% demensia disebabkan oleh penyakit alzheimer. Penyakit alzheimer disebabkan oleh adanya penurunan asetilkolin (ACh) karena dihidrolisis oleh enzim asetilkolinesterase (AChE). Penghambatan aktivitas enzim AChE digunakan sebagai terapi penyakit alzheimer. Tanaman herbal memiliki potensi untuk menghambat enzim asetilkolinesterase karena memiliki banyak kandungan kimia. Tujuan dari penelitian ini adalah menentukan aktivitas peghambatan enzim AChE dari 3 jenis tumbuhan yang ada di Indonesia yaitu jahe merah (Zingiber officinale Roscoe var. sunti), pegagan (Centella asiatica (L.) Urb.), dan kayu manis (Cinnamomum burmanni (C.Ness & T.Ness)) serta kombinasi masing-masing ekstrak. Proses ekstraksi simplisia menggunakan metode maserasi dalam etanol 96%. Pengujian aktivitas penghambat asetilkolinesterase (AChE) menggunakan metode Ellman. Hasil penelitian menunjukkan ekstrak etanol herba pegagan, dan kulit kayu manis berturut-turut sebesar 818,011 ug/mL dan 186,737 ug/mL, sedangkan ekstrak etanol jahe merah memiliki nilai IC50 > 1000 ug/mL. Nilai IC50 zat aktif donepezil adalah 0,277 ug/mL. Ekstrak etanol kulit kayu manis menunjukkan aktivitas penghambatan enzim AChE paling baik. Kombinasi ekstrak rimpang jahe merah dan kulit kayu manis dengan nilai IC50 293,166 ug/mL lebih lemah dari ekstrak tunggalnya, diduga sifat kombinasi kedua ekstrak tersebut antagonis. Ekstrak etanol kulit kayu manis paling berpotensi untuk dikembangkan lebih lanjut sebagai herbal penunda kepikunan. Kata kunci : Kepikunan, jahe merah, pegagan, kayu manis. Abstract Dementia is a syndrome caused by a variety of brain disorder. About 60-70% dementia is caused by alzheimer disease. Decrease in acetylcholine level led by the hydrolysis of acetylcholinesterase enzym (AChE) has been the common cause of Alzheimer disease. Inhibitory activity of AChE enzyme is used in the alzheimer disease therapy. Herbal plants have the potential as the AChE inhibitor because it contains a lot of chemical compounds. This study aims at studying the inhibitory activity of acetylcholinesterase enzyme of three plants existing in Indonesia, namely Red Ginger (Zingiber officinale Roscoe var. sunti), Gotu Kola (Centella asiatica (L.) Urb.) and Cinnamon (Cinnamomum burmanni (C.Ness & T.Ness)) as well as the combination of their respective extracts. Simplicia was extracted with maceration method using ethanol 96%. AChE inhibitory activity was tested using Ellman method. The results show that IC50 value of ethanolic extracts of Gotu Kola and Cinnamon herbs are 818.011 ug/mL and 186.737 ug/mL respectively, while for red ginger is > 1000 ug/mL. The IC50 value of donepezil active substance is 0.277 ug/mL. Ethanolic extract of Cinnamon was found to have the best inhibitory activity of AChE enzyme. Combined extracts of red ginger and cinnamon with the IC50 value of 293.166 ug/mL has been the most effective inhibitor of AChE enzyme. Cinnamon ethanolic extract has the greatest potential for further development in the herbal extracts for dementia prevention. Keywords : dementia, red ginger, gotu kola, cinnamon.

EFEKTIVITAS-BIAYA PENGGUNAAN BEVACIZUMAB DAN RANIBIZUMAB SEBAGAI ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR PADA PASIEN DENGAN GANGGUAN MATA: TINJAUAN SISTEMATIS Cahyono, Nur Sidik; Sukandar, Elin Yulinah
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 1 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i1.658

