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Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions
Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK covers the disciplines of medicine, pharmacy, and health with several types of articles, namely: 1. Research 2. Literature review 3. Case report 4. Evidence-based case report (EBCR), systematic review 5. Other scientific articles Based on the SK Kemendikbudristek Nomor 152/E/KPT/2023, CDK has obtained Rank 4 (SINTA 4) for Scientific Journals.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,276 Documents
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Penggunaan Vitamin D3 Oral Dosis Tinggi Esther Kristiningrum
Cermin Dunia Kedokteran Vol 49 No 10 (2022): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i10.1718

Abstract

Vitamin D is a fat-soluble vitamin with an important role in various skeletal and non-skeletal physiological functions. Vitamin D deficiency has been found in many countries including Indonesia, and has been associated with an increased risk of various diseases. Vitamin D supplementation or even high-dose vitamin D therapy is often necessary to maintain or to achieve optimal vitamin D status, especially if rapid correction is required and/or as adjunctive therapy for other diseases. Various clinical trials have shown that high-dose oral vitamin D3 therapy is effective and relatively safe for vitamin D deficiency patients.
Karsinoma Nasofaring: Faktor Risiko, Deteksi Dini, Diagnosis, dan Tata Laksana: Hasil Penelitian Evita Zevanya; Iswarini, Arin Dwi
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1334

Abstract

Nasopharyngeal carcinoma is a malignant tumor originating from nasopharyngeal epithelium; it is endemic in several regions, including Indonesia. This malignancy is the fourth most frequent cancer case in Indonesia. The etiology is not fully understood. The risk factors involve interactions between genetic and environmental factors, including age, gender, family history of nasopharyngeal carcinoma, consumption of fermented foods, and Epstein-Barr virus (EBV) infection. Early detection used EBV serology, EBV DNA plasma, and endoscopy; the IgG NPC strip is commonly used in Indonesia. The gold standard for diagnosis is biopsy and histopathological examination. The management of the disease depends on its stage. Intensity-modulated radiotherapy (IMRT) has shown several advantages over conventional radiotherapy. Follow-up is necessary to evaluate the outcome and remission.
Pola Kuman Hasil Pemeriksaan Kultur di RSUD Siti Fatimah Kota Palembang, Sumatera Selatan, Indonesia: Hasil Penelitian Husada, Dedi Yanto; Eviningtyas, Ririn
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1350

Abstract

Introduction: Bacterial culture examination is the diagnostic standard for various infectious diseases. This descriptive research aims to determine the microorganism pattern in culture examinations at Siti Fatimah Regional Hospital, Palembang, South Sumatra, Indonesia. Methods: Secondary data were from records of microorganism culture examination results at the Clinical Pathology Laboratory of Siti Fatimah Regional Hospital, South Sumatra Province, from January to December 2022. Result: During that period, 217 samples were collected from various sources: 64 (29.5%) blood samples, 25 (11.5%) urine samples, 47 (21.7%) pus samples, 64 (29.5%) sputum samples, and 17 (7.8%) body fluid samples. Most samples’ characteristics were from patients who were >18-60 years old, male, and non-intensive inpatient ward patients. A total of 137 (63.1%) samples showed positive growth, mostly from sputum (60 samples; 93.8%), with the majority of bacteria being Klebsiella pneumoniae (11 samples; 18.3%). The most frequently detected bacteria in blood and urine cultures was Pseudomonas aeruginosa, in 5 samples (29.5%) and 3 samples (27.3%), respectively. Staphylococcus aureus was largely seen in pus (8 samples; 20%) and body fluid (3 samples; 33.3%) cultures. Conclusion: The results of the culture examination showed that most positive germ growth came from sputum, with the most bacteria found being Pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumoniae.
Perdarahan Perirenal Spontan pada Pasien dengan Sindrom Antifosfolipid: Laporan Kasus Adipurnama, William; Oktaviani, Jacinda Risha; Singgih, Nicholas Andrian; Salim, Cecilia Noviyanti; Derry Wendians Suhanto; Manuputty, Egi Edward; Budiawan Atmadja
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1353

