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Svāsthya: Trends in General Medicine and Public Health
Published by PT Mega Science Indonesia
ISSN : -     EISSN : 30630649     DOI : https://doi.org/10.70347/svsthya
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Svāsthya: Trends in General Medicine and Public Health is a multidisciplinary journal and it is published six times (January, March, May, July, September, and November) a year. The objective is to promote articles on general medicine, infection, public health, Global health Infection, Tropical diseases, One health and eco-epidemiology, Biomedical sciences, Epidemiology and clinical epidemiology, Molecular biology, Biology of disease and infection, Environmental health, Epidemiology and biostatistics, Disease, prevention and health promotion, Health technology and innovation, Microbiology, Pharmacological medicine, Traditional medicine, and Diseases in tropics. Svāsthya publishes original research work across all disciplines of medicine and allied sciences, related to infection, public health, global health, tropical infection, one health and diseases in tropics. The journal publishes original articles, short report, case report, review articles, systematic review - meta analysis and letters to the editor. All articles published in Svāsthya are peer-reviewed and published online for immediate access and citation.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 52 Documents
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Systematic literature review on sterile injectable dates of use, stability and implications for use Dewi, I Gst A A Gangga Samala; Putri, Lucienne Agatha Larasati Nugraha; Silalahi, Lydia Devy; Dewi, I Gusti Ayu Widha Paramistya; Hapsari, Meivanti Diva; Dewa, Julio Angga Purnama; Sarayawati, Kadek Ayu Mas; Prasetya, I Wayan Sindhu Wahyu; Dewi, Ni Pande Kadek Sinta; Noviyanti, Ni Putu Rika; Sari , Putri Ayu Puspita; Rajeswari, Ni Kadek Ida; Wahyuni, Ni Luh Komang; Wulandari, Dewi; Warditiani, Ni Kadek
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 1 (2025): January 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i1.66

Abstract

Beyond-use date (BUD) is crucial for the stability of injectable preparations. However, there is a knowledge gap and a lack of information regarding BUD determination in injection preparations. Therefore, a systematic review is needed to address the BUD of injection preparations. This study aimed to provide comprehensive insights into the stability, BUD data, and associated implications for injectable preparations through a systematic literature review approach. This study employed a systematic literature review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The inclusion criteria were research articles from national and international journals discussing the BUD of sterile injection preparations published in the last 10 years. Fourteen of the 19 articles related to BUD were selected for analysis. The analysis revealed that the stability of the 19 sterile injection preparations was significantly influenced by the characteristics of the preparation, storage conditions, and type of drug. These factors substantially affect the effectiveness and safety of drugs. Intravenous sterile injections involve several critical steps to ensure the safety and efficacy of the medications used. Adhering to BUD guidelines for intravenous injections is crucial for maintaining drug quality, which can help prevent infections or adverse reactions in patients. The stability of sterile injection preparations, which is influenced by various factors, has direct implications for BUD determination. This review highlights the importance of considering these factors when determining BUD to ensure patient safety.
Dual impact analysis of GSTT1 polymorphisms on the metformin response and cardiovascular risk: A novel integrated approach in type 2 diabetes mellitus management Dewi, Ni Luh Made Noviana
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 1 (2025): January 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i1.76

Abstract

Although genetic variations in glutathione S-transferase (GST) have been linked to type 2 diabetes mellitus (T2DM), the relationships among GSTT1 polymorphisms, metformin effectiveness, and cardiovascular risk remain unclear. This study investigated the association between the GSTT1 null genotype and the metformin monotherapy response while simultaneously assessing its impact on atherosclerotic cardiovascular disease risk. This case-control study examined 84 T2DM patients aged 30-70 years, categorized into metformin therapy responders and nonresponders. This study employed multiplex PCR for GSTT1 genotyping and utilized the pooled cohort equation for cardiovascular risk assessment, offering a comprehensive analysis of both genetic and clinical parameters. GSTT1 genetic variations were not significantly associated with metformin response (odds ratio [OR] 1.773, p=0.306) or cardiovascular risk (OR 1.086, 95% CI: 0.46-2.56, p=1.000). The analysis revealed distinct patterns in clinical parameters between the GSTT1 null and wild-type genotypes, particularly in terms of glycemic control indicators and lipid profiles, although these differences did not reach statistical significance. This study presents a novel approach by simultaneously examining both the therapeutic response and cardiovascular risk in relation to GSTT1 polymorphisms, distinguishing it from previous studies that typically focused on either aspect in isolation. These findings suggest that while genetic variations in GSTT1 may influence metabolic parameters, their direct impact on metformin effectiveness and cardiovascular risk may be more complex than previously thought.
The Isolation of mercury-resistant bacteria in the Brantas River, Malang, Indonesia Harmoko, Deni
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 1 (2025): January 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i1.77

