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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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UJI TOKSISITAS AKUT EKSTRAK PROPOLIS LEBAH KELULUT Geniotrigona thoracica DAN Heterotrigona itama TERHADAP MENCIT (Mus musculus L.) Nindya Ila Syafira Ramelan; Paula Mariana Kustiawan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.868

Abstract

Propolis is a product produced by bees that has various benefits. As a natural substance that can be used for medicinal purposes, propolis needs to undergo acute toxicity testing to determine the safety of its use and to estimate the degree of damage that may occur. This study aims to compare the acute toxicity potential of propolis extracts from two species of stingless bees, Geniotrigona thoracica and Heterotrigona itama, based on LD50 and to assess toxic symptoms. The testing was conducted using the Organization for Economic Co-operation and Development (OECD) No. 425 method: Acute Oral Toxicity (UDP). Phytochemical test results showed that propolis extracts from Geniotrigona thoracica and Heterotrigona itama have consistent levels of secondary metabolites, namely flavonoids, alkaloids, tanins, and phenolics. Based on the acute toxicity test results, it can be concluded that the propolis extracts from Geniotrigona thoracica and Heterotrigona itama have consistent LD50 values, exceeding 5000 mg/kg body weight, and are classified as non-toxic.
PENGETAHUAN DAN PENERAPAN PRINSIP HIGIENE SANITASI MAKANAN MINUMAN DI PANTI ASUHAN AISYIYAH AL WALIDATURRAHMAH Putri Indah Permatasari; Vita Pramaningsih; Ratna Yuliawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.870

Abstract

Food and beverage sanitation is a part of environmental health; controlling food and beverages is a primary function that must be carried out for food safety. Unhygienic drinks are just as dangerous as food; for human health, these beverages serve as sources of bacteria, poisoning, and other issues that can lead to death. The method used is descriptive in the form of a narrative about the depiction of knowledge and the application of food and beverage hygiene sanitation. The results of implementing the six principles of food and beverage hygiene and sanitation at the Aisyiyah Al Walidaturahmah Orphanage are as follows: for the variable of food ingredient selection, it meets the requirements with a score of 100%; for the variable of food ingredient storage, it also meets the requirements with a score of 100%; for the variable of food processing, it meets the requirements with a score of 92%; for the variable of storage of cooked food, it meets the requirements with a score of 100%; for food transportation, it meets the requirements with a score of 100%; and for food presentation, it meets the requirements with a score of 100%. The implementation of the six principles of food and beverage hygiene and sanitation has met health standards according to the Minister of Health Regulation Number 1096 of 2011.
ANALISIS PENGGUNAAN OBAT PADA PASIEN PENYAKIT JANTUNG ISKEMIK DI RUMAH SAKIT Z KOTA JAMBI TAHUN 2023 Athayyah Shabirah; Rasmala Dewi; Medi Andriani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.871

Abstract

Ischemic Heart Disease is a condition that mainly occurs due to narrowing of the coronary arteries due to atherosclerosis, spasm, or a combination of both. The aim of this research is to determine the use of drugs which includes the right drug, the right indication, the right patient, the right dose and the right time interval for administering the drug in patients with Ischemic Heart Disease at Z Hospital, Jambi City in 2023. This research is a descriptive study with retrospective data collection. which searches the medical record data of patients in 2023 who meet the inclusion criteria. The results of this study found 115 patient medical record data that met the inclusion criteria with a percentage of drug accuracy of 99,13%, 100% correct indication, 87,83% correct patient, 100% correct dose, and only 33,91% correct time interval for drug.
FORMULASI DAN UJI STABILITAS SEDIAAN KOSMETIK PERONA PIPI (BLUSH ON) DARI EKSTRAK KULIT BUAH RAMBUTAN ( Nephelium lappaceum L) SEBAGAI COLORING AGENT Ika Ayu Mentari; Rahmatang
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.885

Abstract

Blush On is one type of cosmetic that produces color on the cheeks, there are two types of dyes commonly used in cosmetics, namely natural dyes derived from plants and synthetic dyes derived from a mixture of two or more chemical compounds. Plants that are often used to form natural dyes are rambutan fruit skin which has anthocyanin content that can provide color pigments. This study aims to determine the extract of rambutan fruit skin can be formulated into a blush on preparation and to determine the stability of the blush on preparation. The research method was carried out experimentally including the extraction of rambutan fruit skin by the maceration method using 96% ethanol, making blush on preparations with three different concentrations including 10%, 20%, 30%. Checking the physical quality of blush on includes organoleptic testing, stability, preference, pH, irritation, spreadability and homogeneity. The results of the study showed that blush on preparations with a concentration of 10% produced a white color, a concentration of 20% was brown and a concentration of 30% produced a reddish brown color. This happens because there are different concentration levels of each formulation of active substances from rambutan fruit skin extract. The stability of the preparation after 3 weeks of storage showed stable results. The conclusion of this study is that rambutan peel extract can be used as a coloring agent in blush on preparations.
KEGAGALAN PENGENDALIAN DIABETES MELLITUS TIPE II DITINJAU DARI FAKTOR PREDISPOSISI Khusnul Diana; Amalia Purnamasari Zainal; Setaiawati Fadhilah Zainal; Muhammad Rinaldhi Tandah; Dhea Puspita; Nurul Ambianti
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.886

