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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : https://doi.org/10.33508/jfst
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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year in March and October, containing research articles, review and short communication in the pharmacy science field, including medicinal chemistry, analytical chemistry, biological pharmacy, pharmaceutical sciences, and clinical pharmacy researches; the practice of pharmacy in industry, clinic and community, such as pharmacies, distributors and pharmacy education.
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Articles 172 Documents
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Optimasi Formula Tablet Floating Metformin Hidroklorida Menggunakan Polimer Guar Gum Elim, Siska; Hadisoewignyo, Lannie; Sukarti, Emi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2345

Abstract

Metformln hydrochloride Is an orally administered blguanlde derivative drug and functions as an anti hyperglycemic In patient with type 2 diabetes mellitus with bioavallablllty between 50-6096. Floating system Is the one method to enhance absorption and bioavallablllty of metformln hydrochloride. The purpose of this research was to determine the effect of guar gum concentration and concentration effervescent components and Interactions of both components on physical properties of tablets, floating lag time, floating time, and dissolution rate constant and get the optimum formula with drug release pattern according to zero order kinetics. In this research using factorial design with two factors Is concentrations factor of guar gum at 15-2096 and concentrations factor of effervescent components Is citric acid and sodium bicarbonate (1:1) at 5-1096. The method used Is direct compression method. Concentration of guar gum have a significant effect on floating lag time and dissolution rate constant but do not have a significant effect on tablet hardness. While the concentration of effervescent components not have a significant effect on tablet hardness and dissolution rate constant but a significant effect on floating lag time. Interaction between guar gum concentration and concentration effervescent components not have a significant effect on tablet hardness, floating lag time, and dissolution rate constant Based on Design - Expert program optimization, the optimum formula obtained Is formula with combination 19,596 guar gum concentration and 5,596 concentration effervescent components which resulting 11,43 Kp hardness, floating lag time 8,69 min and K dissolution 0,324 mUmln.
Fraksinasi dan Identifikasi SenyawaAntioksidan pada Eksb-ak Etanol buah Goji beny(Lycium barbarum linn.) secaraKromatografi Kolom Albrian, Diga; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2346

Abstract

Goji berry fruit (Lycium barbarum), familia Solanac'eae, is a red berry fruit. The chemical compounds contained in this fruit are polysaccharides, zeaxanthin and beta-carotene. Activity of the chemical compounds is still considered as a family of antioxidant compounds, which are used as a medicine to cure the diseases caused by the presence of free radicals such a~ atherosclerosis, cancer, liver cirrhosis, hypertension and diabetes. The research will be carried on fractionation and identification of the ethanol extract of Goji berry fruit to obtain compounds that have antioxidant power using chromatographic column method and DPPH method. The isolated compounds will be identified using methods phytochemica/s screening, TLC, UV-Vis spectrophotometer and infrared spectrophotometer. The result showed that secondary metabolites of Goji berry fruit which are potential as antioxidant compound were flavonoid (flavono/s or flavones). The isolated compound had higher antioxidant activity compare to the ethanol extract of Goji berry fruit Flavonoids are the major compounds that have antioxidant capacity. Whereas, the ethanol fraction of Goji berry fruits has the best antioxidant activity than the ethanol extract Keywords: Antioxidant, Goji berry, DPPH and chromatographic column
Uji Kestabilan Fisik Krim Tabir Surya Ekstrak Etanol Biji Jintan Hitam (Nigella sativa L.) Subaidah, Windah Anugrah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 2 (2020): Oktober
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2363

