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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 9 No 2 (2024)" : 26 Documents clear
REVIEW: ACTIVITY OF DIOSGENIN COMPOUND AS ATHEROSCLEROSIS THERAPY Rusi Rismawanti; Siti Saidah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1173

Abstract

Atherosclerosis is a disease that causes inhibition of the stability of the cardiovascular system in the body. Cardiovascular disease remains at the top of the list of diseases that cause death. Therefore, cardiovascular disease therapy, including atherosclerosis, still needs to be developed to reduce the mortality rate associated with this disease. Several studies have shown that diosgenin compounds can be used as a therapy for atherosclerosis. The purpose of this study was to determine whether diosgenin compounds and their derivatives can be used for atherosclerosis therapy with various mechanisms of action related to the development of atherosclerosis. This article review was conducted using the article search method on Google Scholar, Pubmed, and Science Direct with various keywords. The results obtained are diosgenin and several diosgenin-derived compounds that can be used as therapies for atherosclerosis with several responses obtained from experiments using rats.  Keywords: diosgenin; atherosclerosis; diosgenin derivatives
REVIEW: POTENTIAL OF NANOEMULGEL FORMULATIONS FOR TOPICAL DRUG DELIVERY Santi Hasanah; Jessie Sofia Pamudji
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1182

Abstract

Nanoemulgel is a combination of two different formulation systems, known as nanoemulsion preparation with gel matrix. In recent years, there has been an increase in the use of topical nanoemulgel preparations because they are easy to apply and can avoid damage to various drugs in the body. Although topical nanoemulgel preparations have some limitations, they are capable of delivering lipophilic drugs topically. The purpose of this review is to summarize the potential of nanoemulgel formulations for topical drug delivery against various physiological challenges and limitations of the formula. Through the publication search, as many as 124 articles were obtained based on the screening results of 29 articles that met the inclusion criteria and were used as a review. The analysis of data for this article was conducted through a narrative review. This preparation may improve the permeability of the drug into the skin by penetrating the stratum corneum through intercellular and intracellular pathways, depending on the components used: oil phase, surfactants, co-surfactants, and gelling agents. Surfactants are responsible for damaging the structure of the skin layer by lowering the surface tension, and gelling agents are responsible for increasing the viscosity and adhesiveness of the skin. Nanoemulgel formulations for topical drug delivery can be used to treat several diseases, such as inflammation, arthritis, wounds, fungal infections, bacterial infections, and psoriasis. The nanoemulgel formulation may provide promising potential in delivering lipophilic drugs topically in the future Keywords: Nanoemulgel, nanoemulsion, gel, topical drug delivery
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF RAMBUTAN HONEY TOOTHPASTE AGAINST Streptococcus mutans Euis Reni Yuslianti; Titta Hartyana Sutarna; Frita Ferlita Shafri Djohan; Amalia Hasna
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1187

Abstract

Dental caries and periodontal diseases are the most common diseases affecting the oral cavity. This can be prevented by maintaining oral hygiene. Toothpaste plays an important role in the reduction of plaque bacteria and inflammatory conditions. Rambutan honey has potential as a natural ingredient to make toothpaste with antibacterial and antioxidant properties owing to the presence of hydrogen peroxide and catalase enzymes, pH, osmolarity, and flavonoid content. The purpose of this study was to obtain a rambutan honey toothpaste formulation that effectively inhibits Streptococcus mutans growth. The laboratory experimental research method was used to combine CaCO3, glycerin, Na CMC, SLS, sodium benzoate, saccharin, menthol, and aquadest as the toothpaste base, which served as the control group. Subsequently, natural ingredients of rambutan honey at concentrations of 20%, 40%, and 60% were added to the toothpaste base to create rambutan honey toothpaste. The formulation of the rambutan honey toothpaste was followed by an antibacterial activity test using the Kirby Bauer method of disc diffusion, where the inhibition zones formed on Mueller Hinton Agar (MHA) medium were calculated. Data were analyzed using one-way and post hoc Tukey’s tests (p<0.05). The results showed that the formulation of rambutan honey toothpaste with a concentration of 60% had the greatest inhibition with 13.88±0.13 mm with a significant difference in each group (p = 0.000), so it can be concluded that rambutan honey toothpaste can inhibit the formation of Streptococcus mutans.  Keywords: antibacterial, formulation, rambutan honey, toothpaste, Streptococcus mutans
REVIEW: ANTIBACTERIAL, ANTIFUNGAL AND WOUND HEALING ACTIVITY OF NANOEMULGEL FORMULATIONS AND PHYSICAL CHARACTERISTICS Rodhia Ulfa; Wildan Khairi Muhtadi; Urva Fresiva; Amraini Amelia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1193

