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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 764 Documents
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Protein Intake, Nutritional Status, and Family Socioeconomic Relationships with Learning Achievement of Children Aged 13-15 Years at Nabil Husein Junior High School Samarinda Year 2022 Jamil Anshory; Aulia Dwi Nur Anggraini; Satriani Satriani
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1669

Abstract

Nutritional problems in adolescents will affect the quality of human resources which can result in reduced generations and have an impact on the nation's economic situation in the future. Vulnerable aged 13-15 years experiencing nutritional needs much faster. Protein intake, nutritional status and socioeconomic status in several studies showed different results. The purpose of this study was to determine the relationship between protein intake, nutritional status, and socioeconomic status with the learning achievement of children aged 13-15 years at SMP Nabil Husein Samarinda. Quantitative research design, correlational descriptive type, cross sectional approach. The sample used was 49 students of class VIII using a purposive sampling technique. Protein intake was obtained through a 24-hour food recall interview, nutritional status measurements based on BMI/Age, and socioeconomic status were obtained by filling out a questionnaire form. The results obtained from this study were the relationship between protein intake and learning achievement with a p-value of 0.670, nutritional status with learning achievement with a p-value of 0.358, parents' education with learning achievement with a p-value of 0.429, parental income with learning achievement with a p-value -value 0.441, parents' work with learning achievement with a p-value of 0.437. The conclusion of this study is that there is no relationship between protein intake, nutritional status and socioeconomic status of parents with learning achievement of class VIII students of Junior High School Nabil Husein Samarinda.
Penanganan pada Pasien yang Mengalami Gangguan Otot Akibat Pemberian Obat Golongan Statin (SAMS): Review: Statin Associated Muscle Symptoms (SAMS) and the Development: Review Putri, Warrantia Citta Citti; Sari, Murtiyana; Wahyuni, Fitri Ayu; Suryani, Nining; Lestaluhu, Annisa Al-Qibityah
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.1676

Abstract

It is crucial to provide information on therapeutic goals, pharmacological side effects, drug interactions, medication adherence, and lifestyle choices because treating dyslipidemia requires a long-term approach in order to lower and stabilize blood cholesterol levels. Due to their effectiveness in lowering mortality and morbidity, statin-class medications are typically used to lower blood lipid levels. The usage of this class of medications is quite safe, and any side effects are generally tolerable. However, the most common side effect, which is quite serious and worth noting, is muscle pain. If these side effects last a long time and increase in severity, Statin Associated Muscle Symptoms (SAMS) will appear and needs to be treated separately. In the majority of adult patients discontinuing statins, SAMS was the primary reason for having a substantial health impact. Patients who stop treatment show the greatest increase in LDL and are the least likely to achieve the target LDL. Statin intolerance is associated with a higher rate of recurrent myocardial infarction, CHD events, and death. As a result, a variety of approaches must be taken to manage and treat SAMS, with the best treatment combining non-statin-based lipid-lowering therapy with maximally tolerable doses of statins to achieve target LDL. Keywords:          statin, dyslipidemia, cholesterol, SAMS, myopathy   Abstrak Pengobatan dislipidemia merupakan pengobatan jangka panjang dengan target menurunkan dan menstabilkan kadar lipid dalam darah sehingga penting untuk memberikan informasi terkait tujuan terapi, efek samping obat, interaksi obat, kepatuhan dalam pengobatan dan pola gaya hidup. Obat golongan statin merupakan pilihan utama dalam menurunkan kadar lipid dalam darah dikarenakan efektivitasnya dalam menurunkan mortalitas dan morbiditas. Penggunaan obat golongan ini cukup aman dan efek samping yang muncul relatif dapat ditoleransi. Namun, efek samping yang paling sering muncul, yang cukup serius dan patut diperhatikan adalah nyeri pada otot. Efek samping ini jika berlangsung lama dan terjadi peningkatan keparahan maka akan muncul diagnosis gangguan otot disebabkan penggunaan statin (SAMS) dan perlu dilakukannya penanganan tersendiri. Mayoritas pasien dewasa yang menghentikan statin, SAMS sebagai alasan utama sehingga memberikan dampak kesehatan yang substansial. Pasien yang menghentikan pengobatan menunjukkan peningkatan paling besar pada LDL dan kecil kemungkinannya untuk mencapai LDL target. Selain itu, intoleransi statin dikaitkan dengan tingkat infark miokard berulang, kejadian PJK hingga kematian yang lebih tinggi. Oleh karena itu, harus dilakukan berbagai strategi untuk mengelola dan mengobati SAMS dimana terapi yang optimal harus menggabungkan dosis statin yang dapat ditoleransi secara maksimal, atau bahkan non-harian, bersama dengan terapi penurun lipid berbasis non-statin untuk mencapai target LDL. Kata Kunci:         statin, dislipidemia, kolesterol, SAMS, miopati
Formulasi dan Evaluasi Sediaan Nanoemulsi Ekstrak Umbi Bawang Putih (Allium sativum L.): Formulation and Evaluation of Nanoemulsion of Garlic (Allium sativum L.) Extract Alvira Intan Widyastuti; Dwi Saryanti
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1677

