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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 822 Documents
 38   39   40   41   42 
LUAS DEFEK MENINGOKEL BERHUBUNGAN DENGAN KADAR TRANSFORMING GROWTH FACTOR β1 (TGF-β1)DAN INSULINE-LIKE GROWTH FACTOR-1 (IGF-1) DALAM TULANG E.S., Moch. Istiadjid
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.775 KB) | DOI: 10.21776/ub.jkb.2004.020.03.4

Abstract

Meningocele pathogenesis is based on skull defect that occurs since the first three month of fertilization period. Through that defect, mening, cerebrospinal liquid, and cerebral parenchym is protruded. Meningocele can cause by folic aciddeficiency that had proved correlation with TGF-β1 and IGF-I level, both in maternal blood or baby rat’s skull. Folic acid deficiency also causes increasing the number of apoptosis and necrosis cells death in baby’s skull. TGF-β1 and IGF-I one growth factors thatstimulate bone synthesis. The purpose of this study is to explore the correlationbetween TGF-β1 and IGF-I level in skull on side defect of meningocele patients and the wide of skull defect to obtain the role of the  two growth factors in meningocele teratogenesis perspectively. Eight meningocele patients that were performed excision by standard procedure have taken a few of bone speciment on sidedefect to count TGF-β1 and IGF-I levels with immunochemistry technic. Wide defect was determined by measuring defect’s diameter, using Martin anthropometer. The correlation between TGF-β1 and IGF-I skull level and defect’s wide was analyzed by SEM (structuralequation modeling) statistic. There was significant negative-correlation between that variable, that mean the lower of the two growth factors level is wider of skull defect. TGF-β1: r = -0.648, p =0.009; IGF-I: r = -0.426, p =0.025. Key words:Meningoencephalocele, Skull defect, TGF-β1, IGF-I.
Laporan Kasus: Tatalaksana Anestesi Penyakit Hirschsprung dengan Sindrom Aspirasi Mekoneum dan Pneumomediastinum pada Neonatus Yupono, Karmini; Hartono, Ruddi
Jurnal Kedokteran Brawijaya Vol 25, No 3 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.581 KB) | DOI: 10.21776/ub.jkb.2009.025.03.9

Abstract

We report  one female  newborn baby suffered from  moderate asphyxia, meconium aspiration syndrome, and Hirschsprung  disease.  The  patient  admitted  in  Neonatal  Intensive  Care  Unit  (NICU)  and  ventilated  with Pressure Controlled Mandatory Ventilation (PCMV)  mode ventilator.  Patient suffered from  pneumodiastinum and therefore  mediastinotomy was performed. Sepsis and Necrotizing Enterocolitis (NEC)  made the  case more  complicated.  On  further  examination,  abdominal  was  distended  and  perforated  and  therefore  we decided  to  perform  exploration  laparatomy  and  sigmoidoctomy .  Anaesthesia  management  with  general anaesthesia  had  been  performed.  Premedication  was  not  given.  We  used  oxygen  and  Sevofluran  for induction;  Oxygen, Sevofluran, Atracurium, Fentanyl,  and  Morphin for  maintenance; and  Morphin for  post operative analgesic. On follow up examination, we found wound disruption and therefore relaparotomy was performed.  T ypes  and  doses  of  anesthesia  drugs  were  chosen  according  to  newborn  immature  organ  noticely . Providing adequate oxygenation, preventing hypotermi, and balancing electrolytes and acid base states still be the  most considerations in  management of this  patient.  Anesthetic management and intensive  care of this patient  gained  a  satisfying  outcome.  The  prognosis  was  good. Keywords:  Hirschsprung  disease,  meconium  aspiration  syndrome,  pneumomediastinum,  sepsis,  NEC.
Polifenol Buah Tin (Ficus carica Linn) Menghambat Peningkatan Kadar MCP-1 pada Tikus dengan Diet Tinggi Lemak Lukitasari, Noorma; Ratnawati, Retty; Lyrawati, Diana
Jurnal Kedokteran Brawijaya Vol 28, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (605.893 KB) | DOI: 10.21776/ub.jkb.2014.028.01.1

