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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : https://doi.org/10.33508/jfst
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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year in March and October, containing research articles, review and short communication in the pharmacy science field, including medicinal chemistry, analytical chemistry, biological pharmacy, pharmaceutical sciences, and clinical pharmacy researches; the practice of pharmacy in industry, clinic and community, such as pharmacies, distributors and pharmacy education.
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Articles 172 Documents
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Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun Beluntas (Pluchea indica L. Less.) Wijaya, Sumi; Setiawan, Henry Kurnia; Ano, Lucyanna Ayu Lestari
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 1 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i1.2178

Abstract

Indian fleabane (Pluchea indica (L.) Less.), on of the species in Asteraceae family, is widely used for traditional medicine. A standardization process is needed as an effort to improve the quality and safety of products, so that it is expected to increase the trust in drugs derived from natural ingredients. This study aims to determine the morphology and anatomy of Indian fleabane leaves and to determine the standardization value of the ethanol extract of Indian fleabane leaves. Dried powder of Indian fleabane leaves are obtained from three different regions (Bogor, Malang and Surabaya). The extract was obtained by maceration method using 96% ethanol as a solvent. Specific standardization includes identity, macroscopic, determination of soluble extract, phytochemical screening, TLC (Thin Layer Chromatography) pattern determination, determination of infrared spectrum profile, determination of UV-Vis spectrum profile, and determination of flavonoid, phenol and alkaloid total content. Nonspecific standardization includes determination of total ash content, water soluble ash content, acid insoluble ash content, drying losses, specific gravity and pH. Organoleptic observations showed the ethanol extract of Indian fleabane leaves has blackish brown and aromatic odour. The mobile phase being used for TLC profile chromatogram was n-hexane: ethyl acetate (7: 3). Based on the results, the screening results of Indian fleabane contain alkaloids, flavonoids, polyphenols, tannins, saponins, steroids and triterpenoids. The Infra red spectrophotometer analysis showed the range of wave numbers of 2924 - 2925, 1515 - 1516, 1259 - 1260, 1159 - 1162, 1112 - 1115, 1046 - 1048, 811 - 812, 505 - 506 and 452 - 454 cm- 1. The standardization value of Indian fleabane ethanol extract showed ethanol soluble extract> 65%, water soluble extract> 49%, water content
Formulasi Sediaan Lipstik Ekstrak Air Buah Syzygium cumini Dalam Bentuk Liquid Sari, Dwi Augusnita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2179

Abstract

Now-a-days decorative cosmetics are essential needs for women especially lipstick. Lipstick is one of the cosmetics products which is used to increasing the aesthetic of facial make-up. A local tradable fruit called Syzygium cumini can be used as an alternative in conventional lipstick. Syzygium cumini anthocyanin-rich fruit contain 892 mg anthocyanins per 100g of fresh fruit. The purpose of this research was to find out the increasing of difference (HPMC) in liquid lipstick and to find out influence of the best formulation based on physical test, effectiveness test, safety test and acceptability test. Lipstick in liquid form was chosen because it has advantages such as can be easy to attached, easy to apply and easy to dry so that the formulation required a thickening agent that has properties to fulfill the characteristics of liquid lipstick. HPMC is a thickening agent and can help improve the viscosity of formulation liquid lipstick. The concentration of Syzygium cumini fruit extract was used 20% formulated using HPMC at a concentration of 0.75%; 1% and 2%. The results showed that the increasing concentration of HPMC significantly affect on pH test, viscosity, adhesion, and drying time; the decreasing of spreadness and the smearness of liquid lipstick. The best formula was the formula contained HPMC 2%, based on physical test (viscosity, homogeneity), effectiveness test (smearness, spreadness, stickiness, drying time), safety test and acceptability test.
Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya Sanjiwani, Kadek Siska Febri; Sugianto, Paulus; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2180

Abstract

Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients
Standarisasi Simplisia Kering Daun Beluntas (Pluchea indica L.) dari Tiga Daerah Berbeda Talia, Sela; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2181