Abstract

Nanoemulgel is an emulsion preparation with a droplet size of 1–100 nm suspended in a hydrogel. This review delves into the research on the impact of incorporating excipient components in nanoemulgel formulations to create products with specific physical attributes for different active ingredients with antifungal, antibacterial, and wound-healing properties. The research approach involves comparing articles on nanoemulgel preparation formulations with different combinations of active ingredients and excipients, as well as their pharmacological effects. Enhancing the level of active ingredients and altering the excipients can boost the effectiveness of nanoemulgel formulations in combating fungi, bacteria, and promoting wound healing. The review includes articles published within the past decade. Keywords: Nanoemulgel, Pharmacological activity, Physical characteristics, Review
FORMULATION OF HAIR TONIC COMBINATION OF ETHANOL EXTRACTS OF MORINGA OLEIFERA LAM LEAVES AND FRAGRANT PANDAN (Pandanus Amaryllifolius Roxb) AND ITS ACTIVITY ON HAIR GROWTH IN WHITE RATS Reski Mulia; Iis Wahyuningsih; Moch Saiful Bachri; Sri Mulyaningsih
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1202

Abstract

Hair is the crown for everyone because hair functions aside from providing warmth, protection, beauty, and support. Hair loss that can cause baldness is one of the most serious problems for everyone. This study aimed to determine the activity of Hair Tonic combination formulations of kelor leaf ethanol extract (Moringa oleifera Lam.) and ethanol extracts of Fragrant Pandan  leaves (Pandanus amaryllifolius Roxb) on rat hair growth compared to single use. The method began with the maseration process of ethanol extract of kelor leaves and ethanol extract of Fragrant Pandan leaves, characterization of extracts (specific and non-specific parameters), chemical content testing of extracts and formulation of Hair Tonic preparations consisting of F1 (positive control), F2 (6% kelor leaf extract), F3 (6% ethanol pandan extract), F4 (combination of 2% kelor leaf extract with 4% ethanol pandan extract), F5 (3% kelor leaf ethanol extract and 3% ethanol pandan leaf extract), F6 (combination of 4% kelor leaf ethanol extract and 2% ethanol pandan leaf extract). The rat hair growth activity was divided into 8 groups: each rat's back was shaved to a size of 4 × 4 cm, the rats were left for 24 hours and then testing was carried out by spraying each formula, and hair growth was observed for 28 days. ...
REVIEW: THE POTENTIAL OF HERBAL PLANTS AS ANTI-ALOPECIA MEDICINES Arif Rubianto; Garnadi Jafar; Deden Indra Dinata; Jajang Japar Sodik
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1204

Abstract

Hair loss, or alopecia, is a common dermatological condition that affects up to 2% of the world's population. It is often caused by genetic factors, such as male or female pattern baldness, but can also be attributed to various environmental factors, an imbalanced diet, or chronic illnesses. While hair loss is not life-threatening, it can lead to significant anxiety, depression, and other psychological issues, ultimately affecting one's quality of life. Various treatments for baldness, including synthetic drugs like minoxidil and finasteride, or herbal remedies, have been approved by the Food and Drug Administration. Although synthetic drugs are effective, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating baldness because many chronic disorders can lead to alopecia. Therefore, this review focuses on identifying efficient alternative treatment agents with limited side effects. Specifically, it considers medicinal plants as potential healing agents for treating baldness. To gather relevant information for this study, several databases were searched, including Scopus, PubMed, and Google Scholar. Comprehensive searches were conducted using various search terms, such as "baldness," "alopecia," "natural remedies for baldness," "herbal treatment for baldness," and others, to extract relevant scientific articles. Many medicinal plants and natural compounds have shown potential for reducing baldness, thanks to their anti-inflammatory and antioxidant properties. According to existing literature, extracts of medicinal plants and formulations derived from plants, such as Eclipta alba (L.) Hassk, Arctium lappa L., Centella asiatica L., Morinda citrifolia, Acorus calamus var. angustatus, Alpinia zerumbet, ...
EFFECTIVITY TEST OF THE COMBINATION OF ETHANOL EXTRACT MAHKOTA DEWA FRUIT (Phaleria macrocarpa (Scheff.) Boerl.) WITH METFORMIN TO LOWERING BLOOD GLUCOSE LEVELS IN ALLOXAN-INDUCED WISTAR WHITE RATS STRAIN Katarina Lulu Widyanti; Tanti Azizah Sujono
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1222

Abstract

Metformin is a first-line biguanid drug for type 2 of diabetes mellitus. Metformin potentially causes liver fibrosis in long-term use, its decrease it in their effectiveness of antidiabetic. Combining metformin with antidiabetic a-glucosidase enzyme inhibitors can increase the effectiveness of metformin. Mahkota dewa fruit is a natural ingredient that has antidiabetic activity with the mechanism of action of inhibiting a-glucosidase enzyme. This study aims to determine the effect of the combination of mahkota dewa fruit extract (EEMF) with metformin on the effectiveness of reducing blood glucose levels in diabetic rats. A total of 20 rats were grouped into 4, namely, group I: given distilled water (negative control); group II: given metformin 45 mg/kgBW; group III: given EEMF 50 mg/kgBW; group IV: given a combination of metformin 45 mg/kgBW and EEMF 50 mg/kgBW. The study was conducted by determining blood glucose levels using the GOD-PAP method. The results showed that the combination of EEMF with metformin had an average decrease per day from after induction to day 7 of 42,9 mg/dL and from day 7 to day 14 of 0,45 mg/dL. It can be concluded that the combination of EEMF dose 50 mg/kgBW with metformin 45 mg/kgBW is not recommended to be used together, because the large decrease has the risk of hypoglycemia effect.  Keywords: antidiabetic, alloxan, metformin, fruit of mahkota dewa.
PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT OF BASIL LEAVES (Ocimum sanctum L.) AGAINST Propionibacterium acne BACTERIA Didin Ahidin; Didi Rohadi; Iin Indawati; Muh Yani Zamzam; Rinto Susilo; Nurcholisah; Andriana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1227