Abstract

Diantara beberapa jalur patogenesa terjadinya aterosklerosis, salah satu mekanismenya disebabkan karena stres oksidatif yang disebabkan ketidakseimbangan antara oksidan dan antioksidan. Buah tin (Ficus carica Linn) mengandung polifenol yang berfungsi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui apakah pemberian polifenol buah tin dapat mencegah aterosklerosis melalui penghambatan peningkatan kadar MCP-1 serum. Penelitian menggunakan desain Post test only, dimana 25 ekor sampel tikus galur Wistar jantan dibagi dalam 5 kelompok dan diberi perlakuan selama 65 hari. Kelompok 1-5 merupakan secara berurutan merupakan kelompok kontrol negatif (diet normal), kontrol positif (diet tinggi lemak), dosis A (diet tinggi lemak+polifenol buah tin 4,5 mg/hari), dosis B (diet tinggi lemak + polifenol buah tin 9 mg/hari) dan dosis C (diet tinggi lemak + polifenol buah tin 18 mg/hari). Hasil penelitian menunjukkan bahwa kadar MCP-1serum pada kelompok kontrol positif meningkat sebesar 1,21% dibanding kelompok kontrol negatif. Pemberian polifenol buah tin pada dosis 9 mg/hari menurunkan kadar MCP-1 sebesar 0,88% dibanding dengan kelompok yang diberi diet tinggi lemak (p=0,000),  dan pada dosis 18 mg/hari kadar MCP-1 sudah kembali normal. Dapat disimpulkan bahwa pemberian polifenol buah tin mampu menghambat peningkatan kadar MCP-1 serum tikus Wistar yang diberi diet tinggi lemak secara bermakna, dengan hasil maksimal pada dosis 18 mg/hari.Kata Kunci: Aterosklerosis, ficus carica, MCP-1 serum, polifenol
Combined Food (Bekatul dan Lemak) Menurunkan Kadar Kolesterol Total, Trigliserida, dan LDL pada Tikus Galur Wistar Jufri, Nur Nashriana; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2015.028.03.8

Abstract

Bekatul merupakan bahan pangan nabati yang berpotensi menurunkan kolesterol karena kandungan serat pangan yang tinggi dan komponen bioaktif seperti oryzanol, fitosterol dan tokoferol serta tokotrienol. Tujuan penelitian ini adalah untuk menganalisis efek pemberian diet komibnasi bekatul dan tinggi kolesterol terhadap kadar kolesterol total, trigliserida dan LDL pada tikus galur wistar. Penelitian ini merupakan penelitian eksperimen dengan rancangan randomized post test only control group design. Dalam penelitian ini 25 ekor tikus galur wistar dibagi menjadi 5 kelompok secara acak diberi perlakuan selama 4 minggu. Kelompok (K-) diberi diet standar,  (K+) diberi diet standar dan tinggi kolesterol, (P1) diberi diet standar, tinggi kolesterol dan bekatul 10%, (P2) diberi diet standar, tinggi kolesterol dan bekatul 30%, (P3) diberi diet standar, tinggi kolesterol dan bekatul 50%. Kadar kolesterol total diukur menggunakan metode CHOD-PAP, trigliserida menggunakan metode GPO-PAP dan LDL menggunakan metode homogen assay. Data dianalisis menggunakan One Way ANOVA dan Tukey HSD. Pemberian bekatul dan diet tinggi kolesterol secara bersamaan memberikan kadar kolesterol total (p=0,000), trigliserida (p=0,001), dan LDL (p=0,048) yang lebih rendah secara bermakna dibandingkan kondisi diet hiperkolesterol. Dosis bekatul sebesar 50% (P3) memberikan penurunan bermakna kadar kolesterol, trigliserida dan LDL hingga sama dengan kondisi normal. Pemberian bekatul dan diet tinggi kolesterol secara bersamaan dapat menurunkan kadar kolesterol total, trigliserida dan LDL pada tikus galur wistar dengan dosis efektif 50%.Kata Kunci: Bekatul, combined food,  kolesterol total, LDL, trigliserida
Ekstrak Daging Putih Semangka (Citrulus vulgaris) Menurunkan Kolesterol Total dan Aktivitas Hidroksi-Metilglutaril-KoA Reduktase Tikus Hiperkolesterolemia Djala, Fany Lairin; Lyrawati, Diana; Soeharto, Setyawati
Jurnal Kedokteran Brawijaya Vol 29, No. 2 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2016.029.02.2

