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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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KOMBINASI MINYAK KULIT JERUK MANIS DAN PEPERMIN SEBAGAI PENGAROMA ALAMI PADA SEDIAAN DEODORAN KRIM: EVALUASI KARAKTERISTIK FISIK DAN IRITASI KULIT Mayangsari, Fransisca Dita; Elasari Dwi Pratiwi; Muhammad Arendra Ardiansyah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.948

Abstract

Sweet orange peel oil (MJ) and peppermint oil (MP) are essential oils. The MJ contained mainly limonene, while the MP contained mainly menthol. These compounds give MJ and MP their distinctive aromas but can also potentially cause skin irritation, especially when used in high concentrations. The purpose of this study was to observe the effect of adding a combination of essential oils (MJ and MP) at a concentration of 3% on the physical characteristics and skin irritation levels of cream deodorants. The ratios of MJ:MP added were 0:0 (F0), 100:0 (FA), 50:50 (FB), and 0:100 (FC). In the physical characteristic test, observations included pH, organoleptic, viscosity, and spreadability. In the irritation test, observations included erythema and edema on the skin of white rat. Based on the organoleptic test, it is known that F0 was odorless, FA had the aroma of MJ, FB had the aroma of MP with a little MJ, and FC had the aroma of MP. All four formulas were white in color and had a semi-solid consistency. They had a pH between 5.27-5.68. The formula with the highest pH was F0. All four formulas had a spreadability value between 5.20-5.53. These values ??were not significantly different. All four formulas had a viscosity value between 14,066-14,980 cP. These values ??were not significantly different. The results of skin irritation observations showed that all formulas had a primary irritation index score of 0. The study concluded that the ratio of MJ and MP affected the aroma and pH of the cream deodorant but did not affect the color, consistency, viscosity, and spreadability. None of the formulas causes skin irritation.
EVALUASI KRIM DENGAN VARIASI KONSENTRASI EKSTRAK BIJI LADA HITAM (Piper nigrum L.) Senny Listy Kartika Falestin; Pra Panca Bayu Chandra; Nia Lisnawati; Mega Efrilia; Pricillya Maria Loimalitna; Indah Nur El Hasanah; Yulius Evan Christian
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.950

Abstract

Black pepper (Piper nigrum L.) is a medicinal plant that contains active compounds such as piperine, flavonoids, and essential oils, which are known to exhibit anti-inflammatory, antioxidant, and antimicrobial properties. This study aims to evaluate the physical quality of cream formulations containing varying concentrations of 96% ethanol extract of black pepper seeds. A descriptive experimental method was employed, focusing on the assessment of organoleptic properties, homogeneity, pH, spreadability, adhesion, and viscosity over a four-week storage period. Four formulations were tested: F0 as a control without extract, F1 with 1% extract, F2 with 2%, and F3 with 3%. The evaluation results showed that all formulations met the required physical quality standards. The creams retained stable color and odor, demonstrated uniform ingredient distribution, and had pH values within the safe range for topical application (4.5–6.5). The spreadability and adhesion properties were within ideal criteria, and viscosity levels ranged between 2000 and 5000 cP, indicating suitable consistency. Among the tested formulations, F2 exhibited the most optimal performance in terms of physical stability and user comfort. Based on these findings, it can be concluded that black pepper seed extract is suitable for formulation into a topical cream preparation, with the 2% concentration showing promising potential for development as a natural-based, safe, and effective topical product.
HUBUNGAN TINGKAT KEPATUHAN BEROBAT TERHADAP KENDALI GLUKOSA DARAH PASIEN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT DIRGAHAYU SAMARINDA Ardila, Rindi; Victoria Yulita
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.958

Abstract

Type 2 diabetes mellitus is a chronic metabolic disease characterized by high blood glucose levels, with incidence rates continuing to rise worldwide, including in Samarinda City, which has the highest prevalence in East Kalimantan (3.04%). Patient adherence to drug therapy is an important factor in achieving successful blood glucose control and preventing complications. This study aimed to assess the level of adherence of outpatients with type 2 diabetes mellitus at Dirgahayu Samarinda Hospital to the use of antidiabetic drugs. This was a prospective study with a cross-sectional design involving 50 respondents with type 2 diabetes mellitus. Data were collected through the MMAS-8 adherence questionnaire and review of patient medical records. Data analysis was performed using statistical software with frequency distribution analysis and chi-square tests. The results showed that 23 respondents (46%) had high compliance, 17 respondents (34%) showed moderate compliance, and 10 respondents (20%) were in the low compliance category. No significant relationship was found between the level of compliance and blood glucose control (p = 0.249 > ? = 0.005). In conclusion, the level of patient compliance with treatment is not the only factor determining success in controlling blood glucose levels, as there are various other aspects that also play a role in influencing the stability of these glucose levels.
FORMULASI DAN UJI EVALUASI PASTA GIGI CANGKANG TELUR BEBEK YANG MENGANDUNG KALSIUM KARBONAT DENGAN VARIASI KONSENTRASI XANTHAN GUM Ghiffari, Habibie Deswilyaz; Fitrya, Dessy; Sari, Diani Mega; Rushd, Ibnu
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.963