Abstract

Failure to control type II diabetes mellitus (DM) has a serious impact on the quality of life and health of DM patients. One of the factors that can influence the failure to control DM is predisposing factors. This study aims to determine predisposing factors including gender, education level, age, smoking, occupation, sports activities, long-suffering, knowledge, and behavior that influence failure to control type II DM. The research method used was descriptive analysis with cross-sectional data collection. This research used a purposive sampling technique and the patients used were 179 respondents. Data was collected using the Diabetes Knowledge Questionnaire (DKQ-24) questionnaire and the Self-Management Diabetes Mellitus (SMDM) questionnaire instrument. The data analysis used is bivariate and multivariate. The results of the bivariate analysis show that the variables that influence the failure to control Type II DM are the length of suffering (p = 0.000), behavior (p = 0.004), sports activities (p = 0.029), and work (p = 0.020). The results of the multivariate analysis of the dominant factors influencing failure to control type II DM are long-suffering with a value of OR = 6.956, behavior with a value of OR = 4.156, knowledge with a value of OR = 2.947, sports activities with a value of OR = 0.690, so it can be concluded that the variable long-suffering is The main factor in the failure to control type II DM because it can increase the risk of complications such as pancreatic cell damage and insulin resistance.
ANALISIS PERBANDINGAN KADAR SENYAWA NITRIT PADA SOSIS AYAM DAN SOSIS SAPI CURAH DENGAN METODE SPEKTROFOTOMETRI UV-VIS Bella Setya Ananda; Anita Agustina Styawan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i2.890

Abstract

In the current era of globalization, processed meat products are one type of fast food widely consumed by the public, especially sausages. Nitrite as a food preservative for processed meat, especially in sausages. However, it needs to be considered so as not to exceed the limit so that it does not adversely affect human health. This study aims to determine the levels of nitrite preservatives in bulk chicken sausages and bulk beef sausages circulating in online stores. The determination of nitrite levels in the samples was carried out using the UV-Vis spectrophotometric method using griess reagent and aquadestilata solution, the maximum wavelength obtained was 545 nm.Qualitative test results were positive for nitrite with pink color results. Quantitative tests using UV-Vis spectrophotometry obtained nitrite preservative levels equal to 3 replicates, the average bulk chicken sausage nitrite level was 1,44 mg/kg and the average bulk beef sausage level was 3,992 mg/kg. From the results of the study, nitrite levels in chicken sausage and bulk beef sausage circulating in online stores are suitable for consumption because nitrite levels in bulk chicken and beef sausages are not more than 30 mg/kg according to BPOM RI No. 36 of 2013 concerning nitrite preservatives in processed meat products.
ANALISIS RHODAMIN B PADA LIPSTIK IMPOR YANG BEREDAR DI PASAR PAGI KOTA SAMARINDA DENGAN SPEKTROFOTOMETRI UV-VISIBLE Ruth Gratia Dwi Pangestika; Nurillahi Febria Leswana; Adhe Septa Ryant Agus
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.848

Abstract

Rhodamine B is commonly used as a dye for textiles (silk, wool, cotton), paint, paper, and clothing. Prolonged ingestion or exposure may irritate the respiratory tract, eyes, and skin, cause nausea and vomiting, and potentially lead to liver cancer or even cell death. This study aims to identify the presence of Rhodamine B dye in imported lipsticks sold at Pasar Pagi, Samarinda City. The research involved both qualitative and quantitative analyses. The qualitative test was conducted using Thin Layer Chromatography (TLC) with an eluent mixture of ethyl acetate : ethanol : ammonia (11:2:1), while the quantitative test employed UV-Vis spectrophotometry. The qualitative results using TLC showed that sample H had an Rf value of 0.529 cm, which closely resembled the standard Rhodamine B Rf value of 0.623 cm. The quantitative analysis revealed Rhodamine B concentrations in sample A (0.12%), sample B (0.19%), sample C (0.16%), sample F (0.20%), sample G (0.16%), sample H (0.37%), sample I (0.27%), and sample J (0.03%). The validity test indicated a linear result. The precision test showed Relative Standard Deviation (RSD) values of 1.7% for samples G, H, and I. The accuracy test yielded recovery percentages in sample G of 92% (2 ppm), 99% (4 ppm), and 86% (6 ppm); and in sample H of 88% (2 ppm), 98% (4 ppm), and 94% (6 ppm).
PENGEMBANGAN MIKROEMULSI DARI EKSTRAK ETANOL 96% KULIT BATANG BALIK ANGIN (Alphitonia incana (Roxb.) Teijsm & Binn. Ex Kurz) Wahyudin Bin Jamaludin; Muhammad Hidayattullah; Muammaroh; Fitriyanti; Marlia Fatwa
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.881

