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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "VOLUME 5, NOMOR 2, AGUSTUS 2015" : 10 Documents clear
Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.) Sayuti, Nutrisia Aquariushinta
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3500

Abstract

Cassia alata L. leaf contains flavonoids which have anti-inflammatory, anti-allergy, antioxidants and antifungal effects. The traditional application of it requires long preparation time so we need a formulation with more practical and durable storage is needed. Gel formulation was chosen because it is easy to dry, forming an easy to wash film layer and give a sense of cold on the skin. Gel components affect the stability of the gel. Physical stability is analyzed to ensure that the formulated gel’s quality, safety and benefits meet the specifications and survive during storage. This study aimed to create a gel formula and analysed its physical stability test of Cassia alata L. leaf extract gel. Research design adopted in this study was an experimental laboratory. Optimum gel formula determined by variations in the concentration of sodium carboxymethyl celulose (CMCNa). Gel that meet the criteria of homogeneity, consistency, pH and spreadibility was set as the optimum formula. Physical stability of optimum formula was analyzed by organoleptic, homogeneity test, pH test, viscosity test and spredability test. Gel that meets the acceptance criteria are Cassia alata L. leaf extract gel with CMC-Na concentration of 3% those determined as the optimum formula. Stability analysis of optimum formula didn’t show any changes in pH, color, smell and taste, although it changes of the shape, viscosity and spreadibility were found. The optimum formula gel obtained by the concentration of CMC-Na 3%. results were less stable during the 8 weeks of storage at a temperature of 40°C.
Konsentrasi Aman Kurkumin dan PGV-0 terhadap Sel Vero Berdasarkan Hasil Uji Sitotoksik Marbawati, Dewi; Sarjiman, Sarjiman
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3687

Abstract

Curcumin (1,7-bis(3-methoxyphenyl 4'hidroksi) -1.6 heptadien, 3,5-dione) is the yellow pigment of Curcuma longa. Curcumin has various biological activities such as antioxidant, antibacterial, antifungal, antiprotozoal and antivirus. Various benefits of curcumin can not be separated from the weakness which is not stable to pH and light. Pentagamavunon-0 (PGV-0) were made by changing the β diketone group on cluster analog of curcumin into monoketon while eliminating active methylene group so it is more stable to pH and light. PGV-0 also has potential as a stronger antioxidant and antiinflammatory agent than other curcumin analogues. The objective of this research was to determine the safe concentrations of curcumin and PGV-0 on vero cells due to the increased use of the two compounds through the cytotoxic test. This research includes experimental research. Cytotoxic test performed with microculture tetrazolium technique (MTT) method. Use of MTT to evaluate the cytotoxic is based on changes of tetrazolium salt into formazan crystals by mitochondrial enzyme succinate dehydrogenase with the help of cellular NADH. The results showed that the safe concentrations of curcumin and PGV-0 on vero cells respectively are 6.25 and 1.5625 ppm. Based on the cytotoxic test the secure concentration of curcumin was higher than PGV-0.
Formulasi Tablet Salut Selaput Katekin dari Ekstrak Gambir (Uncaria gambir Roxb.) Kurniatri, Arifayu Addiena; Adelina, Rosa; Setyorini, Herni Asih; Sulistyowati, Indah
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3688

Abstract

Gambir extract contains a high content of catechin. Catechin has so many benefits, such as antioxidant, antimicrobial, and anti-atherosclerosis.Gambir are widely available in Indonesia, especially in West Sumatra, might be a sustainable source of catechin. Catechin is easily oxidized and hygroscopic. Film coating is used to protect catechin contained in a tablet from moisture and light. Study of film-coated tablet of catechin has not been conducted before. This study aims to formulate film-coated tablet of catechin from gambir and evaluate its physical properties. Catechin was percolated from gambir extract using ethyl astetat. The ethyl acetate fraction of gambir extract contains 92,48±0,28% catechin. Tablets were compressed with direct compression method and coated with a polymer coating material. The physical properties of core tablet and film-coated tablet were evaluated toward weight uniformity, hardness, friability, and disintegration time. Friability testing was conducted only on core tablet. The formulation produced tablets with uniform weight, 16,6 ±1,97 Kp hardness, and 4 minutes 15 seconds disintegration time. Weight uniformity and disintegration time of the tablet meet the requirements.
Profil Disolusi Terbanding, Penetapan Kadar, dan Kualitas Fisik Tablet Atorvastatin Inovator, Generik Bernama Dagang, dan Generik Aini, Nurul; Saraswati, Ratih Dian; Oktoberia, Intan Sari
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3689

Abstract

Atorvastatin is one of the statins which is used as the first line therapy for hyperlipidemia. The patent of atorvastatin innovator ended in 2011. Besides the innovator brand of atorvastatin, several brand and one generic atorvastatin tablet are currently marketed in Indonesia. In this research, dissolution profiles, assay and physical quality were investigated for three atorvastatin tablet samples consist of one innovator sample, two atorvastatin copy layer products (branded generic atorvastatin sample and atorvastatin generic sample). The dissolution testing were done using FDA (Food and Drug Administration) method. The result shows that the innovator and branded generic samples meet all the requirements for physical quality, meanwhile the generic sample failed to meet the disintegration test criteria. The branded generic sample has similar dissolution profile with the innovator, while the generic tablet was not similar. The assay were conducted using High Performance Liquid Chromatography (HPLC) method. The assay result of the innovator, branded generic, and generic samples respectively were 97,54%, 106,36% and 97,65% which means that all samples comply with general requirement of active pharmaceutical ingredient in tablet.
Optimasi Formula Mikroenkapsulasi Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dengan Penyalut Berbasis Air Nugraheni, Ade; Yunarto, Nanang; Sulistyaningrum, Novi
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3692