Abstract

Garlic bulbs (Allium sativum L.) has an active substance in the form of allicin which is thermolabil, allicin as the main antioxidant that can prevent free radicals. Nanoemulsion has a particle size of 20-500 nm which is an oil and water dispersion system stabilized by a combination of surfactant and cosurfactant. The purpose of this study was to obtain the best formula from the variation of VCO concentration 3%, 5%, 8% and determine the stability of nanoemulsion preparations. Nanoemulsions are formulated in oil phase VCO, surfactant Tween 80, and cosurfactant PEG 400. Nanoemulsion preparation performed organoleptic test, pH, viscosity , transmittance%, stability. The best Formula continued particle size test, and zeta potential. This study used laboratory experimental method, the results of the study were analyzed by one way ANOVA test. Obtained the best formula of nanoemulsion preparation of garlic bulb extract at a concentration of 8% VCO, the best formula physical results with clear yellow organoleptic characteristics, distinctive odor, and does not separate, pH value 4.9, viscosity value 7.0 d'pas, transmitan % value 96.11, nanoemulsion preparation of garlic bulb stable after stability test. The best Formula in Continue particle size test is the average value obtained 607.0, 53.4 and the average value of the potential Zeta test obtained -5.7, 0.86. The higher the concentration of VCO, the stability of smakin good preparation, nanoemulsion preparation that has good stability in formula 3 with a concentration of 8% VCO. Keywords: Nanoemulsion, Antioxidants, VCO, PEG 400, Tween 80 Abstrak Umbi bawang putih (Allium sativum L.) memiliki zat aktif berupa allicin yang bersifat termolabil, allicin sebagai antioksidan utama yang dapat mencegah radikal bebas. Nanoemulsi memiliki ukuran partikel 20-500 nm yang merupakan suatu sistem dispersi minyak dan air yang distabilkan oleh kombinasi surfaktan dan kosurfaktan. Tujuan penelitian ini untuk mendapatkan formula terbaik dari variasi konsentrasi VCO 3%, 5%, 8% dan mengetahui kestabilan sediaan nanoemulsi. Nanoemulsi diformulasikan dalam fase minyak VCO, surfaktan Tween 80, dan kosurfaktan PEG 400. Sediaan nanoemulsi dilakukan uji organoleptis, pH, viskositas, % transmitan, stabilitas. Formula terbaik dilanjutkan uji ukuran partikel, dan zeta potensial. Hasil penelitian dianalisis dengan uji one way anova. Berdasarkan % transmitan tertinggi didapatkan formula terbaik sediaan nanoemulsi ekstrak umbi bawang putih pada konsentrasi VCO 8%, dengan karakteristik organoleptis kuning bening, bau khas, dan tidak memisah, pH 4,9, viskositas 7,0 d’Pas, % transmitan 96,11%. Sediaan nanoemulsi umbi bawang putih stabil setelah dilakukan uji stabilitas. Formula terbaik mempunyai ukuran partikel yaitu 607,0±53,4 nm dan nilai zeta potensial sebesar -5,7±0,86 mV. Semakin tinggi konsentrasi VCO maka stabilitas sediaan semakin baik, sediaan nanoemulsi yang memiliki stabilitas yang baik yaitu pada formula 3 dengan konsentrasi VCO 8%. Kata Kunci: Nanoemulsi, Antioksidan, VCO, PEG 400, Tween 80
Asuhan Kefarmasian Beberapa Kasus Penggunaan Obat Penyakit Kulit Niken Indriyanti; Antadini Antadini; Jorgi Imanuel Emor; Pabely Nahwan Maulana
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1681

