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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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EFEKTIVITAS MEDIA VIDEO TERHADAP PENGETAHUAN ANTIBIOTIK DI KECAMATAN MENDO BARAT KABUPATEN BANGKA Hesty; Lana Sari; Dela Lanaya
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.899

Abstract

Antibiotics are drugs used to prevent and treat infections caused by bacteria, but there is still a lot of inappropriate use of antibiotics. Inaccurate use of antibiotics increases the risk of antibiotic resistance, namely, bacteria becoming resistant to antibiotics. One effort to increase knowledge related to antibiotics is to use video media. Providing digital health information and education with video media is more effective and innovative than other methods. The technique used in this research is quantitative analytic with a one-group pretest-posttest design. Retrieval of data in research using an accidental sampling technique. The number of samples in the study was 394 respondents. The measuring instrument used in the study was a questionnaire given to the people sampled using video media in two pretest and posttest measurements. The study results showed significant differences in changes in knowledge before and after giving knowledge related to antibiotics using video media with a p-value = (0.001 < 0.05). Video media effectively increases the understanding of the people of the West Mendo District about antibiotics.
RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN DIABETES MELITUS DENGAN ULKUS DIABETIKUM DI BANJARMASIN, KALIMANTAN SELATAN, INDONESIA Annida Mujahidah Nurul Azmi; Yulistia Budianti Soemarie; Juwita Ramadhani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.901

Abstract

otential to cause serious complications. Antibiotic therapy is one of the treatment options for patients with diabetic ulcers. Overuse of antibiotics can lead to resistance, which can make therapy less successful. This study aims to determine the percentage of rational antibiotic use and its effect on therapy outcomes in diabetic ulcer patients. This study aims to identify the percentage of rational antibiotic use and its effect on therapeutic outcomes in diabetic ulcer patients in Banjarmasin Hospital. This study was an observational study with a cross-sectional method and data collection in this study was carried out retrospectively during the period July-December 2023. The rationality of antibiotic use was evaluated using the Gyssens method and the correlation of rationality with therapeutic outcomes was analyzed using the chi square test. The study subjects were 94 patients with diabetic ulcers who met the inclusion criteria. The rationality of antibiotic use with the Gyssens category was in category 0 (appropriate) for 65 patients (69%), category IIb (inappropriate interval) for 3 patients (3%), category IIIa (too short) for 10 patients (11%), category IIIb (too long) for 6 patients (6%), category IVa (more effective) for 3 patients (3%), and category IVc (cheaper alternative) for 7 patients (7%). The results of the Chi-Square Test state that there is a significant correlation between the rationality of antibiotic use and therapeutic outcomes in the form of a decrease in the degree of diabetic ulcers. 69% of patients received rational antibiotic therapy and 31% received irrational therapy based on the Gyssens method and there was a correlation between the rationality of antibiotic use and therapeutic outcomes in the form of a decrease in the degree of diabetic ulcers.
EKSPLORASI KANDUNGAN FENOLIK TOTAL BUAH OKRA (Abelmoschus esculentus L.) SEBAGAI KANDIDAT PRODUK HERBAL Mega Efrilia; Yulius Evan Christian Evan; Pra Panca Bayu Chandra; Ema Hermawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.903

