cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Ramadhanti Salma Ulwanda
Contact Email
actaneurologicaindonesia@gmail.com
Phone
-
Journal Mail Official
actaneurologicaindonesia@gmail.com
Editorial Address
Departemen Neurologi RSCM, Jl. Pangeran Diponegoro No.71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta 10430
Location
Kota depok,
Jawa barat
INDONESIA
Acta Neurologica Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 30326303     DOI : https://doi.org/10.69868/ani.v2i02
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience Public Health
Acta Neurologica Indonesia is the official publication of the Department of Neurology, Faculty of Medicine, Universitas Indonesia under Directorate of Administration, Data, and Product Management of Research and Innovation Universitas Indonesia. This journal is published in trimonthly cycle with e-ISSN: 3032-6303. The Journal aims for continuous dissemination of updates in relation to neurology and its related fields in the form of original articles, case reports and reviews.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 68 Documents
 3   4   5   6   7 
Asymmetric Spinal Cord Compression by Intradural Extramedullary Tumor at Thoracic Level: A Case Report Gavrila, Priska Gian; Dermoredjo, Sutaryanu
Acta Neurologica Indonesia Vol. 4 No. 01 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Spinal tumors are a rare type of tumor, accounting for approximately 15% of all tumors in the central nervous system. Most cases occur in individuals of working age. Symptoms may include localized pain or radiating pain to the extremities, and in some cases, severe motor deficits. Back pain tends to develop gradually, is independent of activity, and may worsen when lying down. CT scans, MRI, histopathological, and immunohistochemical examinations assist in establishing the diagnosis. The primary management of spinal tumors is surgical intervention, with the surgical approach varying depending on the type of tumor. Objective: To report the case of a 44-year-old female patient with a spinal tumor treated at Bethesda Hospital Yogyakarta. Case Description: A 44-year-old female presented with complaints of back pain lasting one month and bilateral lower extremity edema. In 2014, the patient experienced a fall in the bathroom resulting in loss of consciousness, and she undergoes spinal surgery in 2022. A non-contrast MRI revealed an intradural extramedullary mass at the level of thoracic vertebrae T2–T3, located on the left posterolateral aspect. Histopathological examination showed tumor tissue consistent with meningothelial and psammomatous meningioma, with a differential diagnosis of schwannoma. The patient undergoes a laminectomy as definitive management. Conclusion: Spinal tumors often present with pain and may result in severe motor deficits. Diagnosis is supported by imaging studies, histopathology, and immunohistochemistry to guide appropriate management.
Loss of Consciousness in Nasopharyngeal Carcinoma with Brainstem Infiltration Tiara Aninditha; Ikhlas Rahmadi; Ferucha Moulanda; Ardhi Rahman Ahani; Radius Kusuma; Henry Riyanto Sofyan; Irma Savitri
Acta Neurologica Indonesia Vol. 3 No. 03 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i03.90

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is prone to intracranial infiltration in advanced stages due to its proximity to the skull base, despite the protective bony structures. Loss of consciousness in NPC patients with brainstem involvement should be distinguished from other causes. Case Report: A 70-year-old man developed progressive symptoms, including left otalgia and trismus, within eight months before admission. CT revealed a nasopharyngeal mass infiltrating the medullary and pontine cisterns, confirmed as nonkeratinized NPC from biopsy. One month prior, he underwent tracheostomy for airway obstruction. Ten days before admission, he experienced nausea, vomiting, and altered consciousness. During hospitalization, severe hyponatremia was detected and confirmed as the main etiology, further proven by the fact that the patient only regained consciousness after hypertonic saline infusion while being unresponsive after prior dexamethasone administration. After four days, he was discharged with plans for chemotherapy and radiotherapy. Discussion: Brainstem infiltration in NPC is rare, even in advanced stages, due to the protective skull base. However, intracranial spread can occur via foramina or direct bony destruction. Loss of consciousness in NPC patients with suspected brainstem infiltration requires careful evaluation, as non-tumoral causes like hyponatremia should be considered. Tumor-induced malnutrition, impairing mastication and intake, may contribute to electrolyte imbalances. Conclusion: In NPC patients with brainstem infiltration, loss of consciousness should not be immediately attributed to direct tumor invasion. Other treatable causes, such as hyponatremia, must be promptly detected to ensure appropriate management.
Managing Elevated Intracranial Pressure as the Complication of Angiomatous Meningioma Adriana Damayanti; Tiara Aninditha; Henry Riyanto Sofyan; Irma Savitri; Rahmad Mulyadi; Mohamad Saekhu
Acta Neurologica Indonesia Vol. 3 No. 04 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i04.92