Abstract

Penggunaan obat untuk gangguan pada kulit berupa alergi maupun infeksi memerlukan instruksi khusus. Laporan kasus ini bertujuan untuk membahas asuhan kefarmasian yang tepat untuk beberapa kasus penggunaan obat penyakit kulit. Metode yang digunakan adalah metode prospektif pada pelayanan kefarmasian di beberapa apotek di Samarinda. Perijinan pengambilan data berdasarkan perjanjian kerjasama antara Fakultas Farmasi Unmul dengan apotek. Didapatkan hasil bahwa asuhan kefarmasian pada kondisi alergi dan infeksi kulit perlu disampaikan oleh apoteker dan dipahami oleh pasien, sehingga terapi bisa maksimal. Kesembuhan keluhan pasien menuntut kepatuhan penggunaan obat. Beberapa kendala pengaplikasian sediaan untuk kulit perlu diantisipasi supaya tepat dosis. Batas waktu penggunaan obat menjadi bagian asuhan kefarmasian yang penting. Dengan demikian, asuhan kefarmasian yang tepat dapat memaksimalkan terapi kulit.
Laporan Kasus: Pengobatan pada Melena et causa NSAID Ulkus peptikum pada Pasien Anemia dan Nefrolitiasis dengan CKD: Case Report: Treatment of Melena et causa NSAIDs Peptic Ulcers in Patients with Anemia and CKD Nephrolithiasis Riski Sulistiarini; Hajrah Hajrah; Muhammad Ardan; Reny Anggraini; Adam M. Ramadhan
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1682

Abstract

Melena atau berak darah adalah kondisi umum yang terjadi pada pasien dengan ulkus peptikum. Kami melaporkan kasus pasien yang mengalami melena et causa NSAID ulkus peptikum dengan riwayat hipertensi dan gagal ginjal dengan komplikasi anemia, nefrolitiasis serta CKD saat masuk rumah sakit.
Evaluasi Pengobatan Pasien Diabetes Mellitus Dengan Hipertensi Di RSUD Abdul Wahab Sjahranie Samarinda: Evaluation Treatment of Diabetes Mellitus with Hypertension in RSUD Abdul Wahab Sjahranie Samarinda Helmi Helmi; Fika Aryati; Reny Anggraini
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1683

Abstract

Diabetes Melitus (DM) merupakan salah satu penyakit degeneratif yang ditandai dengan terjadinya hiperglikemia atau peningkatan kadar glukosa darah. Secara klinis, DM seringkali disertai dengan berbagai penyakit kronis lainnya, salah satunya adalah hipertensi. Penelitian ini dilakukan secara retrospektif dengan mengambil data rekam medik pasien DM dengan hipertensi di RSUD Abdul Wahab Sjahranie Samarinda. Berdasarkan data yang diperoleh dilakukan analisa mendalam terhadap pola pengobatan yang diterima pasien selama dirawat di RSUD tersebut dan diketahui bahwa pengobatan pasien DM dengan hipertensi di RSUD Abdul Wahab Sjahranie telah sesuai dengan pedoman pengobatan yang berlaku.
Laporan Kasus: Kajian Pengobatan CKD Stage 5 dengan Hiperkalemia Noviyanty Indjar Gama; Ferdian George Sarung Allo; Fahriani Istiqomah; Angga Cipta Narsa
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1684

Abstract

Gagal Ginjal Kronis adalah kondisi ketidaknormalan penurunan fungsi ginjal. Laporan Kasus ini berfokus pada kondisi pasien yang mengalami gagal ginjal kronis dengan kondisi hiperkalemia. Pasien mengalami hipertensi dengan tekanan darah 180/ 90 mmHg, saturasi oksigen 92%. Pasien mengeluhkan lemas, nyeri ulu hati, mual, tidak mau makan, kulit gatal dan bengkak pada kedua kaki. Hasil laboratorium darah diketahui nilai Leukosit yaitu 6,2×103/µl, Ureum 255 mg/dL, Kreatinin 7,2 mg/dl , Natrium 138 mmol/L , Kalium 7,0 mmol/L, serta Hemoglobin 6,3 g/dl dan diagnosa adalah CKD stage V.
Studi Kasus: Pasien Gagal Ginjal Kronis (Stage V) dengan Edema Paru dan Ketidakseimbangan Cairan Elektrolit: Case Study: Chronic Kidney Disease (Stage V) Patient with Pulmonary Edema and Fluid Electrolyte Imbalance Angga Cipta Narsa; Vina Maulidya; Dea Reggina; Wina Andriani; Hifdzur Rashif Rijai
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1685