Abstract

Jintan hitam (Nigella sativa L.) diketahui memiliki kandungan flavanoid yang dapat menangkal radikal bebas karena adanya gugus kromofor (ikatan rangkap terkonjugasi). Gugus kromofor pada falavonoid dalam jintan hitam (Nigella sativa L.) mampu menyerap radiasi sinar UVA dan UVB. Penelitian ini bertujuan untuk mengetahui kestabilan fisik krim tabir surya ekstrak etanol biji jintan hitam (Nigella sativa L) dengan variasi emulgator polisorbat 60 dan sorbitan 60 setelah penyimpanan dipercepat. Ekstrak biji jintan hitam (Nigella sativa L) yang diperoleh dengan metode maserasi menggunakan pelarut etanol 70%. Aktivitas tabir surya ekstrak biji jintan hitam (Nigella sativa L) ditentukan dengan mengukur nilai persen transmisi eritema (%Te) dan nilai persen transmisi pigmentasi (%Tp) menggunakan spektrofotometer UV. Ekstrak biji jintan hitam (Nigella sativa L) diformulasikan kedalam sediaan krim kemudian di evaluasi sifat fisik sebelum dan sesudah penyimpanan dipercepat. Hasil penelitian menunjukkan Ekstrak biji jintan hitam (Nigella sativa L.) masuk kedalam kategori sunblock dengan nilai transmisi eritema sebesar 0,5707% dan nilai transmisi pigmentasi sebesar 0,7074%. Ekstrak biji jintan hitam (Nigella sativa L.) yang diformulasikan kedalam sediaan krim dengan variasi emulgator polisorbat 60 dan sorbitan 60 setelah penyimpanan dipercepat tidak mengalami perubahan organoleptis, homogenitas dan tipe emulsi. Perubahan terjadi pada viskositas dan pH sediaan krim.
Formulasi Pasta Gigi Ekstrak Etanolik Herba Ashitaba (Angelica keiskei) Juliantoni, Yohanes; Subaidah, Windah Anugrah; Wirasisya, Dyke Gita
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 2 (2020): Oktober
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2365

Abstract

Ashitaba (Angelica keiskei) memiliki khasiat sebagai antibakteri Streptococcus aureus mutans yang merupakan penyebab karies gigi. Pasta gigi merupakan salah satu bentuk sediaan untuk pembersih gigi. Penelitian ini dilakukan untuk membuat formulasi ekstrak herba ashitaba dalam bentuk pasta gigi. Metode maserasi digunakan untuk mengekstraksi ashitaba dengan larutan penyari etanol 96%. Pasta gigi dibuat dengan tiga variasi konsentrasi dari karbopol 940 secara berurutan yaitu 1% (formulasi I), 2% (formulasi II), dan 3% (formulasi III). Parameter uji formula pasta gigi meliputi pH, homogenitas, tinggi busa, dan uji hedonik. Rendemen ekstrak etanol ashitaba diperoleh sebesar 18,13%. Hasil uji sifat fisik tiga sediaan pasta gigi menunjukkan bahwa ketiga formula homogen, memenuhi syarat pH, dan Formula II memiliki nilai respon kesukaan yang paling baik.
Validasi Metode Identifikasi Sildenafil Sitrat, Tadalafil dan Fenilbutazon dalam Jamu Obat Kuat Secara Kromatografi Lapis Tipis – Densitometri Setiawan, Henry Kurnia; Kahar, Neysa Marcella; Stephanie, Stephanie; Sukarti, Emi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2389

Abstract

Jamu/Herbal Medicine that contain chemical compounds/Pharmaceutical compounds has been banned by The National Agency of Drug and Food Control in Indonesia, but in December 2017, BPOM released a public warning about aphrodisiac herbal medicine that contain chemical compound like sildenafil citrate and phenylbutazone in the market. The aim of this study was to find out the valid method for identification of sildenafil citrate and phenylbutazone in aphrodisiac herbal medicine. In this study, the developed method was applied to 22 brands of aphrodisiac herbal medicine sample. Sample was extracted with methanol, then 5 µl of sample spotted on silica gel plate 60 F 254 and eluated by chloroform : methanol : amonia (70 : 3 : 1.5, v/v/v). The spots were analyzed by TLC scanner at λ 286 nm. Sildenafil citrate was appeared at Rf 0.76; tadalafil at 0.6 and phenylbutazone at Rf 0.12 with resolution (Rs) value of sildenafil and tadalafil was 1.1 meanwhile tadalafil and phenylbutazone was 5.4. Limit of detection of sildenafil citrate was 8.552 µg/ml (2.053 mg/600 mg capsul), tadalafil was 1.629 µg/ml (0.391 mg/600 mg capsul), and phenylbutazone was 7.877 µg/ml (1.890 mg/600 mg capsul). This study found 14 brands that gave a positive result containing sildenafil citrate and no sample contain tadalafil and phenylbutazone.
Efektivitas dan Keamanan Furosemid Continuous Infusion Dosis 10 dan 20 mg/jam pada Pasien Penyakit Ginjal Kronik Kondisi Fluid Overload Syndrome disertai Hipoalbumin di RSUD Abdul Wahab Sjahranie Setiadi, Diga Albrian; Widyati, Widyati; Yakti, Kuntjoro
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2390