Abstract

Introduction: Meningioma is the most common central nervous system primary tumor, which can grow at the cranial base. Angiomatous meningioma, with a prevalence of 2.1%, is classified as the World Health Organization (WHO) grade I meningioma. Although considered benign, it has high Vascular Endothelial Growth Factor (VEGF) activity. Case Report: A 41-year-old woman presented with clear nasal discharge upon sitting, progressive headaches, blurred vision, and right-sided hemiparesis following prior surgeries for angiomatous meningioma. Initial symptoms included episodic headaches, later worsening with visual impairment and motor deficits. She underwent decompressive craniectomy, VP shunt placement for hydrocephalus, and cranioplasty but had a functional decline. Examination revealed decreased consciousness, anisocoria, right facial nerve palsy, spastic hemiparesis, and pressure ulcers. Imaging confirmed tumor progression with uncal herniation and hydrocephalus. After infection management, VP shunt revision improved her condition, and tumor resection was planned. The prognosis remained poor regarding survival, function, and recovery. Discussion: Although considered benign, it has high activity of Vascular Endothelial Growth Factor (VEGF). Massive peritumoral edema may lead to complications by increasing intracranial pressure (ICP). The management of elevated ICP includes tumor resection, cerebrospinal fluid (CSF) diversion, and administration of anti-edema agents. Due to its challenging access and proximity to vital structures such as cranial nerves and blood vessels, determining an appropriate management strategy poses a significant challenge to avoid disability. Conclusion: Skull base meningioma in women aged 40–70 poses a high risk of complications and disability if mismanaged, especially angiomatous meningioma with high vascularity despite being WHO Grade I.
Management High Grade Glioma in Elderly Sofyan, Henry Riyanto; Pratiwi, Intan; Fahmi Radityamurti; Anastasia Asylia Dinakrisma; Aninditha, Tiara; Savitri, Irma
Acta Neurologica Indonesia Vol. 3 No. 03 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i03.93

Abstract

Introduction: High-grade glioma (HGG) is an aggressive primary brain tumor with poor prognosis, particularly in elderly patients. Management is complex due to comorbidities, decreased functional status, and increased risk of treatment-related toxicity. Personalized approaches balancing efficacy and quality of life are essential in this population. Case Report: A 67-year-old male presented with progressive headache, limb weakness, and visual disturbances. MRI revealed a large right temporoparietal lesion suggestive of HGG. Craniotomy and biopsy confirmed a high-grade glioma. The patient had a Karnofsky Performance Status (KPS) of 40, with significant cognitive and functional impairments, along with comorbidities including diabetes and hypertension. Given his frailty, he was treated with hypofractionated radiotherapy and concurrent temozolomide. Discussion: Treatment decisions in elderly HGG patients should consider age, KPS, cognitive status, and comorbidities. Hypofractionated radiotherapy combined with temozolomide is effective and better tolerated in frail patients. Multidisciplinary care is crucial to manage physical, cognitive, and emotional needs. Cognitive assessment before therapy aids in anticipating treatment impact. Prophylactic treatment for opportunistic infections such as Pneumocystis jirovecii is recommended during chemotherapy. Conclusion: Elderly patients with HGG require individualized, multidisciplinary care. Factors such as performance status, cognitive function, and comorbidities must guide treatment to achieve optimal outcomes while preserving quality of life
Rare Case of Solitary Brain Metastasis from Colorectal Cancer Ririhena, Fiorentina C; Aninditha, Tiara; Sofyan, Henry Riyanto; Madjid, Irma Savitri
Acta Neurologica Indonesia Vol. 4 No. 02 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v4i02.94