Abstract

Gagal Ginjal Kronik (GGK) merupakan kondisi gangguan fungsi ginjal yang progresif dan tidak dapat pulih kembali, dimana tubuh tidak mampu memelihara metabolisme dan gagal memelihara keseimbangan cairan dan elektrolit. Pada penelitian ini pengambilan data dilakukan secara retrospektif yang dilihat dari data rekam medik. Penelitian ini bertujuan untuk membahas pengkajian pengobatan pada pasien gagal ginjal kronik dengan komplikasi. Seorang pasien Ny. WN usia 42 tahun masuk rumah sakit dengan keluhan sesak nafas, dada berdebar, mual muntah, pusing, demam dan BAB encer. Dari hasil pemeriksaan fisik dan laboratorium diketahui diagnose pasien adalah gagal ginjal kronik (GGK) stage 5 disertai edema paru, dyspnea, hipokalsemia, hiponatremia dan hiperkalemia. Pasien memiliki riwayat Hipertensi yang merupakan salah satu faktor resiko terjadinya gagal ginjal kronik (GGK).Terapi yang telah diberikan pada studi kasus ini adalah terapi yang telah sesuai dengan asuhan kefarmasian pada pasien GGK stage 5.
Test the Effect of Miana Leaf Ethanol Extract on Ureum and Creatinine Levels in Male White Rats Joni Tandi; Yustin Yustin; Rezky Yanuarty; Tien Wahyu Handayani
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1686

Abstract

This study aims to determine the content of secondary metabolites in miana leaf ethanol extract, and to determine the effective dose of miana leaf ethanol extract in reducing urea and creatinine levels in male white rats. This study used 30 rats divided into 6 treatment groups, each group consisting of 5 test animals, namely normal group, negative control, positive control, dose of 150 mg/kg BW, dose 200 mg/kg BW, and dose 250 mg/kg. kg body weight. The data obtained will then be tested for normality and homogeneity to find out the data is normally distributed and homogeneous. If the data is normally distributed and homogeneous, then it is continued using One Way Anova statistical analysis at a 95% confidence level and further LSD test is carried out. If the data obtained is not normal and homogeneous, then it is analyzed using non-parametric statistics Kruskal-Wallis test and continued with Mann Whitney further test to determine the difference between all treatments. The results showed that the ethanolic extract of miana leaves contained secondary metabolites of alkaloids, flavonoids, saponins,and tannins; miana leaf ethanol extract has an effect on reducing urea and creatinine; Miana leaf ethanol extract at a dose of 250 mg/kg BW was an effective dose in reducing urea and creatinine with an average decrease of 18.8 mg/dl and 0.64 mg/dl.
Analytical Method Validation of Sulfamethoxazole in Human Plasma and Urine by HPLC-PDA Dion Notario; Aprillia Suwita; Kelviyana Kelviyana
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1687

Abstract

An analytical method for analyzing SMZ in human plasma and urine using high-performance liquid chromatography (HPLC) was developed. The separation was carried out on a Shim-pack GIST® C18 column (150 × 4.6 mm, 5 ?m) with a temperature setting of 30°C. The mobile phase consisted of glacial acetic acid pH 2.5: methanol: acetonitrile (70:25:5, v/v/v) at a rate of 0.8 mL/min. Detection was done using a PDA detector in the range of ?190-800 nm, and quantification was carried out at ?265 nm. Plasma sample preparation used the protein precipitation method with acetonitrile as the precipitating solvent (1:3, v/v), while urine preparation used the liquid-liquid extraction method with 0.03 M H2SO4 and ethyl acetate. The developed method was proven selective, linear (r = 0.998) for plasma and (r = 0.996) for urine, accurate (%error ?11.76% for LLOQ and ?14.08% for concentrations above), precision (%RSD ?4.52% for LLOQ and ?4.48% for the concentrations above), sensitive with 0.7 ?g/mL (plasma) and 0.17 ?g/mL (urine). Stability tests were carried out to determine the shelf life of the samples under several conditions. The developed method is valid and suitable for pharmacokinetic studies of SMZ in human plasma and urine.

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