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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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ANALISIS BIAYA DAN RASIONALITAS PENGOBATAN EKSASERBASI ASMA PASIEN RAWAT INAP Amelia Lorensia; Marthy Meliana Ariyanti Jalmav; Lafia Lailatul Fadik
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.774

Abstract

Asthma is a heterogeneous disease characterized by chronic airway inflammation and asthma-related costs are very high. The aim is to determine cost analysis and evaluate the difference in real costs with INA-CBG’s rates, and evaluate the rationality of treating asthma exacerbations. This design is retrospective by looking at medical record data of patients with asthma exacerbations at RSU Anwar Medika Sidoarjo, for the period January 2020-December 2022. The variables are the real costs and rates of INA-CBGs, and the incidence of drug-related problems (DRPs) of patient treatment data during in the hospital. The data collection method is by observing medical record data and details of medical costs. Data analysis used Mann-Whitney to determine differences in real costs and rates for INA-CBGs. Analysis of rational treatment with MTO is presented descriptively. The number of respondents was 108, with mild (85.19%) and severe (14.81%) asthma rates. The highest direct costs were incurred for accommodation room costs and laboratory costs. The results of the Mann-Whitney test showed that the p value of 0.096 was greater than the alpha value of 0.05, it was concluded that there was no difference in real costs compared to the INA-CBGs rate in asthma patients. Of the patients who experienced MTO, 63 samples (51.21%) experienced DRP and 60 samples (48.78%) did not experience DRP, so it can be concluded that the percentage of DRP events is still high. The total number of DRP incidents that occurred was 182 cases, and the types of DRP that occurred most frequently were unnecessary medication in 179 cases (98.35%) and suboptimal drug effects in 3 cases (1.65%).
PENGARUH PEMBERIAN EDUKASI TERHADAP TINGKAT PENGETAHUAN PENGGUNAAN ANTIBIOTIK PADA PASIEN RAWAT JALAN RSUD Dr. MOEWARDI TAHUN 2023 Magdalena Retnoningsih; Jason Merari Peranginangin; Nur Anggreini Dwi Sasangka
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.779

Abstract

Antibiotics are drugs to fight bacterial infections. Based on the large amount of antibiotic use, WHO states that the amount of irrational antibiotic use is relatively high, causing the risk of increasing resistance. This research was conducted to determine the level of patient knowledge about the use of antibiotics before and after being given education. This research used a pre-experiment design with one group pre-test and post-test with measuring instruments in the form of questionnaires. The number of samples used was 306 respondents, sample data was collected using purposive sampling by providing verbal education and leaflet media. Data analysis to determine the description of respondents based on characteristic criteria uses univariate analysis, to determine the relationship between respondent characteristics and level of knowledge using bivariate analysis, while to determine the influence between the independent variable and the dependent variable using statistical analysis the Wilcoxon difference test. The results of this research show that the level of knowledge at pre-test was 31% with high knowledge, 30.7% with moderate knowledge, 38.2% with low knowledge. In the post-test 99% had high knowledge, 0.7% had medium knowledge, 0.3% had low knowledge. The results obtained were tested using the Wilcoxon test which obtained a significance value of 0.000 < 0.05. From these results it can be concluded that there is an influence of providing education on the level of knowledge of outpatients at Dr. RSUD. Moewardi, and there is a significant relationship between the characteristics of respondents and the level of knowledge, p value <0.05.
VALIDASI METODE ANALISIS KUERSETIN DARI EKSTRAK ETANOL DAUN KEMANGI (Ocimum sanctum L) SECARA SPEKTROFOTOMETRI UV-Vis Evi Kurniawati; Tri Puji Lestari; Krisna Kharisma Pertiwi
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.780