Abstract

Acne is a skin disease often experienced by teenagers and young adults. Basil leaves (Ocimum sanctum L.) could be used as an alternative treatment for acne. This study aimed to determine the secondary metabolite content and antibacterial activity of Ocimum sanctum ethanol extract against Propionibacterium acne. Simplicia was extracted from basil leaves by maceration with 96% ethanol solvent. The extracts were tested for parameters, phytochemical screening, and antibacterial activity using the disc diffusion method. Ocimum sanctum ethanol extract was used at concentrations of 20%, 30%, and 40%. Ocimum sanctum ethanol extract has a brownish-black color with a distinctive aromatic aroma and a bitter, slightly sour taste, with a moisture content of 5.6%, ash content of 7.71%, and drying shrinkage of 7.1%. Ocimum sanctum ethanol extract contains flavonoids, tannins, steroids, and saponins. Antibacterial activity of clindamycin 0.01% and Ocimum sanctum ethanol extract concentration of 20%, 30%, and 40% could inhibit Propionibacterium acne bacteria as much as 11.95 mm, 4.47 mm, 4.91 mm, and 6.30 mm. The antibacterial activity of the Ocimum sanctum ethanol extract was 20%. The 30% and 40% treatments differed significantly from the positive controls. The ethanol extract of basil leaves has antibacterial activity against Propionibacterium acne bacteria with the best antibacterial activity at a concentration of 40% as much as 6.30 mm. Keywords: Basil leaf (Ocimum sanctum L.), phytochemical screening, antibacterial activity
FORMULATION AND EVALUATION OF MANALAGI APPLE PEEL (Malus sylvestris Mill) SUNSCREEN SPRAY AS HALAL COSMETICS Ginanjar Putri Nastiti; Faradillah Maulida; Agisha Salwa Salsabila
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1228

Abstract

Manalagi apple peel is known to contain flavonoid compounds that are active as photoprotectors, as well as antioxidants that can absorb UV-A and UV-B exposure and release free radicals. Apple peel has the potential to be formulated as an active ingredient in natural sunscreen, which is considered safer and less likely to irritate when applied to the peel. In this study, halal sunscreen preparations from 70% ethanol extracts of manalagi apple peel with varying concentrations of manalagi apple peel extract were 15%, 20%, and 25%. The purpose of this study was to determine the critical halal point of sunscreen spray preparation, physical characteristics (organoleptic, homogeneity, pH, viscosity, and spray pattern), and SPF value. The data analysis methods in this study were descriptively and quantitatively performed. Based on the results of this study, no halal critical point ingredients were used in the formulation. The physical characteristic test results of all spray sunscreen formulas met the requirements of good physical characteristics criteria, and the resulting SPF values of F1, F2, and F3 were 22.66, 26.51, and 31.22, respectively. The SPF value of the Manalagi apple peel waste sunscreen spray formula was very high (>15).    Keywords: Halal, cosmetics, manalagi apple peel, SPF, spray sunscreen
FORMULATION AND NUTRITIONAL EVALUATION OF HIGH-FAT DIET FEED FOR FATTY LIVER INDUCEMENT IN RODENT MODELS Putri Anggreini; Jutti Levita; Hadi Kuncoro; Andi Tenri Kawareng; Sri Adi Sumiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1233

Abstract

Non-alcoholic fatty Liver Disease (NAFLD) is one of the most prevalent lipid disorders worldwide. In the pursuit of drug discovery and development, animal modeling is crucial to elucidate the mechanisms underlying a disease. One form of animal model of NAFLD involves the induction of a high-fat diet (HFD). However, most HFDs exhibit complexity in the formulation, and commercial HFDs tend to be costly. This study aimed to formulate an HFD feed with minimal ingredients that are capable of inducing liver steatosis. This study commenced with the development of 4 dietary formulations (F1, F2, F3, and F4) comprising various food components with specific proportions and treatments. A proximate analysis was conducted for each formulation. Subsequently, the most promising formulation was administered to the rats for 14 days. On day 15, liver organs were harvested for histological analysis. The results showed that among the four formulations developed, HFD F4 exhibited the best physical appearance and nutritional proximate components, characterized by its stability in form and high fat (41.8%), high protein (21.5%), and low carbohydrate (23.2%) content. Histology examination revealed that two weeks of administration of F4 administration led to severe degeneration, inflammation, and necrosis in rat hepatocytes compared to the normal group (p < 0.001), thus confirming that HFD F4 may be developed as an inducer of steatosis in rats.  Keywords: experimental animal model; high-fat diet; liver steatosis ; NAFLD

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