Abstract

Indian Fleabane (Pluchea indica L.) are commonly used as hedgerows and traditionally the leaves are used as fresh salad or medicines to eliminate body odor, febrifuge, cough medicine, and antidiarrheal drugs. Along with the increasing technology of natural materials and the tendency of people to use products derived from natural materials, especially medicinal plants, a reference which contains the requirements for the quality of natural ingredients that are suitable for use as medicinal ingredients is needed. This research aims to determine the profile of specific and non specific standardization of dried powder of indian fleabane leaves. Standardization of indian fleabane leaves covers specific parameters and non specific parameters, characterization of microscopic characteristics of indian fleabane (Pluchea indica L.) leaves, characterization of the content of secondary metabolites using thin layer chromatography (TLC), determination of spectrum profiles using infrared spectrophotometer (IR), and determination of the levels of secondary metabolites by spectrofotometry. The data obtained is descriptive data that reflect the acquisition of data from 3 different locations. Based on microscopic observations indian fleabane leaf dried powder has vascular bundles with spiral thickening, anomocytic stomata, and multicellular trichomes. Ethanol solubility of dried powder indian fleabane is ≥5% while water solubility in water is ≥26%. The results of phytochemical screening showed positive results on the observations of alkaloids, flavonoids, phenols, steroids and terpenes. Total ash content is
Pola Penggunaan Ranitidine pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Nurohmawati, Weni; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2182

Abstract

HIV is a retrovirus that attacks CD4 lymphocyte cells. AIDS is a retrovirus disease caused by infection with retrovirus HIV-1 or HIV-2 which causes opportunistic diseases, secondary neoplasms and neurological abnormalities. In patients with HIV & AIDS often experience gastrointestinal disorders such as nausea and vomiting caused by side effects of the use of antiretroviral or due to other factors. Ranitidine is an H2 inhibitory receptor that will selectively and reversibly reduce excess gastric acid secretion. In this study ranitidine was used as a stress ulcer prophylaxis in hospitalized patients. This study aims to display ranitidine therapy data including type, dose, route of drug administration, prevalence, duration of use and qualitative analysis of interactions associated with medical record data at UPIPI RSUD Dr. Soetomo Surabaya. The research method used was observational prospectively on patient medical record with HIV & AIDS. Sampling was carried out by consecutive sampling period from November 1, 2016 to December 31, 2016. The results of this study give information that ranitidine was most widely used for stress ulcer prophylaxis therapy in hospitalized patients in UPIPI RSUD Dr. Soetomo Surabaya in a dose of 50mg / 2ml with a frequency of 2x1 while for oral ranitidine with a dose of 150mg / tablet with a frequency of 2x1. The use of ranitidine on HIV & AIDS patients in UPIPI RSUD Dr Soetomo Surabaya, related to dosage, route, frequency, interval, and duration of administration is in accordance with the existing guidelines.
Uji Potensi Antibakteri dan Antibiofilm Minyak Atsiri Umbi Teki (Cyperus rotundus L.) terhadap Staphylococcus aureus ATCC 6538 Uthari, Ni Made; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2183

Abstract

Infectious disease is a disease that is caused by an invasion of pathogenic microorganisms in the body. Biofilm is a group of microorganisms that are able to differentiate and proliferate in the complex way as well as being able to communicate between cells through a matrix of polysaccharides. In chronic infection, biofilm has an important role to maintain the bacteria which can cause resistance to antibiotics. Teki (Cyperus rotundus L.) is one of the plants that has many benefits for different treatment. The aim of this study was to determine the antibacterial activity and inhibition of biofilm activity of essential oil of Cyperus rotundus L. tubers against Staphylococcus aureus. Essential oil was extracted by distillation using Stahl with water as the solvent and the yield of essential oil obtained was 0.22%. Determination of antibacterial activity and antibiofilm activity were carried out by microdilution method using microplate 96 U-PVC bottom wells against Staphylococcus aureus which is equivalent to the solution standard of ½ Mc Farland I. The results of antibacterial activity tests showed that MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values were 0.05% (v/v) and 12.5% (v/v). Antibiofilm activity test showed that the essential oil of Cyperus rotundus L. tubers is able to inhibit 89.01% of the biofilm formation of Staphylococcus aureus on the concentration of 0.09% (v/v).
Profil Terapi Diare Akut pada Pasien Anak Rawat Inap di Rumah Sakit Bhayangkara Surabaya Sandra, Pipit; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2184