Abstract

Penelitian ini bertujuan untuk mengetahui apakah ekstrak daging putih semangka mempengaruhi profil lipid dan memiliki efek hambatan terhadap HMG-KoA reduktase. Pada penelitian ini digunakan 4 kelompok Rattus norvegicus Wistar jantan dengan diet tinggi kolesterol sebagai model hiperkolesterolemia, yaitu (1) tanpa ekstrak, (2) dengan ekstrak daging putih semangka 250, atau (3) 500mg/kgBb/hari, (4) simvastatin 0,9mg/kgBb/hari, dan 1 kelompok tikus diet normal. Profil lipid dianalisis menggunakan metode Cholesterol Peroxidase-Phenol Quinoneimine (CHOD-PAP), sedangkan aktivitas HMG-KoA reduktase dianalisis secara spektrofotometri. Hasil penelitian menunjukkan bahwa pada tikus hiperkolesterolemia ekstrak daging putih semangka ekivalen dengan simvastatin dalam menurunkan kadar kolesterol total (p=0,038), meningkatkan kadar HDL (p=0,021) dan menghambat aktivitas HMG-KoA reduktase (p=0,012). Hal ini menunjukkan bahwa ekstrak daging putih semangka 250 atau 500 mg/kgBb/hari dapat dikembangkan sebagai antihiperlipidemia.Kata Kunci: Aktivitas HMG-KoA reduktase, hiperkolesterolemia, profil lipid, semangka
Ekstrak Etanol Buah Semangka (Citrullus lanatus) sebagai Antiinflamasi melalui Pengamatan Tebal Epitel Duodenum Mencit BALB/c Makiyah, Sri Nabawiyati Nurul; Arifah, Rizka Ulfatin
Jurnal Kedokteran Brawijaya Vol 30, No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2018.030.01.5

Abstract

Buah semangka (Citrullus lanatus) mengandung senyawa flavonoid. Flavonoid bermanfaat sebagai agen antiinflamasi. Potensi antiinflamasi ekstrak etanol buah C. lanatus terhadap ketebalan epitel duodenum mencit BALB/c belum pernah diteliti. Penelitian ini bertujuan untuk mengetahui perubahan ketebalan epitel duodenum mencit BALB/c diinduksi ovalbumin setelah pemberian ekstrak etanol buah Citrullus lanatus (EECL). Jenis penelitian ini adalah eksperimental in vivo pada hewan uji dengan posttest only control group design. Tiga puluh ekor mencit BALB/c jantan dibagi enam kelompok. Kelompok kontrol (normal, negatif, metilprednisolon) dan kelompok perlakuan EECL dosis 175mg/kg bb, 350mg/kg bb, dan 700mg/kgbb. Perlakuan EECL dan metilprednisolon diberikan selama 28 hari berturut-turut. Ovalbumin diberikan secara intraperitoneal pada hari peroral ke-15 dan ke-22 dan hari ke-23 hingga ke-28. Pada hari ke-29, mencit dikorbankan dan duodenum dibuat preparat histologi dengan teknik pewarnaan Hematoxylin Eosin. Efek antiinflamasi EECL dinilai dari tebal epitel duodenum. Data tebal epitel duodenum dianalisis menggunakan one-way ANOVA dilanjutkan uji Tukey. Hasil penelitian menunjukkan tebal epitel duodenum tertinggi adalah kelompok kontrol normal 20,02±3,50µm dan kelompok kontrol negatif memiliki tebal epitel duodenum terendah 15,98±3,22µm. Pemberian EECL dosis 175, 350, dan 700mg/kg bb serta metilprednisolon meningkatkan tebal epitel duodenum secara bermakna (p<0,05). Tebal epitel duodenum kelompok perlakuan EECL dosis 350mg/kg bb tidak berbeda bermakna (p>0,05) dengan tebal epitel duodenum kelompok kontrol normal dan kelompok metilprednisolon. Disimpulkan bahwa ekstrak etanol buah Citrullus lanatus mampu meningkatkan ketebalan epitel duodenum BALB/c diinduksi ovalbumin dengan dosis efektif EECL 350mg/kg bb sehingga berpotensi sebagai agen antiinflamasi.
Rosuvastatin Attenuated Elastic Fiber Degradation in Chronic Obstructive Pulmonary Disease Sprague-Dawley Rats Sabirin, Rahmaningsih Mara; -, Prasetyastuti; Agustiningsih, Denny
Jurnal Kedokteran Brawijaya Vol 30, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (533.817 KB) | DOI: 10.21776/ub.jkb.2019.030.03.2