Anti-vascular endothelial growth factor (VEGF) given by intravitreal injection can be used to treat patients with eye disorders. The anti-VEGF drugs used include bevacizumab, ranibizumab, aflibercept, and brolucizumab. These drugs are high-cost drugs, so the cost-effectiveness of each drug must be considered in order to save on treatment costs. This systematic review aims to provide a comprehensive picture of the cost-effectiveness of bevacizumab and ranibizumab. The databases used to identify relevant studies are PubMed, Science Direct and Google Scholar. This research is limited to randomized control trials (RCT), clinical trials, and research articles, studies that explain the cost-effectiveness of intravitreal injections of bevacizumab and ranibizumab and other drugs as anti-VEGF for patients with eye disorders, as well as articles in English. Electronic data-based searches resulted in 2414 articles; 27 articles were selected that had full text access and discussed the cost-effectiveness of ranibizumab or bevacizumab, but only 12 articles suitable for inclusion were considered. Bevacizumab is more cost-effective than ranibizumab.

AKTIVITAS ANTIOKSIDAN DAN INHIBITOR NITRIT OKSIDA EKSTRAK ETANOL KULIT BIJI KACANG HIJAU (Vigna radiata L.) Suryani, Suryani; Amalia, Rizanty; Fajriati, Julia Rahma; Febrianto, Yudhistira Eko; Aziizah, Retno Nuur; Kahla, Mutia Ghaida; Hanifa, Rd. Isma Zikra; Anjali, Inayatus Syahra
Kartika : Jurnal Ilmiah Farmasi Vol 8 No 2 (2023)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v8i2.712

Kulit biji kacang hijau (Vigna radiata L.) saat ini tidak dimanfaatkan dan menjadi limbah sisa produksi makanan, salah satunya sebagai limbah dari tauge. Kulit biji kacang hijau diketahui kaya akan flavonoid sehingga besar peluang untuk memanfaatkan limbah menjadi salah satu komponen yang baik untuk kesehatan tubuh yaitu sebagai sumber antioksidan. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan dan potensi inhibisi nitrit oksida dari ekstrak etanol kulit biji kacang hijau. Ekstrak diperoleh melalui metode maserasi menggunakan etanol 96% dengan rendemen sebesar 0,9947%. Aktivitas antioksidan diuji menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil), sedangkan potensi inhibisi nitrit oksida diukur melalui penguraian SNP menjadi NO yang diukur dengan pereaksi Griess. Hasil penelitian menunjukkan bahwa ekstrak etanol kulit biji kacang hijau memiliki aktivitas antioksidan yang kuat dengan nilai IC50 sebesar 91,36 ug/mL terhadap radikal bebas DPPH. Selain itu, ekstrak juga menunjukkan kemampuan yang signifikan dalam menghambat pembentukan nitrit oksida dengan nilai IC50 sebesar 88,05 ug/mL. Aktivitas ini diduga berkaitan dengan kandungan senyawa flavonoid dalam ekstrak, terutama vitexin dan luteolin. Hasil penelitian ini mengindikasikan bahwa ekstrak etanol kulit biji kacang hijau berpotensi sebagai sumber antioksidan alami dan dapat dikembangkan lebih lanjut untuk pencegahan penyakit degeneratif terkait stres oksidatif. Kata kunci : Antioksidan, dpph, nitrit oksida, Vigna radiata (L.) Abstract Mung bean (Vigna radiata L.) seed coats are currently underutilized and become waste from food production, including as a waste product of bean sprouts. Mung bean seed coats are known rich in flavonoids compound. It was presenting a significant opportunity to utilize this waste as a beneficial component for human health as antioxidant. This study aimed to evaluate the antioxidant activity and potential nitric oxide inhibition of ethanol extracts from mung bean seed coats. The extract was obtained through maceration using 96% ethanol, yielding 0.9947%. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, while nitric oxide inhibition potential was measured through the decomposition of SNP into NO, quantified using Griess reagent. Results showed that the ethanol extract of mung bean seed coats exhibited strong antioxidant activity with an IC50 91.36 ug/mL against DPPH free radicals. Additionally, the extract demonstrated significant ability to inhibit nitric oxide formation with an IC50 88.05 ug/mL. This activity is likely related to the flavonoid content in the extract, particularly vitexin and luteolin. These findings indicate that the ethanol extract of mung bean seed coats has potential as a natural antioxidant source and could be further developed for the prevention of degenerative diseases associated with oxidative stress. Keywords: Antioxidant, dpph, nitrite oxide, Vigna radiata (L.)