Abstract

Furosemide continuous infusion is the first choice drug in overcoming the condition of Fluid overload syndrome with hypoalbuminemia in patients with Chronic Kidney Disease (CKD). However, in these conditions, the dose of furosemide used by clinicians is between 10 and 20 mg/hour. No studies have compared the effectiveness and safety of different doses of furosemide. This study aimed to evaluate the effectiveness and safety of 10 and 20 mg/hour furosemide given in continuous infusion in CKD patients with fluid overload syndrome with hypoalbuminemia. The method is a Single-blind, Randomized Clinical Trial conducted during the period of February-April 2017 in the inpatient ward of Abdul Wahab Sjahranie Hospital. Data processing was carried out by statistical analysis, Two Independent T-Test parametric test for data that normally distributed and those that did not correlate with each other, whereas for data that not normally distributed and those that did not correlate with each other, non-parametric test Mann Whitney and Wilcoxon were used. Outcomes studies were 24-hour urine volume, shortness of breath, duration of oxygen consumption, Ronchi and safety of therapy seen from drug side effects (hypotension, hyperuricemia, hyperglycemia, hyponatremia, hypokalemia). The results of the study, 34 patients with CKD with fluid overload syndrome with hypoalbuminemia (2.5-3.0 g/dL) were registered. On the effectiveness of therapy, there was no significant difference in 24-hour urine volume (P = 0.324; P> 0.05; 95%; CI=714.6-1017.8 ml group 1; CI=818.0-1113.2 ml group 2), shortness of breath (P = 0.781; P> 0.05; 95 % CI=0.68-1.32 group 1; CI=0.72-1.40 group 2), duration of oxygen use (P = 0.363; P> 0.05; 95% CI=1.34-2.66 day group 1; CI=1.72-3.10 day group 2), Ronk (P = 0.692; P> 0.05 ) and the absence of drug adverse events (P = 1.000; P> 0.05) between the two groups. In conclusion, the dose of 10 and 20 mg/hour furosemide has the same
Skrining Senyawa Antibakteri dari Minyak Atsiri Rimpang Temu Kunci (Boesenbergia pandurata) terhadap Staphylococcus aureus dengan Metode Bioautografi Kontak Christiana, Indah; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2391

Abstract

Fingerroot are generally used as a remedy for rheumatism, gastroenteritis, mucositis, diuretic, malaria, bowel disorders, flatulence, skin diseases, diarrhea, mouth sores, and intestinal worms. Essential oils found in Fingerroot are generally used as antibacterial. The purpose of this study is to determine the antibacterial activity of Fingerroot essential oils against Staphylococcus aureus and to determine the antibacterial compound of Fingerroot essential oils (Boesenbergia pandurata) using contact biautography methods. Fingerroot essential oil was obtained by the Stahl distillation method. Determination of the class of efficacious compounds was carried out by contact bioautography method and anisaldehyde-sulfuric acid and vanillin sulfate were used as spray reagent. The Fingerroot essential oil yields 0.38% and monoterpenes was determined as an antibacterial agent against Staphylococcus aureus.
Studi Penggunaan Kombinasi Obat Fenitoin dan Natrium Valproat terhadap Serum Magnesium dan Jumlah Kejang pada Pasien Epilepsi di RSUD DR. Soetomo Sambono, Vonneth Glorya; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2392