Abstract

Mercury (Hg) is a toxic heavy metal that can originate from various sources, such as gold mining, the industrial sector, atmospheric deposition, and natural activities. Mercury contamination can cause liver, kidney, and enzyme system damage, as well as DNA damage. Because microorganisms are more sensitive to heavy metal stress than are animals and plants, the characteristics of microorganisms can be potential indicators of environmental health. This study aimed to isolate and identify mercury-resistant bacteria in the Brantas River, Malang as potential indicators of Hg pollution. Samples were isolated on nutrient agar (NA) media supplemented with 0.01 ppm HgCl₂ as a selective medium. The growing bacterial colonies were purified, and further resistance tests were carried out by adding HgCl₂ at concentrations of 0.03 ppm, 0.05 ppm, and 0.1 ppm. Bacterial isolates that survived at a concentration of 0.1 ppm HgCl₂ were then tested for sensitivity to concentrations of 0.15 ppm and 0.2 ppm HgCl₂. Bacterial isolation via HgCl₂ 0.01 ppm selective media produced 28 bacterial isolates. Further testing revealed that 19 isolates were resistant to 0.03 ppm HgCl₂, 13 isolates (0.05 ppm), and five isolates (0.1 ppm. Sensitivity tests on five bacterial isolates revealed that at a HgCl₂ concentration of 0.15 ppm, isolates RS118, RS1221, and RS1323 showed no growth inhibition, whereas at a concentration of 0.2 ppm, an inhibition zone formed for all five isolates. Although mercury-resistant bacteria were detected, this finding does not directly indicate the presence of mercury pollution in the river because bacterial resistance can be caused by various factors, including horizontal gene transfer between bacterial communities. Comprehensive testing of Hg concentrations in rivers is required to accurately determine the status of Hg pollution. This study highlights the importance of considering multiple biomarkers and environmental parameters alongside bacterial resistance patterns when assessing Hg contamination in riverine ecosystems.
Front and Back Matter for Volume 2 Issue 1, January 2025 Trends in General Medicine and Public Health, Svāsthya:
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 1 (2025): January 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Volume 2, Issue 1, January 2025 This issue consists of 5 articles contributed by 23 authors affiliated with 7 affiliations from two countries, including Indonesia (Universitas Maarif Hasyim Latif, Universitas Negeri Makassar, Universitas Mega Buana Palopo, Universitas Hindu Indonesia, Universitas Udayana), and Ethiopia (Jimma University, Jigjiga University, College of Veterinary Medicine).
Organizational, environmental, and sustainability of inputs to the implementation of a smoke-free area policy: A path analysis of Makassar's health facilities Ismaniar, Nur Inayah; Wahyudin , Wahyudin; Paratama, Faradillah
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 2 (2025): March 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i2.78