MASKER WAJAH DENGAN BAHAN AKTIF EKSTRAK CEMPAKA KUNING Wulantresna, Dewi; Zuhrotun, Ade; Chaerunisaa, Anis Yohana
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 1 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i1.648

Sediaan kosmetika masker wajah yang mengandung bahan alami saat ini telah banyak beredar dipasaran, namun belum ada sediaan masker wajah dengan bahan aktif ekstrak bunga cempaka kuning. Adanya aktivitas antioksidan bunga cempaka kuning telah dilaporkan dari ekstrak dengan nilai IC50 5,12 µg/mL dan dari masker gel peel off yang mengandung ektrak bunga dengan nilai persen peredaman sebesar 51,75% mengandung 2 x IC50 (F2) dan 54,5% mengandung 3 x IC50 (F3). Namun sediaan masker gel tersebut belum diketahui keamanan dan kestabilan fisik sediaannya. Studi literatur ini bertujuan untuk melihat dan mengetahui potensi ekstrak cempaka kuning dalam pengembangan pada sediaan masker wajah dan beberapa pengujian kualitas dan kestabilan sediaan masker wajah. Metode dalam kajian literatur ini adalah pencarian artikel jurnal dan buku yang bersumber dari database PubMed, Sciencedirect dan Google Scholar. Hasil penelusuran pustaka diperoleh 99 artikel dipilih untuk skrining awal. Berdasarkan kajian literatur dapat disimpulkan bahwa ekstrak cempaka dapat memungkinkan untuk dikembangkan menjadi bentuk sediaan masker wajah, baik masker peel off atau sediaan masker lainnya. Kata kunci: Antioksidan, ekstrak bunga cempaka kuning, masker wajah Abstract Face mask as cosmetic preparations containing natural ingredients are currently widely distributed in the market, but there is no face mask preparation with the active ingredient yellow champaka flower extract. Antioxidant activity of yellow champaka flower has been reported from extract with an IC50 value of 5.12 µg/mL and from a peel off gel mask containing this extract with a percent inhibition of 51.75% containing 2xIC50 (F2) and 54.5% containing 3xIC50 (F3). However, this gel mask preparation is not yet known for its safety and physical stability. This literature study aims to know the potential of yellow champaka extract in the development of facial mask preparations and its several quality and stability tests. The method in this literature review is the search for journal articles and books sourced from the PubMed, Sciencedirect and Google Scholar databases. The results of the literature search obtained 99 articles selected for initial screening. Based on the literature review, it can be concluded that champaka extract can allow it to be developed into a face mask dosage form, either a peel off mask or other mask preparations. Keywords: Antioxidant, yellow champaka flower extract, face mask

STUDI IN SILICO SENYAWA AKTIF PADA DAUN SAMBILOTO (ANDROGRAPHIS PANICULATA) SEBAGAI INHIBITOR ANDROGEN PADA KANKER PROSTAT Davinali, Belva Annora Alfita; Stephanie, Manuela Joy; Hanifa, Hasya Qanita Ali; Aurelia, Khanna Ragita; Prasiska, Rizky; Nurdin, Halwa Aulia; Nuwarda, Rina Fajri
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.721