Abstract

Epilepsy is a clinical condition that is recognized by the pattern of seizures ranging from neurological development status according to age, history of seizures, and prognosis. Clinical research in humans and animals shows that magnesium deficiency can cause seizures. Drug therapy in epilepsy patients can be done by monotherapy and polytherapy. The combination of phenytoin and sodium valproate can be used as a polytherapy. The purpose of this study was to describe the serum magnesium levels and the number of seizures in epilepsy patients who received phenytoin and sodium valproate using a descriptive method prospectively. The parameters used are the conditions of the patient while receiving treatment. Ten epilepsy patients which treated with combination therapy of phenytoin and sodium valproate were used for this research.The results showed that the highest dose used in polytherapy was phenytoin 500 mg and sodium valproate 500 mg 2 x 1 po. The highest normal magnesium level was 2.21 mg / dL (10%). The highest number of seizures was 7 times a month (10%) and no adverse drug interactions occured. Phenytoin and sodium valproate therapy can minimize the number of seizures but do not affect the patient's magnesium level.
Studi Penggunaan Carboplatin untuk Penderita Kanker Payudara di RUMKITAL Dr. Ramelan Surabaya Giovani, Alfin; Hasmono, Didik; Surdijati, Siti; Semedi, Joko
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2393

Abstract

Cancer is an abnormal growth of new cells that grow beyond normal limits. Cancer can metastasize by attacking parts of the body and spread to other organs. The prevalence of cancer Indonesian’s people in 2013 is estimated at 347,792. Breast cancer is the most common cancer in women with a percentage of 23%. Breast cancer is the second most common cancer with death after cervical cancer. Breast cancer is divided according to histologic subtype to Ductal Carcinoma in Situ (DCIS) and Lobular Carcinoma in Situ (LCIS). Carboplatin is a platinum analog cancer drug that belongs to the class of antineoplastic agents. Carboplatin doses used in AUC 6 (i.v) breast cancer chemotherapy for 1 cycle with 21 days to 6 cycle times. This research was conducted observasional with descriptive research design and retrospective data retrieval. The purpose of this study was to know the profile of carboplatin as an anti-cancer drug that is expected to provide safe treatment. This research was conducted at Dr. RUMKITAL Ramelan Surabaya with the number of inclusion of 30 patients in the period January 1, 2017 - December 31, 2017. From the results of this study obtained the use of single carboplatin as much as 7% and a combination of 93%. Patients with chemotherapy administered without surgery and surgery were 73% and 27%, respectively. Toxicity of nausea and vomiting happen as much as 42% and pain as much as 19%.
Standarisasi Simplisia Daun Ekor Kucing (Acalypha hispida Burm.f.) dari Tiga Daerah Berbeda Bay, Wilhelmina Walu; Hermanu, Liliek S.; Sinansari, Restry
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2394

Abstract

The fox tail (Acalypha hispida) is known for its many benefits and has been used in traditional medicine. This aim of this research was determining the profile of specific and non specific standardization of fox tail leaves from three different areas (Batu, Bogor and West Sumba). The specific parameters consist of identity, organoleptic, microscopic, water soluble extract, ethanol soluble extract, phytochemical screening, chromatogram profile determination by thin layer chromatography (TLC), determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of secondary metabolite content (phenol and flavonoid). Non spesific parameters include shrinkage drying, ash content, acid insoluble ash, water soluble ash, percent foreign material and pH measurement. The result of standardization of dried powder fox tail leaves, have value of soluble ethanol extract ˃ 14%, water soluble extract ˃ 23%, contain flavonoids compounds, polyphenols, tannins, quinones and triterpenoids, total flavonoid levels > 0.2% and phenol > 0.7%, pectrophotometry IR result showed the presence of O-H, C-H, C = C and C-C groups, total ash content < 15.5%, acid insoluble ash < 2.5%, water soluble ash < 5.5%, drying shrinkage level < 10% and pH 4.5-5.

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