Abstract

Basil leaves, scientifically known as Ocimum sanctum L., are a medicinal plant commonly used by the public because of their abundant secondary metabolite chemical compounds. One of them is flavonoids, secondary metabolites found in basil leaves, which have antioxidant properties. Quercetin, a flavonoid compound, exhibits valuable biological properties beyond its antioxidant effects, including antibacterial, anticancer, antiviral and anti-inflammatory activities. This research was carried out with the aim of determining the quercetin content contained in the ethanol extract of basil leaves (Ocimum sanctum L) by validated UV-Vis Spectrophotometry. Basil leaves are macerated with 70% ethanol. The extract is then concentrated using a rotary evaporator. Next, phytochemical screening was carried out to identify secondary metabolites in the extract, followed by UV-Vis spectrophotometric quantification. Based on the test results, it can be seen that the analysis of quercetin levels using UV-Vis spectrophotometry is validated for all parameters that meet the requirements. A significant relationship is shown by the linearity test, the correlation coefficient (r) is 0.9963. These results show good specificity, with test accuracy ranging from 90% to 107%, namely 103.9%. In addition, the precision test shows the %RSD value is less than 2%. The ethanol extract of basil leaves has an average quercetin content of 10.811% w/w.
FORMULASI DAN UJI ANTIBAKTERI SEDIAAN SABUN MANDI CAIR EKSTRAK DAUN RAMBAI PADI (Sonneratia caseolaris L.) TERHADAP Staphylococcus aureus Adhila Ghina; Fitri Handayani; Achmad Kadri Ansyori; Panji Ratih Suci; Erna Fitriany
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.784

Abstract

Rampai padi (Sonneratia caseolaris L.) grows along the coast Mahakam River in Samarinda. It was identified to contain flavonoids with, high potential as antioxidants and antibacterials. Previous studies have explored the content, pharmacological activity, and development of preparations. This study aimed to formulate the ethanol extract of rambai padi leaves (EEDRP) in liquid bath soap and to determine its pharmacological activity as an antibacterial (Staphylococcus aureus). The sample used is EEDRP which is formulated in liquid bath soap in three formulations, A (5%), B (10%), and C (15%). The results of the phytochemical screening of EEDRP contained flavonoids, phenolics, tannins, saponins, and steroids. The EEDRP can be formulated into a liquid bath soap that is homogeneous, has a characteristic odor, and is blackish-brown to dark green-gray. The pH test results on the 1st, 3rd, and 7th day met the quality requirements, namely pH 4-10, the foam height test which met the foam height requirements of 1 - 10 cm. The total plate number test result was 0 colonies/g. The antibacterial activity of EEDRP liquid soap in formula A (5%) had an inhibition zone of 4.11 mm, formula B (10%) of 4.17 mm, and formula C (15%) of 6.38 mm.
FORMULASI DAN EVALUASI SEDIAAN KRIM PEWARNA RAMBUT KOMBINASI EKSTRAK BUNGA TELANG (Clitoria ternatea L.) DAN BUNGA ROSELLA (Hibiscus sabdariffa L.) Marini; Ayu Saputri; Nur Azizah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.789

Abstract

Cosmetic hair dye preparations generally use synthetic dyes which often cause allergic reactions, one of which is Para-phenylenediamine. Butterfly pea flowers (Clitoria ternatea L.) and rosella flowers (Hibiscus sabdariffa L.) contain anthocyanins which can be used as natural dyes. The aim of this research was to formulate a hair coloring cream preparation from a combination of butterfly pea flower extract and rosella flower extract using three different formulas. The extraction method to extract the dye from both flowers uses the maceration method and 70% ethanol solvent. The dye resulting from the maceration of telang flowers is deep purple and for rosella flowers it is heart red, the combination of the two produces several color variations. The results of the cream formulation of butterfly pea flower extract and rosella flower extract with a ratio of 15:5 (F1) produce a royal purple color, a ratio of 10:10 (F2) produces a vivid violet color and a ratio of 5:15 (F3) produces plum. The results of the evaluation of the physical preparations of the three formulas met the requirements for homogeneity, pH and spreadability. The results of the color stability test showed that soaking for 4 hours produced hair color, purple (F1), light purple (F2) and light magenta (F3) and washing did not last long up to 15 times. The results of the color stability test against exposure to sunlight show that the color produced in the hair does not change with 5 hours of exposure to sunlight. The irritation test produces an irritation index of F0=0.11, F1=0.22, F2=0.27 and F3=0.22 which states that the irritation is very mild.
OPTIMASI KOMPOSISI SETIL ALKOHOL DAN PROPILENGLIKOL PADA SEDIAAN LOTION TABIR SURYA EKSTRAK ANGGUR HITAM (Vitis vinifera L.) DENGAN METODE SIMPLEX LATTICE DESIGN Repining Tiyas Sawiji; Elisabeth Oriana Jawa La; Fitriyani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.790