Kanker prostat adalah penyakit kanker yang berkembang di sel-sel kelenjar prostat pria, yang dapat menyebar ke bagian tubuh lainnya, terutama tulang dan nodus limfa. Di Indonesia, kanker prostat menjadi kanker kelima yang paling umum terjadi pada pria, dan menempati urutan kedua kanker paling umum terjadi pada pria di dunia. Reseptor Androgen (AR) adalah protein reseptor yang berperan penting dalam pertumbuhan sel kanker prostat dan telah digunakan sebagai sel target untuk pengembangan obat terkait penyembuhan kanker prostat. Penelitian ini bertujuan untuk studi in silico aktivitas senyawa kimia pada daun tanaman sambiloto (Andrographis paniculata) untuk menghambat reseptor Androgen (1E3G) untuk mengobati kanker prostat. Penelitian dilakukan dengan metode molecular docking menggunakan perangkat lunak Chemdraw, Chem3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, dan Ligandscout. Hasil penelitian menunjukkan bahwa senyawa Andrografolid mempunyai energi ikatan bebas terendah yaitu -10.73 KKal/mol serta interaksi pada beberapa residu asam amino yang sama dengan ligan alami, yaitu Metribolon. Karena itu dapat disimpulkan bahwa dari daun sambiloto senyawa andrografolid merupakan senyawa yang paling berpotensi dalam penghambatan reseptor Andorgen. Kata kunci : Andrographolide, reseptor androgen, studi in silico Abstract Prostate cancer is a malignancy in men’s prostate gland cells, which can spread to other parts of the body, most commonly bones and lymph nodes. In Indonesia, prostate cancer is the third most common type of cancer among men, and is the second most commoncancer in men in the world. Androgen receptor (AR) is a receptor protein that plays an important role in the growth of prostate cancer cells and has been used as a target cell for developing drugs for prostate cancer treatment. This research aims to study in silico the activity of chemical compounds in the leaves of the sambiloto plant (Andrographis paniculata) to inhibit the Androgen receptor (1E3G) to treat prostate cancer. Tests were Carried out with molecular docking method using the software Chemdraw 3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, and Ligandscout. The results showed that Andrographolid compounds had the lowest free bond energy of -10.73 KKal/mol and interactions in several amino acid residues that were the same as natural ligands, namely Metribolon. Therefore, it can be concluded that from sambiloto leaves, andrographolid compounds are the most potential compounds in inhibiting Andorgen receptors. Keywords : Andrographolide, Androgen receptor, in silico study.

PENANGANAN PERMASALAHAN SIFAT HIGROSKOPIS PADA FORMULASI SEDIAAN TABLET Ratih, Hestiary; Gosepa, Oke Setiawan
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.728

Sebagian besar bahan aktif farmasi (BAF) bersifat sangat higroskopis dalam bentuk padatan. Higroskopisitas yang tinggi dapat menimbulkan beberapa permasalahan antara lain terjadinya perubahan sifat fisikokimia pada bahan aktif. Perubahan sifat fisiko kimia tersebut dapat berdampak pada usia simpan sediaan tablet sehingga menjadi lebih singkat. Kajian literatur ini bertujuan untuk memberikan informasi mengenai penanganan pada proses produksi sediaan tablet yang memiliki sifat padatan bahan baku higroskopis. Metode penyusunan kajian literatur ini bersumber dari 42 artikel yang berasal dari artikel jurnal nasional maupun internasional yang telah terbit pada sepuluh tahun terakhir (2014-2024), artikel yang terkumpul dilakukan seleksi dan identifikasi berdasarkan kriteria inklusi dan eksklusi. Hasil kajian penelusuran pustaka terkait dengan upaya yang dapat dilakukan dalam penanganan permasalahan sifat higroskopis padatan farmasi pada formulasi sediaan tablet, antara lain yaitu, dengan teknik penyalutan film, teknik enkapsulasi (dengan spray-drying/freeze-drying dan koaservasi kompleks), teknik ko-proses (co-process), dan rekayasa kristal (co-crystal). Berdasarkan kajian literatur yang telah dilakukan dapat disimpulkan bahwa beberapa teknik dalam memodifikasi sifat fisik bahan aktif farmasi pada formulasi sediaan tablet dapat menangani permasalahan sifat higroskopis bahan aktif dengan meningkatkan pengendalian higroskopisitas suatu padatan sehingga dapat meningkatkan stabilitas bahan aktif. Kata kunci: Formulasi, higroskopis, penanganan, sediaan, tablet. Abstract The majority of active pharmaceutical ingredients (API) are highly hygroscopic in solid form. High hygroscopicity can cause several problems, including changes in the physicochemical properties of active ingredients which can cause difficulties in formulating a preparation such as tablets, so that this can affect the shelf life of tablet preparations which become shorter. This literature review aims to find out the formulation handling in the production process of tablet preparations that have the characteristics of highly hygroscopic solids. The method of preparing this literature review comes from 42 articles originating from national and international journal articles that have been published in the last ten years (2014 - 2024), the collected articles were selected and identified based on the inclusion and exclusion criteria. The results of the literature search review related to efforts that can be made in handling the problem of hygroscopic properties of pharmaceutical solids in tablet dosage formulations, including film coating techniques, encapsulation techniques (by spray-drying/freeze-drying and complex coacervation), co-process techniques, and crystal engineering (co-crystal). Based on the literature review that has been conducted, it can be concluded that several techniques in modifying the physical properties of active pharmaceutical ingredients in tablet formulations can handle the problem of the hygroscopic nature of active ingredients by increasing the control of hygroscopicity of a solid so as to increase the stability of active ingredients. Keywords: Formulation, hygroscopic, handling, preparation, tablets.