Abstract

Acute diarrhea in children is defined as defecation more than 3 times per day, with changes in the consistency of feces into fluids with or without mucus and blood lasting either less than a week or up to 14 days, but not more than 14 days in children or infant. Treatment of acute diarrhea can shorten the duration of diarrhea and eradicate the organism which causes the disease. The purpose of this research was to analyze the profile of acute diarrhea treatment in hospitalized pediatric patients at Bhayangkara Hospital Surabaya including the type, dosage, route and the timing of administration which is related to the patient’s medical record data. This research is an observational study in the form of retrospective study in patients with acute diarrhea with a t o t a l sampling technique. The results showed the most commonly used medications for acute diarrhea in children were parenteral rehydration fluid of KDN-1 of (41 patients, 80%) with the most widely used dose (500 cc / 4 hours → 1000 cc / 24 h) IV, t h e pa t t e r n o f single antibiotic use was (43 patients, 84%), the penicillin group, ampicillin, as many as (22 patients, 44%) with the most widely used dose (4 x 250 mg) IV, the most commonly prescribed single antibiotic when discharged from the hospital was cephalosporin group, cefixime, with 17 patients (33%), with the most widely used dose (2 x 20 mg) P.O, sinbiotic with (36 patients, 70%) and the most widely used was dose (1 x 1 sachet) P.O, zinc with (49 patients, 96%) and the most widely used was dose (1 x 1 cth) P.O, vitamin A with (21 patients, 41%), and the most widely used was dose (1 x 500 IU) P.O, antidiarrhea dioctahedral smectite was (43 patients, 84%) and the most commonly used was dose (3 x 1/3 sachets) P.O.
Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya Bura, Ursula Dua Klowe; Hasmono, Didik; Surdijati, Siti; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2185

Abstract

Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of ≤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patient’s blood pressure mostly meets the target of ≤ 140 mmHg.
Optimasi Formula Tablet Ekstrak Kering Daun Jati Belanda Menggunakan Kombinasi Starch 1500 sebagai Pengikat dan Crospovidone sebagai Penghancur Gunawan, Indra; Darsono, Farida Lanawati; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2186

Abstract

Bastard cedar leaves (Guazuma ulmifolia L.) can lower cholesterol level on blood. Tannins and musilago are the components in bastar cedar leaves that play a role in lowering cholesterol. The purpose of this study was to determine the effect of starch 1500, crospovidone and its interaction on the physical quality of tablets. Tablets were made using wet granulation method. Optimization of tablet formulation consists of two factors. The first factor is the Starch 1500 which is used as a binder with the level (+1) that is 3% and the level (-1) that is 1.5%, and the second factor is the crospovidone used as disintegrant with the level (+1) that is 5% (-1) that is 2%. The response used is tablet hardness, fragility, and time of disintegration. The results of this study indicate that starch 1500 can increase the hardness, but can prolong the disintegration time of the tablet and can decrease the tablet fragility, while crospovidone can decrease the hardness, increase the fragility, and accelerated tablet disintegration time. The interaction of these two factors has a significant effect on tablet hardness, fragility and time of disintegration. The optimum formula was obtained with the combination of Starch 1500 2.22% and crospovidone 3.54% with estimated result of physical hardness test quality of 5.2Kgf; Fragility 0.643%; and disintegration time 11.54 minutes.
Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun dandang Gendis (Clinacanthus nutans) Wijaya, Sumi; Setiawan, Henry Kurnia; Purnama, Veronica Bella
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 2 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i2.2224

Abstract

Standardization of natural materials is needed as an effort to improve the quality and safety of products that are expected to further increase trust in medicines derived from natural ingredients. Snake grass leaf has several pharmacological activities including antioxidants, anticancer, anti-inflammatory, analgesic, enhancing the immune system, antibacterial, antivenom, even there are also uses in the cosmetics field. In this study macroscopic and microscopic observation of Snake grass leaves and determination of specific and non-specific standardization on ethanol extracts of Snake grass leaves have been done. The parameters tested on Snake grass leaf extract include the identity of the extract, organoleptic, ethanol soluble extract, water soluble extract, phytochemical screening, chromatogram profile using TLC, spectrum profile using UV-Vis spectrophotometer, spectrum profile using IR (infrared)spectrophotometer, determination of secondary metabolite content, total ash content, water soluble ash content, acid insoluble ash content, water content, pH, and specific gravity. The results showed the characteristics of ethanol extract of Snake grass leaf in the form of green-black extract, aromatic distinctive odor; ethanol soluble extract content> 54%; water soluble extract content> 37%; phytochemical screening results showed the presence of alkaloid compounds, flavonoids, polyphenols, saponins, steroids and terpenoids; the results of IR spectrophotometer analysis show spectrum profiles in the range wave of numbers 3325-3351 cm-1, 2924-2919 cm-1, 1622 -1633 cm-1, 1341-1345 cm-1 and 1020-1047 cm-1; total phenol levels> 0.16%; total flavonoid levels> 0.11%; total alkaloid levels> 0.03%; water content

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