Abstract

Introduction: Spontaneous perirenal hemorrhage (SPH), also known as Wunderlich syndrome, is a rare condition that can potentially progress into life-threatening non-traumatic retroperitoneal hemorrhage. Common symptoms include acute flank or abdominal pain, a palpable flank mass, and fulminant hypovolemia, collectively referred to as Lenk’s triad, and diagnosis is typically established radiologically using a CT scan. Antiphospholipid syndrome (APS) - a rare, immune-mediated hypercoagulable disorder that occurs in only 5 cases per 100,000 people per year worldwide. It is immune-mediated, characterized by persistent antiphospholipid antibodies (APLA) that cause both arteries and venous thrombosis, and can present as peripheral arterial disease (PAD), acute arterial occlusion, and early atherosclerosis. Case : A 33-year-old woman with chronic kidney disease (CKD) presented with SPH and incidentally diagnosed with peripheral arterial disease (PAD) and APS. Conclusion : Conservative management was beneficial for SPH without the need for surgical intervention; however, antithrombotic therapy for PAD posed additional challenges before the patient was eventually discharged in improved condition for outpatient follow-up.
Neoplasia Limfoid yang Menyerupai Mesotelioma: Laporan Kasus Irianto; Puteri, Made Widya Wirayanti; Sunaka, I Wayan; Novitasari
Cermin Dunia Kedokteran Vol 52 No 6 (2025): Kesehatan Jiwa
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i6.1366

Abstract

Introduction: Lymphoid neoplasms are abnormalities of the hematopoiesis process of the lymphoid line, which can lead to lymphoma or leukemia. Mesothelioma is an abnormal mesothelial cell growth strongly associated with asbestos exposure. In radiology, mesothelioma is usually described as a tissue-dense lesion with well-defined, spiculated borders attached to the thoracic wall. The picture actually only depicts a tissue attached to the thorax, which can be suspected as mesothelioma, but can also be due to other disease processes, such as leukemia, lymphoma, and tuberculosis. Case: A 58-year-old man presented to the emergency room with complaints of shortness of breath. The patient was initially suspected of mesothelioma with suspicion of blood malignancy, but it turned out that the biopsy results were more likely to lead to infiltration of lymphoid neoplasms. Conclusion: In this patient, a lymphatic neoplasm infiltrated the mesothelial tissue and produced a well-demarcated and spiculated tissue picture resembling mesothelioma. Biopsy examination as the gold standard cannot be replaced by radiologic imaging at this time, as many other disease processes can mimic a malignancy.
Trauma Kandung Kemih Ekstraperitoneal Tak Teridentifikasi: Kasus dengan Sistografi Normal: Laporan Kasus Affandi, Reza; Azmi, Yufi Aulia; Wirjopranoto, Soetojo
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1372

Abstract

Introduction: Bladder trauma is the second most commonly injured organ in the genitourinary system after the kidney. The injury can be caused by a variety of mechanisms, including blunt trauma, penetrating trauma, and iatrogenic procedures. Case: A 21-year-old male with multiple injuries following a motorbike accident. Upon examination, a foreign body was detected in the right thigh. A CT scan revealed a metal rod impaled in the patient’s bladder without any contrast leakage. The patient was planned for foreign body removal and bladder repair. During the removal, bladder leakage was detected. The patient underwent foreign body removal and bladder repair. Discussion: This case underscores the importance of considering bladder injury in trauma patients, even in the absence of classic clinical signs such as haematuria. It also highlights the potential limitations of initial imaging techniques like cystography in detecting bladder injuries when foreign bodies are present. Conclusion: This case emphasizes the importance of maintaining a high index of suspicion and considering intraoperative exploration or additional diagnostic methods when imaging findings are inconclusive. Revising the diagnostic protocol for trauma patients with suspected bladder injury, especially if a foreign body is present, is essential to avoid missed diagnoses and improve patient outcomes.
Hubungan Tingkat Stres dengan Kualitas Hidup Pasien Tuberkulosis di Puskesmas Perumnas II Pontianak, Indonesia: Hasil Penelitian Sakila, Shella; Fitriangga, Agus; In’am Ilmiawan, Muhammad
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1386

Abstract

Introduction: Tuberculosis patients need long-term treatment. The effects of anti-tuberculosis drugs and stigma in society may cause stress, which can decrease the patient’s quality of life. This research aims to search for the correlation between stress level and quality of life in tuberculosis patients in Puskesmas Perumnas II Pontianak. Methods: An analytical study with a cross-sectional approach was conducted in January 2021 at Puskesmas Perumnas II Pontianak. The total sampling technique acquired 24 respondents. Analysis was performed using the Spearman rank correlation test. Results: The stress level was 83.3% in normal stress, 8.3% mild stress, 8.3% moderate stress, 79% of respondents had a good quality of life, and 21% of respondents had a poor quality of life. The Spearman rank correlation test results showed no significant correlation between stress level and quality of life (p=0,195). Conclusion: No significant correlation between stress level and quality of life in tuberculosis patients in the Puskesmas Perumnas II Pontianak.
Diagnosis dan Tata Laksana Tuberkuloma Serebral: Tinjauan Pustaka Putri, Lulu Anandita
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1451