Abstract

Java turmeric (Curcuma xanthorrhiza Roxb.) is a native plant of Indonesia which has been proved as anti-inflamation, antioxidant, antimicrobial, antitumor, hepatoprotective and antihyperlipidemic agent. The bitter taste with pungent aroma of java turmeric, improper storage that decreasing essential oil and curcuminoid level can be prevented by coating java turmeric as microcapsule. Recently, many microcapsule formulation is made based on organic solvent which have high risk on toxicity and also flammable. The study aimed to produce microcapsule using water based coating material from mixture of tapioca starch and carboxymethylceIlulose (CMC). There are 3 formulas of coating material that were used in this study, with proportion (w/v) of tapioca starch and CMC in formula I (3% : 1 %), formula II (2% : 2 %), and formula III (1% : 3%). The results showed that microcapsule with coating material made from formula III was the best, regarding to the measurements of physical parameter (recovery, water content, absorption efficiency, flow rate and particle size) and chemical parameter (curcumin content) compared to formula I and II. The higher CMC concentration on coating material compotition, the better microcapsule will be produced.
Deskripsi Hasil Uji Angka Lempeng Total (ALT) Pada Beberapa Susu Formula Bayi Puspandari, Nelly; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3693

Abstract

Infant formula is the nutrient source for some babies who were not breastfed. Risk factors for infection in infants less than 6 months old who consume formula are greater than those who were breastfed. This is due to the baby's immune system is not well formed. Therefore, it is important to supervise formula safety more strict than adult’s food. Total plate count (TPC) is one of the factors considered in the infant formula. The aim of this study is to define safety of infant formula based on total plate count within infant formula distributed in Indonesia in 2011. The study was a cross sectional study. The samples were representative of infant formula distributed in 23 province. Total plate count method and interpretation were conducted based on ISO/TS 22964. The TPC of each samples were examined three times. The TPC of all infant formulas were below of SNI breakpoint, which is less than 104cfu/gram. TPC ranged from
Risiko Penggunaan ACEi Terhadap Kejadian Batuk Kering pada Pasien Hipertensi di RSUD Cengkareng dan RSUD Tarakan DKI Jakarta Halim, Margareth Christina; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3694

Abstract

The use of angiotensin converting enzyme inhibitors (ACEi) as an antihypertensive agent can cause side effects such as dry cough. The aim of this study is to evaluate risk of ACEi administration on dry cough incidence with captopril as the standard against lisinopril and ramipril in hypertensive patients at RSUD Cengkareng and RSUD Tarakan Jakarta. The design of this study is prospective cohort. The inclusion criteria were patients who received ACEi as hypertension therapy for ≤ 3 months gathered from outpatient and willing to participate as sample in this study at RSUD Cengkareng and RSUD Tarakan. Subject of this study consist of 54 patients who received captopril and 54 patients received non captopril ACEi, taken by consecutive sampling from January-July 2014. Data was collected using structured interviews and medical record. Dry cough incidence due to ACEi was evaluated using Naranjo Algorithm and analyzed using Chi Square test. Dry cough incidence was found in 19,44% of sample. No significant relationship of age, gender, ethnic, comorbidity, body mass index (BMI), dosage, and duration of use with the dry cough incidence due to the use of ACEi. There is no difference on dry cough incidence between the use of captopril, lisinopril and ramipril.
Tradisi Masyarakat dalam Penanaman dan Pemanfaatan Tumbuhan Obat Lekat di Pekarangan Sari, Ida Diana; Yuniar, Yuyun; Siahaan, Selma; Riswati, Riswati; Syaripuddin, Muhamad
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3695

Abstract

Home yard has been used to plant certain medicinal plants, also as known as TOGA program. This research was aimed to study the implementation of TOGA program and community tradition in planting and using medicinal plants. A qualitative research was conducted in West Java, Central Java, East Java and Bali which based on National Basic Health Research 2010 data had the highest percentage of jamu usage. Data was collected in 2011 through in depth interview and focus group discussion with related stakeholder and observation in research location. Result in Bogor district showed TOGA program has been included in Family Welfare Development Program and similar program was also developed in some villages. There was no certain TOGA program in Karanganyar, Sumenep and Gianyar districts. TOGA program in Karanganyar was inserted in other program due to economic needs while in Gianyar the program was originated from ornamental plants. The community usually used medicinal plants for the prime medication before going to health facility. Planting medicinal plants is an inherited tradition where parents become the main source of planting and usage information. The Agriculture Office and village officials had more significant roles to guide the community while the Health office only suggested or monitored them.
Front Matter Volume 5 No 2 Tahun 2015 JKI, Editor
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3810

Abstract

Back Matter Volume 5 No 2 Tahun 2015 JKI, Editor
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3813

Abstract

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