Abstract

Black grapes have natural antioxidants which contain flavonoid compounds, namely resveratrol which acts as a UV absorbent so that it can be used as a sunscreen. To facilitate its use, cosmetic preparations are made in the form of lotions. The physical properties and stability of lotion preparations are influenced by emulsifiers and humectants which can maintain the water content when used. The aim of this study was to determine the composition of cetyl alcohol and propylene glycol to produce a formula with optimum physical properties and SPF value. This study used a laboratory experimental research design using the active ingredient of black grape extract (Vitis vinifera L.) at a concentration of 3%. The sunscreen lotion was made in 8 runs with a concentration range of 2-5% cetyl alcohol and 7-10% propylene glycol. The composition of cetyl alcohol and propylene glycol was optimized using Design Expert software version 13 with test parameters of spreadability, adhesion, and viscosity, as well as in-vitro SPF values ​​using a Uv-Vis spectrophotometer. The optimal formula is determined using a numerical method, then intelligence and re-tested its physical properties with predicted values ​​that have been set by the software. The results showed that the optimum formula for black grape extract lotion was 2.1% cetyl alcohol and 9.8% propylene glycol. Black grape extract lotion is in the form of a semi-solid dosage form, with a homogeneous light brown color, and a pH according to the skin. The optimum black grape extract lotion produced a spreading power value of 53.7 g.cm/minute, an adhesion of 1.4 seconds, a viscosity of 142 dPa.S, and an SPF value of 4.6. Based on the research, it can be concluded that the emulsifier and humectant components have an effect on the physical quality of the preparation, including viscosity, adhesion, spreadability.
KARAKTERISASI DAN SKRINING FITOKIMIA EKSTRAK BUNGA TELANG (Clitoria ternatea L.) Bebie Ayu Rismayuti; Risa Supriningrum; Supomo
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.796

Abstract

Characterization is a step to determine the quality of an extract of natural materials, which includes specific, non-specific parameters, and phytochemical screening. This study aims to determine the specific, non-specific characteristics and secondary metabolite compounds of telang flower extract. Telang flowers are made into powdered simplisia, and the drying shrinkage is determined. Furthermore, extraction was carried out using the maceration method with 70% ethanol solvent. The drying shrinkage of the simplisia was 10% and the extract yield was 43.8%. Specific characterization results include organoleptic observations in the form of thick blue-black extract with a distinctive odor and bitter taste. The average content of soluble compounds in water is 58% and the average content of soluble compounds in ethanol is 17.67%. Non-specific characterization results include an average moisture content of 21.93%. Average ash content of 5% and acid insoluble ash content of 2%. The average specific gravity was 1.015 g/ml and the results of mold/chamir numbers were 1 × 102 colonies/g and total plate numbers were 1.3 × 103 colonies/g. Secondary metabolite compounds contained in telang flower extract include alkaloids, flavonoids, saponins, steroids and terpenoids.
AKTIVITAS ANTIOKSIDAN DAN ANTIMIKROBA SARANG BURUNG WALET (Collocalia Fuciphaga) DARI BERBAGAI JENIS KELAS SARANG DAN JENIS BANGUNAN Andi Syahid Khalid Assegraff; Wiwin Suwinarti; Isna Yuniar Wardhani; Agus Sulistyo Budi; Irawan Wijaya Kusuma; Enos Tangke Arung
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.804