Abstract

Chronic obstructive pulmonary disease (COPD) is an incurable disease which causes disability and death. The main pathogenesis of COPD is oxidative stress due to cigarette smoke which initiates various reactions and lead to lung elastic fibers destruction. Statins are known to have antioxidant effects and reduce mortality in COPD. We studied the effects of cigarette smoke exposure cessation and rosuvastatin on oxidative stress and the level of elastic fiber destruction in COPD model rats. Thirty 10-week old male Sprague-Dawley rats were divided into 2 groups: Control (n=6, did not received fumigation nor treatment) and Smoking (n=24, received fumigation for 70 days) groups. Afterwards, the smoking group was divided into 4 groups: Sham, R2, R5,R10, and received 0.9% NaCl, 2.5, 5 and 10 mg/kg/day of rosuvastatin, respectively. Examination of malondialdehyde (MDA) and desmosine serum were conducted to measure oxidative stress and elastic fiber degradation level, respectively. After smoke exposure, MDA and desmosine levels of COPD rats were found to be significantly higher (p=0.000 and 0.000) than controls. The MDA level in Sham, R2, R5 and R10 groups decreased significantly after therapy (p=0.000; 0.033; 0.015; 0.002). However, the post-treatment desmosine level was increase significantly in Sham and R2 groups (p=0.006 dan 0.012) and insignificantly (p=0.117 dan 0.278) in the R5 and R10 groups. It can be concluded that the cessation of exposure to cigarette smoke can reduce oxidative stress, but not elastic degradation process. The administration of rosuvastatin of 5 or 10 mg/kg/day attenuated elastic degradation process.
Kemampuan Whole Cell Helicobacter pylori dalam Menginduksi Degradasi Kolagen Tipe IV Melalui Peningkatan Aktivitas Makrofag Peristiowati, Yuly; Sumarno, Sumarno; Muliarta, I Ketut Gede; Murwani, Murwani
Jurnal Kedokteran Brawijaya Vol 26, No 1 (2010)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1126.587 KB) | DOI: 10.21776/ub.jkb.2010.026.01.4