Abstract

Okra fruit (Abelmoschus esculentus L.) is a plant that contains phenolic and flavonoid compounds that have the potential as natural antioxidants and can be utilized in pharmaceutical formulations and health products. This study aims to determine the total phenolic content in 70% ethanol extract of okra fruit and evaluate its physical characteristics. The method used in this study consists of several stages. Extraction was done using the maceration method, with 1,005.88 grams of simplistic powder soaked in 10 liters of 70% ethanol for 5 days, stirring every 24 hours. After maceration, the filtrate from the extraction is filtered using Whatman No.1 filter paper, then evaporated using a rotary vacuum evaporator at 40°C until a thick extract is obtained. The extract obtained was tested for physical characteristics through organoleptic testing, including color, odor, and taste. Furthermore, total phenolic content was determined using the Folin-Ciocalteu method, with gallic acid (GAE) as a standard. Absorbance measurements were taken using a UV-Vis spectrophotometer at a wavelength of 765 nm. The results showed that the thick extract yielded 9.47%, with a DER-native value of 10.56. Organoleptic tests showed that the extract had a blackish-brown color, a distinctive odor of okra fruit, and a bitter taste with a slight tartness, indicating the presence of phenolic compounds and tannins. Determination of total phenolic content showed that okra fruit extract had a phenolic content of 921.21 mg GAE/g extract, which showed potential as a natural antioxidant. The 70% ethanol extract of okra fruit has high phenolic content, so it has the potential to be used as a natural antioxidant in pharmaceutical formulations and natural ingredient-based health products.
PENGARUH UKURAN HOST TERHADAP MUTU FISIK DAN PROFIL DISOLUSI TABLET CAMPURAN INTERAKTIF NIFEDIPIN Ilham Kuncahyo; Siti Aisiyah; Shabrina Nindya Hutami; Raden Roro Sri Wulandari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.910

Abstract

Homogeneity remains a significant challenge in the production of tablets containing low-dose active pharmaceutical ingredients such as nifedipine. According to the Biopharmaceutics Classification System (BCS), nifedipine is categorized as a BCS Class II drug, characterized by high permeability but low solubility. The use of an interactive mixture method between a large host as a carrier and a micronized drug/active substance that is interactively attached to the host is an innovation to prevent this problem. This study aims to evaluate the effect of varying host particle sizes on the homogeneity, physical quality, and dissolution profile of nifedipine interactive mixture tablets. Five tablet formulations were developed, each employing different host particle sizes: formula 1 (16/40 mesh), formula 2 (18/40 mesh), formula 3 (20/40 mesh), formula 4 (25/40 mesh), and formula 5 (30/40 mesh). The host carrier was prepared by mixing Avicel PH 101 and lactose in a 1:1 ratio, followed by granulation using PVP as a binder. Tablet production was conducted via direct compression, involving a one-hour mixing of nifedipine with each host size (homogeneity test), followed by a five-minute mixing with magnesium stearate prior to compression. The resulting tablets were evaluated for their physical quality, including friability, hardness, disintegration time, and dissolution rate. The findings indicated that host particle size significantly influenced both the physical characteristics and the dissolution behavior of the nifedipine interactive mixture tablets. Among all formulations, formula 5, with a 30/40 mesh host particle size, yielded tablets with greater hardness, lower friability, and an enhanced dissolution rate compared to formula 1 (16/40 mesh), formula 2 (18/40 mesh), formula 3 (20/40 mesh) dan formula 4 (25/40 mesh).
FORMULASI DAN EVALUASI FISIK SEDIAAN EYESHADOW STICK DARI EKSTRAK KULIT BUAH TERONG BELANDA (Solanum betaceum Cav.) SEBAGAI PEWARNA ALAMI Habibie Deswilyaz Ghiffari; Rastria Meilanda; Larasati Dinda Meditha
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.912

