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INDONESIA
Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions
Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK covers the disciplines of medicine, pharmacy, and health with several types of articles, namely: 1. Research 2. Literature review 3. Case report 4. Evidence-based case report (EBCR), systematic review 5. Other scientific articles Based on the SK Kemendikbudristek Nomor 152/E/KPT/2023, CDK has obtained Rank 4 (SINTA 4) for Scientific Journals.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,276 Documents
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Trakeostomi Dilatasi Perkutan dengan Bimbingan Ultrasonografi Waktu Nyata pada Pasien Kritis III: Laporan Kasus Rikardi, Fachrizal; Adiyanto, Bowo
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1392

Abstract

Introduction: Tracheostomy is a common procedure in intensive care units for critically ill patients with mechanical ventilation. Case: This case report describes the use of real-time ultrasonography (USG) guidance for percutaneous dilatational tracheostomy (PDT) in a 63-year-old female with prolonged mechanical ventilation following craniotomy. The patient had relative contraindications including short neck and morbid obesity (BMI 40.8). On day 7 of ICU admission, a PDT was successfully performed using real-time ultrasonography (USG) guidance. USG was utilized to identify key anatomical landmarks, such as tracheal rings and vascular structures, ensuring safe and accurate needle placement. The use of real-time USG significantly reduced the risk of complications including hemorrhage, tracheal injury, or pneumothorax. The procedure was completed without incident, and the patient showed clinical improvement post-intervention, including enhanced respiratory function and gradual weaning from mechanical ventilation. Conclusion: This report highlights the safety and efficacy of USG-guided PDT, especially in high-risk patients with difficult neck anatomy. It also underlines the importance of ultrasound as a widely available and cost-effective tool in ICU settings. The case supports further implementation of real-time USG-guided techniques in percutaneous tracheostomy to improve procedural success and patient outcomes. Further research involving a larger cohort is needed to establish standardized protocols and evaluate long-term outcomes of this approach.
Manifestasi Klinis dan Komplikasi Infeksi Dengue pada Anak-Anak: Wawasan dan Perbandingan dengan Kasus pada Dewasa: Tinjauan Pustaka Kusuma, Sonia Sudana
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1518

Abstract

Dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) have become significant global health concerns, particularly affecting children more severely than adults. In children, dengue infection is distinct from that in adults due to its higher mortality rate and increased risk of developing dengue hemorrhagic fever or dengue shock syndrome. Clinical manifestations vary by age; children more commonly present with vomiting, rash, and abdominal pain, while adults often experience muscle and joint pain. Symptoms of DHF, a severe type of dengue infection, include abnormal hemostasis, plasma leakage, and protein-losing shock syndrome (dengue shock syndrome/DSS). Dengue infection in children can cause various complications from each organ system. During the critical phase, children are prone to plasma leakage, shock, and bleeding, potentially leading to severe complications such as liver dysfunction, electrolyte imbalance, and organ failure. Proper management and prevention of dengue are required to prevent dengue complications.
Peran Tumor Necrosis Factor-Alpha Sistemik pada Respons Imun Toksoplasmosis Okuler Wahyudi, I Nyoman Surya Ari; Sofia, Ovi
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1538

Abstract

Ocular toxoplasmosis (OT) is the most common infection causing posterior uveitis worldwide, caused by the parasite Toxoplasma gondii. Many cytokines such as TNF α, IL-6, and IL-10 are involved in the development of uveitis. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine released primarily during inflammatory response of macrophages and T cells, to mediate the activation and infiltration of leukocytes and T helper (Th)1 lymphocyte responses in the tissue. Macular inflammation caused by TO can lead to substantial visual impairment. High level of TNF-α cause disruption of the blood-retinal barrier in uveitis. TNF-α plays a role as a positive regulator of the immune response. Systemic TNF-α levels in ocular infections, particularly TO, increase, which is associated with an increased inflammatory response, contributing to choroidal and retinal tissue damage in TO patients. The TNF-α levels in tissues and intraocular fluid can vary depending on the type and severity of infection. Detection of systemic TNF-α may act a potential clinical biomarker for ocular toxoplasmosis.
Tato dan Risiko Komplikasinya Putri, Putu Ayu Krisna Cahyaning; Saraswati, Putu Dyah Ayu
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1584