Abstract

Duck egg shells are an organic waste that is rich in calcium carbonate (CaCO?) and has the potential to be used as a natural abrasive in toothpaste preparations. This research aims to formulate toothpaste using duck eggshell powder as a source of calcium carbonate and evaluate the effect of varying concentrations of xanthan gum as a thickening agent on the physical quality of the resulting toothpaste. This research is experimental. Formulations are made with varying concentrations of xanthan gum, namely 0.5%, 1%, 1.5% and 2%. Evaluation of the preparation includes organoleptic tests, homogeneity, pH, viscosity, cycling test, stress test, long-term stability, and foam tests which are analyzed descriptively. The research results showed that all formulas produced toothpaste that met organoleptic, homogeneity and pH requirements (4.5–10.5). Increasing the concentration of xanthan gum affects viscosity. The formula with a xanthan gum concentration of 2% had the highest viscosity, while the formula with a concentration of 0.5% showed a lower viscosity. The foam test showed that the four formulas were able to produce foam with sufficient volume. In conclusion, formula 2 is a good, stable formula, and has the potential to be developed as a duck egg shell toothpaste preparation.
FORMULASI DAN UJI EVALUASI SEDIAAN SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DARI EKSTRAK METANOL AKAR PANDAN LAUT (PANDANUS ODORIFER) Ghiffari, Habibie Deswilyaz; Suhendra, Arif; Vonikartika, Arie; Roza Erda
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.964

Abstract

Background: Pandanus odorifer is a coastal plant in Southeast Asia with roots rich in bioactive compounds such as phenolics, flavonoids, saponins, and alkaloids. Limited solubility and bioavailability of lipophilic compounds hinder therapeutic effectiveness. Objective: To develop and evaluate Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation from sea pandanus root methanol extract to enhance solubility and stability. Methods: Root extraction was performed using soxhlet method with methanol solvent. Six SNEDDS formulas were developed with variations of Tween 80/Tween 20 surfactant combinations and PEG 400/propylene glycol cosurfactants. Evaluation included simplicia characterization, organoleptic tests, creaming tests, pH and viscosity measurements, centrifugation, freeze-thaw stability, solubility, and droplet size analysis. Results: Extract yield reached 7.72% with simplicia characterization meeting pharmacopoeial standards. Formula F3 (Tween 80 21.4%, PEG 400 21.4%, VCO 4.75%, extract 5%) demonstrated optimal stability with pH 6.91±0.04, viscosity 253.33±11.55 cPs, HLB value 14.50, and average droplet size 530 nm. This formula maintained homogeneity throughout all stability tests without phase separation. Conclusion: SNEDDS from Pandanus odorifer root methanol extract formula F3 possesses physicochemical characteristics and stability suitable for nanoemulsion-based drug delivery systems.
ANALISIS FENOLIK DAN FLAVONOID DALAM EKSTRAK METANOL DAUN SUNGKAI (Peronema canescens Jack.) SECARA SPEKTROFOTOMETRI Nofita, Dewi; Setiawan, Budi; Marthia, Cut Mina; Putri, Desi Eka
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.967

Abstract

Sungkai (Peronema canescens Jack.) is an indigenous Indonesian plant traditionally used for the treatment of fever, enhancing immune function, and managing hypertension. This study aimed to determine the total phenolic and flavonoid contents of methanol extracts of Sungkai leaves using spectrophotometric analysis. Phenolic content was measured using the Folin–Ciocalteu reagent with gallic acid as the standard, while flavonoid content was quantified using quercetin as the reference compound. The results showed that the methanol extract of Sungkai leaves contained a total phenolic content of 255.760 ± 0.0146 mg GAE/g extract and a total flavonoid content of 52.014 ± 0.0301 mg QE/g extract. These findings indicate that Sungkai leaves represent a promising natural source of bioactive metabolites with potential health benefits.

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