Abstract

The skin of the Dutch eggplant contains anthocyanin compounds that serve as colorants. The skin exhibits an attractive red color, making it a potential natural dye alternative in cosmetics. This study aims to formulate and evaluate the physical properties of an eyeshadow stick made from Dutch eggplant skin extract. An experimental research method was employed, creating four formulations of the eyeshadow stick by varying the concentration of the Dutch eggplant skin extract: F0 (0%), F1 (6%), F2 (12%), and F3 (24%). Physical evaluations of the eyeshadow stick were conducted weekly over four weeks at room temperature (25°C), assessing parameters such as organoleptic properties, homogeneity, spreadability, and melting point. Additionally, a cycling test was performed over six cycles for 12 days, along with irritation tests and preference tests involving 10 volunteers. The results indicated that the organoleptic properties of the three formulations resulted in light pink, medium pink, and dark pink colors, with a white base, a rose scent, and a semi-solid form. There was a significant difference (p < 0.05) in spreadability among F0, F1, F2, and F3, showing that as the extract concentration increased, spreadability decreased, falling within the range of 5-7 cm. All formulations remained stable during storage according to the cycling test results. The irritation tests revealed that none of the formulations caused redness, itching, or swelling. The best formulation was identified as F3 with a 24% extract concentration.
EVALUASI KIMIA FISIKA DAN UJI STABILITAS SEDIAAN COLD CREAM YANG MENGANDUNG EKSTRAK ETANOL DAUN CIPLUKAN (Physalis angulata L.) DENGAN 3 JENIS MINYAK Olive, Caprylic Dan Parafin Habibie Deswilyaz Ghiffari; Delladari Mayefis; Ayu Amelia; Gina Fernanda
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.917

Abstract

Physalis angulata L. (ciplukan) is an annual plant with potential medicinal properties, including pain relief. This study aims to formulate a cold cream containing ciplukan leaf extract and evaluate its physical stability. The leaf extract was obtained by maceration using 96% ethanol and concentrated using a rotary evaporator. Cold cream formulations were prepared with extract concentrations of 0%, 5%, and 10%, utilizing three types of oils (olive, caprylic, and paraffin). Evaluations included organoleptic properties, pH, homogeneity, adhesion, spreadability, viscosity, cream type, and stability, analyzed using One-Way ANOVA. Results showed that all formulations exhibited good physical properties and were classified as oil-in-water (O/W) type creams. pH values ranged from 4 to 6, adhesion times from 1.19 to 4.94 seconds, and spreadability from 4.52 to 5.16 cm, with no significant differences among extract concentrations or oil types (p > 0.05). Increasing the extract concentration from 5% to 10% resulted in a slight decrease in pH, which remained within the safe range, maintained homogeneity, slightly reduced spreadability, and improved physical stability, especially at 10%. The formulation containing 10% ciplukan leaf extract showed the best stability and was well accepted as a cold cream preparation.
POTENSI EKSTRAK ETANOL 50% TERPURIFIKASI BIJI PINANG (Areca Catechu L.) SEBAGAI PENYEMBUH LUKA BAKAR Egi Ramadhan Sm; Humaryanto; Fathnur Sani Kasmadi; Wahyu Indah Aurora; Hanina
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.914

Abstract

Burns require effective therapy to accelerate healing and prevent complications. Areca nut (Areca catechu L.) extract contains secondary metabolite compounds that have wound healing activities, namely anti-inflammatory and antioxidant. The purpose of this study was to analyze the potential of the purification process of 50% ethanol extract of areca nut (Areca catechu L.) on the potential for wound healing in test animals. The method used in this study was an experimental method. The mice used in each group consisted of 5 mice, namely a negative control (vaselin flavum), a positive control (Bioplacenton®), and three treatment groups of areca nut extract of 2%, 4%, and 6% mixed with vaselin flavum ad 100%. Second-degree burns were treated topically every day for 21 days, with wound diameter measurements every three days and histopathological analysis on the 22nd day. The 6% extract gave the best results, with wound healing of 51.58%. Histopathology showed better epidermal regeneration, collagen formation, vascularization, and decreased inflammation in the treatment group. The results of the study showed that a 50% purified ethanol extract of areca nut seeds has potential as a burn healing agent. Statistically, a 6% extract was the best for burn healing (P<0.05).
KADAR FLAVONOID EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) BERDASARKAN VARIASI KONSENTRASI PELARUT ETANOL Henny Nurhasnawati; Risa Supriningrum; Rusdiati Helmidanora; Margareta, Sully
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.921