Abstract

The 96% ethanol extract of Balik angin stem bark contains secondary metabolite compounds that have potential antioxidant activity with a value of 37.00 ± 1.46µg/ml (bpj), the potential for use can be maximized in microemulsion preparations. In microemulsions, one of the ingredients that can affect the stability of the microemulsion is a cosurfactant which can affect the globule size and polydispersity index. Microemulsions were formulated by varying the type and concentration of cosurfactants to determine the optimal formula based on the test parameters of physical characteristics and stability of the preparation. The method used in this research is experimental and in the manufacture of microemulsions, namely the spontaneous emulsification method. The test results show that all formulas in the organoleptic test are clear except F1, the Tyndall test can transmit light, the pH value is 5.4 -5.6, the microemulsion type is M/A, the specific gravity is 1.038-1.064, the viscosity value is less than 200 cPs and the percent transmittance obtained ranges from 90-97%. The globule size test of F2 to F6 (55.03-1045) and the polydispersity index test of F2 to F6 (0.277-0.827), but the results were not detected in F1. The results of statistical tests on pH and specific gravity tests obtained p-value (>0.05), F3 viscosity test obtained p-value (<0.05) and T% test on F1, F4, and F5 obtained p-value (<0.05) so it can be concluded that microemulsion preparations with variations in the type and concentration of cosurfactants have an influence on physical characteristics and stability, and the most optimal formula is F6.
OPTIMASI KOMBINASI SETIL ALKOHOL DAN LANOLIN PADA FORMULA BALSAM STIK DENGAN METODE SIMPLEX LATTICE DESIGN Ratih Dyah Pertiwi; Fayza Maghfira Solachudin; Hermanus Ehe Hurit
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.895

Abstract

A Balsam stick is a stick-shaped balsam that is made easier to use. Stiffening agents and emollients are needed to maintain the consistency of the balsam stick. This study aims to determine the optimum formula for balsam sticks with a combination of cetyl alcohol and lanolin. Using the Simplex Lattice Design method, the optimum formula for balsam sticks is obtained through the Design Expert version 13. The analysis results of spreadability, adhesion, and hardness were obtained using the ANOVA test. The optimum formula was obtained with a combination of cetyl alcohol concentration of 40.5% and lanolin 59.5% with a desirability value of 1.000 and the predicted results of spreadability of 3.506 cm, adhesion of 11.597 seconds, and hardness of 9.259 mm. In the evaluation results carried out in the laboratory, the value of the spreadability test was 3.62 ± 0.08 cm, the adhesion test was 10.92 ± 0.44 seconds, and the hardness test was 9.029 ± 0.31 mm. The verification results of the optimum formula were a sig 2-tailed value on spreadability of 0.139, adhesion of 0.120, and hardness of 0.328 where sig 2-tailed >0,05, indicating no significant difference. This suggests that the optimum formula of balsam sticks gives good results and meets the requirements.
PERESEPAN BERPOTENSI TIDAK TEPAT, LUARAN KLINIS DAN EFEK SAMPING OBAT PADA PASIEN GERIATRI DENGAN TERAPI ANTIHIPERTENSI Muh. Irham Bakhtiar; Dinny Seppraudiva
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.898

Abstract

Hypertension in geriatric patients poses a clinical challenge due to age-related physiological changes that increase the risk of Potentially Inappropriate Medications (PIM), adverse drug events (ADE), and difficulty in achieving target blood pressure. This study aimed to evaluate potentially inappropriate antihypertensive prescribing using the Indonesian version of the STOPP criteria, assess blood pressure target achievement based on three guidelines (NICE 2019, JNC 8, and ACC/AHA 2017), and identify ADEs assessed using the Naranjo algorithm. This was a descriptive observational study with a prospective approach conducted through medical record review and interviews with hospitalized geriatric patients at Hospital X in Samarinda. The results showed a 23.08% prevalence of PIM, including the use of furosemide without clear indication, clonidine as an antihypertensive, and high-risk diuretic combinations. Failure to achieve blood pressure targets was found in 35.71% (NICE 2019), 28.57% (JNC 8, 2014), and 78.57% (ACC/AHA, 2017), indicating that stricter targets are more difficult to achieve in older adults. There were three ADE cases (21.43%), consisting of two cases of renal dysfunction associated with candesartan and one case of abdominal pain due to furosemide. Causality was assessed using the Naranjo algorithm and validated by clinical pharmacists using the 30th edition of the Drug Information Handbook (2021). This study highlights the importance of individualized antihypertensive therapy evaluation in elderly patients to prevent PIM, improve clinical outcomes, and reduce adverse events. Active involvement of clinical pharmacists and data-driven clinical decision support systems are essential to enhance medication safety and therapeutic effectiveness in the geriatric population.

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