Abstract

Tattoos are a form of body modification that involves inserting indelible ink into the dermis to alter skin pigmentation. Based on the duration of pigment retention, tattoos are classified into two types: temporary tattoos and permanent tattoos. The increase in the prevalence of tattooing has raised awareness of the adverse reactions associated with tattoos, which are not limited to the risk of dermatological complications, but also systemic complications. Adverse reactions related to tattoos are classified into infection, inflammatory, and neoplastic complications. Risks of infection and neoplasia are only observed in permanent tattoos. Hypersensitivity reactions to tattoo pigments are the most common adverse effects for both permanent and temporary tattoos. Risk of infection during permanent tattooing varies based on the causative pathogens, which may include bacterial, viral, fungal, and parasitic infections, manifesting as both localized and systemic issues. Adverse reactions have also been reported in relation to the pigment colors used in tattoos, suggesting that certain pigment components may be associated with harmful effects. A standardized regulatory framework is necessary to ensure the safety of tattoo inks and to prevent adverse health outcomes.
Hubungan Tingkat Stres Akademik dan Kejadian Gastroesophageal Reflux Disease (GERD) pada Mahasiswa S1 Program Studi Kedokteran, Fakultas Kedokteran Universitas Ahmad Dahlan: Hasil Penelitian Nirwani, Rr Syifa Aurora; Arifin, Zainul; Laariya, Tira Alfiani
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1594

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is a digestive system disorder characterized by recurrent reflux of stomach contents into the esophagus, leading to symptoms or complications. Academic stress is one of the risk factors for GERD. This research aims to determine the relationship between academic stress levels and the incidence of GERD among undergraduate students in the Medical Study Program, Faculty of Medicine, Ahmad Dahlan University. Methods: This study uses a quantitative observational analytical research method with a cross-sectional approach, employing total sampling based on inclusion and exclusion criteria. GERD is measured using the GERD-Q, and stress levels are assessed with the MSSQ questionnaire. Results: GERD was suffered by 26 respondents (14.8%), the majority were female. The majority of respondents, 85 in total (48.3%) experienced moderate stress; academic stress was the most common cause. The results of the chi-square analysis test between the level of academic stress and the incidence of GERD obtained a p-value of 0.052 (p>0.05). Conclusion: There is no significant relationship between academic stress levels and the incidence of GERD among undergraduates in the Medical Study Program at Ahmad Dahlan University Faculty of Medicine.
Perspektif Medis, Sosial, dan Kebijakan dalam Memahami Infertilitas di Indonesia: Sebuah Tinjauan Naratif Sutanto, Reynardi Larope; Suskhan, Rizki Fauzi; Pratama, Satria Arief; Christian, Christopher; Putra, Elza Nur Warsa; Faruqi, Muhammad; Simanjuntak, Kevin Tadeus; Ali, Najma; Setyawan, Dhanis Adrianto; Suryoadji, Kemal Akbar
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1598

Abstract

Introduction: Infertility is a reproductive health problem in various countries, including Indonesia, with a significant impact on population and community productivity. This study aims to assess the urgency of addressing infertility in the context of public health and population control in Indonesia. Methods: This research employs a literature review method, referencing relevant sources. Document searches were conducted through Google Scholar and manual searching using the keywords “(Infertility) AND (Indonesia).” Results: The review found 53 literatures consisting of scientific research, medical consensus, review papers, news, and legal products. Discussion: Infertility is a complex problem that requires a multidisciplinary approach. The discussion is organized into several multidisciplinary sections which include a discussion from the medical side in the form of etiology, risk factors, diagnosis flow, and management of infertility, a review of infertility as a public health problem, the impact of infertility on patients and society, sensitive public communication methods regarding infertility, and recommendations for management and policy regulation regarding infertility for government officials. Conclusion: Addressing infertility in Indonesia requires the support of various parties, including the government, health workers, and the community, to overcome its complex impact.
Penyembuhan Luka Tanpa Bekas: Kemajuan dan Inovasi Terkini Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1678

Abstract

Scarless wound healing, a hallmark of mid-gestation fetal skin, is characterized by minimal inflammation, balanced transforming growth factor-β isoforms, and a provisional extracellular matrix rich in type III collagen and hyaluronan. Decades of mechanistic studies have mapped how these features collectively enable rapid, regenerative closure without fibrosis. Contemporary adult-tissue strategies therefore focus on recapitulating the fetal milieu through targeted cytokine modulation, notably down-regulating TGF-β1/β2 while supplementing antifibrotic TGF-β3. Mesenchymal stem cells (MSCs) and their secretome have emerged as potent immunomodulators and angiogenic stimulants that steer wounds toward regeneration rather than scarring. Genetic engineering, biomaterial scaffolds, and extracellular-vesicle delivery platforms further enhance MSC persistence, homing, and paracrine potency. Parallel advances in bio-inspired hydrogels, microneedle arrays, and nanofiber dressings provide spatiotemporal release of growth factors, antimicrobial agents, and oxygen to orchestrate orderly repair. Such combinatorial nanotechnologies not only accelerate re-epithelialization but also limit hypertrophic collagen deposition, leading to flatter, more elastic neodermis.
Human Metapneumovirus (HMPV): Gambaran Klinis dan Tata Laksana: Tinjauan Pustaka Situmorang, Theresia Murniwati
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1807