Abstract

Butterfly pea (Clitoria ternatea L.) is a plant used for medicinal purposes, including therapeutic, cosmetic, nutritional, and beauty applications. Flavonoids, as secondary metabolites with diverse chemical structures in plants, perform various important functions. These functions include growth regulation, coloration, protection from UV rays, and roles in defense mechanisms and signaling systems with microorganisms. These compounds also have pharmacological effects as antidiabetics, antioxidants, and antibacterials. Solvent concentration plays an important role, as it can affect the amount of active compounds extracted from natural materials. The purpose of this study was to determine the flavonoid content in butterfly pea flower extracts using ethanol solvents at concentrations of 50%, 70%, and 95%. The results of phytochemical screening tests showed that all extracts contained secondary metabolites in the form of flavonoids. Other parameters analyzed included yield, moisture content, and flavonoid content from the three ethanol concentration variations. The yields obtained were 57.14%, 54.08%, and 40.72%, respectively, while the moisture content was 9.44 ± 2.17%, 8.99 ± 2.12%, and 7.75 ± 1.97%, respectively.The highest flavonoid content was obtained in the extract with 95% ethanol solvent at 1.2939 ± 0.0880%, followed by 70% ethanol at 0.6958 ± 0.0573%, and 50% ethanol at 0.5811 ± 0.0142%. Statistical analysis using ANOVA showed that there were differences in flavonoid content between the ethanol concentration variation groups
EVALUASI PERESEPAN OBAT ANTIKOLESTEROL PADA PASIEN GERIATRI PERIODE JANUARI-FEBRUARI 2023 Heny Puspasari; Deny Kusuma; Rayna Iza Azyra
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.923

Abstract

Hypercholesterolemia is a disease that is a leading cause of total mortality in Indonesia as well as worldwide. The prevalence of hypercholesterolemia is approximately 45% globally, around 30% in Southeast Asia, 35% in Indonesia, and 37.7% in West Kalimantan. In the management of hypercholesterolemia, evaluation and prescription patterns are crucial to reduce the risk of errors in prescribing anti-cholesterol drugs. The aim of this study was to evaluate the prescription of anti-cholesterol drugs in geriatric patients at Bhayangkara Anton Soedjarwo Hospital, Pontianak, during the period of January–February 2023. This study is a quantitative descriptive study using prescription data from outpatient geriatric patients receiving anti-hypercholesterolemia medication. The sample size was determined using the Lemeshow formula, resulting in 100 respondents selected through simple random sampling. The results showed that hypercholesterolemia patients were most prevalent in the 61–65-year age group, accounting for 22%, with females comprising 56%. The most frequently used anti-cholesterol drug was Atorvastatin (78%), with a dose of 20 mg, administered once daily in 98% of cases, and the most common comorbidity was heart disease (49%). The use of anti-cholesterol drugs was considered rational if it met the criteria of correct diagnosis, correct patient, correct disease indication, correct drug selection, and correct dosage, achieving a rationality rate of 100%. The study findings indicate that the most frequently prescribed anti-hypercholesterolemia drug was Atorvastatin, with rational prescribing practices observed in hypercholesterolemia patients.
ANALISIS EFEKTIVITAS PENGGUNAAN ANTIDEPRESAN TERHADAP KUALITAS HIDUP PASIEN DEPRESI DI KLINIK KEJIWAAN X BALIKPAPAN Diva Nur Fadhila; Dewi Rahmawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.946

Abstract

Depression is a medical disorder that can affect thoughts and disrupt psychological well-being, manifesting as feelings of sadness and loss of interest in life, which may impair an individual’s ability to carry out daily activities normally, and in the most severe conditions, depression can lead to suicidal thoughts or ideation. Depression symptoms can be managed using antidepressants, which help balance brain chemistry. This study aims to analyze the effectiveness of antidepressant use on the quality of life of patients with depression at Mental Health Clinic X in Balikpapan. A one-group pre- and post-test design was used, involving 30 patients. Statistical analysis was conducted and presented descriptively. The results indicate that the antidepressant treatment used were not yet fully effective in significantly reducing depression levels, as most patients were still in the early stages of treatment (less than six months). However, the treatment showed considerable effectiveness in improving patients’ quality of life.

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