Abstract

Introduction: Solitary brain metastasis (BM) from colorectal cancer (CRC) is rare (0.6–3.2%) and presents management challenges, especially in eloquent brain regions where surgical resection carries high risk. Stereotactic radiotherapy (SRT) is often preferred when surgery is not feasible, particularly in patients with good functional status. Case Illustration: A 49-year-old male with a KPS of 90 presented with worsening right-sided pulsating headaches for five days, accompanied by left-sided facial nerve palsy. MRI revealed a solitary intra-axial metastasis in the right temporal lobe, an eloquent region, with microbleeds and surrounding edema, suggestive of BM from rectal adenocarcinoma. Given the lesion's eloquent location, where surgery posed high risks, SRT was selected as the primary treatment modality, alongside corticosteroids for edema control and psychiatric support for depression Discussion: Solitary CRC BM in eloquent regions is a clinical dilemma. While surgery is standard for accessible lesions, SRT offers effective tumor control while reducing neurological complications, making it preferable for patients with high KPS (≥90) as it preserves cognitive function and improves survival outcomes. A multidisciplinary and holistic treatment approach, addressing both oncological and psychological aspects, is essential. Conclusion: Managing solitary CRC BM in eloquent brain regions requires special strategies. SRT was favored to reduce the risk of neurological impairment while maintaining tumor control, especially when surgery was not viable. A multidisciplinary approach is crucial to optimizing care and improving quality of life. Keywords: solitary brain metastasis, colorectal cancer, stereotactic radiotherapy, eloquent brain region
Distinguishing Spinal Cancer and Degenerative Disease: Enhancing Diagnosis and Treatment Outcomes in Plasmacytoma -, Liana Alviah Saputri; Riyanto Sofyan, Henry; Aninditha, Tiara; Savitri, Irma; Saekhu, Mohammad; Kusuma, Radius
Acta Neurologica Indonesia Vol. 4 No. 01 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Spinal lesions commonly exhibit overlapping clinical presentations and imaging characteristics, which can obscure the distinction between malignant and degenerative etiologies. This diagnostic ambiguity may lead to delayed or inappropriate treatment, particularly in uncommon neoplastic entities such as plasmacytoma, a solitary manifestation of plasma cell dyscrasia that often involves the spine. Case Report: We report the case of a 63-year-old male presenting with one month of persistent back pain, progressive bilateral lower limb weakness, and tingling sensations radiating from the inguinal region to the toes. Imaging studies revealed bilateral pedicle destruction at the L2 and L5 vertebrae, along with significant spinal canal and foraminal stenosis. The patient underwent decompression surgery, and histopathological analysis of the lesion confirmed the diagnosis of plasmacytoma. Discussion: Spinal plasmacytoma is a rare neoplastic condition that can clinically mimic degenerative spine disorders, often leading to delays in diagnosis and treatment. Symptoms such as chronic back pain, radiculopathy, and motor weakness are commonly attributed to more prevalent degenerative pathologies, particularly in older adults. Back pain in individuals with a history of malignancy serves as a crucial warning sign, prompting clinicians to urgently assess for potential metastatic disease in the spine. Conclusion: Increased awareness and a high index of suspicion are crucial when evaluating spinal lesions. Pain should be considered a key red flag warranting prompt assessment for possible spinal malignancy. Early diagnosis is critical, as it directly affects therapeutic decisions and overall prognosis.
Bacterial Meningitis as a complication of Urosepsis: A case report Nagpal, Chand; Maharani, Kartika; Estiasari, Riwanti; Imran, Darma
Acta Neurologica Indonesia Vol. 3 No. 04 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bacterial meningitis is a severe bacterial infection that infiltrates the meninges and is characterized by headache, fever and neck stiffness. We present a case of a 60-year-old female with urosepsis consulted to the neurology department with loss of consciousness. Her clinical symptoms progressed over 7 days, with loss of consciousness, fever, meningeal signs and right-sided hemiparesis, suggestive of acute meningitis. Lumbar puncture was performed and CSF analysis suggested partially treated meningitis. Blood culture revealed growth of Enterococcus faecalis. Intravenous dexamethasone and meropenem were given and oral antibiotics were continued until the patient regained consciousness completely. Bacterial meningitis should be suspected in any severe systemic infection with clinical symptoms such as loss of consciousness. Establishing a diagnosis with the help of CSF analysis, culture, and appropriate treatment with antibiotic selection and dosage is imperative to ensure adequate penetrance to the central nervous system. Physician’s clinical judgement to establish an early diagnosis and initiate treatment is crucial and determines patient outcome. Initial phase of BM can be clinically severe, and often requires treatment in the ICU initially.
Posterior Reversible Encephalopathy Syndrome (PRES) with Hypertensive Retinopathy and Hyperaldosteronism Nagpal, Chand; Mesiano, Taufik; Rasyid, Al; Hidayat, Rakhmad; Pangeran, David; Kurniawan, Mohammad; Harris, Salim
Acta Neurologica Indonesia Vol. 4 No. 01 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Posterior Reversible Encephalopathy Syndrome (PRES) is a neurological syndrome with an acute or subacute onset characterized by reversible cerebrovascular dysregulation. Hypertension is the primary risk factor for PRES, however other conditions such as hyperaldosteronism accompany and precipitate PRES. Case Report: This case illustrates a 32-year-old man without prior medical history with loss of consciousness and seizures 1 day prior to admission with blurry vision and vomiting 2 weeks prior that progressed gradually. Brain MRI revealed vasogenic edema of bilateral occipital lobes. The patient was assessed for hypertensive retinopathy and suspected primary hyperaldosteronism. Management with anti-hypertensives, anti-epileptic medications, electrolyte correction and supportive therapy was given, and the patient improved gradually and was discharged 10 days later without any complications. Discussion: No diagnostic criteria is available for PRES, however brain MRI is the crucial to establish a diagnosis of PRES. The resolution of symptoms with blood pressure regulation is another validation of the diagnosis of PRES. Ruling out differentials is prudent to ensure appropriate therapy. Management of PRES encompasses blood pressure regulation, anti-epileptic medications, treating other causes such as drug exposure and metabolic disorders. Previous reports PRES due to secondary hypertension attributed to primary hyperaldosteronism have been reported, although evidence about this causality is limited, nonetheless must be explored and treated as a cause of the hypertension triggering PRES. Conclusion : PRES is a neurological syndrome that is reversible, with hypertension as the primary risk factor that could be secondary due to disorders like primary hyperaldosteronism, that could ultimately trigger PRES.
Systematic Review of Angiotensin-Converting Enzyme Inhibitors and Calcium Channel Blockers in Ischemic Stroke Prevention: Evaluating the Comparative Effectiveness of ACE Inhibitors and Calcium Channel Blockers for Secondary Stroke Prevention Hasanah, Miftahul; Avini Mawarni Soedarsono
Acta Neurologica Indonesia Vol. 3 No. 04 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i04.104