Abstract

The implementation of smoke-free policies in healthcare facilities represents a critical public health strategy; however, maintaining sustainable compliance remains a challenge globally. While healthcare institutions are expected to exemplify tobacco control measures, the effectiveness of smoke-free policies depends on multiple factors at the institutional and governmental levels. This study aimed to examine the influence of organizational, environmental, and sustainability factors on input indicators for smoke-free area policy implementation in healthcare facilities in Makassar, Indonesia. A quantitative correlational study was conducted across seven healthcare facilities that provide inpatient services. Using random cluster sampling, 232 healthcare workers were selected from a population of 736. Path analysis was employed to evaluate causal relationships between independent variables (organizational, environmental, and sustainability factors) and dependent variables (input indicators, including written policies, monitoring personnel, and promotional media). Data were collected through validated questionnaires and analyzed via structural equation modeling. Path analysis revealed that sustainability factors significantly influenced input indicators, particularly written policies (t statistic = 2.592, p<0.05, β=0.194). Key sustainability components, including funding stability, partnerships, organizational capacity, program evaluation, adaptation, and strategic planning, have demonstrated positive effects on policy implementation. Organizational and environmental factors had no significant impact on the input indicators. Sustainability factors emerged as crucial determinants for the successful implementation of smoke-free policies in healthcare facilities in Makassar city. Future research should investigate the barriers to policy implementation and explore additional input indicators to increase the effectiveness of smoke-free policies.
Water, sanitation and hygiene (WASH) and its association with stunting in developing countries in Asia: A systematic review Rizaldi, Muhammad Addin; Ali, Khaidar; Rara, Swara Mega Hasanah; Panjaitan, Bintang Sri Rezeki
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 2 (2025): March 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i2.81

Abstract

Stunting is a vital health issue in developing Asian countries, where millions of individuals suffer from chronic malnutrition. Stunting not only is caused by chronic malnutrition but is also influenced by inadequate water supply, sanitation problems, and poor hygiene practices in the community. However, research on water, sanitation, and hygiene (WASH) and its association with stunting is limited, particularly in developing countries. This study aimed to analyze the associations between water, sanitation, and hygiene practices and the occurrence of stunting in Asia. This article is a systematic literature review using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. A total of 1,002 articles were reviewed, of which 560 were published. Additionally, articles could be selected and dropped because they had no original research. After duplicate articles were removed, 168 articles were removed. The screening and extraction results revealed 14 articles eligible for review. After the article was reviewed and read, only five articles were eligible, and only 5 articles could be reviewed because the article discussed WASH and stunting in developing countries in Asia. Inadequate WASH practices were strongly associated with stunting among children under five years of age. An insufficient water supply and access to safe drinking water contribute to this condition, as inadequate water availability can increase the risk of stunting. Additionally, groundwater unfit for consumption increases the likelihood of undernutrition, including stunting, underweight, and wasting in children. Access to improved drinking water sources is essential for reducing stunting, as households with such access report lower stunting rates. Solutions to address stunting in children under five years of age include enhancing drinking water sources, improving sanitation facilities, and promoting better hygiene practices. Local governments should provide adequate water provision and accessible drinking water.
Chandipura viral encephalitis: A re-emerging threat to public health and regional security in South Asia Parmar, Rugved; Parihar, Ranjeet; Rebuma, Tesfaye; Pal, Mahendra
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 2 (2025): March 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i2.82

Abstract

Chandipura viral encephalitis (CHPV) has emerged as a significant public health challenge in South Asia, particularly in pediatric populations, with alarming mortality rates. This review synthesizes the current knowledge about the impact of CHPV on human health and healthcare systems. A comprehensive analysis of the published literature, outbreak reports, and clinical studies was conducted to evaluate the epidemiology, clinical manifestations, diagnostic approaches, and treatment strategies of CHPV. CHPV has a distinct predilection for children under 15 years of age, with case fatality rates ranging from 55–70% in severe pediatric cases. Disease progression is characterized by the rapid onset of symptoms, typically evolving from initial influenza-like manifestations to severe neurological complications within 48 h. The clinical presentations include high-grade fever, altered consciousness, seizures, and various neurological deficits. Diagnostic challenges persist, particularly in resource-limited settings, despite advances in molecular detection methods. Treatment remains primarily supportive, with a focus on managing severe complications and maintaining vital organ function. Socioeconomic impacts are substantial, with catastrophic healthcare costs affecting vulnerable populations and straining healthcare systems in endemic regions. The reemergence of CHPV poses serious challenges to public health systems, particularly in resource-limited settings. Rapid progression of the virus, high mortality rates, and significant socioeconomic burden necessitate enhanced surveillance systems, improved diagnostic capabilities, and strengthened healthcare infrastructure. The priority areas for intervention include developing point-of-care diagnostics, establishing standardized treatment protocols, and implementing sustainable vector control programs.
Frequency, clinical presentation, and management of Bartholin’s abscess: A case study at Rabia Balkhi Hospital, Afghanistan in 2022 Hamidi, Hamida
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 2 (2025): March 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i2.87