Abstract

ABSTRAKHelicobacter pylori  berperan dalam infark miokard  akut dan penyakit jantung koroner.  Sitotoksin H.pylori  dapat menginduksi sitokin inflamasi IL1-β dan TNFα yang mengaktivasi enzim proteolitik MMP-9 dan menyebabkan degradasi kolagen melalui plak aterosklerosis. Penelitian ini dilakukan untuk membuktikan kemampuan whole cell H.pylori dalam menginduksi degadrasi kolagen tipe IV melalui peningkatan aktifitas makrofag. Aktivitas makrofag dilihat dari kadar TNFα dan IL1-β yang diukur dengan metode Elisa. Hasil uji ANOVA mengindikasikan perbedaan signifikan (p<0,001) aktifitas makrofag pada kelompok normal dan whole cell H.pylori. Produksi enzim MMP-9 dapat dideteksi melalui gelatine zymography dilanjutkan dengan western blotting pada berat molekul 93 kDa. Fragmenliasi kolagen didapatkan pada fragmen 61,2 kDa  dan 29 kDa. Dapat disimpulkan bahwa H.pylori dapat menginduksi degradasi kolagen tipe IV melalui peningkatan makrofag. Temuan ini juga mendukung patomekanisme infark miokard.Kata Kunci : Kolagen Tipe IV, makrofag, whole cell H.pylori
HUBUNGAN ANTARA PENINGKATAN KADAR LEKOTRIEN B4 (LTB-4) DENGAN HIPOSELULARITAS SUMSUM TULANG (PENELITIAN PADA ASPIRAT SUMSUM TULANG) Widjajanto, Edi
Jurnal Kedokteran Brawijaya Vol 21, No 2 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2005.021.02.2

Abstract

ABSTRACT Previous study on human bone marrow culture showed that leukotrien B-4 (LTB-4) which was added to granulocyte-macrophage and erytroid colony, suppressed the growth of colonies. This study assessed the correlation between LTB-4 and marrow cellular. Marrow aspirate which was taken from 60 adult patients (26 men and 34 women) suffering from various haematopoietic problems was examined for amount of LTB-4 and the degree of marrow cellular. ELISA principle was applied for LTB-4 measurement and marrow cellular assessed by counting the member of nucleated cells per cubic-mm of marrow aspirate using microscopic counting chamber principle. Existing difference of the strength of correlation of LTB-4  and  marrow  cellular  was  analized  using  manova and  path  analysis  and  expressed  as  path  coefficient.The difference of confounding factors such as gender, age and type of diseases (haematopoitic problems) were controlled and homogenized during statistical analysis using SPSS 10 program. Path coefficient in the multi cellular marrow (n = 60) was – 0.092 (p = 0.495) and path coefficient in hypo cellular marrow (n = 28) was – 0.406 (p = 0.013). This study concludes that the increase of amount of LTB-4 in hypo cellular marrow is associated with the decrease of marrow cellular. Keywords : Leukotrien B-4, Hypocelular marraw, Apoptosis, Hematopoisis
THEAFLAVIN MENGHAMBAT DIFERENSIASI PREADIPOSIT VISERAL MANUSIA MELALUI PPARγ γγ γSECARA IN VITRO Indra, Rasjad
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (964.975 KB) | DOI: 10.21776/ub.jkb.2007.023.01.3

Abstract

Differentiation of pre-adipocytes into adipocytes, is a complex process that involves coordination of  expression of specific genes and proteins associated with each stage of differentiation. This process is regulated by several signaling pathways. CCAAT element-binding proteins (C/EBP)  αand  βand sterol response element-binding protein 1 (ADD1/SREBP1) are active during the early stages of the differentiation process and induce the expression and/or activity of the peroxisome proliferator-activated receptor  γ(PPARγ), a pivotal coordinator of adipocyte differentiation. Recently, many biological effects of black tea have been reported and these effects may be partially related to its antioxidant  properties. The recent study showed that black tea flavonoids inhibited adipocyte differentiation. The aim of this study was to investigate the role of theaflavin, a flavonoids in black tea, in inhibiting adipocyte differentiation through inhibition of PPARγexpression. Preadipocytes were incubated in media containing standard-differentiated stimulator: Insulin, dexamethasone, IBMX and FBS. After 24 hours, preadipocytes culture media wasadded with theaflavin 50, 100, or 200  µM. The cells were harvested after TF incubation for 24 hours and then the expression of PPARγwas identified by immunocytochemistry and Western blot.

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