Abstract

Introduction : Ischemic stroke is a leading cause of disability and death worldwide, with hypertension being one of the most significant modifiable risk factors. Among antihypertensive agents, ACE Inhibitors (ACEIs) and Calcium Channel Blockers (CCBs) are commonly used. However, their relative efficacy in preventing ischemic stroke remains a subject of clinical interest. Methods : A systematic search was conducted using PubMed, Cochrane Library, and ScienceDirect for articles published between 2010 and 2025. Eligible studies included research article that evaluated the effect of ACE inhibitors or Calcium Channel Blockers on the prevention of ischemic stroke in adults with hypertension. Reviewers independently screened titles, abstracts, and full texts, and extracted data. Study quality was assessed using the Cochrane Risk of Bias tool. Results : From 8,991 screened articles, 17 studies met the inclusion criteria. Both ACE inhibitors and Calcium Channel Blockers showed effectiveness in reducing ischemic stroke risk. Some studies showed a slightly better effect with Calcium Channel Blockers like amlodipine, while others reported similar results between ACE inhibitors and Calcium Channel Blockers. Differences in study designs and patient groups made direct comparison difficult. Discussion : Both ACE Inhibitors and Calcium Channel Blockers are effective in reducing the risk of ischemic stroke in hypertensive patients, although the relative benefit between the two remains complex. Calcium Channel Blockers may offer a slight advantage in certain populations, but ACE Inhibitors continue to be a cornerstone of stroke prevention strategies, particularly in patients with additional cardiovascular risk factors. Keywords : ACEi, CCBs, Stroke, Systematic Review
First Seizure in a 16-Year-Old Girl Associated With Tuberous Sclerosis Complex: A Case Report Sari, Cindy Permata; Sumada, I Ketut; Yuliani, Desie; Jayanthi, Ni Made Kurnia Dwi
Acta Neurologica Indonesia Vol. 4 No. 02 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v4i02.106

Abstract

Introduction : Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder causing benign tumors in multiple organs. It affects 1 in 6,000 births globally, with a prevalence of 1 in 20,000. However, data in Indonesia remain limited. TSC is marked by seizures, developmental delays, and distinct skin lesions. Case Report : A 16-year-old girl experienced her first seizure. She had no prior TSC diagnosis. Clinical examination revealed generalized tonic clonic seizure, cognitive impairment, and distinctive skin features, including hypomelanotic macules, angiofibromas, a shagreen patch, and non-renal hamartomas. A non-contrast head CT scan confirmed multiple punctate calcifications in the periventricular regions of both lateral ventricles, consistent with TSC. Diagnosis was delayed until her first seizure. Discussion : Diagnosing TSC is challenging. Seizures are often the first noticeable sign. Cognitive delays highlight the need for early screening in children with learning difficulties, particularly when TSC symptoms are present. Limited awareness among healthcare providers and the public contributes to delayed diagnosis. Mutations in TSC1/TSC2 genes disrupt the mTOR pathway, leading to abnormal cell growth and hamartoma formation, increasing seizure risk. Raising awareness is crucial for early detection and timely intervention. Conclusion : TSC often goes undiagnosed until adolescence due to limited awareness and missed early signs. Seizures are a key warning sign requiring evaluation, making TSC a crucial consideration in new-onset seizures, particularly with characteristic skin or brain findings. Early detection and comprehensive care are essential for preventing complications and improving quality of life.

Page 6 of 7 | Total Record : 68

 3   4   5   6   7 

Filter by Year

2023 2026


Reset
Filter By Issues
All Issue Vol. 4 No. 02 (2026): Acta Neurologica Indonesia Vol. 4 No. 01 (2026): Acta Neurologica Indonesia Vol. 3 No. 04 (2025): Acta Neurologica Indonesia Vol. 3 No. 03 (2025): Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia Vol. 2 No. 03 (2024): Acta Neurologica Indonesia Vol. 2 No. 02 (2024): Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia Vol. 1 No. 01 (2023): Acta Neurologica Indonesia