Abstract

Tuberkulosis merupakan penyakit yang disebabkan oleh infeksi bakteri Mycobacterium tuberculosis. Ketika bakteri ini menginfeksi sistem saraf pusat, dapat terbentuk tuberkuloma serebral, yaitu massa granulomatosa berisi jaringan nekrotik di parenkim otak. Meskipun termasuk manifestasi ekstra paru yang jarang (1,4% kasus TB), tuberkuloma serebral memiliki gambaran luaran klinis yang berat, terutama pada kelompok berisiko seperti anak-anak, penderita HIV/AIDS, dan individu dengan imunosupresi. Penegakan diagnosis pada pasien sering terlambat karena memiliki gejala yang tidak khas, seperti nyeri kepala, kejang, atau defisit neurologis fokal yang menyerupai tumor otak. Pemeriksaan penunjang seperti MRI menunjukkan gambaran khas ring enhancement dengan edema perilesional, sedangkan analisis cairan serebrospinal (CSF) dapat menunjukkan pleositosis limfositik. Tata laksana utama berupa terapi obat anti-tuberkulosis (OAT) kombinasi minimal 12 bulan, dengan isoniazid dan rifampicin. Corticosteroid digunakan untuk mengatasi respons paradoksal atau edema serebral. Intervensi bedah dipertimbangkan pada lesi yang berukuran di atas 2 cm yang dapat menyebabkan efek massa atau hidrosefalus. Prognosis bergantung pada kecepatan diagnosis dan ketepatan terapi, dengan angka kesembuhan mencapai 85% jika ditangani secara adekuat.
Seorang Pria Sehat Berusia 23 Tahun dengan Pingsan Setelah Bermain Futsal: Kasus Rhabdomyolysis yang disebabkan oleh aktivitas: Laporan Kasus David Kristianus; Jonkie Budi Tirtadjaja
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1508

Abstract

Introduction: Exertional rhabdomyolysis (ER) is a medical condition resulting from strenuous exercise characterized by skeletal muscle damage followed by the release of intracellular components into the circulation. ER has various clinical manifestations and is associated with various complications that increase morbidity and mortality. Case: A 23-year-old male came to the emergency department with decreased consciousness after playing futsal. After urinary catheter insertion, brown-colored urine was observed. Laboratory examination showed increased serum CK level (199,011 IU/L), increased serum creatinine, hyperkalemia, and metabolic acidosis. The diagnosis was exertional rhabdomyolysis, acute kidney injury, hyperkalemia, and metabolic acidosis. Conclusion: The condition of the patient improved after aggressive intravenous rehydration, intravenous insulin, and sodium bicarbonate therapy. Prompt diagnosis and appropriate management can reduce complications, morbidity and mortality.
Efikasi Statin pada Tata Laksana Oftalmopati Graves: Analisis Ekaputri, Maria Vania Tri; Tanu, Megawati
Cermin Dunia Kedokteran Vol 52 No 7 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i7.1546

Abstract

Graves’ ophthalmopathy (OG) is an ocular manifestation of autoimmune thyroid disease. The inflammation and tissue remodeling of OG can cause mild to severe symptoms that can damage the nerves in the eye and lead to blindness. Early identification of diagnosis, classification of activity and severity of the disease, and risk factors for the disease are crucial. Those steps can support comprehensive further management to prevent severe and permanent damage. The complex interactions between endogenous (unmodifiable), exogenous (modifiable), and environmental factors play as risk factors for OG development. Hypercholesterolemia which is also caused by long-term systemic inflammation is one of the risk factors associated with OG. Hypercholesterolemia can be treated by administering statin. Beside it’s role in lowering cholesterol level, statins have preventive and therapeutic effects especially in patient with active moderate to severe OG. Statin also have pleiotropic effects, act as immunoregulator, inhibiting adipogenesis and synergize with methylprednisolone in management of OG.

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