Abstract

Bartholin gland abscesses represent a significant gynecological condition requiring proper clinical management to prevent complications. These abscesses develop from ductal obstruction or infection of the bartholin glands, manifesting as localized pain, swelling, and erythema. Understanding their clinical presentation and management is crucial for optimal patient care in resource-limited settings. This study aimed to evaluate the incidence, clinical presentation, management strategies, and treatment outcomes of bartholin gland abscesses at Rabia Balkhi Hospital, Afghanistan, in 2022. This retrospective cohort study analyzed the hospital records of women diagnosed with Bartholin's gland abscesses. The study identified 23 cases (n = 23), representing 0.6% of all gynecological admissions. The data collected included demographic information, clinical presentations, treatment approaches, and outcome measures. Among the 4,140 gynecological admissions, 23 cases (0.6%) of Bartholin gland abscesses were identified. The majority of cases (52%) occurred in women aged 25-35 years, with predominant clinical manifestations, including severe localized pain (96%), erythema (96%), and swelling (87%). This study employed three primary treatment modalities: incision and drainage (74%), marsupialization (17%), and drainage tube insertion (9%). Treatment outcomes demonstrated favorable results, with pain resolution achieved in 87% of patients within 48 hours postintervention. The overall recurrence rate was 13%, with no major complications observed during the study period. Bartholin gland abscesses predominantly affect women aged 25-35 years, and incisions and drainage are the most effective treatments. These findings emphasize the importance of early intervention and appropriate treatment selection on the basis of patient characteristics
Neuromuscular adaptations to plyometric exercises in late-phase ACL reconstruction rehabilitation: A case report Fadhilah, Siti; Pristianto, Arif; Mardianto, Halim
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 2 (2025): March 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i2.88

Abstract

Postanterior cruciate ligament (ACL) reconstruction rehabilitation poses significant challenges in restoring optimal neuromuscular function and athletic performance.This study aimed to evaluate the therapeutic efficacy of a structured plyometric exercise protocol on muscle strength, dynamic balance, and functional outcomes in young athletes who underwent ACL reconstruction. A single-case study of a 16-year-old male soccer athlete who underwent right anterior cruciate ligament (ACL) reconstruction was conducted. The intervention comprised three sessions of progressive plyometric exercises over a seven-day period. Outcomes were assessed via a modified sphygmomanometer test for muscle strength, the Y balance test for dynamic balance, and the Tegner Lysholm knee scoring scale for functional ability. Knee flexor strength improved from 50 to 100 mmHg (100% increase), and extensor strength increased from 110 to 130 mmHg (18.2% increase). The dynamic balance composite score increased from 88% to 108%. The functional performance on the Tegner-Lysholm scale improved from 90 to 95 points, primarily because of reduced pain scores. This case demonstrates that a structured plyometric exercise protocol may effectively improve muscle strength, dynamic balance, and functional performance during late-stage ACL rehabilitation. These findings suggest the potential utility of return-to-sport protocols, although large-scale investigations are warranted.
Front and Back Matter for Volume 2 Issue 2, March 2025 Trends in General Medicine and Public Health, Svāsthya
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 2 (2025): March 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Volume 2 Issue 2, March 2025This issue consists of 5 articles contributed by 15 authors affiliated with 12 affiliations from four countries, including Indonesia (Universitas Muhammadiyah Surakarta, K.R.M.T. Wongsonegoro Hospital, Universitas Negeri Makassar, Universitas Sawerigading, Universitas Jenderal Soedirman, Universitas Sriwijaya, Universitas Negeri Manado), Afghanistan (Rabia Balkhi Hospital), India (B. J. Medical College, Civil Hospital Campus, Mobile Veterinary Units (MVUs) India, Narayan Consultancy on Veterinary Public Health and Microbiology), and Ethiopia (Sebeta Sub-City Agricultural Office).

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