Abstract

Human Metapneumovirus has recently gained global attention due to an outbreak in China. HMPV is an RNA virus of the Pneumoviridae family, a respiratory pathogen generally occuring seasonally and causes periodic epidemic. HMPV is transmitted through droplets, with the virus incubating for about three to five days, varying between individuals. Its symptoms are difficult to differentiate from symptoms by human respiratory syncytial virus (HRSV) infection. Common clinical symptoms experienced by HMPV patients include fever, cough, upper respiratory tract infection, or lower respiratory tract infection. HMPV can infect all age groups, but symptoms are more severe in infants, the elderly, and patients with comorbidities or immunosuppression. Real-time polymerase chain reaction (RT-PCR) remains the primary modality for diagnosing HMPV infection. Therapy is supportive as no vaccine or causal therapy is available, such as antipyretics, oxygen supplementation, and fluid hydration therapy. Several studies related to the management of HMPV are continued to be searched.
Model Prediktor Prognosis Pasien Trauma Multipel Berdasarkan Lokasi Anatomis Cedera di RSSA Malang, Indonesia: Sub-Studi dalam Penyusunan Model Multikomponen: Hasil Penelitian Prasetyadjati, Ari; Setijowati, Nanik; Irsan, Istan Irmansyah; Zaiyanah, Munsifah; Johan, Willy
Cermin Dunia Kedokteran Vol 52 No 9 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i9.1316

Abstract

Introduction: Management of trauma still poses a challenge in Indonesia without significant improvement in mortality rates in the last 12 years, especially in multiple trauma involving at least 2 organ systems. This study aims to predict the prognosis of multiple trauma patients treated at Saiful Anwar Hospital (RSSA) Malang based on the anatomical location of the injury. Methods: Retrospective cohort study of 506 multiple trauma patients in RSSA during 2021-2022. The analyses used a chi square test and logistic regression test to obtain a regression equation. Results: Multiple trauma cases in RSSA were dominated by males in productive age (15-54 years). Head injury was the most influential variable in predicting the prognosis of multiple trauma patients in hospital, followed by thoracic injury, spinal injury, and abdominal injury. The logistic regression model was quite capable of explaining the data (p=0.931; Hosmer-Lameshow test), while the area under the curve (AUC-ROC) for prognosis in hospital care from this equation was 0.706 with a 95% confidence interval of 0.653-0.759 (good category). Conclusion: Head injuries, thoracic injuries, abdominal injuries, and spinal injuries are predictors of mortality of trauma cases in hospital care in RSSA, Malang, Indonesia.
Respons Radioterapi Karsinoma Serviks Stadium Lanjut Jenis Sel Skuamosa dan Adenokarsinoma di RSUD Ulin, Banjarmasin, Indonesia: Hasil Penelitian Sindunata, Natasha Bharat; Pratiwi, Eka Indah; Lubis, Arlavinda Asmara
Cermin Dunia Kedokteran Vol 52 No 9 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i9.1355

Abstract

Introduction: Cervical carcinoma (cancer) is a malignancy in the cervix and is one of the most common cancers in women. Data released by GLOBOCAN in 2022 showed that cervical cancer ranks eighth globally. The main treatment for advanced cervical cancer is radiotherapy. The aim of this study is to compare the radiotherapy response in squamous cell carcinoma cervical cancer with the response in adenocarcinoma cervical cancer at Ulin Regional Hospital, Banjarmasin, Indonesia. Methods: This cross-sectional research used an analytical observational design. Total sample during the research period from January 2021 to December 2022. Results: Total of 128 cervical cancer patients consisting of 91 squamous cell carcinomas and 37 adenocarcinomas. Chi-square analysis found a significant association between histopathology and response to therapy; squamous cell carcinoma histopathology was more radiosensitive than adenocarcinoma. Conclusion: Histopathological type is the only characteristic significantly associated with radiation response, whereas age, stage, and tumor size are not significantly associated with radiation response.

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