PENGARUH VARIASI WAKTU EKSTRAKSI TERHADAP KADAR SAPONIN TOTAL EKSTRAK AIR AKAR TEBU HITAM (Saccharum officinarum L.) SECARA SPEKTROFOTOMETRI UV-VIS Sarwendah, Adzkia Salsa; Lindawati, Novena
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.695

Black Sugar Cane (Saccharum officinarum L.) is an annual plant that is often used for medicine, food and, drink. Black Sugar Cane Root decoction has various pharmacological effects as antibacterial, immunomodulatory and antianemic due to the presence of saponins. This study aims to determine total saponin levels with variations in boiling time for Black Sugar Cane Roots using the UV-Vis Spectrophotometry method. The method for identifying saponin compounds uses the foam method and Liebermann-Burchard reagent. Determination of levels was carried out using the UV-Vis Spectrophotometry method at a wavelength of 543 nm and an operating time of 15 minutes. The comparison standard used is Diosgenin. The results showed that the decoction of Black Sugar Cane Roots positively contained steroid saponins. The results of determining total saponin levels with varying boiling times of 10 minutes, 20 minutes, and 30 minutes were respectively 1.123 mg DE/g with a KV of 0.679%, 2.086 mg DE/g with a KV of 0,276%, and 2.933 mg DE/g with KV 0.196%, the boiling time is 30 minutes, Black Sugar Cane Roots have the highest saponin content. Homogeneity of Variences Test, a significance value of 0.641 > 0.05 was obtained. The Anova test obtained a significance value of 0.000 < 0.05, that there is a significant difference between the saponin content and the boiling time for Black Sugar Cane Roots.

PENAMBATAN MOLEKUL SENYAWA AKTIF CURCUMA XANTHORRHIZA ROXB KANDIDAT ANTI KANKER KOLOREKTAL TERHADAP RESEPTOR LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE Sativa, Nasywa Oryza; Putri, Adelia Ofira; Natasya, Zaskiya; Rislia, Rana Atikah; Ulfa, Lutfiyana; Karima, Miska Aulia; Balqis, Selvi; Saputro, Anjar Hermadi; Auli, Winni Nur
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.702

Background: Temulawak (Curcuma xanthorrhiza Roxb) contains essential oils and curcuminoid compounds which have anti-cancer activity. Temulawak (Curcuma xanthorrhiza Roxb) can increase colorectal cancer chemotherapy agents against Lck receptors on colon epithelial cells. Purpose(s): The aim of this research is to identify active compounds that have the potential to act as colorectal anticancer contained in Temulawak (Curcuma xanthorrhiza Roxb) against Lck receptors through in silico studies using molecular docking methods. Methods: This study was carried out of molecular docking using software AutoDock Tools-1.5.6., Lipinski predictions with LigandScout, and visualitation using Biovia Discovery Studio 2021 Client. Results: Xanthorrizol has hydrogen bonds with the same amino acid residues as native ligand and reference compound, namely GLU317 and MET319. The results of the molecular binding energy of the native ligand are -10.12 kcal/mol. Conclusion: Based on research results, the xanthorrizol compound has the best potential to be a colorectal anticancer candidate and qualified of Lipinski's rules so it is safe to be administered orally.

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Achsan

Contact Email
kjif@unjani.ac.id

Phone
+6222-6629821

Journal Mail Official
kjif@unjani.ac.id

Editorial Address
FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia

Location
Kota cimahi,

Jawa barat

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Achsan

Contact Email kjif@unjani.ac.id

Phone +6222-6629821

Journal Mail Official kjif@unjani.ac.id

Editorial Address FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia

Location Kota cimahi, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Achsan

Contact Email
kjif@unjani.ac.id

Phone
+6222-6629821

Journal Mail Official
kjif@unjani.ac.id

Editorial Address
FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia

Location
Kota cimahi,

Jawa barat

INDONESIA