Abstract

The community has traditionally utilized the swallow’s nest (Collocalia fuciphaga), an edible bird’s net (EBN), as a component in medicines and cosmetics. Within the cave’s walls lies the environment for the swallow’s nest. The nest’s quality and form are taken into account when determining the nest wallet’s selling price. This study intends to ascertain the possible suppression of the bacteria Staphylococcus sp. and Escherichia sp. activity as well as the antioxidant activity of the swallow’s nest from the nest class formed from wood and concrete construction types. The study was conducted directly on dry, hair- and dirt-free, finely powdered, and dissolved in distilled water swallow nests (Collocalia fuciphaga). Testing for antibacterial activity was conducted. Agar well testing for antibacterial activity was carried out using Mueller Hinton Agar (MHA) and chloramphenicol media as positive controls. Ascorbic acid was used as a positive control while 1,1-diphenyl-2-picrylhydrazyl (DPPH) was tested for its ability to scavenge free radicals. The test findings demonstrated that the swallow (Collocalia fuciphaga) had substantial antioxidant activity against DPPH and that the swallow’s nest (Collocalia fuciphaga) had antibacterial activity against Staphylococcus sp. and Escherichia sp. germs. The swallow’s nest’s (Collocalia fuciphaga) antioxidant and antibacterial properties are specific to different nest classes and building kinds, so they may be utilized as a foundation for thought about raising the selling price of bowls, powders, and crumbles in each form of structure.
PERBANDINGAN METODE EKSTRAKSI MASERASI DAN SOKHLETASI TERHADAP KADAR FLAVONOID TOTAL EKSTRAK ETANOL 96% DAUN KLUWIH (Artocarpus camansi) Regita Wananda Putri Gita; M. Hidayatullah; Eka Fitri Susiani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.840

Abstract

The utilization of medicinal plants is one of the steps for alternative medicine. One of them is the kluwih plant (Artocarpus camansi) which is also similar to the breadfruit plant but has differences in its fruit. The purpose of this research is to analyze the total flavonoid content of 96% ethanol extract of kluwih leaves and which method has the potential to produce greater total flavonoid content. Extraction of kluwih leaves was done by maceration and sokhletation. The method implemented was UV-Vis spectrophotometry with AlCl3 reagent and involving quercetin as a comparator. Based on the analysis by applying the maceration method, an average level of 23.05 mg QE/g extract was obtained for the total flavonoid content of 96% ethanol extract of kluwih leaves, while the sokhletation method obtained an average of 31.33 mg QE/g extract. So it can be concluded that the extraction method that produces a greater total flavonoid content of 96% ethanol extract of kluwih leaves is sokhletasi.
GAMBARAN PENGGUNAAN OBAT TRADISIONAL UNTUK PENYAKIT HIPERTENSI PADA MASYARAKAT KELURAHAN BUDAYA PAMPANG KECAMATAN SAMARINDA UTARA Septiana Dewi; Dwi Elfira Kurniati; Lizma Febrina
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.866

Abstract

The Budaya Pampang community still adheres to the tradition of using traditional medicine. This is interesting to study, especially in hypertension which has a high prevalence. This study aims to determine the characteristics of the Budaya Pampang Village community who use traditional medicine for hypertension and the pattern of using traditional medicine for hypertension in the community. This research is a descriptive study with total sampling technique. Data collection was carried out using a questionnaire given to 48 respondents. Data were analyzed by descriptive statistics using SPSS. The results showed that the characteristics of the most respondents were male (54.2%), aged >45 years (81.2%), elementary school education (41.7%), housewife occupation (39.6%), duration of hypertension >1 year (77.1%), and duration of taking traditional medicine >1 year (64.6%). The most widely used plant type was bay leaf (16.7%), the most common dosage form was fresh preparation (91.7%), the most common processing method was boiling (68.7%), the frequency of use was 2x a day (43.8%). The reason for using traditional medicine is because it is cheaper (89.6%), easy to obtain or grow yourself (81.3%), and easy to prepare or mix (79.2%). Based on the results of the study, there are 16 species of medicinal plants with antihypertensive properties that can be the basis for drug development in the future.

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